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Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu Zheng Hong-Yi Tang hua-zhi li Xin-Yu Cui Shuai Ding Duo liu Cui-Ying li Jiu-Hui Jiang Rui-li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(liPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that liPUS could reduce the duration of orthodontic treatment;however,how liPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of liPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and liPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by liPUS could be attenuated by YAP siRNA ***,liPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

Joint Design of Clustering and In-cluster Data Route for Heterogeneous Wireless Sensor Networks

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International Journal of Automation and computing 2017年第6期14卷 637-649页

作者： liang Xue Ying liu zhi-Qun Gu zhi-hua li Xin-Ping Guan School of Information and Electrical Engineering Hebei University of Engineering State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications System Control and Information Processing Key Laboratory of Ministry of Education Shanghai Jiao Tong University

A heterogeneous wireless sensor network comprises a number of inexpensive energy constrained wireless sensor nodes which collect data from the sensing environment and transmit them toward the improved cluster head in a coordinated way. Employing clustering techniques in such networks can achieve balanced energy consumption of member nodes and prolong the network *** classical clustering techniques, clustering and in-cluster data routes are usually separated into independent operations. Although separate considerations of these two issues simplify the system design, it is often the non-optimal lifetime expectancy for wireless sensor networks. This paper proposes an integral framework that integrates these two correlated items in an interactive entirety. For that,we develop the clustering problems using nonlinear programming. Evolution process of clustering is provided in simulations. Results show that our joint-design proposal reaches the near optimal match between member nodes and cluster heads.

关键词： Heterogeneous wireless sensor networks clustering technique in-cluster data routes integral framework network lifetimes

Generation of Four-Photon Cluster State with Coherent light via Cross-Kerr Nonlinearity

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Communications in Theoretical Physics 2008年第9期50卷 623-626页

作者： DU Qian-hua YE Ming-Yong CHEN zhi-hua li Xing-hua liN Xiu-Min School of Physics and Optoelectronics Technology Fujian Normal University Fuzhou 350007 China

We propose two schemes for preparing four-photon cluster state through cross-Kerr nonlinearity. Two coherent fields interact when they enter a nonlinear Kerr medium. If the interaction time is chosen appropriately in each Kerr medium, four-photon cluster state can be generated based on the results of two homodyne detectors in the first scheme. These schemes only use Kerr medium and homodyne measurements on coherent light fields, which can be effciently made in quantum optical laboratories. In addition, weak cross-Kerr nonlinearity is sufficient. All of the properties make these schemes feasible in experiments.

关键词： cluster state cross-Kerr nonlinearity homodyne measurement

Simulation of Potential Production and Optimum Population Quantitative Indices for the Second Hybrid Rice

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Agricultural Sciences in China 2006年第7期5卷 498-505页

作者： YAN li-Jiao YAO Zhong ZHENG zhi-ming li hua-bin Agro-Ecology Institute Life Science College Zhejiang University Hangzhou 310029 P.R.China

The article established the HDRICE model by modifying the structure of the ORYZA1 model and revising its parameters by field experiments. The HDRICE model consists of the modules of morphological development of rice, daily dry matter accumulation and partitioning, daily CO2 assimilation of the canopy, leaf area, and tiller development. The model preferably simulated the dynamic rice development because of the thorough integration of the effects of temperature and light on the rates of rice development, photosynthesis, respiration, and. other ecophysiological processes. In addition, this model has attainable grain yield in the test experiment that showed the potential yield of cultivar Xieyou 46 ranged from 11 to 13 tons ha-~. Besides, the model was used to optimize the combinations of the transplanting date, seedling age and density for cultivar Xieyou 46 at Jinhua area, and the population quantitative indices to attain the potential yield such as maximum stems, effective panicles, filled grain number/leaf area, and so on. The result showed that the combination of transplanting date on July 25, seedling age of 35 days and base seedling density of 1.33 x 106ha-1 is the optimum combination for the second hybrid rice production in Jinhua County, China. And the maximum stems, the effective panicles, the filled grain per panicle, the peak of optimum LAI, LAI in later filling stage, and the filled grain number/leaf were 6.03×10^6ha, 3.99×10^6ha, 119.2, 8.59, 5-6, and 0.64, respectively.

关键词： simulation model potential production optimum population quantitative indices second hybrid rice

Wear-resistant coating spraying technique for wear-proofing cover of coke dry quenching furnace

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Journal of Iron and Steel Research International 2019年第2期26卷 123-129页

作者： Zhang-fu Yuan Shan-shan Xie Xiang-tao Yu Jian liu Ping Du zhi-hua li Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Jiangsu Shagang Iron and Steel Research Institute Co. Ltd.Suzhou 215625JiangsuChina

During the operation of a coke dry quenching system of coking plant, wear-proofing cover of the boiler was seriously eroded, and even the ceiling tube of the boiler was worn and torn. Thus, attentions were paid to the research, development and application of the wear-resistant coating spraying technique for wear-proofing cover of the coke dry quenching furnace. The Cr3C2–NiCr coatings for wear-proofing cover were fabricated via supersonic arc spraying process, and the residual coating of wear-proofing cover would be sampled for being analyzed after two years. The coating presents a dense microstructure with few pores and micro-cracks (the porosity is 4.65%). After thermal spraying of the wear-proofing cover, the hardness and the wear resistance of the surface are improved. The remaining coating is continuous and compact, with an average thickness of about 147μm. Transverse micro-cracks parallel to the spreading direction of the coating surface are displayed on different areas of the coating, which demonstrates its serious erosion wear effect. The main chemical component of white zone is Fe–18Cr–Ni. The Cr level of light gray phase is about 77.57 wt.% and the O level is 22.43 wt.%. And the main chemical components of dark gray phase are C, O, Al, Si and Ca. X-ray diffraction patterns were adopted to implement phase analysis on the surface of coating sample, which indicated that the coating was composed of a large amount of Cr3O2 and a small amount of metal Cr.

关键词： Coke dry quenching Wear-proofing cover Thermal spraying technique Coating property Cr3C2-NiCr coating

Molecular insights of organochlorine biocide-induced toxicity in zebrafish:Whole-adult-organism toxicogenomics,targeted gene expression and histological analyses

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Journal of Genetics and Genomics 2016年第8期43卷 525-528页

作者： eei yin lui caixia li zhi-hua li zhiyuan gong siew hong lam nus environmental research institute national university of singapore117411Singapore department of biological sciences national university of singapore117543Singapore yangtze river fisheries research institute chinese academy of fishery sciencesWuhan 430223China

Organochlorine biocides （OCBs）, such as lindane and dichlorodi- phenyltrichloroethane （DDT）, have been used for control of vector- borne diseases in public health and for insect pest control in agri- culture. These chemicals are extremely persistent in the environ- ment and they tend to bioaccumulate via food chains, thus posing risk to human and ecological health （Cooney et al., 2010; Wang et al., 2013）. Due to their persistence in the environment and continuous use in certain countries despite the banning of some of these chemicals, monitoring and studies of OCBs have continued intensely and remain relevant in foreseeable future （ Cohn et al.,

关键词： Molecular insights of organochlorine biocide-induced toxicity in zebrafish gene

Association between Polymorphism of Interleukin-23 Receptor and Hashimoto＇s Thyroiditis in Chinese Han Population of Shandong

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Chinese Medical Journal 2015年第15期128卷 2050-2053页

作者： zhi-hua li Jie Han Yu-Fei Wang Jun Dai Hui Zhang Chun-Xia li Qun Ma Academy of Basic Medicine Jining Medical University Jining Shandong 272067 China Department of Surgery The Affiliated Hospital of Jining Medical University First People's Hospital of Jining Jining Shandong 272011 China

Objective：The interleukin-23 receptor （IL-23R） has been shown to be associated with autoimmune diseases in many different *** study aimed to investigate the association between IL-23R gene polymorphism and susceptibility to Hashimoto＇s thyroiditis （HT） in Chinese Han population of ***：A case-control cohort study was performed in 145 HT patients from First People＇s Hospital of Jining between February 2010 to October 2013 and 150 healthy *** single nucleotide polymorphisms located in the promoter region ofIL-23R gene （rs 17375018 and rs7517847） were examined by polymerase chain reaction-restriction fragment length polymorphism ***-Weinberg equilibrium was performed using the Chi-square *** frequencies were estimated by direct counting,and allele and genotype frequencies between patients and controls were analyzed by the Chi-square ***：The rs 17375018 GG genotype and the G allele were significantly increased in HT patients compared with healthy controls （P =0.034 and P =0.013,respectively）.No association was identified between HT patients and healthy controls in ***：The study demonstrated that polymorphism of IL-23R gene rs17375018 is highly associated with HT in Chinese Han population of Shandong,suggesting that IL-23R gene polymorphism （rs 17375018 G） may play a critical role in susceptibility to HT.

关键词： Genotype Hashimoto's Thyroiditis Interleukin-23 Receptor Polymorphism

Development of a new 17-item Asthenopia Survey Questionnaire using Rasch analysis

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1867-1875页

作者： Na lin Xiao-Man li Mao-Yuan Yang li Tian zhi-hua li Jie-li Mao Jia-Fang Zhang Jie Chen Fan Lyu Ru-zhi Deng National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina

AIM:To develop the 17-item Asthenopia Survey Questionnaire(ASQ)-17 by Rasch analysis,and to generate a predictiveness ***:Totally 739 participants were recruited and 680 were involved in the result analysis in this prospective,cross-sectional *** rounds of Rasch analysis were used to analyze the psychometric characteristics of items and ***:Phase 1 assessed the original ASQ-19,adjusted the item scoring mode to a four-point likert response rating scale and combined the 18th and 19th items into a new *** 2 deleted the 11th *** 3 and 4 assessed the new *** the evaluation indexes of ASQ-17 were *** Infit and Outfit MnSq values of items were 0.67-1.48,the variance explained by the principal component and the unexplained variance explained by the first contrast were 53.90%-59.40%and 1.50-1.80 in three *** curve peaks of scores in each dimension were separated and in the same *** PSR and PSI values were 2.80 and 0.89,*** mean scores of dimensions A(9.5±4.1 vs 3.5±3.2),B(7.3±3.3 vs 2.5±2.7),C(4.3±2.2 vs 1.4±2.0)and total(21.1±8.1 vs 7.4±7.0)in asthenopia participants were significantly higher than those without asthenopia(all Plity than *** is an effective assessment tool for asthenopia with an optimal cut-off threshold value of 12.5,which is suitable for diagnosis and curative effect evaluation.

关键词： asthenopia 17-item Asthenopia Survey Questionnaire Rasch analysis scoring mode

Neutron irradiation influence on high-power thyristor device under fusion environment

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Nuclear Science and Techniques 2024年第4期35卷 65-81页

作者： Wei Tong hua li Meng Xu zhi-Quan Song Bo Chen School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

Because of their economy and applicability,high-power thyristor devices are widely used in the power supply systems for large fusion *** high-dose neutrons produced by deuterium–tritium(D–T)fusion reactions are irradiated on a thyristor device for a long time,the electrical characteristics of the device change,which may eventually cause irreversible *** this study,with the thyristor switch of the commutation circuit in the quench protection system(QPS)of a fusion device as the study object,the relationship between the internal physical structure and external electrical parameters of the irradiated thyristor is ***,a series of targeted thyristor physical simulations and neutron irradiation experiments are conducted to verify the accuracy of the theoretical *** addition,the effect of irradiated thyristor electrical characteristic changes on the entire QPS is studied by accurate simulation,providing valuable guidelines for the maintenance and renovation of the QPS.

关键词： Fusion device Neutron irradiation effects Thyristor Quench protection