Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

作     者：Xuewei Jiang Zhichao Fan Yili Yu Chenying Shao Yuanzhen Suo Xunbin Wei Yi Zhou 

作者机构：Department of StomatologyHuashan HospitalFudan University ShanghaiP.R.China Institutes of Biomedical SciencesFudan UniversityShanghaiP.R.China Department of ChemistryFudan UniversityShanghaiP.R.China Med-X Research InstituteShanghai Jiao Tong University ShanghaiP.R.China School of Biomedical EngineeringShanghai Jiao Tong University ShanghaiP.R.China Shanghai Stomatological Disease CenterShanghaiP.R.China Division of Inflammation BiologyLa Jolla Institute for Allergy&ImmunologyLa JollaCaliforniaUSA 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2015年第8卷第4期

页      面：32-38页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grants of the National Major Scientic Research Program of China (Grant No.2011CB910404) the National Nature Science Foundation of China (Grant No.61227017) 

主　　题：Photodynamic therapy periodontitis toluidine blue O endogenous photosensitizer survival rate 

摘      要：Photodynamic therapy(PDT)has been commonly used in treating many diseases,such as cancer and infectious *** investigated the different effects of PDT on three main pathogenic bacteria of periodontitis-Prevotella melaninogenica(P.m.),Porphyromonas gingitvalis(P.g.)and Aggregatibacter actinomycetercomitans(A.a-).The portable red light-ermitting diode(LED)phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations(Toluidine blue O,TBO).The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensit izers(porphyrin)under dfferent light *** found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria ***,the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.