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Distributive characteristics of Ser49Gly and Gly389Arg genetic polymor-phisms of β1-adrenoceptor in Chinese Han and Dai populations

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Acta Pharmacologica Sinica 2006年第2期27卷 254-258页

作者： Zhao-qian LIU Jie LIU zhi-hua xiang Min-yu HU Wei MO Lian-sheng WANG Dong-sheng OU-YANG Nan HE Dan WANG Hong-hao ZHOU Pharmacogenetics Research Institute,Institute of Clinical Pharmacology,xiang-Ya School of Medicine.Central South University,Changsha 410078.China PharmacogeneticsResearchInstitute InstituteofClinicalPharmacologyXiang-YaSchoolofMedicineCentralSouthUniversityChangsha410078China

Aim:Genetic polymorphisms causing Ser49Gly and Gly389Arg mutants of β1-adrenoceptor may result in significant changes in the function of this *** aim of the present study was to investigate the frequencies of the Ser49Glyand Gly389Arg mutant alleles in healthy Chinese populations and to investigatethe differences between 2 Chinese ethnic groups(Han and Dai populations)withrespect to the frequencies of these ***:A total of 225 Han Chineseand 175 Dai Chinese unrelated healthy volunteers were recruited for this *** DNA was extracted from peripheral blood leukocytes by using a stan-dard manual chloroform-phenol *** spanning the 2 polymor-phisms were amplified by using polymerase chain reaction with template genomicDNA and relevant *** DNA products including the polymorphic lociwere subjected to restriction endonuclease digestion with Eco01091 and *** fragments were detected with an ultraviolet detector after electrophore-sis(100 V for approximately 1.5 h).Results:The frequencies of the Gly49 andArg389 alleles were,respectively,16.2% and 76.4% in the Han population and 14.6%and 75.7% in the Dai ***:The polymorphisms causing theSer49Gly and Gly389Arg mutations of the β1-adrenoceptor existed in both healthyHan and Dai Chinese *** frequencies of the Ser49Gly and Gly389Argmutant alleles were not significantly different in the Han and Dai ***,the frequency of the Gly389 variant seems to be significantly lower inthese 2 populations than in an African-American population.

关键词： β1-adrenoceptor genetic polymorphism Ser49Gly Gly389Arg

Pyridine-regulated Sb@InSbS_(3)ultrafine nanoplates as high-capacity and long-cycle anodes for sodium-ion batteries

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Rare Metals 2024年第5期43卷 2080-2092页

作者： Jia-Ying Ren xiang-Lin yu Chang-Miao Chen Xin-yu Hu Ting Yang Ming Zhang College of Materials Science and Engineering and College of Science Central South University of Forestry and TechnologyChangsha 410004China College of Semiconductors(College of Integrated Circuits) Changsha Semiconductor Technology and Application Innovation Research InstituteHunan UniversityChangsha 410082China

Sb-based materials exhibit considerable potential for sodium-ion storage owing to their high theoretica ***,the bulk properties of Sb-based materials always result in poor cycling and rate *** overcome these issues,pyridine-regulated Sb@InSbS_(3)ultrafine nanoplates loaded on reduced graphene oxides(Sb@InSbS_(3)@rGO)were designed and *** the synthesis process,pyridine was initially adopted to coordinate with In^(3+),and uniformly dispersed In_(2)S_(3)ultrafine nanoplates on reduced graphene oxide were generated after ***,partial In^(3+)was exchanged with Sb^(3+),and Sb@InSbS_(3)@rGO was obtained by using the subsequent annealing *** unique structure of Sb@InSbS_(3)@rGO effectively shortened the transfer path of sodium ions and electrons and provided a high *** the anode in sodium-ion batteries,the Sb@InSbS_(3)@rGO electrode demonstrated a significantly higher reversible capacity better stability(445 m Ah·g^(-1)at 0.1 A·g^(-1)after 200 cycles and 212 mAh·g^(-1)at 2 A·g^(-1)after 1200 cycles),and superior rate(210 mAh·g^(-1)at 6.4 A·g^(-1))than the electrode without pyridine(355 mAh·g-1at 0.1 A·g-1after 55 cycles and 109 mAh·g^(-1)at 2 A·g^(-1)after 770 cycles)Furthermore,full cells were assembled by using the Sb@InSbS_(3)@rGO as anode and Na_(3)V_(2)(PO_(4))_(3)as cathode which demonstrated good cycling and rate performances and exhibited promising application *** results indicate that adjusting the microstructure of electrode materials through coordination balance is A·good strategy for obtaining high-capacity,high-rate,and longcycle sodium storage performances.

关键词： Sodium-ion battery Sb-based anode material Pyridine coordination Reduced size nanostructure Half/full cell

Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang xiang-Cui Liu yu-Chao Wang Huan-Ran Zheng Jin-Xian Wang Jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng yu Bai Ying-Bi Chen Tong Zhang zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

The effect of Ti and Zr content on the structure,mechanics and energy-release characteristics of Ti—Zr—Ta alloys

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Defence Technology（防务技术） 2024年第1期31卷 343-350页

作者： Jia-yu Meng Jing-zhi He Bin Zhang Jin Chen Shun Li Dun Niu yu Tang Xi’an Modern Chemistry Research Institute Xi'an710065China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China

Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage *** this work the microstructure,mechanical properties and energy release characteristics of multi-element Ti-Zr-Ta alloys with good casting performance were *** microstructure of the Ti_(x)ZrTa alloys gradually change from BCC+HCP to single BCC structure with the increase of *** the Ti_(2)Zr_(y)Ta alloys was still uniform and single BCC structure with the increase of *** evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti-Zr-Ta *** synergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation *** as Zr content increases,the fracture strain of Ti_(2)Zr_(y)Ta alloys decrease,then the oxidation reaction rate and fragmentation degree gradually *** higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of Ti_(x)ZrTa alloys with low Ti content and Ti_(2)Zr_(y)Ta alloys with high Zr content.

关键词： Energetic structural materials Ti-Zr-Ta Multi-element alloy Energy release characteristics

NbB_(2)Modified Al-Cu Alloys Fabricated by Freeze-Ablation Casting under High Cooling Rate Solidification

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 921-938页

作者： xiang Kong yu Wang Hong Xu Haotian Fan yuewu Zheng Beibei Xie School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

At present,improving the properties of aluminum alloys is generally achieved by increasing the cooling rate of the melt and adding micro-nano *** the cooling rate of the melt to improve the refining effect of grain refiner is still a difficult problem in the aluminum alloy casting *** innovative and environmentally friendly casting process,known as freeze ablation,was introduced during the preparation of an Al–NbB_(2) intermediate *** process significantly enhanced the cooling rate of the *** results indicated that the Al–NbB_(2) intermediate alloy produced under high cooling rates had a noticeable refining effect on Al–Cu alloys,with smaller NbB2 particles demonstrating superior refining *** average grain size of the refined Al–Cu alloy decreased from 154 to 69μm,the tensile strength increased by 12%,the fluidity increased by 18.4%,and the hot tearing index decreased from 144 to *** matching degree between NbB_(2) andα-Al was calculated using high-resolution transmission electron microscopy and the edge-to-edge *** was found that the atomic interplanar spacing and the interatomic spacing mismatch between NbB_(2)’splane and Al were both less than 10%,which further proved that NbB2 could serve as an effective nucleation site forα-Al grains to achieve grain refinement.

关键词： Grain refinement Freeze ablation Particle size control Mechanical properties Process properties

Sexual Dimorphism and Female Reproductive Characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South China

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Asian Herpetological Research 2024年第1期15卷 49-58页

作者： yu DU Xiaming ZHU Chixian LIN yuntao YAO xiang JI Hainan Key Laboratory for Herpetological Research College of Fisheries and Life SciencesHainan Tropical Ocean UniversitySanya 572022HainanChina Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection College of Life and Environmental SciencesWenzhou UniversityWenzhou 325035ZhejiangChina Institute for Eco-environmental Research of Sanyang Wetland Wenzhou UniversityWenzhou 325014ZhejiangChina

We studied sexual dimorphism in body size and shape and female reproductive characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South *** our sample the largest female and male were 61.1 and 55.2 mm snout-vent length(SVL),*** mean SVL was larger in adult females(52.0 mm)than in adult males(48.3 mm).Juveniles were sexually dimorphic in head length but not in other examined morphological *** males were longer in head length and shorter in abdomen length and fore-limb length than adult females of the same *** shifts in sexual dimorphism in body shape were evident,as revealed by the fact that morphological differences between the sexes were more pronounced in adults than in *** produced a single litter of 3–6 offspring per season from early August to early *** size,litter mass and offspring(neonate)mass were positively related to female *** mass was independent of relative *** the above findings we draw three main ***,females are the larger sex in ***,and sexual dimorphism in body shape is more pronounced in adults than in ***,larger female *** produce more and larger offspring and thus heavier litters than smaller ***,the offspring size-number trade-off does is not evident in ***.

关键词： fecundity morphology offspring size-number trade-off reproduction scincidae sexual dimorphism

Self-assembled high-entropy nitride multilayer coating

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Rare Metals 2024年第6期43卷 2876-2883页

作者： xiang-yu Zhang Yan Liu Vasiliy Pelenovich Xiao-Mei Zeng Jie Liu Qiang Wan Alexander Pogrebnjak Long-Jian Xue zhi-Wen Chen Yan Lei Bing Yang School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Hubei JiuFengShan Future Science and Technology Laboratory Wuhan 420000China Institute of Technological Sciences of Wuhan University Wuhan 430072China Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration Wuhan UniversityWuhan 430072China College of Engineering Huazhong Agricultural UniversityWuhan 430070China Sumy State University Sumy 40007Ukraine Institute of Materials Science Slovak University of Technology in BratislavaJána Bottu2591724 TrnavaSlovak Republic Shenzhen Research Institute of Wuhan University Shenzhen 518057China

The development of advanced materials and construction of multilayer structure contribute to enhancing the performance of protective coatings,further improving the industrial productivity and conserving *** this paper,the self-assembled high-entropy nitride(HEN)AlCrNbSiTiN multilayer coating was designed by harnessing the plasma distribution characteristics and depos-ited by arc ion plating using single target.

关键词： coating energy multilayer

Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： Jia-xin yu Xiao-yu Wang Jun-wei Shen Jin-sen Hu xiang-qing Zhang Da-qing He yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden *** present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the ***,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are ***,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and ***,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can Hu Yan-Qiang Zhang Peng-Cheng yu Yi Wang zhi-yuan Xu Huan-Ying Fu xiang-Dong Cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade