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A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F

Journal of Biomedical Research 2024年第5期38卷 451-463页

作者： Jing Xue Linwei Zhang Jingxian Tao Xuexue Xie Xi Wang Linlin Wu Shuhu Du Ninghua Tan Yang Jin Jianming Ju Junting Fan Jun Wang Fei Huan Rong gao Key Laboratory of Modern Toxicology Ministry of EducationDepartment of ToxicologySchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Taizhou Center for Disease Control and Prevention TaizhouJiangsu 225300China Wuxi Center for Disease Control and Prevention WuxiJiangsu 214023China School of Pharmacy Jiangsu Province Engineering Research Center of Antibody DrugNanjing Medical UniversityNanjingJiangsu 211166China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China Department of Pharmaceutical Analysis School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Laboratory of Quality and Metabolomics of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsu 210028China Department of Hygienic Analysis and Detection Key Laboratory of Modern ToxicologyMinistry of EducationSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

As a potential endocrine-disrupting chemical,bisphenol F(BPF)may cause nonalcoholic fatty liver disease(NAFLD)-like changes,but the mechanisms under its pathogenesis as well as the intervention strategies remain *** the electron microscopy technology,along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays,we observed that BPF treatment elicited a striking accumulation of lipid droplets in HepG2 cells,accompanied by an increased total level of *** the molecular level,the lipogenesis-associated mRNAs and proteins,including acetyl-CoA carboxylase,fatty acid synthase,stearoyl-CoA desaturase-1,peroxisome proliferator-activated receptor gamma,and CCAAT-enhancer-binding proteins,increased significantly via the AMP-activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)signaling regulation in both in vitro and in vivo ***,the immunofluorescence results also showed the robust lipogenesis induced by BPF,evident in its ability to promote the translocation of sterol regulatory element-binding protein-1c from the cytoplasm to the *** investigate the intervention strategies for BPF-induced NAFLD-like changes,we demonstrated that bellidifolin,isolated and purified from Swertia chirayita,significantly attenuated BPF-induced lipid droplet deposition in HepG2 cells and NAFLD-like changes in mice by blocking the expression of lipogenesis-associated ***,the present study elucidates the mechanisms underlying the BPF-induced lipid accumulation in HepG2 cells,while also highlighting the potential of bellidifolin to mitigate BPF-induced NAFLD-like changes.

关键词： bisphenol F lipogenesis non-alcoholic fatty liver disease bellidifolin

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Prognostic factors and its predictive value in patients with metastatic spinal cancer

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World Journal of Clinical Cases 2021年第20期9卷 5470-5478页

作者： Qing-Peng gao Da-zhi Yang Zheng-Bin Yuan Yu-Xia Guo Department of Spine Surgery The Second Clinical Medical College of Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Spine Surgery Shenzhen People’s Hospital2nd Clinical Medical College of Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Gynecology Shenzhen People’s Hospital2nd Clinical Medical College of Jinan UniversityShenzhen 518020Guangdong ProvinceChina

BACKGROUND The spine is the most common location of metastatic *** a metastatic spinal tumor depends on many factors,including patients’overall health and life *** present study was conducted to investigate prognostic factors and clinical outcomes in patients with vertebral *** To investigate prognostic factors and their predictive value in patients with metastatic spinal *** A retrospective analysis of 109 patients with metastatic spinal cancer was conducted between January 2015 and September *** prognoses and survival were analyzed,and the effects of factors such as clinical features,treatment methods,primary lesions and affected spinal segments on the prognosis of patients with metastatic spinal cancer were *** prognostic value of Frankel spinal cord injury functional classification scale,metastatic spinal cord compression(MSCC),spinal instability neoplastic score(SINS)and the revised Tokuhashi score for prediction of prognosis was explored in patients with metastatic spinal *** Age,comorbidity of metastasis from elsewhere,treatment methods,the number of spinal tumors,patient’s attitude toward tumors and Karnofsky performance scale score have an effect on the prognosis of patients(all P<0.05).With respect to classification of spinal cord injury,before operation,the proportion of grade B and grade C was higher in the group of patients who died than in the group of patients who survived,and that of grade D and grade E was lower in the group of patients who died than in the group of patients who survived(all P<0.05).At 1 mo after operation,the proportion of grade A,B and C was higher in the group of patients who died than in the group of patients who survived,and that of grade E was lower in patients in the group of patients who died than in the group of patients who survived(all P<0.05).MSCC occurred in four(14.3%)patients in the survival group and 17(21.0%)patients in the death group(P<0.05).

关键词： Metastatic spinal tumors Frankel spinal cord injury functional classification scale Metastatic spinal cord compression Spinal instability neoplastic score Revised Tokuhashi score

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麝香保心丸与通心络胶囊治疗冠状动脉粥样硬化性心脏病心绞痛的药物经济学评价

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中国药物经济学 2024年第8期19卷 30-37,43页

作者：王志军吕冬梅张桂娟高志成陈小菲李勇华北理工大学附属医院心内科河北唐山063000

目的评价麝香保心丸与通心络胶囊治疗冠状动脉粥样硬化性心脏病(CHD)心绞痛的成本-效果。方法检索国内外涉及麝香保心丸对比通心络胶囊治疗CHD心绞痛随机对照试验的相关已发表文献,经过筛选后进行质量评价,并采用Stata 16.0统计软件进... 详细信息

目的评价麝香保心丸与通心络胶囊治疗冠状动脉粥样硬化性心脏病(CHD)心绞痛的成本-效果。方法检索国内外涉及麝香保心丸对比通心络胶囊治疗CHD心绞痛随机对照试验的相关已发表文献,经过筛选后进行质量评价,并采用Stata 16.0统计软件进行荟萃分析。此外,参考我国各省市区挂网药物价格并结合用药量来计算成本,进一步分析成本-效果比。结果最终纳入文献11篇,涉及受试者990例。与通心络胶囊相比,麝香保心丸症状有效率相差9%(95%CI:-5%~21%,P=0.23),心电图有效率相差12%(95%CI:1%~23%,P=0.03),表明麝香保心丸的症状有效率和心电图有效率优于通心络胶囊。基于全国平均情况进行增量成本-效果比分析,与通心络胶囊比较,麝香保心丸在改善临床症状方面的增量成本-效果比为-285.26,表明麝香保心丸更具经济性;敏感性分析结果显示,在全国大部分省市区与通心络胶囊相比,麝香保心丸在改善临床症状方面的增量成本-效果比均为负数,提示麝香保心丸具有显著的经济学优势。在全国范围内,麝香保心丸与通心络胶囊相比,在改善心电图结果方面的增量成本-效果比为-570.53,麝香保心丸表现出绝对的经济性优势;敏感性分析结果显示,在全国大部分省市区麝香保心丸与通心络胶囊相比,在改善心电图结果方面的增量成本-效果比均为负数,同样证明了麝香保心丸更具绝对经济性。结论在CHD心绞痛的临床治疗中,麝香保心丸在改善临床症状和心电图结果方面的效果均优于通心络胶囊,且在全国大部分省市区,麝香保心丸相比通心络胶囊具有绝对的经济性。

关键词：麝香保心丸通心络胶囊冠状动脉粥样硬化性心脏病心绞痛药物经济学

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Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： Yu Zhang Xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao Li Can-xing Yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao Yan Liang Chuan-ying Xu Mei-juan Liu Chen gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treatment of LID by current guidelines,but it is far from meeting clinical *** Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Parkinson’s disease Tianqi Pingchan Granule Levodopa-induced dyskinesia

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一种单相四象限五电平变换器

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电机与控制学报 2016年第2期20卷 43-51页

作者：高志刚柯龙北京理工大学自动化学院北京100081

为了驱动高压大容量电机并将电机制动过程中的能量回馈入电网,提高电能的利用效率,提出了一种单相四象限五电平变换器。针对提出的拓扑结构,分析了变换器的工作模式,并建立了开关模型,并得出了开关脉冲与系统输出电压之间的关系。讨论... 详细信息

为了驱动高压大容量电机并将电机制动过程中的能量回馈入电网,提高电能的利用效率,提出了一种单相四象限五电平变换器。针对提出的拓扑结构,分析了变换器的工作模式,并建立了开关模型,并得出了开关脉冲与系统输出电压之间的关系。讨论了变换器不同开关状态下系统的等效电路,提出了一种判断开关状态是否合法的策略。分析了变换器中的电容电压均衡控制问题,提出了一种优化调制策略,给出了开关状态的计算流程图,实现了变换器的多电平输出。建立了实验样机平台,实验结果表明,提出的变换器可实现五电平输出,系统的控制策略和调制算法有效可行。

关键词： H桥五电平四象限脉冲宽度调制多电平

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刈割期对土默川平原苜蓿生产性能及经济效益的影响

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饲料研究 2024年第15期47卷 98-102页

作者：李文龙李峰张晨倪苗高洁魏晓斌刘楠陶雅中国农业科学院草原研究所/农业农村部饲草高效生产模式创新重点实验室内蒙古呼和浩特010010 鄂尔多斯市农牧业科学研究院内蒙古鄂尔多斯017010 内蒙古伊禾绿锦农业发展有限公司内蒙古赤峰025500 包头市农牧科学技术研究所农牧业资源与耕地保护中心内蒙古包头014010 国家乳业技术创新中心内蒙古呼和浩特010000

试验旨在探究土默川平原苜蓿的最佳刈割时期,为苜蓿规模化生产应用提供参考。试验设置现蕾期、初花期和盛花期3个处理,每个处理3次重复。测定了土默川平原紫花苜蓿(WL319HQ)不同刈割时期的产量、营养品质和经济效益指标。结果表明:苜蓿... 详细信息

试验旨在探究土默川平原苜蓿的最佳刈割时期,为苜蓿规模化生产应用提供参考。试验设置现蕾期、初花期和盛花期3个处理,每个处理3次重复。测定了土默川平原紫花苜蓿(WL319HQ)不同刈割时期的产量、营养品质和经济效益指标。结果表明:苜蓿在现蕾期刈割,全年可收获干草13011.60 kg/hm2,其粗蛋白(CP)、中性洗涤纤维(NDF)、酸性洗涤纤维(ADF)含量分别为20.69%DM、36.91%DM、26.64%DM,相对饲喂价值(RFV)为172.11,收益为16131.34~20034.83元/hm2。在初花期刈割,全年可收获干草12829.81 kg/hm2,其CP、NDF、ADF含量分别为18.55%DM、41.03%DM、30.70%DM,RFV为147.78,收益为11791.53~15640.47元/hm2。在盛花期刈割,全年可收获干草14444.64 kg/hm2,其CP、NDF、ADF含量分别为16.80%DM、45.82%DM、35.57%DM、RFV为124.40,收益低于9889.27元/hm2。研究表明,土默川平原苜蓿在现蕾期刈割的营养价值和经济效益更高。

关键词：土默川平原紫花苜蓿刈割期生产性能经济效益

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原子尺度断裂模拟进展

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力学学报 2024年第2期56卷 347-364页

作者：丁彬高源陈玉丽李晓雁北京航空航天大学固体力学研究所北京100191 清华大学工程力学系北京100084

材料/结构的断裂是一个多尺度过程,绝大多数断裂过程都涉及到原子键的断裂,因此原子尺度的演化对材料的宏观断裂行为有重要影响.随着实验技术的飞速进步,高清电子显微镜已经可以观察到原子尺度的裂纹,而计算能力的日渐强大使得原子尺度... 详细信息

材料/结构的断裂是一个多尺度过程,绝大多数断裂过程都涉及到原子键的断裂,因此原子尺度的演化对材料的宏观断裂行为有重要影响.随着实验技术的飞速进步,高清电子显微镜已经可以观察到原子尺度的裂纹,而计算能力的日渐强大使得原子尺度模拟成为揭示实验现象背后的断裂机制、研究众多典型纳米结构材料断裂行为的有力工具.在本综述文章中,首先介绍了原子尺度断裂模拟的加载方法,包括均匀加载、速度梯度加载、K场加载和静水应力加载,并综合对比了上述加载方法的适用范围,然后给出了基于原子尺度信息定量计算断裂韧性的方法,包括能量释放率法、线下面积积分法、临界应力强度因子法、原子尺度内聚力模型法和原子尺度J积分法.随后介绍了近年来有代表性的不同类型的纳米结构材料(包括单晶、多晶、孪晶等晶体结构,非晶结构,异质界面结构)断裂行为模拟研究,例如钝化处理的单晶硅太阳能电池裂纹抗力大大增加、锂离子电池中锂化浓度控制的硅电极韧脆转变、错配应力驱动界面自发分层一步制备大尺度纳米硅片.这些研究结果揭示了实验现象背后的机理,同时和实验结果的一致性也印证了原子尺度模拟的可靠性与准确性.最后强调了原子尺度模拟面临的一些问题和挑战,并对将来的发展方向进行了展望.

关键词：纳米结构材料断裂行为断裂韧性原子尺度模拟

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浅析“岩土工程三角形”——译与议

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土木工程学报 2024年第4期57卷 71-80页

作者：杜斌高文生李广信秋仁东中国建筑科学研究院有限公司地基基础研究所北京100013 清华大学水沙科学与水利水电工程国家重点实验室北京100084

由Burland提出并经不断演进的“岩土工程三角形”,既是一个反映岩土工程各项工作内容的图示化框架,也是一个解决岩土工程问题的思维框架。岩土工程三角形由4个要素构成:(1)地层剖面;(2)量测到的特性;(3)合适的模型;(4)经验。其中,前三... 详细信息

由Burland提出并经不断演进的“岩土工程三角形”,既是一个反映岩土工程各项工作内容的图示化框架,也是一个解决岩土工程问题的思维框架。岩土工程三角形由4个要素构成:(1)地层剖面;(2)量测到的特性;(3)合适的模型;(4)经验。其中,前三个要素分别构成三角形的三个顶点,而经验占据三角形的中心,并与顶点相连。成功的岩土工程必须考虑岩土工程三角形中的各个要素,并使其保持“平衡”。将岩土工程三角形应用于不同的场景,可进一步扩展其外延。文章旨在结合中文语境,对岩土工程三角形的核心思想进行剖析和阐释,力图更加准确地展现原作的意思表达,助力掌握这一具有实用价值的工作方法。

关键词：岩土工程三角形成熟的经验框架

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典型作战流程和分级环境下发射车生存能力改进ADC评估模型

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国防科技大学学报 2024年第1期46卷 222-230页

作者：王冬高钦和黄通刘志浩火箭军工程大学导弹工程学院陕西西安710025

为了综合评估发射车在作战中的生存能力,区分参数-性能-能力-效能四个层次建立武器装备评估空间,构建对象、内容和层次三个维度的评估框架,划分五类自然环境、三级威胁环境和三种作战状态,将外界环境引入评估过程,用被发现概率和损毁概... 详细信息

为了综合评估发射车在作战中的生存能力,区分参数-性能-能力-效能四个层次建立武器装备评估空间,构建对象、内容和层次三个维度的评估框架,划分五类自然环境、三级威胁环境和三种作战状态,将外界环境引入评估过程,用被发现概率和损毁概率表征发射车隐蔽伪装能力和抗毁防护能力,建立发射车作战状态转移概率矩阵,提出典型作战流程和分级环境下的发射车生存能力改进可靠性、可信性、可用性综合评估模型。通过仿真分析,在不同环境和作战状态下各型发射车生存能力差异明显,模型能在性能空间、环境空间、作战流程空间多个维度动态评估发射车的生存能力,为发射车性能设计、战场运用提出量化和优化建议。

关键词：作战流程分级环境发射车生存能力

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Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3445-3456页

作者： Fan Zeng Da-Ya Zhang Shi-Ju Chen Run-Xiang Chen Chen Chen Shi-Mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology Qionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of Gastroenterology Sanya Central HospitalSanya 572022Hainan ProvinceChina Department of Gastroenterology Hainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of Gastroenterology Dongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan Province Haikou 570216Hainan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean

关键词： Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province

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