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Whispering-gallery mode hexagonal micro-/nanocavity lasers [Invited]

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Photonics Research 2019年第5期7卷 594-607页

作者： Yue-De Yang Min Tang Fu-Li Wang zhi-xiong xiao Jin-Long xiao Yong-Zhen Huang State Key Laboratory of Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China

Whispering-gallery-mode(WGM) hexagonal optical micro-/nanocavities can be utilized as high-quality(Q) resonators for realizing compact-size low-threshold lasers. In this paper, the progress in WGM hexagonal micro-/nanocavity lasers is reviewed comprehensively. High-Q WGMs in hexagonal cavities are divided into two kinds of resonances propagating along hexagonal and triangular periodic orbits, with distinct mode characteristics according to theoretical analyses and numerical simulations;however, WGMs in a wavelength-scale nanocavity cannot be well described by the ray model. Hexagonal micro-/nanocavity lasers can be constructed by both bottom-up and top-down processes, leading to a diversity of these lasers. The ZnO-or nitride-based semiconductor material generally has a wurtzite crystal structure and typically presents a natural hexagonal cross section. Bottom-up growth guarantees smooth surface faceting and hence reduces the scattering loss *** emissions have been successfully demonstrated in hexagonal micro-/nanocavities synthesized with various materials and structures. Furthermore, slight deformation can be easily introduced and precisely controlled in top-down fabrication, which allows lasing-mode manipulation. WGM lasing with excellent singletransverse-mode property was realized in waveguide-coupled ideal and deformed hexagonal microcavity lasers.

关键词： Whispering-gallery-mode(WGM) high-quality(Q) hexagonal micro- nanocavity lasers

Variable-curvature microresonators for dual-wavelength lasing

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Photonics Research 2017年第6期5卷 214-220页

作者： MIN TANG YONG-ZHEN HUANG YUE-DE YANG HAI-ZHONG WENG zhi-xiong xiao State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors University of Chinese Academy of Sciences Chinese Academy of Sciences

Stable dual-mode semiconductor lasers can be applied for the photonic generation of microwave and terahertz waves. In this paper, the mode characteristics of a variable curvature microresonator are investigated by a twodimensional finite element method for realizing stable dual-mode lasing. The microresonator features a smooth boundary and the same symmetry as a square resonator. A small variable-curvature microresonator with a radius of 4 μm can support the fundamental four-bounce mode and the circular-like mode simultaneously, with quality factors up to the order of 10~4 and 10~5, respectively. The dual modes in the phase space of the Poincarésurface of sections distribute far from each other and can maintain enough stability for dual-mode ***, the refractive index and waveguide can modulate the dual-mode wavelength difference and quality factors efficiently thanks to the spatially separated fields of these two modes.

关键词： VCM Variable-curvature microresonators for dual-wavelength lasing

小鼠TAp63γ及两种突变体的原核表达、纯化和DNA结合活性

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中国生物工程杂志 2008年第9期28卷 39-45页

作者：严君喜黄新河杜林方 zhi-xiong Jim xiao 四川大学生命科学学院生物资源与生态环境教育部重点实验室成都610064 四川大学纳米生物医学技术与膜生物学研究所成都610041 School of Medicine Boston University Boston MA02118 USA

采用PCR扩增法得到小鼠TAp63γ野生型及两种缺失突变体的cDNA,3种cDNA与表达载体pGEX-2TK重组构建成GST融合表达质粒并转化感受态*** BL21(DE3),经IPTG诱导了小鼠TAp63γ野生型及两种缺失突变体的可溶性表达。诱导表达的菌液经离心收集... 详细信息

采用PCR扩增法得到小鼠TAp63γ野生型及两种缺失突变体的cDNA,3种cDNA与表达载体pGEX-2TK重组构建成GST融合表达质粒并转化感受态*** BL21(DE3),经IPTG诱导了小鼠TAp63γ野生型及两种缺失突变体的可溶性表达。诱导表达的菌液经离心收集菌体、超声破碎及Triton X-100增溶后获得可溶性表达蛋白粗提液。利用Glutathione Sepharose 4 Fast Flow亲合层析纯化出电泳均一的3种GST融合蛋白。凝胶滞留分析证实仅野生型小鼠TAp63γ蛋白能特异结合p53靶序列,经序列比对及同源建模分析,表明小鼠TAp63γDBD结合区的完整性、关键氨基酸的保守性及三维结构的相似性可能是其DNA结合活性所必需的。

关键词：融合蛋白缺失突变原核表达凝胶滞留序列比对同源建模

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黑洞吸积盘系统的喷流加速机制研究

物理学报 2017年第3期66卷 393-400页

作者：徐佳迪姜志雄龚小龙长江大学物理与光电工程学院荆州434023 北京师范大学天文系北京100875

提出了一种从旋转黑洞吸积盘热冕系统中提取能量的喷流加速机制.在吸积盘热冕中,通过求解广义相对论框架下的盘冕系统的动力学方程,得出了吸积盘热冕内区的磁场强度;进一步根据黑洞磁层的电路理论推导出喷流功率的解析表达式.结果表明:... 详细信息

提出了一种从旋转黑洞吸积盘热冕系统中提取能量的喷流加速机制.在吸积盘热冕中,通过求解广义相对论框架下的盘冕系统的动力学方程,得出了吸积盘热冕内区的磁场强度;进一步根据黑洞磁层的电路理论推导出喷流功率的解析表达式.结果表明:模型中喷流功率随着黑洞自转参数a_*和磁力矩参数?_ε的增加而明显增大,并且大部分功率应来自于在吸积盘热冕系统的内区.此外,用一组高功率喷流的活动星系核样本探讨了该喷流加速机制,分析表明所有高功率喷流源能被模型喷流功率所拟合.

关键词：吸积吸积盘喷流冕

The oncogenic activity of MDMx is associated with physical interaction and suppression of retinoblastoma protein

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The oncogenic activity of MDMx is associated with physical i...

The landscape of aging

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Haibo zhang Yujun Zhang Qiu Wei zhi-xiong xiao Center of Growth Metabolismand Aging College of Life SciencesSichuan University Department of Biochemistry Boston University School of Medicine Center of Growth Metabolism and Aging College of Life Sciences Sichuan University

The aim of this study is to investigate the role of MDMx(or MDM4) on the regulation ofretinoblastoma protein(Rb). Inactivation of Rb plays a critical role in the development ofhuman malignancies. We have previously shown that MDM2, an ubiquitin E3 ligase and amajor negative regulator of p53, binds to and promotes proteasome-mediated degradationof Rb independent of p53. MDMX, a homolog of MDM2, also binds to and inhibitsp53 transactivation activity, yet it does not possess an ubiquitin E3 ligase activity. In thisstudy, we show that MDMX binds to and promotes proteasome-mediated degradation ofRb in a MDM2-dependent manner. The C-terminal Ring domain of MDMX binds to the RbC-pocket and enhances MDM2-Rb interaction. Knockdown of MDMX induces Rb proteinaccumulation, cell cycle G1 arrest, and premature cellular senescence, which can be revertedby simultaneous knockdown of Rb. Furthermore, ablation of MDMXsignificantly suppressestumor growth, concomitant with Rb accumulation, in an animal xenograft ***, these results demonstrate that MDMX possesses oncogenic activity associatedwith suppression of Rb and suggest that both MDM2 and MDMX can be targets for cancertherapy.

关键词： MDMX retinoblastoma protein(Rb)

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Science China(Life Sciences) 2022年第12期65卷 2354-2454页

作者： Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou xiao-Li Tian zhi-xiong xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Frontier Science Center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International Laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to *** is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and ***,the growing emphasis on “healthy aging” raises a series of important questions in life and social *** recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological *** an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

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NaCl溶液改良膨胀土滞回曲线形态特征

科学技术与工程 2022年第13期22卷 5322-5330页

作者：李宝平支枭雄张玉平高权西安工业大学建筑工程学院西安710021 西安理工大学陕西省黄土力学与工程重点实验室西安710048

为研究NaCl溶液改良膨胀土滞回曲线变化规律,基于GDS动三轴仪,开展了不同NaCl溶液浓度和固结围压条件下膨胀土的动三轴试验研究,通过4个特征参数:长轴斜率(k)、内面积(S)、不闭合大小(εp)和饱满度(α)分别对滞回曲线的应变轴倾斜程度... 详细信息

为研究NaCl溶液改良膨胀土滞回曲线变化规律,基于GDS动三轴仪,开展了不同NaCl溶液浓度和固结围压条件下膨胀土的动三轴试验研究,通过4个特征参数:长轴斜率(k)、内面积(S)、不闭合大小(εp)和饱满度(α)分别对滞回曲线的应变轴倾斜程度、面积大小程度、不闭合程度和宽窄程度进行形态特征的定量描述。结果表明:膨胀土滞回曲线呈斜椭圆形;相同NaCl溶液浓度下,随着加载围压的增大,k增大,S、εp和α均呈非线性衰减;相同加载围压下,随着NaCl溶液浓度的增大,εp减小,S、k和α均呈非线性增大;不同加载条件下,S和α有类似的变化关系,当动应变小于0.1%时,S和α基本无变化,随着动应变逐渐增大,S和α呈指数形式迅速增大;与未改良膨胀土相比,经NaCl溶液改良后膨胀土滞回曲线的k、S和α均增大,εp减小。综合分析,NaCl溶液改良膨胀土的动力特性较未改良土有显著提高。

关键词： NaCl溶液膨胀土滞回曲线动三轴试验动力特性

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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电动汽车绝缘电阻检测方法研究

天津职业技术师范大学学报 2018年第3期28卷 47-51页

作者：张志雄李小鹏天津职业技术师范大学汽车与交通学院天津300222

为解决电动汽车绝缘电阻实时检测和动力电池开路状态下检测的问题,在现有绝缘电阻检测方法的基础上,提出了一种新的绝缘电阻检测模型,该模型采用在不同状态下注入交直流电压的方法对电动汽车绝缘电阻进行检测,并根据检测模型进行理论分... 详细信息

为解决电动汽车绝缘电阻实时检测和动力电池开路状态下检测的问题,在现有绝缘电阻检测方法的基础上,提出了一种新的绝缘电阻检测模型,该模型采用在不同状态下注入交直流电压的方法对电动汽车绝缘电阻进行检测,并根据检测模型进行理论分析和系统设计。试验结果表明:该检测模型能够弥补现有检测方法的不足,系统测量精度符合设计要求,达到预期效果。

关键词：电动汽车绝缘电阻在线检测开路检测