Association between Polymorphism of Interleukin-23 Receptor and Hashimoto＇s Thyroiditis in Chinese Han Population of Shandong

作     者：Zhi-Hua Li Jie Han Yu-Fei Wang Jun Dai Hui Zhang Chun-Xia Li Qun Ma Li Zhi-Hua;Han Jie;Wang Yu-Fei;Dai Jun;Zhang Hui;Li Chun-Xia;Ma Qun

作者机构：Academy of Basic Medicine Jining Medical University Jining Shandong 272067 China Department of Surgery The Affiliated Hospital of Jining Medical University First People's Hospital of Jining Jining Shandong 272011 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第15期

页      面：2050-2053页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 0713[理学-生态学] 

基　　金：TheResearchProjectoftheEducationDepartmentofShandongProvince(No.J12LK16) 

主　　题：Genotype Hashimoto's Thyroiditis Interleukin-23 Receptor Polymorphism 

摘      要：Objective：The interleukin-23 receptor （IL-23R） has been shown to be associated with autoimmune diseases in many different *** study aimed to investigate the association between IL-23R gene polymorphism and susceptibility to Hashimoto＇s thyroiditis （HT） in Chinese Han population of ***：A case-control cohort study was performed in 145 HT patients from First People＇s Hospital of Jining between February 2010 to October 2013 and 150 healthy *** single nucleotide polymorphisms located in the promoter region ofIL-23R gene （rs 17375018 and rs7517847） were examined by polymerase chain reaction-restriction fragment length polymorphism ***-Weinberg equilibrium was performed using the Chi-square *** frequencies were estimated by direct counting,and allele and genotype frequencies between patients and controls were analyzed by the Chi-square ***：The rs 17375018 GG genotype and the G allele were significantly increased in HT patients compared with healthy controls （P =0.034 and P =0.013,respectively）.No association was identified between HT patients and healthy controls in ***：The study demonstrated that polymorphism of IL-23R gene rs17375018 is highly associated with HT in Chinese Han population of Shandong,suggesting that IL-23R gene polymorphism （rs 17375018 G） may play a critical role in susceptibility to HT.