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Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy

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Chinese Medical Journal 2019年第21期132卷 2628-2635页

作者： zhi-sheng wu Wen-Li Huang Shu-Jie Gong Department of Neurology The First Affiliated Hospital of QuanzhouFujian Medical UniversityQuanzhouFujian 362000China.

Background:Epilepsy is a chronic and severe neurological *** and tensin homolog deleted on chromosome ten(PTEN)-deficient mice exhibit learning and memory deficits and spontaneous *** aim of this study was to investigate the role of PTEN in brain oxidative damage and neuroinflammation in a rat model of ***:An adenovirus(Ad)-PTEN vector was constructed,and status epilepticus(SE)was induced in 41 model rats using lithium ***-six SE rats were then allocated into the Ad-PTEN,Ad-LacZ,and SE groups,those were administered intracerebroventricular injections of Ad-PTEN,Ad-enhanced green fluorescent protein,and phosphate buffer saline,*** normal group was comprised of healthy Sprague-Dawley *** staining was conducted to evaluate neuronal damage,and immunohistochemistry was conducted to observe the morphology of cells in the hippocampal CA1 region and the distribution of ionized calcium-binding adaptor molecule 1(Iba1)and ED1(rat homologue of human CD68).Levels of apoptosis-related proteins,inflammatory-related factors,and oxidative stress-related markers(reactive oxygen species[ROS],glutathione[GSH],superoxide dismutase[SOD],and malondialdehyde[MDA])were *** between multiple groups were conducted using oneway analysis of variance(ANOVA),and pairwise comparisons after ANOVA were conducted using the Tukey multiple comparisons ***:After SE induction,PTEN expression in the rat brain exhibited a four-fold decrease(P=0.000)and the expression of both Iba1 and ED1 ***,significant neuronal loss,oxidative damage,and neuroinflammation were observed in the SE rat *** intracerebroventricular injection of Ad-PTEN,PTEN expression exhibited a three-fold increase(P=0.003),and the expression of both Iba1 and ED1 ***,neurons were restored and neuronal apoptosis was ***,ROS and MDA levels decreased,GSH level and SOD activity

关键词： Epilepsy Status epilepticus Brain injuries Oxidative stress Neurons Inflammation

Suppression of indium-composition fluctuations in InGaN epitaxial layers by periodically-pulsed mixture of N2 and H2 carrier gas

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Chinese Physics B 2018年第12期27卷 504-509页

作者： Hai-Long Wang Xiao-Han Zhang Hong-Xia Wang Bin Li Chong Chen Yong-Xian Li zhi-sheng wu Hao Jiang State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Indium-composition fluctuations in InGaN epitaxial layers are suppressed by using periodically-pulsed mixture(PPM)of N2and H2carrier gas. Photoluminescence, optical transmission, reciprocal space map and space-resolved cathodoluminescence are employed to characterize the InGaN epilayers. It is shown that the lateral In-fluctuations mainly occur as hillock-like In-rich regions. Both the number and size of In-rich regions are reduced by introducing the PPM carrier ***, the measurements first experimentally demonstrate that the H2carrier gas has a stronger decomposition effect on the In-rich region. As the duration time of the PPM carrier gas increases, the reduction of In-content in the In-rich region reaches up to 12%, however, only 2% for the In-homogeneous region. These factors lead to the suppression of In-fluctuations.

关键词： InGaN alloys suppression of In-fluctuations periodically-pulsed mixture of nitrogen and hydrogen

Experimental evaluation of interface states during time-dependent dielectric breakdown of GaN-based MIS-HEMTs with LPCVD-SiNχgate dielectric

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Chinese Physics B 2020年第6期29卷 419-425页

作者： Ya-Wen Zhao Liu-An Li Tao-Tao Que Qiu-Ling Qiu Liang He Zhen-Xing Liu Jin-Wei Zhang Qian-Shu wu Jia Chen zhi-sheng wu Yang Liu School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhou 510275China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China

We experimentally evaluated the interface state density of GaN MIS-HEMTs during time-dependent dielectric breakdown(TDDB).Under a high forward gate bias stress,newly increased traps generate both at the SiNx/AlGaN interface and the SiNx bulk,resulting in the voltage shift and the increase of the voltage *** prolonging the stress duration,the defects density generated in the SiNx dielectric becomes dominating,which drastically increases the gate leakage current and causes the catastrophic *** recovery by UV light illumination,the negative shift in threshold voltage(compared with the fresh one)confirms the accumulation of positive charge at the SiNx/AlGaN interface and/or in SiNx bulk,which is possibly ascribed to the broken bonds after long-term *** results experimentally confirm the role of defects in the TDDB of GaN-based MIS-HEMTs.

关键词： GaN-based MIS-HEMTs gate dielectric time-dependent dielectric breakdown interface states

Effect of overdrive voltage on PBTI trapping behavior in GaN MIS-HEMT with LPCVD SiNx gate dielectric

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Chinese Physics B 2020年第3期29卷 340-345页

作者： Tao-Tao Que Ya-Wen Zhao Liu-An Li Liang He Qiu-Ling Qiu Zhen-Xing Liu Jin-Wei Zhang Jia Chen zhi-sheng wu Yang Liu School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhou 510275China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China

The effect of high overdrive voltage on the positive bias temperature instability(PBTI)trapping behavior is investigated for GaN metal–insulator–semiconductor high electron mobility transistor(MIS-HEMT)with LPCVD-SiNx gate dielectric.A higher overdrive voltage is more effective to accelerate the electrons trapping process,resulting in a unique trapping behavior,i.e.,a larger threshold voltage shift with a weaker time dependence and a weaker temperature *** the degradation of electrical parameters with the frequency–conductance measurements,the unique trapping behavior is ascribed to the defect energy profile inside the gate dielectric changing with stress time,new interface/border traps with a broad distribution above the channel Fermi level are introduced by high overdrive voltage.

关键词： gallium nitride LPCVD-SiNx MIS-HEMTs overdrive voltage trapping behavior

Distribution of donor states on the surface of AlGaN/GaN heterostructures

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Chinese Physics B 2021年第12期30卷 620-624页

作者： Yue-Bo Liu Hong-Hui Liu Jun-Yu Shen Wan-Qing Yao Feng-Ge Wang Yuan Ren Min-Jie Zhang zhi-sheng wu Yang Liu Bai-Jun Zhang School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

The uniform distribution model of the surface donor states in AlGaN/GaN heterostructures has been widely used in the theoretical calculation.A common and a triple-channel AlGaN/GaN heterostructure Schottky barrier diodes have been fabricated to verify the models,but the calculation results show the uniform distribution model can not provide enough electrons to form three separate 2DEGs in the triple-channel Al GaN/GaN *** experiments indicate the uniform distribution model is not quite right,especially for the multiple-channel AlGaN/GaN ***,it is found the exponential distribution model possibly matches the actual distribution of the surface donor states better,which allows the 2DEG to form in each channel structure during the *** exponential distribution model would be helpful in the research field.

关键词： AlGaN/GaN surface states exponent distribution

An Effctive Palladium/Monothiourea Catalyst System for the Suzuki Cross-coupling Reaction

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An Effctive Palladium/Monothiourea Catalyst System for the S...

Overview of in-situ oxygen production technologies for lunar resources

第十四届全国催化学术会议

作者： zhi-sheng wu Min Yang Hong-ling Li Yan-xing Qi National Engineering Research Center for Fine Petrochemical Intermediates Lanzhou Institute of Chemical Physics Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences

＜正＞The cross-coupling of aryl halides with arylboronic acids in the presence of palladium and base,namely the Suzuki reaction,has become a standard synthetic method for biaryls,which are an important class of organic compounds useful as precursors to pharmaceuticals,polymers and ligands for catalysis.1Similar to other palladium catalytic reactions,an effective ligand which can increase reactivity and stability of the metal catalysts is *** most widely used ligands in the Suzuki reaction are phosphine-based,

关键词： Non-chiral Monothiourea Ligand Suzuki cross-coupling reaction Recyclable

来源： cnki会议评论

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cnki会议

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng wu zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue wu zhi Geng Wenjie Hu Panpan Hu Xingqi wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity