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Prognostic values of chromosome 18q microsatellite alterations in stage Ⅱ colonic carcinoma

World Journal of Gastroenterology 2010年第47期16卷 6026-6034页

作者： wei Wang Guo-Qiang Wang Xiao-wei Sun Yuan-Fang Li Hai-Bo Qiu Chun-Yu Huang You-Qing Zhan zhi-wei zhou Li-Yi Zhang Gong Chen Department of Gastric and Pancreatic Surgery State Key Laboratory of Oncology in South China Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong ProvinceChina Department of Colorectal Surgery China

AIM: To investigate the prognostic value of chromosome 18q microsatellite alterations (MA) in stage Ⅱ colon cancer. METHODS: One hundred and six patients with sporadic stage Ⅱ colon cancer were enrolled in this study. DNA was extracted from formalin-fixed, paraffin-embedded tumor and adjacent normal mucosal tissue samples. MA, including loss of heterozygosity (LOH) and microsatellite instability (MSI), was analyzed by polymerase chain reaction, polyacrylamide gel-electrophoresis and DNA sequencing at 5 microsatellite loci on chromosome 18q (D18S474, D18S55, D18S58, D18S61 and D18S64).RESULTS: Among the 102 patients eligible for MA information, the overall frequencies of LOH, high and low frequency MSI/microsatellite stable were 49.0%, 17.6% and 82.4%, respectively. The high frequency of 18q-LOH was signif icantly associated with the poor 5-year overall survival (OS) (P=0.008) and disease free survival (P=0.006). High levels of MSI were significantly associated with a longer 5-year OS (P=0.045) while the higher frequency of 18q-LOH at the loci of D18S474 and D18S61 was significantly associated with a poorer 5-year OS (P=0.010 and 0.005, respectively). But multivariate analysis showed that only the frequency of 18q-LOH was significantly associated with the prognosis of the disease. CONCLUSION: High frequency of 18q-LOH is an independent prognostic factor indicating poor prognosis of the patients with stage Ⅱ colon cancer.

关键词： Chromosome 18q Loss of heterozygosity Microsatellite instability Stage Ⅱ colon cancer Prognosis

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Long-term clinical outcomes and health-related quality of life in patients with isolated methylmalonic acidemia after liver transplantation:experience from the largest cohort study in China

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World Journal of Pediatrics 2024年第8期20卷 809-821页

作者： Yi-zhou Jiang Guang-Peng zhou Lin wei wei Qu zhi-Gui Zeng Ying Liu Yu-Le Tan Jun Wang zhi-Jun Zhu Li-Ying Sun Department of Critical Liver Diseases Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityNo.101 Lu Yuan Dong RoadTong-Zhou DistrictBeijing110112China Liver Transplantation Center National Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijingChina Clinical Center for Pediatric Liver Transplantation No.101 Lu Yuan Dong RoadTong-Zhou DistrictCapital Medical UniversityBeijing110112China

Background Liver transplantation(LT)has been proposed as a viable treatment option for selected methylmalonic acidemia(MMA)***,there are still controversies regarding the therapeutic value of LT for *** systematic assessment of health-related quality of life(HRQoL)-targeted MMA children before and after LT is also *** study aimed to comprehensively assess the long-term impact of LT on MMA,including multiorgan sequelae and HRQoL in children and *** We retrospectively evaluated 15 isolated MMA patients undergoing LT at our institution between June 2013 and March ***-and post-transplant data were compared,including metabolic profiles,neurologic consequences,growth parameters,and *** further assess the characteristics of the HRQoL outcomes in MMA,we compared the results with those of children with biliary atresia(BA).Results All patients had early onset MMA,and underwent LT at a mean age of 4.3 *** 1.3–8.2 years of follow-up,the patient and graft survival rates were 100%.Metabolic stability was achieved in all patients with liberalized dietary protein *** was a significant overall improvement in height Z scores(P=0.0047),and some preexisting neurological complications remained stable or even improved after *** the Pediatric Quality of Life Inventory(PedsQL™)generic core scales,the mean total,physical health,and psychosocial health scores improved significantly posttransplant(P<0.05).In the family impact module,higher mean scores were noted for all subscales post-LT,especially family function and daily activities(P<0.01).However,the total scores on the generic core scales and transplant module were significantly lower(Cohen’s d=0.57–1.17)when compared with BA *** particular,social and school functioning(Cohen’s d=0.86–1.76),treatment anxiety,and communication(Cohen’s d=0.99–1.81)were far behind,with a large effect *** This large single-center study of the mainland of China sh

关键词： Health-related quality of life.Inborn error of metabolism Isolated methylmalonic acidemia Liver transplantation:Outcomes

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Comparison of transthoracic and transabdominal surgical approaches for the treatment of adenocarcinoma of the cardia

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Chinese Journal of Cancer 2010年第8期29卷 747-751页

作者： Bin Zheng Ying-Bo Chen Yi Hu Jun-Ye Wang zhi-wei zhou Jian-Hua Fu State Key Laboratory of Oncology in South China GuangzhouGuangdong 510060P.R.China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Gastric and Pancreatic Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background and Objective: Transthoracic and transabdominal approaches are commonly used for the surgical treatment of adenocarcinoma of the cardia. Which approach is better has been controversial for quite a long time. Our study aimed to compare the surgical trauma, range of lymph node dissection, and the prognosis of the transthoracic and transabdominal approaches for the treatment of adenocarcinoma of the cardia. Methods: The medical records of 331 patients with adenocarcinoma of the cardia treated in our hospital between 1994 and 2003 were analyzed. Of the 331 patients, 284 underwent operation via transthoracic approach and 47 via transabdominal approach. Surgery-related status, postoperative complications, range of removed lymph nodes and prognosis of the two groups were compared. Results: There was no significant difference in surgery-related status and postoperative complications between the two groups (P >0.05). The mean number of removed lymph nodes from the thoracic cavity was much higher in transthoracic group than in transabdominal group (P < 0.001), while that from the abdominal cavity was similar in both groups (P = 0.404). The thoracic lymph node metastasis rate was 18.8% in transthoracic group and 13.3% in transabdominal group. The median survival time was 29 months in transthoracic group and 28 months in transabdominal group, and the 5-year survival rates were 34.9% and 40.1% (P= 0.599). Conclusions: For the surgical treatment of adenocarcinoma of the cardia, the surgical trauma of the transthoracic approach is similar with that of transabdominal approach. The transthoracic approach has the advantage in thoracic lymph node dissection. The two approaches have no obvious effect on the prognosis.

关键词：手术治疗腺癌手术创伤生存时间淋巴结并发症预后 Pgt

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A function-based behavioral modeling method for air combat simulation

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Journal of Systems Engineering and Electronics 2024年第4期35卷 945-954页

作者： WANG Tao ZHU zhi zhou Xin JING Tian CHEN wei College of Systems Engineering National University of Defense TechnologyChangsha 410073China Institute of Communication and Navigation Air Force Research AcademyBeijing 100085China

Today’s air combat has reached a high level of uncertainty where continuous or discrete variables with crisp values cannot be properly represented using fuzzy sets. With a set of membership functions, fuzzy logic is well-suited to tackle such complex states and actions. However, it is not necessary to fuzzify the variables that have definite discrete ***, the aim of this study is to improve the level of model abstraction by proposing multiple levels of cascaded hierarchical structures from the perspective of function, namely, the functional decision tree. This method is developed to represent behavioral modeling of air combat systems, and its metamodel,execution mechanism, and code generation can provide a sound basis for function-based behavioral modeling. As a proof of concept, an air combat simulation is developed to validate this method and the results show that the fighter Alpha built using the proposed framework provides better performance than that using default scripts.

关键词： air combat behavioral modeling intelligent agent

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Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients

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World Journal of Gastroenterology 2012年第29期18卷 3910-3916页

作者： Shi Chen Ying-Bo Chen Yuan-Fang Li Xing-Yu Feng zhi-wei zhou Xiu-Hong Yuan Chao-Nan Qian State Key Laboratory of Oncology in South China Sun Yat-sen Univer- sity Cancer Center Guangzhou 510060 Guangdong Province China

AIM:To evaluate pretreatment serum carcinoembryonic antigen(CEA) as a predictor of survival for patients with locally advanced gastric cancer receiving perioperative ***:We retrospectively studied a cohort of 228 gastric cancer patients who underwent D2 gastrectomy combined with chemotherapy at the Sun Yat-sen University Cancer Center between January 2005 and December *** them,168 patients received 6-12 cycles of oxaliplatin-based adjuvant(post-operative) chemotherapy,while 60 received perioperative chemotherapy(2 cycles of FOLFOX6 or XELOX before surgery and 4-10 cycles after surgery).Serum CEA was measured using an enzyme *** followup lasted until December ***:In the group that had elevated serum CEA,the difference in survival time between patients receiving perioperative chemotherapy and those receiving adjuvant chemotherapy had no statistical significance(P > 0.05).However,in the group that had normal serum CEA,patients receiving perioperative chemotherapy had a longer survival *** multivariate analysis,T staging and lymph node metastatic rate were independent prognostic factors for the *** chemotherapy improved the overall survival of patients who had a normal pretreatment CEA level(P = 0.070).CONCLUSION:Normal pretreatment serum CEA is a predictor of survival for patients receiving perioperative chemotherapy.

关键词： Carcinoembryonic antigen Perioperative chemotherapy Prognosis Gastric adenocarcinoma Survival

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Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes:an externally validated approach using real-world data

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Military Medical Research 2022年第5期9卷 565-575页

作者： wei Wang Yu-Jie Yang Ri-Hong Zhang Jing-Yu Deng Zhe Sun Sharvesh Raj Seeruttun Zhen-Ning Wang Hui-Mian Xu Han Liang zhi-wei zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Gastric Cancer Surgery Tianjin Medical University Cancer Institute and HospitalTianjin 300000China Department of Surgical Oncology the First Hospital of China Medical UniversityShenyang 110000China

Background:Currently,there is no formal consensus regarding a standard classification for gastric cancer(GC)patients with<16 retrieved lymph nodes(rLNs).Here,this study aimed to validate a practical lymph node(LN)staging strategy to homogenize the nodal classification of GC cohorts comprising of both<16(Limited set)and≥16(Adequate set)***:All patients in this study underwent R0 *** overall survival(OS)difference between the Limited and Adequate set from a large Chinese multicenter dataset was *** the 8th American Joint Committee on Cancer(AJCC)pathological nodal classification(pN)for GC as base,a modified nodal classification(N’)resembling similar analogy as the 8th AJCC pN classification was *** performance of the proposed and 8th AJCC GC subgroups was compared and validated using the Surveillance,Epidemiology,and End Results(SEER)dataset comprising of 10,208 multi-ethnic GC ***:Significant difference in OS between the Limited and Adequate set(corresponding N0–N3a)using the 8th AJCC system was observed but the OS of N0_(limited)vs.N1_(adequate),N1_(limited)vs.N2_(adequate),N2_(limited)vs.N3_(aadequate),and N3_(alimited)vs.N3_(badequate)subgroups was almost similar in the Chinese ***,we formulated an N’classification whereby only the nodal subgroups of the Limited set,except for pT1N0M0 cases as they underwent less extensive surgeries(D1 or D1+gastrectomy),were re-classified to one higher nodal subgroup,while those of the Adequate set remained unchanged(N’0=N0_(adequate)+pT1N0M0_(limited),N’1=N1_(adequate)+N0_(limited)(excluding pT1N0M0_(limited)),N’2=N2_(adequate)+N1_(limited),N’3a=N3_(aadequate)+N2_(limited),and N’3b=N3_(badequate)+N3_(alimited)).This N’classification demonstrated less heterogeneity in OS between the Limited and Adequate *** analyses demonstrated superior statistical performance of the pTN’M system over the 8th AJCC edition and was successfully validated using the SEER

关键词： Lymph nodes Limited Adequate Gastric cancer American Joint Committee on Cancer Tumor-node-metastasis Staging system Overall survival

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Asymmetric epoxidation of gibberellates by the modified Sharpless reagent

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Chinese Journal of Chemistry 1990年第1期8卷 84-88页

作者： WANG,zhi-Min zhou,wei-Shan Shanghai Institute of Organic Chemistry,Academia Sinica.Shanghai 200032 Shanghai Institute of Organic Chemistry Academia Sinica Shanghai 200032

Asymmetric epoxidation of methyl gibberellate by the modified Sharpless reagent at various temperature is *** 8 and 9 can be used as the key intermediates for the syntheses of the polyhydroxygibberellins.

关键词： Asymmetric epoxidation of gibberellates by the modified Sharpless reagent

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Evolution of chemistry and selection technology for DNA-encoded library

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Acta Pharmaceutica Sinica B 2024年第2期14卷 492-516页

作者： Peixiang Ma Shuning Zhang Qianping Huang Yuang Gu zhi zhou wei Hou wei Yi Hongtao Xu Shanghai Key Laboratory of Orthopedic Implants Department of OrthopedicsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology The NMPA and State Key Laboratory of Respiratory DiseaseGuangzhou Medical UniversityGuangzhou 511436China College of Pharmaceutical Science and Institute of Drug Development&Chemical Biology Zhejiang University of TechnologyHangzhou 310014China

DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical *** analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical ***,DNA-compatible synthesis is the key to expanding the DEL chemical ***,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection *** this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.

关键词： DNA-encoded library Drug discovery High-throughput selection DNA-compatible synthesis In vitro evolution Chemical central dogma

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Miniaturized power detection module operating in millimeter wave band

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Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： Xiang zhou zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

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Engineering singlet and triplet excitons of TADF emitters by different host-guest interactions

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Aggregate 2024年第1期5卷 337-344页

作者： wei Zhang Jie Kong Rui zhi An Jiachen Zhang Yujie zhou Lin-Song Cui Meng zhou Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefeiChina Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China(USTC)HefeiChina CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiChina

Understanding the host-guest interactions for thermally activated delayed fluorescence(TADF)emitters is critical because the interactions between the host matrices and TADF emitters enable precise control on the optoelectronic performance,whereas technologically manipulating the singlet and triplet excitons by using different kinds of host-guest interactions remains ***,we report a comprehensive picture that rationalizes host-guest interaction-modulated exciton recombination by using time-resolved *** found that the early-time relaxation is accelerated in polar polymer because dipole-dipole interaction facilitates the stabilization of the 1CT ***,an opposite trend is observed in longer delay time,and faster decay in the less polar polymer is ascribed to theπ-πinteraction that plays the dominant role in the later stage of the excited *** findings highlight the technological engineering singlet and triplet excitons using different kinds of host-guest interactions based on their electronic characteristics.

关键词： host-guest interaction singlet TADF triplet

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