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中国儿童特应性皮炎的疾病经济负担与医疗资源利用情况

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Journal of Chinese Pharmaceutical Sciences 2024年第5期33卷 458-469页

作者：聂智峰肖若薇宋佳芳韩晟李薇朱贺史录文北京大学药学院北京100191 北京大学医药管理国际研究中心北京100191

本研究的主要目的是测算中国儿童特应性皮炎患者疾病治疗相关的年均总费用和医疗资源利用率,次要目的是调查与特应性皮炎费用相关的因素。研究采用方便抽样的横断面研究。患者层面的数据来自于2022年2月至3月期间在中国31个省份开展的... 详细信息

本研究的主要目的是测算中国儿童特应性皮炎患者疾病治疗相关的年均总费用和医疗资源利用率,次要目的是调查与特应性皮炎费用相关的因素。研究采用方便抽样的横断面研究。患者层面的数据来自于2022年2月至3月期间在中国31个省份开展的一项基于互联网的全国性问卷调查。研究招募了经医生确诊为特应性皮炎的18岁以下儿童的照护者,并收集了所有符合条件的参与者的社会人口学、临床特征、医疗资源利用数据、疾病相关的照护时间和疾病相关的各种成本。共纳入599个符合条件的家庭。82.5%的家庭表示其患儿在过去12个月中至少接受过一次门诊或急诊治疗,5.8%的家庭表示其患儿在过去1年内曾住院治疗。每个家庭因特应性皮炎而产生的总费用约为28591.92元/年,其中92.8%为直接成本。门诊或急诊费用的90.7%、住院费用的43.4%为自付费用。中度(coefficient±SE:0.22±0.09,P=0.012)和重度AD患者组(coefficient±SE:0.58±0.15,P<0.001)、AD发病部位在头颈部或手部(coefficient±SE:0.57±0.14,P<0.001)、使用生物制剂(coefficient±SE:0.64±0.11,P<0.001)、使用中医治疗(coefficient±SE:0.26±0.09,P=0.003)与其各自参照组相比,年总费用更高。因此可以得出,中国儿童特应性皮炎患者的病情严重程度不同,造成的疾病经济负担也不同。除疾病严重程度外,儿童特应性皮炎患者可能会因临床因素和治疗方法的不同而产生更高的治疗相关费用。

关键词：特应性皮炎经济负担医疗资源利用相关因素

Impact of the zero-markup drug policy on volume of medical service:based on 57 county hospitals of China

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Journal of Chinese Pharmaceutical Sciences 2020年第3期29卷 220-226页

作者： zhifeng nie Chunxia Man Xin Yi Yi Liu Zhigang Guo Xiaodong Guan Luwen Shi International Research Center for Medicinal Administration Peking UniversityBeijing 100191China Department of Pharmacy Aerospace Center HospitalBeijing 100049China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Pharmacy Peking University School and Hospital of StomatologyBeijing 100081China

In the present study,we aimed to assess the long-term impact of zero-markup drug policy on volume of medical service in county hospitals of *** study used 57 county hospitals’records of medical service from 2011 to 2015,and a fixed effect model was applied to examine the impact of the zero-markup drug policy on volume of medical *** outcome indicators included the number of patient visits,the number of prescriptions,the number of discharged patients,the length of stay,the number of patients who had surgeries and the number of patients who had CT or MRI,*** number of hospitals which implemented the zero-markup drug policy was increased *** the end of 2015,41 hospitals(71.9%)implemented this *** panel regression showed that most indicators were insignificantly decreased,including the number of patient visits(P<0.01),the length of stay(P<0.05),the number of patients who had surgeries(P<0.01)and the number of patients who had CT or MRI(P<0.01).However,the number of prescriptions and the number of discharged patients were not significantly *** implementation of the zero-markup drug policy might affect the reduction of the volume of medical service in county-level hospitals and the reason needs to be clarified in future studies.

关键词： Zero-markup drug policy Volume of medical service County hospitals China

Simulation and evaluation study of atmospheric aerosol nonsphericity as a function of particle size

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Particuology 2024年第7期90卷 281-291页

作者： Qianjun Mao Xin nie School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China College of New Energy and Materials Northeast Petroleum UniversityDaqing163318China

Aerosol nonsphericity causes great uncertainty in radiative forcing assessments and climate *** considerable studies have attempted to quantify this uncertainty,the relationship between aerosol nonsphericity and particle size is usually not considered,thus reducing the accuracy of the *** this study,a coupled inversion algorithm combining an improved stochastic particle swarm optimization algorithm and angular light scattering is used for the nonparametric estimation of aerosol nonsphericity variation with particle size,and the optimal sample selection method is employed to screen the *** on the verification of inversion accuracy,the variation of aerosol aspect ratio with particle size based on the ellipsoidal model in global regions has been obtained from Aerosol Robotic Network(AERONET)data,and the effect of nonsphericity on radiative forcing and dry deposition has been *** results show that the aspect ratio increases with particle size in all regions,with the maximum ranging from 1.4 to 1.8 in the desert,reflecting the differences in aerosol composition at different particle *** radiation calculations,considering aerosol nonsphericity makes the aerosol cooling effect weaker and surface radiative fluxes increase,but hardly changes the aerosol absorption,with maximum differences of 9.22%and 22.12%at the bottom and top of the atmosphere,***,the differences in radiative forcing between aspect ratios as a function of particle size and not varying with particle size are not significant,averaging less than 2%.Besides,the aspect ratio not varying with particle size underestimates the deposition velocity of small particles and overestimates that of large particles compared to that as a function of particle size,with maximum differences of 7%and 4%,respectively.

关键词： Aerosol nonsphericity Inversion Aspect ratio Radiative forcing Dry deposition velocity

Comprehensive insights:unraveling the mechanisms of gut commensals in glucose metabolism regulation

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Science China(Life Sciences) 2024年第2期67卷 414-417页

作者： Zhipeng Li Qixing nie Shao-Ping nie State Key Laboratory of Food Science and Resources China-Canada Joint Lab of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang 330047China

The prevalence of type 2 diabetes(T2D)has escalated to a global epidemic,garnering widespread *** research utilizing germ-free(GF)mice,antibiotic treatments,and fecal microbiota transplantation approaches has established the critical role of gut microbiota in modulating glucose *** microbiota interacts with diets and the mucosal immune system,influencing intestinal permeability and the penetration of microbial products.

关键词： metabolism utilizing insight

Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications

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Nano Research 2024年第2期17卷 649-662页

作者： Mingzhe nie Qilong Zhao Xuemin Du Institute of Biomedical&Health Engineering Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of Sciences(CAS)Shenzhen 518055China

Small-scale robots,ranging in size from micrometers to centimeters,have gained significant attention in the biomedical ***,conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human *** to the rigid counterpart,small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus,outstanding biocompatibility and accessible stimuli-responsive *** attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions,further enhancing the adaptability in manipulation and tasks execution for various biomedical *** this review,we present recent advances in small-scale hydrogel-based *** first summarize the design principles of small-scale hydrogel-based robots including materials,fabrication techniques and manipulation strategies,then highlighting their upgraded functions and adaptive biomedical ***,we discuss existing challenges and future perspectives for small-scale hydrogel-based robots.

关键词： small-scale robot hydrogel locomotion multi-function adaptability

Collectively induced transparency and absorption in waveguide quantum electrodynamics with Bragg atom arrays

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Communications in Theoretical Physics 2024年第8期76卷 19-28页

作者： Haolei Cheng Wei nie Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology Tianjin UniversityTianjin 300350China

Collective quantum states, such as subradiant and superradiant states, are useful for controlling optical responses in many-body quantum systems. In this work, we study novel collective quantum phenomena in waveguide-coupled Bragg atom arrays with inhomogeneous *** atoms without free-space dissipation, collectively induced transparency is produced by destructive quantum interference between subradiant and superradiant states. In a large Bragg atom array, multi-frequency photon transparency can be obtained by considering atoms with different frequencies. Interestingly, we find collectively induced absorption(CIA) by studying the influence of free-space dissipation on photon transport. Tunable atomic frequencies nontrivially modify decay rates of subradiant states. When the decay rate of a subradiant state equals to the free-space dissipation, photon absorption can reach a limit at a certain frequency. In other words, photon absorption is enhanced with low free-space dissipation, distinct from previous photon detection schemes. We also show multi-frequency CIA by properly adjusting atomic frequencies. Our work presents a way to manipulate collective quantum states and exotic optical properties in waveguide quantum electrodynamics(QED) systems.

关键词： waveguide quantum electrodynamics collective quantum states photon absorption Bragg atom array

Matched Volterra reduced-order model for an airfoil undergoing periodic translation

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Chinese Journal of Aeronautics 2024年第1期37卷 19-23页

作者： Lianrui nie Ziniu WU Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

This paper is devoted to application of the Reduced-Order Model(ROM)based on Volterra series to prediction of lift and drag forces due to airfoil periodic translation in transonic flow *** there is large amplitude oscillation of the relative Mach number,as appeared in helicopter rotor movement in forward flight,the conventional Volterra ROM is found to be *** cover such applications,a matched Volterra ROM,inspired from previous multistep nonlinear indicial response method based on Duhamel integration,is thus considered,in which the step motions are defined inside a number of equal intervals with both positive and negative step motions to match the airfoil forward and backward movement,and the kernel functions are constructed independently at each *** shows that,at least for the translation movement considered,this matched Volterra ROM greatly improves the accuracy of ***,the matched Volterra ROM,with the total number of step motions and thus the computational cost close to those of the conventional Volterra ROM method,has the additional advantage that the same set of kernels can match various translation motions with different starting conditions so the kernels can be predesigned without knowing the specific motion of airfoil.

关键词： Airfoil periodic translation Lift and drag Reduced-order model Transonic flow Unsteady flow

Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng nie Dong Han Xiang Li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

A variable structure passivity control method for elastic joint robots based on cascaded high-order state estimation

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Science China(Technological Sciences) 2024年第2期67卷 395-407页

作者： ZHANG JieXin nie PingYun ZHANG Bo State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction ***,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure *** method ensures the tracking error converges in a finite time,even when the system faces *** method also preserves the passivity of the ***,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity *** observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation *** particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot *** effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints.

关键词： motion control elastic joint robot finite-time convergence high-order system state estimation physical human-robot interaction