Advancing application of mesenchymal stem cell-based bone tissue regeneration

作     者：Fengqing Shang Yang Yu Shiyu Liu Leiguo Ming Yongjie Zhang Zhifei Zhou Jiayu Zhao Yan Jin 

作者机构：State Key Laboratory of Military Stomatology&National Clinical ResearchCenter for Oral Diseases&Shaanxi Key Laboratory of Oral DiseasesCenter for Tissue EngineeringFourth Military Medical UniversityXi'anShaanxi710032China Department of StomatologyThe 306th Hospital of PLABeijing100101China Department of PeriodontologySchool and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanShandong250012China Department of StomatologyGeneral Hospital of Tibetan Military CommandLhasa850000China Bureau of Service for Veteran Cadres of PLA in BeijingBeijing100001China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第3期

页      面：666-683页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：supported by the National Key Research and Development Program of China(2016YFC1101400) the National Natural Science Foundation of China(No.81930025,81620108007,81901010) Open Foundation of Shandong Provincial Key Laboratory of Oral Tissue Regeneration(No.SDKQ201904) 

主　　题：Mesenchymal stem cells Bone healing Regenerative medicine Biomaterials Extracellular matrix Cytotherapy Cell-sheets/-aggregates Exosomes 

摘      要：Reconstruction of bone defects,especially the critical-sized defects,with mechanical integrity to the skeleton is important for a patient s rehabilitation,however,it still remains *** biomaterials of human origin bone tissue for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural bone tissue with regard to its ***,not only efficacious and safe but also costeffective and convenient are important for regenerative biomaterials to achieve clinical translation and commercial *** in our understanding of regenerative biomaterials and their roles in new bone formation potentially opened a new frontier in the fast-growing field of regenerative *** inspiration from the role and multicomponent construction of native extracellular matrix(ECM)for cell accommodation,the ECM-mimicking biomaterials and the naturally decellularized ECM scaffolds were used to create new tissues for bone *** the other hand,with the going deep in understanding of mesenchymal stem cells(MSCs),they have shown great promise to jumpstart and facilitate bone healing even in diseased microenvironments with pharmacology-based endogenous MSCs rescue/mobilization,systemic/local infusion of MSCs for cytotherapy,biomaterials-based approaches,cell-sheets/-aggregates technology and usage of subcellular vesicles of MSCs to achieve scaffolds-free or cell-free delivery system,all of them have been shown can improve MSCsmediated regeneration in preclinical studies and several clinical ***,following an overview discussed autogenous/allogenic and ECM-based bone biomaterials for reconstructive surgery and applications of MSCsmediated bone healing and tissue engineering to further offer principles and effective strategies to optimize MSCs-based bone regeneration.