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Autophagy and circadian rhythms:interactions and clinical implications

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BIOCELL 2024年第1期48卷 33-45页

作者： TIANKAI DI zhifei zhou FEN LIU YUJIANG CHEN LULU WANG State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for Oral DiseasesDepartment of Pediatric DentistrySchool of StomatologyThe Fourth Military Medical UniversityXi’an710032China Department of Stomatology The 969th HospitalJoint Logistics Support Force of the Chinese People’s Liberation ArmyHohhot010000China Department of Stomatology General Hospital of Tibetan Military CommandLhasa850000China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Clinical Research Center of Shaanxi Province for Dental and Maxillofacial DiseasesDepartment of Pediatric DentistryCollege of StomatologyXi’an Jiaotong UniversityXi’an710000China Department of Neurobiology and Institute of Neurosciences School of Basic MedicineFourth Military Medical UniversityXi’an710032China

Autophagy is a widespread biological process that controls cellular growth,survival,development,and *** rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightness and *** of the fundamental physiological processes in mammals,such as the sleep-wake pattern and the rhythm of nutrition and energy metabolism,are governed by circadian *** has indicated that autophagy exhibits a specific circadian pattern in both normal and abnormal *** can modulate circadian rhythms by breaking down proteins that regulate the circadian *** potential regulatory connection between the two has been a popular subject of clinical and fundamental *** the interaction between circadian rhythm and autophagy could potentially lead to the development of novel approaches for disease treatment in the *** present analysis presented a summary of the molecular processes implicated in the interplay between autophagy and circadian rhythm,as well as the pathological importance of the disrupted regulatory association between these two phenomena.

关键词： Autophagy Circadian rhythms Mechanism Application

Wafer-scale synthesis of monolayer WS2 for high-performance flexible photodetectors by enhanced chemical vapor deposition

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Nano Research 2018年第6期11卷 3371-3384页

作者： Changyong Lan Ziyao zhou zhifei zhou Chun Li Lei Shu Lifan Shen Dapan Li Ruoting Dong SenPo Yip Johnny C. Ho Department of Materials Science and Engineering City University of Hong Kong Hong Kong 999077 China School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 China State Key Laboratory of Millimeter Waves City University of Hong Kong Kowloon Hong Kong 999077 China Centre for Functional Photonics City University of Hong Kong Kowloon Hong Kong 999077 China

Two-dimensional （2D） nanomaterials have recently attracted considerable attention due to their promising applications in next-generation electronics and optoelectronics. In particular, the large-scale synthesis of high-quality 2D materials is an essential requirement for their practical applications. Herein, we demonstrate the wafer-scale synthesis of highly crystalline and homogeneous monolayer WS2 by an enhanced chemical vapor deposition （CVD） approach, in which precise control of the precursor vapor pressure can be effectively achieved in a multi-temperature zone horizontal furnace. In contrast to conventional synthesis methods, the obtained monolayer WS2 has excellent uniformity both in terms of crystallinity and morphology across the entire substrate wafer grown （e.g., 2 inches in diameter）, as corroborated by the detailed characterization. When incorporated in typical rigid photodetectors, the monolayer WS2 leads to a respectable photodetection performance, with a responsivity of 0.52 mA/W, a detectivity of 4.9 × 10^9 Jones, and a fast response speed （〈 560μs）. Moreover, once fabricated as flexible photodetectors on polyimide, the monolayer WS2 leads to a responsivity of up to 5 mA/W. Importantly, the photocurrent maintains 89% of its initial value even after 3,000 bending cycles. These results highlight the versatility of the present technique, which allows its applications in larger substrates, as well as the excellent mechanical flexibility and robustness of the CVD-grown, homogenous WS2 monolayers, which can promote the development of advanced flexible optoelectronic devices.

关键词： wafer-scale WS2 monolayer chemical vapor deposition flexible optoelectronics

Layer-number determination of two-dimensional materials by optical characterization

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Chinese Optics Letters 2018年第2期16卷 52-58页

作者： You Zheng Changyong Lan zhifei zhou Xiaoying Hu Tianying He Chun Li State Key Laboratory of Electronic Thin Films and Integrated Devices and School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 China

Initiated by graphene, two-dimensional（2D） layered materials have attracted much attention owing to their novel layer-number-dependent physical and chemical properties. To fully utilize those properties, a fast and accurate determination of their layer number is the priority. Compared with conventional structural characterization tools, including atomic force microscopy, scanning electron microscopy, and transmission electron microscopy, the optical characterization methods such as optical contrast, Raman spectroscopy, photoluminescence, multiphoton imaging, and hyperspectral imaging have the distinctive advantages of a high-throughput and nondestructive examination. Here, taking the most studied 2D materials like graphene, MoS2, and black phosphorus as examples, we summarize the principles and applications of those optical characterization methods. The comparison of those methods may help us to select proper ones in a cost-effective way.

关键词： Mo LN

Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

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International Journal of Oral Science 2024年第3期16卷 539-552页

作者： Fen Liu Bofeng Zhu Ying An zhifei zhou Peiying Xiong Xuan Li Yang Mi Tongqiang He Faming Chen Buling Wu Shenzhen Stomatology Hospital(Pingshan) Southern Medical UniversityShenzhenChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Laboratory Center of StomatologyDepartment of Paediatric DentistryCollege of StomatologyXi’an Jiaotong UniversityXi’anChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Stomatology General Hospital of Tibetan Military CommandLhasaChina Department of Stomatology Center Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Obstetrics Northwest Women’s and Children’s HospitalXi’anChina

Periodontitis is a critical risk factor for the occurrence and development of *** gingivalis may participate in insulin resistance(IR)caused by periodontal inflammation,but the functional role and specific mechanisms of *** in IR remain *** the present study,clinical samples were analysed to determine the statistical correlation between *** and IR *** culturing of hepatocytes,myocytes,and adipocytes,and feeding mice *** orally,the functional correlation between *** and IR occurrence was further studied both in vitro and in *** data suggested that the amount of *** isolated was correlated with the Homeostatic Model Assessment for IR *** vitro studies suggested that coculture with *** decreased glucose uptake and insulin receptor(INSR)protein expression in hepatocytes,myocytes,and *** fed *** tended to undergo *** was detectable in the liver,skeletal muscle,and adipose tissue of experimental *** distribution sites of gingipain coincided with the downregulation of *** proteolysed the functional insulin-binding region of *** with *** significantly decreased the INSR–insulin binding *** out gingipain from *** alleviated the negative effects of *** on IR in *** together,these findings indicate that distantly migrated *** may directly proteolytically degrade INSR through gingipain,thereby leading to *** results provide a new strategy for preventing diabetes by targeting periodontal pathogens and provide new ideas for exploring novel mechanisms by which periodontal inflammation affects the systemic metabolic state.

关键词： gingivalis inflammation resistance

Advancing application of mesenchymal stem cell-based bone tissue regeneration

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Bioactive Materials 2021年第3期6卷 666-683页

作者： Fengqing Shang Yang Yu Shiyu Liu Leiguo Ming Yongjie Zhang zhifei zhou Jiayu Zhao Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral DiseasesCenter for Tissue EngineeringFourth Military Medical UniversityXi'anShaanxi710032China Department of Stomatology The 306th Hospital of PLABeijing100101China Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanShandong250012China Department of Stomatology General Hospital of Tibetan Military CommandLhasa850000China Bureau of Service for Veteran Cadres of PLA in Beijing Beijing100001China

Reconstruction of bone defects,especially the critical-sized defects,with mechanical integrity to the skeleton is important for a patient's rehabilitation,however,it still remains *** biomaterials of human origin bone tissue for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural bone tissue with regard to its ***,not only efficacious and safe but also costeffective and convenient are important for regenerative biomaterials to achieve clinical translation and commercial *** in our understanding of regenerative biomaterials and their roles in new bone formation potentially opened a new frontier in the fast-growing field of regenerative *** inspiration from the role and multicomponent construction of native extracellular matrix(ECM)for cell accommodation,the ECM-mimicking biomaterials and the naturally decellularized ECM scaffolds were used to create new tissues for bone *** the other hand,with the going deep in understanding of mesenchymal stem cells(MSCs),they have shown great promise to jumpstart and facilitate bone healing even in diseased microenvironments with pharmacology-based endogenous MSCs rescue/mobilization,systemic/local infusion of MSCs for cytotherapy,biomaterials-based approaches,cell-sheets/-aggregates technology and usage of subcellular vesicles of MSCs to achieve scaffolds-free or cell-free delivery system,all of them have been shown can improve MSCsmediated regeneration in preclinical studies and several clinical ***,following an overview discussed autogenous/allogenic and ECM-based bone biomaterials for reconstructive surgery and applications of MSCsmediated bone healing and tissue engineering to further offer principles and effective strategies to optimize MSCs-based bone regeneration.

关键词： Mesenchymal stem cells Bone healing Regenerative medicine Biomaterials Extracellular matrix Cytotherapy Cell-sheets/-aggregates Exosomes

Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

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Bioactive Materials 2021年第6期6卷 1839-1851页

作者： Zhiyuan Zou Le Wang zhifei zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Department of Spine SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Department of Pathology Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhou 510120China Department of Orthopaedics Hunan Provincial People’s HospitalChangsha 410002China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen518132China

Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related ***,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron *** characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related *** found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of *** of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment *** the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future.

关键词： Parathyroid hormone Hydrogels Bone regeneration Tissue engineering

数字人文视域下《人民日报》(1949—1966)生产的中国翻译话语研究

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外语电化教学 2023年第1期 18-24页

作者：耿强周知非上海外国语大学语料库研究院上海市201620

中国翻译话语是中国翻译学界长期关注的一个核心话题,但是对于1949—1966年间的翻译话语关注较少,且已有研究主要采用质性分析,聚焦少量代表性数据。本研究采取数字人文的途径,综合语料库和主题建模等量性分析手段以及质性分析方法,考... 详细信息

中国翻译话语是中国翻译学界长期关注的一个核心话题,但是对于1949—1966年间的翻译话语关注较少,且已有研究主要采用质性分析,聚焦少量代表性数据。本研究采取数字人文的途径,综合语料库和主题建模等量性分析手段以及质性分析方法,考察《人民日报》1949—1966年间所生产的中国翻译话语。本研究揭示了中国翻译话语的特点,并发现了此话语由信仰和技术所构成的深层两维结构,这深化了我们对中国当代翻译话语的再认识。

关键词：数字人文翻译话语语料库主题建模《人民日报》