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Journal of Innovative Optical Health Sciences 2015年第4期8卷 32-38页

作者： Xuewei Jiang zhichao fan Yili Yu Chenying Shao Yuanzhen Suo Xunbin Wei Yi Zhou Department of Stomatology Huashan HospitalFudan University ShanghaiP.R.China Institutes of Biomedical Sciences Fudan UniversityShanghaiP.R.China Department of Chemistry Fudan UniversityShanghaiP.R.China Med-X Research Institute Shanghai Jiao Tong University ShanghaiP.R.China School of Biomedical Engineering Shanghai Jiao Tong University ShanghaiP.R.China Shanghai Stomatological Disease Center ShanghaiP.R.China Division of Inflammation Biology La Jolla Institute for Allergy&ImmunologyLa JollaCaliforniaUSA

Photodynamic therapy(PDT)has been commonly used in treating many diseases,such as cancer and infectious *** investigated the different effects of PDT on three main pathogenic bacteria of periodontitis-Prevotella melaninogenica(P.m.),Porphyromonas gingitvalis(P.g.)and Aggregatibacter actinomycetercomitans(A.a-).The portable red light-ermitting diode(LED)phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations(Toluidine blue O,TBO).The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensit izers(porphyrin)under dfferent light *** found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria ***,the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

关键词： Photodynamic therapy periodontitis toluidine blue O endogenous photosensitizer survival rate

基于核壳柱的高效液相色谱法快速测定环境水中11种三嗪类除草剂

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分析试验室 2024年第9期43卷 1311-1315页

作者：王斐张会强李楠周弛张新颖张秦铭范智超陕西省环境介质痕量污染物监测预警重点实验室陕西省环境监测中心站西安710054 西北大学城市与环境学院西安710127

建立了采用核壳色谱柱的高效液相色谱快速测定水中11种三嗪类除草剂的方法。比较了全多孔填料色谱柱和核壳填料色谱柱对11种三嗪类除草剂的分离效果,优化了检测波长、流动相pH、柱温、流速以及梯度变化速率等条件,仅在15.5 min内完成了... 详细信息

建立了采用核壳色谱柱的高效液相色谱快速测定水中11种三嗪类除草剂的方法。比较了全多孔填料色谱柱和核壳填料色谱柱对11种三嗪类除草剂的分离效果,优化了检测波长、流动相pH、柱温、流速以及梯度变化速率等条件,仅在15.5 min内完成了高效液相色谱分离检测。在优化条件下,11种三嗪类除草剂的线性范围为0.20~50.0μg/L,线性相关系数均≥0.9992。方法检出限为0.04~0.05μg/L,定量限为0.16~0.20μg/L,加标回收率为85.2%~106.5%,相对标准偏差为1.8%~6.1%。本方法适用于地表水和地下水等环境水样中11种三嗪类除草剂的测定。

关键词：核壳柱三嗪类除草剂高效液相色谱快速测定环境水样

渭南市矿山企业周边农田土壤中重金属污染源解析及风险评价

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中国无机分析化学 2024年第9期14卷 1234-1241页

作者：郭晋君周弛王蕾朱瑞瑞范智超陈富民葛毅张锋国家环境保护重金属污染监测重点实验室长沙410004 陕西省环境监测中心站西安710054 湖南省生态环境监测中心长沙410019 渭南市环境保护监测站陕西渭南714000 陕西省审计厅西安710000

渭南市是陕西的“粮仓”,农田土壤更是矿山企业与人类关系最为密切的区域之一,研究矿山企业周边农田土壤的重金属污染状况具有重要意义。通过对渭南市矿山企业周边农田土壤进行科学布点,采集具有代表性的土壤样品180个,来研究样品中8种... 详细信息

渭南市是陕西的“粮仓”,农田土壤更是矿山企业与人类关系最为密切的区域之一,研究矿山企业周边农田土壤的重金属污染状况具有重要意义。通过对渭南市矿山企业周边农田土壤进行科学布点,采集具有代表性的土壤样品180个,来研究样品中8种重金属的污染状况。通过使用SPSS软件进行Spearsman相关系数计算与主成分分析,发现重金属元素Hg、Cu、Zn、Pb、Cd的污染主要来源于人类活动,交通、燃煤、矿山开采、经济高速发展都是污染的原因。重金属元素As、Cr、Ni的污染受人类活动影响小,主要来源于土壤母质。使用积累指数法、富集因子法、潜在生态危害指数法对重金属污染进行综合评价,发现土壤中元素Pb属于中度污染,元素Cd、Hg、As存在一定的潜在生态危害,其余重金属为无污染到轻微污染。研究结果表明,渭南市矿山企业周边农田土壤已受到人类经济发展的影响,目前重金属污染状况属于轻微污染。

关键词：土壤重金属污染污染源解析评价

ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells

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Journal of Innovative Optical Health Sciences 2018年第2期11卷 17-30页

作者： Yuanzhen Suo Wei Lin Yuting Deng zhichao fan Lizeng Qin Guosheng Jiang Yiwei Chu Xunbin Wei Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030P.R.China Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH School of Basic Medical Sciences and Biotherapy Research Centre Fudan UniversityShanghai 200032P.R.China Shandong Academy of Medical Sciences Jinan 250030P.R.China

T-cell activation requires the formation of the immunological sy napse(IS)bet ween a T-cll and anantigen-presenting cell(AP C)to control the development of the adaptive immune ***-ever,calcium release,an initial signal of T-cell activation,has been found to occur before IS *** mechanism for triggering the calcium signaling and relationship bet ween calciumrelease and IS format ion remains ***,using live-cell imaging,we found that int ercellularadhesion molecule 1(ICAM-1),an essential mdlecule for IS formation,accumulated and then wasdepleted at the center of the synapse before complete IS *** the proces of ICAM1depletion,calcium was *** ICAM-1 failed to be depleted from the center of the synapse,thesustained calcium signaling could not be ***,depletion of ICAM-1 in ISs preferen-tially ccurred with the contact of antigen-specific T-cels and dendritic clls(DCs).Blocking thebinding ofICA M-1 and lymphocy te finction-associated antigen 1(LFA-1),ICAM-1 failed to depleteat the center of the synapse,and calcium release in T-clls *** studying the mechanism ofhow the depletion ofiCA M1 could influence calcium release in T-clls,we found that the movementof ICAM-1 was associat ed with the localization of LFA-1 in the IS,which afected the localization ofcalcium microdomains,ORAIl and mitochondria in ***,the depletion of ICAM-1 in the center of the synapse is an important factor for an initial sust ained calcium release in T-cells.

关键词： T-cell activation immunological synapse ICAM-1 calcium signaling

Rail-Pillar Net:A 3D Detection Network for Railway Foreign Object Based on LiDAR

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Computers, Materials & Continua 2024年第9期80卷 3819-3833页

作者： fan Li Shuyao Zhang Jie Yang Zhicheng Feng zhichao Chen School of Electrical Engineering and Automation Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Provincial Key Laboratory of Maglev Technology Ganzhou341000China School of Information Engineering Jiangxi University of Science and TechnologyGanzhou341000China

Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,we propose Rail-PillarNet,a three-dimensional(3D)LIDAR(Light Detection and Ranging)railway foreign object detection method based on the improvement of ***,the parallel attention pillar encoder(PAPE)is designed to fully extract the features of the pillars and alleviate the problem of local fine-grained information loss in PointPillars pillars ***,a fine backbone network is designed to improve the feature extraction capability of the network by combining the coding characteristics of LIDAR point cloud feature and residual ***,the initial weight parameters of the model were optimised by the transfer learning training method to further improve *** experimental results on the OSDaR23 dataset show that the average accuracy of Rail-PillarNet reaches 58.51%,which is higher than most mainstream models,and the number of parameters is 5.49 *** with PointPillars,the accuracy of each target is improved by 10.94%,3.53%,16.96%and 19.90%,respectively,and the number of parameters only increases by 0.64M,which achieves a balance between the number of parameters and accuracy.

关键词： Railway foreign object light detection and ranging(LiDAR) 3D object detection PointPillars parallel attention mechanism transfer learning

STUDYING THE ROLE OF MACROPHAGES IN CIRCULATING PROSTATE CANCER CELLS BY IN VIVO FLOW CYTOMETRY

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 39-47页

作者： JIN GUO zhichao fan ZHENGQIN GU XUNBIN WEI Department of Chemistry Fudan UniversityShanghaiP.R.China Institutes of Biomedical Sciences Fudan UniversityShanghaiP.R.China Med-X Research Institute Shanghai Jiao Tong University 1954Huashan RoadShanghai 200240P.R.China School of Biomedical Engineering Shanghai Jiao Tong University ShanghaiP.R.China Department of Urology Xinhua Hospital Shanghai Jiao Tong University 1665Kongjiang RoadShanghai 200092P.R.China

Metastasis is a very complicated multi-step process and accounts for the low survival rate of the cancerous *** metastasize,t he malignant cells must detach from the primary tumor and migrate to secondary sites in the body through either blood or lymph *** appear to be directly involved in tumor progression and ***,the role of macrophages in affecting cancer metast asis has not been fully ***,we have utilized an emerging technique,namely in vivo flow cytometry(IVFC)to study the depletion kinetics of circulating prostate cancer cells in mice and determine how depletion of macrophages by the liposome encapsulated clodronate affects the depletion *** results show diferent depletion kinetics of PC-3 cells between the macrophagedeficient group and the control *** number of circulating tumor cells(CTCs)in the macrophage-deficient group decreases in a slower manner compared to the control mice *** differences in depletion kinetics indicate that the absence of macrophages facilitates the stay of prostate cancer cells in *** addition,our imaging data suggest that macrophages might be able to arrest,phagocytose and digest PC-3 ***,phagocy tosis may mainly contribute to the de-pletion kinetic *** developed methods elaborated here would be useful to study the relationship between macr ophages and tumor metastasis in small animal cancer models.

关键词： Prostate cancer macrophages liposome-encapsulated clodronate in vrivo flow cytometer circulating tumor cells

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我国危化品承压设备防灾减灾技术进展

中国机械工程 2020年第2期31卷 237-245页

作者：范志超陈学东董杰艾志斌合肥通用机械研究院有限公司(国家压力容器与管道安全工程技术研究中心)

灾害环境下如何确保危化品承压设备“不漏不爆”,灾害发生后如何对设备受损情况进行快速甄别评价,是工程界急需解决的技术难题。介绍了近年来我国在高耸塔式容器风振响应分析、风振疲劳寿命预测和抗振优化设计技术,海底油气管道大尺度... 详细信息

灾害环境下如何确保危化品承压设备“不漏不爆”,灾害发生后如何对设备受损情况进行快速甄别评价,是工程界急需解决的技术难题。介绍了近年来我国在高耸塔式容器风振响应分析、风振疲劳寿命预测和抗振优化设计技术,海底油气管道大尺度悬跨和偏移安全性评价技术,火灾过烧压力容器的损伤快速检测诊断技术等方面的研究进展,并结合当前工业物联网、大数据、人工智能技术的发展趋势,针对今后危化品承压设备防灾减灾技术的研究提出了建议。

关键词：危化品压力容器压力管道台风浪流火灾

改进Logistic蠕变应变预测模型及其有限元实现

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机械工程学报 2023年第16期59卷 82-89页

作者：周煜范志超姜恒王宇轩合肥通用机械研究院有限公司合肥230031 国家压力容器与管道安全工程技术研究中心合肥230031

提出一种针对蠕变全过程的改进Logistic蠕变应变预测(Logistic creep strain prediction,LCSP)模型,减少模型参数数量并解决初始蠕变应变复数值问题,结合加钒改进型2.25Cr1Mo钢的蠕变变形与断裂寿命数据,利用基于最小二乘法原理的模型... 详细信息

提出一种针对蠕变全过程的改进Logistic蠕变应变预测(Logistic creep strain prediction,LCSP)模型,减少模型参数数量并解决初始蠕变应变复数值问题,结合加钒改进型2.25Cr1Mo钢的蠕变变形与断裂寿命数据,利用基于最小二乘法原理的模型参数识别方法,实现对材料的蠕变应变及应变速率的准确预测。综合分析Larson-Miller主曲线方程的寿命预测精度及寿命随应力的变化趋势,确定用于预测蠕变断裂寿命的模型多项式阶数。根据改进LCSP模型的蠕变应变解析公式,推导蠕变应变增量及其对等效应力以及蠕变应变的导数的计算表达式,确保计算收敛性,利用Fortran语言开发了针对改进LCSP模型的usercreep蠕变子程序,通过光滑圆棒试样蠕变有限元分析验证该蠕变子程序的准确性。

关键词：蠕变本构模型有限元分析变形断裂寿命

420℃下16MnR钢的寿命预测方法及疲劳设计曲线研究

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机械强度 2006年第3期28卷 387-391页

作者：范志超陈学东蒋家羚浙江大学化工机械研究所杭州310027 国家压力容器与管道安全工程技术研究中心合肥230031

提出另一种循环总应变能密度疲劳寿命预测方法，根据不同的应力比，给出对疲劳损伤起作用的循环总应变能密度计算表达式。针对应力控制下的脉动循环试验，设计两种加载方式把循环蠕变对寿命的影响与疲劳的影响区别开，将循环蠕变损伤与... 详细信息

提出另一种循环总应变能密度疲劳寿命预测方法，根据不同的应力比，给出对疲劳损伤起作用的循环总应变能密度计算表达式。针对应力控制下的脉动循环试验，设计两种加载方式把循环蠕变对寿命的影响与疲劳的影响区别开，将循环蠕变损伤与疲劳损伤进行线性累积，得到16MnR钢420℃兼有疲劳、循环蠕变影响的寿命预测方法，预测结果与实测结果吻合良好。将循环蠕变对寿命的影响扣除在外，得到16MnR钢375℃～420℃之间的疲劳设计曲线，对JB4732—95疲劳设计曲线作有益的补充。

关键词：应力控制循环蠕变寿命预测疲劳设计

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基于延性耗竭理论的疲劳蠕变寿命预测方法

金属学报 2006年第4期42卷 415-420页

作者：范志超陈学东陈凌蒋家羚国家压力容器与管道安全工程技术研究中心合肥230031 浙江大学化工机械研究所杭州310027

延性耗竭理论认为,高温疲劳和蠕变产生的材料流动可以用粘性流进行描述,失效判据为材料动粘性等于材料韧性, ∑ud=Tm．本文在此基础上提出一种新的疲劳蠕变寿命预测方法,认为只有拉伸应力引起的塑性变形或蠕变变形才构成延性耗竭,并提... 详细信息

延性耗竭理论认为,高温疲劳和蠕变产生的材料流动可以用粘性流进行描述,失效判据为材料动粘性等于材料韧性, ∑ud=Tm．本文在此基础上提出一种新的疲劳蠕变寿命预测方法,认为只有拉伸应力引起的塑性变形或蠕变变形才构成延性耗竭,并提出以拉伸应力达到(σmax-^(σmaxσa)/(1/2))作为开始塑性变形的条件．该方法适用于应力控制模式,且能综合反映应力比、加载速率、拉伸保载时间和平均应变速率的影响．用该方法对1．25Cr0．5Mo钢540℃应力控制下的疲劳区、蠕变区及疲劳蠕变交互作用区的寿命进行预测,预测结果与实测结果吻合较好,精度明显优于频率修正法及应变能频率修正法．

关键词：疲劳蠕变延性应力控制高温