Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

作     者：Fan Zeng Da-Ya Zhang Shi-Ju Chen Run-Xiang Chen Chen Chen Shi-Mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen Fei-Hu Bai 

作者机构：Graduate SchoolHainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of GastroenterologyQionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of GastroenterologySanya Central HospitalSanya 572022Hainan ProvinceChina Department of GastroenterologyHainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of GastroenterologyDongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of GastroenterologyThe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan ProvinceHaikou 570216Hainan ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第8期

页      面：3445-3456页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Innovation Platform for Academicians of Hainan Province,No.2022136 the Specific Research Fund of the Innovation Platform for Academicians of Hainan Province,No.YSPTZX202313 Hainan Province Clinical Medical Center,No.2021818 Hainan Provincial Health Industry Research Project,No.22A200078 National Clinical Key Specialty Capacity Building Project,China,No.202330 

主　　题：Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province 

摘      要：BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean