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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： ling-Xia Kong Yan-Hong Zhao zhi-lin feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

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Effect of resilience on quality of life and anxiety in patients with breast cancer

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World Journal of Psychiatry 2024年第10期14卷 1458-1466页

作者： ling-Xia Kong Yong-Xia Yang Qian Zhao zhi-lin feng Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of Psychiatry Zhangjiakou Shalingzi Hospital(Zhangjiakou Mental Health Center)Zhangjiakou 075200Hebei ProvinceChina

BACKGROUND The incidence of breast cancer is high,with serious implications in terms of lives and *** data show that there are approximately 1 million new cases of breast cancer reported annually,with a rising *** patients have poor treatment effects and are prone to anxiety and other negative emotions,which affect their quality of life(QoL).AIM To explore the correlation between mental resilience,QoL,and anxiety in patients with breast *** Using convenience sampling,200 patients with breast cancer were selected from the First Affiliated Hospital of Hebei North *** patients were investigated using the Conner-Davidson Resilience Scale,Self-Rating Anxiety Scale,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire to analyze the impact of resilience in patients with breast cancer on their QoL and *** The mean(SD)mental resilience score of the patients with breast cancer was 59.68(±9.84)points,the anxiety score was 49.87(±8.26)points,and the QoL score was 59.73(±8.29)***,they showed low mental resilience,mild anxiety,and medium *** was negatively correlated with mental resilience and QoL(r=-0.275,r=-0.289,P<0.05).QoL was positively correlated with mental resilience(r=0.513,P<0.05).Anxiety was a mediating variable between mental resilience and QoL,accounting for 8.58%of the mediating *** Regarding psychological elasticity,anxiety plays an intermediary role in QoL among patients with breast *** staff can improve patients'mental resilience by reducing their anxiety and improving their QoL.

关键词： Breast cancer Mental resilience Quality of life Anxiety Psycho-oncology Mediation effect

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连翘提取物对肺炎链球菌感染慢性阻塞性肺疾病急性加重期大鼠的干预机制

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中华医院感染学杂志 2024年第5期34卷 678-683页

作者：王蓓李皖豫张珂林智峰刘冬石河子大学第一附属医院呼吸一科新疆石河子832008 石河子大学药学院新疆石河子832008 石河子大学第一附属医院肾病内科新疆石河子832008

目的探究连翘提取物对肺炎链球菌感染慢性阻塞性肺疾病急性加重期(AECOPD)大鼠的干预机制。方法选取SPF级40只SD大鼠随机分成正常组、模型组、低剂量连翘提取物组、高剂量连翘提取物组,各10只。肺炎链球菌构建肺炎链球菌感染AECOPD大... 详细信息

目的探究连翘提取物对肺炎链球菌感染慢性阻塞性肺疾病急性加重期(AECOPD)大鼠的干预机制。方法选取SPF级40只SD大鼠随机分成正常组、模型组、低剂量连翘提取物组、高剂量连翘提取物组,各10只。肺炎链球菌构建肺炎链球菌感染AECOPD大鼠模型,对照组不做处理。建模完成后干预,检测管壁面积与血管总面积比(WA%)、肌性动脉的管壁厚度与血管外径比(WT%);分析肺功能指标、炎性因子水平、肺组织中黏蛋白5AC(MUC5AC)、表皮生长因子受体(EGFR)、磷酸化-丝裂原活化蛋白激酶p38抗体(p38MAPK)的相对表达量。结果与对照组相比,模型组、连翘提取物低、高剂量组的WT%、WA%、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8、p38MAPK、MUC5AC、EGFR表达量升高,最大呼吸峰流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)水平降低(P<0.05);相较于模型组,低、高剂量连翘提取物组的PEF、FEV1、FVC表达升高,WA%、WT%、IL-6、IL-8、TNF-α、MUC5AC、p38MAPK、EGFR表达降低(P<0.05);与连翘提取物低剂量组相比,连翘提取物高剂量组的PEF、FVC、FEV1表达上升,WA%、WT%、TNF-α、IL-8、IL-6、EGFR、MUC5AC、p38MAPK表达下降(P<0.05)。结论连翘提取物可有效改善肺炎链球菌感染AECOPD大鼠的肺功能,抑制炎症因子表达,调节肺血管重塑,改善预后。

关键词：连翘提取物肺炎链球菌感染慢性阻塞性肺疾病急性加重期肿瘤坏死因子-α 用力肺活量大鼠模型

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紫草提取物对大鼠支气管哮喘肺部感染的干预效果及作用机制

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中华医院感染学杂志 2024年第10期34卷 1447-1452页

作者：李皖豫王蓓张珂林智峰刘冬石河子大学第一附属医院呼吸与危重症医学科新疆石河子832008 石河子大学第一附属医院肾病内科新疆石河子832008 石河子大学药学院新疆石河子832008

目的分析紫草提取物对支气管哮喘肺部感染大鼠的干预效果及作用机制。方法选取50只SPF级SD大鼠,10只大鼠作为对照组,另外40只建立支气管哮喘肺部感染模型,将30只建模成功大鼠分为模型组、药物对照组、紫草提取物组,每组各10只,观察各组... 详细信息

目的分析紫草提取物对支气管哮喘肺部感染大鼠的干预效果及作用机制。方法选取50只SPF级SD大鼠,10只大鼠作为对照组,另外40只建立支气管哮喘肺部感染模型,将30只建模成功大鼠分为模型组、药物对照组、紫草提取物组,每组各10只,观察各组大鼠肺组织病理变化,检测抗氧化情况、炎症因子、肺功能、细胞外调节蛋白激酶/p38丝裂原活化蛋白激酶(ERK/p38MAPK)通路相关mRNA及蛋白表达量。结果与对照组相比,模型组、药物对照组、紫草提取物组丙二醛(MDA)、可溶性髓系细胞触发受体-1(sTREM-1)、降钙素原(PCT)、白细胞介素-6(IL-6)水平、ERK/p38MAPK通路相关mRNA及蛋白表达量升高(P<0.05),超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC水平降低(P<0.05);与模型组相比,药物对照组、紫草提取物组MDA、sTREM-1、PCT、IL-6水平、ERK/p38MAPK通路相关mRNA及蛋白表达量降低(P<0.05),SOD、GSH-Px、FEV_(1)、FVC、FEV_(1)/FVC水平升高(P<0.05);与药物对照组相比,紫草提取物组MDA、sTREM-1、PCT、IL-6水平、ERK/p38MAPK通路相关mRNA及蛋白表达量降低(P<0.05),SOD、GSH-Px、FEV_(1)、FVC、FEV_(1)/FVC水平升高(P<0.05)。结论采用紫草提取物对支气管哮喘肺部感染大鼠干预,可使大鼠抗氧化情况得到改善,并降低大鼠体内炎症因子水平,提高大鼠肺功能,其作用机制与ERK/p38 MAPK信号通路有关。

关键词：支气管哮喘肺部感染紫草提取物肺功能炎症因子

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头花蓼提取物调控PI3K/Akt信号通路对大肠埃希菌感染肾盂肾炎大鼠的干预效果

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中华医院感染学杂志 2024年第7期34卷 968-972页

作者：林智峰刘冬张珂张春江刘刚石河子大学第一附属医院肾病科新疆石河子832008 石河子大学第一附属医院呼吸内科新疆石河子832008 石河子大学药学院新疆石河子832008

目的分析头花蓼提取物通过调控磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号通路对大肠埃希菌感染肾盂肾炎大鼠的干预效果。方法选取SPF级Wistar大鼠45只,10只为对照组,其余35只建立大肠埃希菌感染肾盂肾炎模型,共有30只大鼠成功建模,将其... 详细信息

目的分析头花蓼提取物通过调控磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号通路对大肠埃希菌感染肾盂肾炎大鼠的干预效果。方法选取SPF级Wistar大鼠45只,10只为对照组,其余35只建立大肠埃希菌感染肾盂肾炎模型,共有30只大鼠成功建模,将其分为模型组、药物对照组、头花蓼提取物组3组,每组10只。药物对照组给予左氧氟沙星灌胃;头花蓼提取物组给予头花蓼提取物灌胃;对照组、模型组不做处理,给予0.5ml生理盐水灌胃,7d干预后观察各组大鼠的情况变化。结果与对照组比较,模型组、药物对照组、头花蓼提取物组的白细胞介素(IL)-6、IL-4、IL-10、分泌型免疫球蛋白A(SIgA)、血清肌酐(Scr)、尿素氮(BUN)、24h蛋白尿量、PI3K、AKT表达量上升(P<0.05);与模型组比较,药物对照组、头花蓼提取物组的SIgA、IL-4、IL-6、IL-10、BUN、24h蛋白尿量、Scr、PI3K、AKT表达量下降(P<0.05);与药物对照组比较,头花蓼提取物组的IL-6、IL-10、IL-4、SIgA、BUN、Scr、24h蛋白尿量、AKT、PI3K表达量降低(P<0.05)。结论对大肠埃希菌感染肾盂肾炎大鼠给予头花蓼提取物进行干预,可有效降低炎症反应,促进免疫系统对SIgA的分泌,保护大鼠的肾脏组织,以减轻肾损伤,其机制可能与PI3K/Akt信号通路相关。

关键词：大肠埃希菌感染肾盂肾炎头花蓼提取物磷脂酰肌醇3激酶/蛋白激酶B

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鱼腥草提取物对肺炎支原体感染大鼠的抗炎作用及其作用机制

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中华医院感染学杂志 2024年第2期34卷 172-176页

作者：刘冬林智峰张珂王蓓李皖豫石河子大学第一附属医院呼吸与危重症医学科新疆石河子832008 石河子大学第一附属医院肾病内科新疆石河子832008 石河子大学药学院新疆石河子832008

目的对肺炎支原体感染大鼠进行鱼腥草提取物治疗,对其所产生抗炎功效及作用机制进行分析。方法SPF级Wistar雄性大鼠分为空白组、肺炎支原体感染模型组、鱼腥草提取物低剂量组和高剂量组各9只。空白组、模型组只进行生理盐水灌胃,低剂量... 详细信息

目的对肺炎支原体感染大鼠进行鱼腥草提取物治疗,对其所产生抗炎功效及作用机制进行分析。方法SPF级Wistar雄性大鼠分为空白组、肺炎支原体感染模型组、鱼腥草提取物低剂量组和高剂量组各9只。空白组、模型组只进行生理盐水灌胃,低剂量组和高剂量组给予鱼腥草提取物125 mg/kg、500 mg/kg灌胃,持续7 d后检测外周血转化生长因子-β(TGF-β)、涎液化糖链抗原-6(KL-6)、表面活性蛋白D(SP-D)、炎症因子及Toll样受体4(TLR4)、髓样分化因子88(MyD88)、核因子κB(NF-κB)mRNA相对表达量,免疫印迹法检测肺组织中TLR4、MyD88、NF-κB蛋白表达。结果与空白组比较,模型组、鱼腥草提取物低剂量组、高剂量组TGF-β、KL-6、SP-D、IL-13、TNF-α水平、TLR4、MyD88、NF-κB mRNA表达量、TLR4、MyD88、NF-κB蛋白表达量均升高,IL-12水平降低(P<0.05);与模型组、低剂量组比较,高剂量组TGF-β、KL-6、SP-D、IL-13、TNF-α水平、TLR4、MyD88、NF-κB mRNA表达量、TLR4、MyD88、NF-κB蛋白表达量均降低,IL-12水平升高(P<0.05)。结论通过鱼腥草提取物对肺炎支原体感染大鼠进行治疗干预,以改善局部乃至支气管和肺组织炎症反应,达到较好的干预效果。

关键词：鱼腥草提取物肺炎支原体感染抗炎作用作用机制

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Comparison Between the Effects of 2-Selenium Bridged β-Cyclodextrin and Ebselen on Treating SHRsp Stroke

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Chemical Research in Chinese Universities 2008年第3期24卷 322-329页

作者： JIA zhi-dan lin feng LIU Lei MU Ying YAN Gang-lin LUO Gui-min Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education Jilin University Changchun 130021 P R. China

A glutathione peroxidase（GPX） mimic, 2-selenium bridged β-cyclodextrin（2-SeCD）, was synthesized. In order to examine its role and mechanism in treating stroke we chose stroke-prone spontaneously hypertensive rats（SHRsp） as animal model. 56 SHRsps of 8-week olds were randomly divided into several groups： test groups （low, moderate, high dose of 2-SeCD） and control groups（positive and negative）. After onset of the stroke, the rats in test groups were orally administrated with different amounts of 2-SeCD, the positive control group with ebselen, and the negative control group with drinking water. The treatment lasted two weeks, followed by observation of the rats for 10 days, meanwhile blood pressure, biochemical parameters of plasma, and the contents of nitric oxide（NO） and malondialdehyde（MDA） in plasma and brain were determined. The results show that there were significant differences in contents of NO and MDA in plasma and brain between the test groups（high, moderate dose of 2-SeCD） and negative control group. The NO contents of the test groups were obviously higher than that of the negative control group （P〈0.01）. The MDA contents of the test groups（high, moderate dose of 2-SeCD） were obviously lower than that of the negative control group（P〈0.01）. The mechanism of 2-SeCD in treating stroke was discussed, which maybe related to the increase of NO and the decrease of MDA in plasma and brain tissue, but the exact mechanism should be further studied. Moreover, the tendencies of changes in systolic blood pressure, contents of NO and MDA, and other physiological parameters for the test groups were shown to be much better than the corresponding parameters for the positive group（the group with ebselen）（P〈0.05）, indicating that the treatment effect of 2-SeCD is better than that of ebselen.

关键词： 2-Selenium bridged β-cyclodextrin Glutathione peroxidase Enzyme mimic Stroke Stroke-prone spontaneously hypertensive rat Nitric oxide Malondialdehyde

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2005—2022年防城港市艾滋病患者累积死亡率趋势及艾滋病相关和无关死亡危险因素分析

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现代预防医学 2024年第10期51卷 1729-1735+1765页

作者：严芝蔓林志峰黄雪刚卢平黄祖龙吴叶舟莫实德林燕马平梁冰玉防城港市第一人民医院感染性疾病科档案管理科广西医科大学广西艾滋病防治研究重点实验室防城港市疾病预防控制中心

目的了解广西防城港市抗病毒治疗艾滋病病毒感染者和艾滋病患（HIV/AIDS）的死亡情况及艾滋病死亡的影响因素，为减少艾滋病死亡提供科学依据。方法通过全国艾滋病综合防治信息系统收集2005年1月1日至2022年7月5日期间在防城港市接受... 详细信息

目的了解广西防城港市抗病毒治疗艾滋病病毒感染者和艾滋病患（HIV/AIDS）的死亡情况及艾滋病死亡的影响因素，为减少艾滋病死亡提供科学依据。方法通过全国艾滋病综合防治信息系统收集2005年1月1日至2022年7月5日期间在防城港市接受抗逆转录病毒治疗（Antiretroviral Therapy, ART）治疗的2 728例HIV/AIDS的基本情况和随访资料。采用竞争风险累积发生率（CIF）和部分分布比例风险回归模型（F-G模型）,分析影响艾滋病相关和非艾滋病相关死亡的影响因素。结果本研究纳入了2 728例HIV/AIDS,平均随访人年为6.7人年。295例发生艾滋病相关死亡，病死率为1.06/100人年；227例发生艾滋病无关死亡，病死率为1.2/100人年。考虑竞争风险的情况下，HIV/AIDS患者确诊后1年、5年和13年的艾滋病相关死亡累积发生率分别为2.5%、8.5%和15.0%。多因素分析结果显示，60岁及以上(adjusted Hazard Ratio,aHR=1.50, 95%Confidence Interval（CI）:1.05～2.15)、当前配偶的HIV感染状态未查或不详（aHR=1.39, 95%CI:1.03～1.90）、曾接受预防机会性感染治疗（aHR=1.40,95%CI:1.06～1.84）和出现机会性感染或肿瘤（aHR=1.65, 95%CI:1.12～2.45）的患者发生艾滋病相关死亡风险较高。女性（aHR=0.67, 95%CI:0.49～0.90）、初始治疗方案为依非韦伦（EFV）(aHR=0.41,95%CI:0.25～0.68)、有变更治疗方案（aHR=0.19,95%CI:0.12～0.29）、首次CD4细胞计数≥200个/μL（aHR=0.3,95%CI:0.20～0.45）、初始病毒载量（viral load, VL）为50～1000 copies/ml（aHR=0.31,95%CI:0.18～0.54）和<50 copies/ml （aHR=0.61,95%CI:0.44～0.84）的患者发生艾滋病相关死亡风险较低。60岁及以上（aHR=2.82,95%CI:1.80～4.43）,被动检测（aHR=1.41, 95%CI:1～1.98）、配偶的HIV感染状态未查或不详（aHR=1.40,95%CI:1.01～1.95）、首次CD4细胞计数≥200个/μL（aHR=1.68,95%CI:1.27～2.22）,发生艾滋病无关死亡风险较高。女性（aHR=0.55,95%CI:0.37～0.81）、接受抗病毒治疗后有变更过治疗方案（aHR=0.33,95%CI:0.21～0.50）、初始治疗方案含EFV（aHR=0.55,95%CI:0.34～0.88）和奈韦拉平（NVP）(aHR=0.50,95%CI:0.30～0.83)的患者发生艾滋病无关死亡风险较低。结论防城港市HIV/AIDS抗病毒治疗患者的死亡发生率较低。本研究强调了预防和治疗机会性感染或肿瘤对HIV/AIDS患者生存的重要性。艾滋病护理门诊应重点关注男性、年龄较大的患者、被动检测发现的HIV/AIDS的监测和随访，提高患者的服药依从性，扩大重点人群的HIV检测，以降低艾滋病患者的死亡率。

关键词：艾滋病病毒感染者/艾滋病患者生存分析竞争风险模型

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Esophageal mycobiome landscape and interkingdom interactions in esophageal squamous cell carcinoma

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Gastroenterology Report 2023年第1期11卷 300-308页

作者： Wen-Qing Rao Zheng lin Jian Jiang Jian-Wen Wang zhi-feng lin Rong Fu Wei-lin Chen Yuan-Mei Chen Xian-EPeng zhi-Jian Hu Department of Epidemiology and Health Statistics Fujian Medical University Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public HealthFujian Medical UniversityFuzhouFujianP.R.China Department of Medical Services Fujian Provincial HospitalFuzhouFujianP.R.China Department of Digestive Endoscopy Anxi County HospitalAnxiFujianP.R.China Department of Radiation Oncology Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujianP.R.China Department of Thoracic Surgery Fujian Provincial Cancer Hospital Affiliation to Fujian Medical UniversityFuzhouFujianP.R.China Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical UniversityFuzhouFujianP.R.China

Background The study purpose was to characterize the mycobiome and its associations with the expression of pathogenic genes in esophageal squamous cell carcinoma(ESCC).Methods Patients with primary ESCC were recruited from two central *** performed internal transcribed spacer 1(ITS1)ribosomal DNA sequencing *** compared differential fungi and explored the ecology of fungi and the interaction of bacteria and *** The mycobiota diversity was significantly different between tumors and tumor-adjacent *** further analysed the differences between the two groups,at the species level,confirming that Rhodotorula toruloides,Malassezia dermatis,Hanseniaspora lachancei,and Spegazzinia tessarthra were excessively colonized in the tumor samples,whereas Preussia persica,Fusarium solani,Nigrospora oryzae,Acremonium furcatum,Golovinomyces artemisiae,and Tausonia pullulans were significantlymore abundant in tumor-adjacent *** fungal co-occurrence network in tumor-adjacent samples was larger and denser than that in ***,themore complex bacterial–fungal interactions in tumor-adjacent samples were also *** expression ofmechanistic target of rapamycin kinase was positively correlated with the abundance of *** and *** in tumor-adjacent *** tumors,the expression ofMET proto-oncogene,receptor tyrosine kinase(MET)had a negative correlation and a positive correlation with the abundance of *** and ***,*** This study revealed the landscape of the esophageal mycobiome characterized by an altered fungal composition and bacterial and fungal ecology in ESCC.

关键词： esophageal squamous cell carcinoma mycobiome fungi interkingdom co-occurrence network

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Progress in processing of porous titanium:a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang Xian-feng Du zhi-lin Xu Zhong-Shuai Liang Li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi'an Jiaotong UniversityXi'an 710049China

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace,marine engineering and biomedical fields due to their high corrosion resistance,low density,good biocompatibility and excellent mechanical ***,in this paper,a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes)for fabricating porous titanium is firstly covered in terms of their working principles,capabilities,shortcomings and ***,the influencing factors of various methods on final pore structure of porous Ti are ***,a summary of the chemical methods(CM)to obtain the porous Ti is also provided,such as dealloying method and reduction ***,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

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