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A deep reinforcement learning(DRL)based approach for well-testing interpretation to evaluate reservoir parameters

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Petroleum Science 2022年第1期19卷 264-278页

作者： Peng Dong zhi-Ming chen Xin-wei Liao wei Yu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Beijing(CUP)Beijing102249China University of Texas at Austin Austin78731TexasUSA

Parameter inversions in oil/gas reservoirs based on well test interpretations are of great significance in oil/gas *** well test interpretations based on artificial intelligence are the most promising to solve the problem of non-unique *** this work,a new deep reinforcement learning(DRL)based approach is proposed for automatic curve matching for well test interpretation,by using the double deep Q-network(DDQN).The DDQN algorithms are applied to train agents for automatic parameter tuning in three conventional well-testing *** addition,to alleviate the dimensional disaster problem of parameter space,an asynchronous parameter adjustment strategy is used to train the ***,field applications are carried out by using the new DRL *** show that step number required for the DDQN to complete the curve matching is the least among,when comparing the naive deep Q-network(naive DQN)and deep Q-network(DQN).We also show that DDQN can improve the robustness of curve matching in comparison with supervised machine learning *** DDQN algorithm to perform 100 curve matching tests on three traditional well test models,the results show that the mean relative error of the parameters is 7.58%for the homogeneous model,10.66%for the radial composite model,and 12.79%for the dual porosity *** the actual field application,it is found that a good curve fitting can be obtained with only 30 steps of parameter adjustment.

关键词： Well testing Deep reinforcement learning Automatic interpretation Parameter evaluation

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying chen Fa Shen Chang cheng Yu-Han Wang Wen-Chao cheng De-zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

超声波辅助复合酶法制备藏系绵羊胎盘肽的工艺优化

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食品工业科技 2017年第21期38卷 130-136页

作者：张丙云王聪谢言言任海伟范文广黄思瑶李志忠陈伟兰州理工大学生命科学与工程学院甘肃兰州730050 兰州名德农牧科技有限公司甘肃兰州730010

为实现羊胎盘深度开发利用,以肽得率和水解度为指标,筛选确定多种蛋白酶复合水解的最佳组合方案,并利用响应面法优化超声波辅助复合酶法水解制备羊胎盘肽的预处理参数。结果表明,响应面法优化后的超声预处理参数为超声时间18 min、温度2... 详细信息

为实现羊胎盘深度开发利用,以肽得率和水解度为指标,筛选确定多种蛋白酶复合水解的最佳组合方案,并利用响应面法优化超声波辅助复合酶法水解制备羊胎盘肽的预处理参数。结果表明,响应面法优化后的超声预处理参数为超声时间18 min、温度28℃和功率420 W,超声波预处理后羊胎盘经木瓜蛋白酶和风味酶联合同步复合酶解制备羊胎盘肽的肽得率为39.89%,水解度为21.78%;该最优条件下平均肽链长度为4.59,分子量约500~600。结论:超声波辅助复合酶法制备藏系绵羊胎盘肽的工艺可行且有效。

关键词：藏系绵羊羊胎盘肽木瓜蛋白酶风味酶超声波预处理工艺优化

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang Liu Huopo chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

New Amines and Activation Modes in Asymmetric Aminocatalysis

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Chinese Journal of Chemistry 2021年第7期39卷 1775-1786页

作者： zhi-Chao chen wei Du Ying-Chun chen Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China College of Pharmacy Third Military Medical UniversityShapingbaChongqing 400038China

Asymmetric aminocatalysis has become one of the most powerful strategies for the transformations of carbonyl substances over the past two ***,we describe the research from our laboratory that significantly expands the horizon of *** includes the development and application of cinchona-based primary amines,fruitful reactions based on HOMO-raising strategy,and the disclosure of amine/thiol double activation catalysis.

关键词： Organocatalysis Aminocatalysis Amine/thiol double catalysis Cycloaddition Domino reactions

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling chen Danyang chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

衬管完井水平井新型布酸技术研究与应用——以安岳气田磨溪构造龙王庙组气藏为例

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天然气地球科学 2017年第8期28卷 1264-1268页

作者：王业众段国彬桑宇彭华张林周长林余良志陈伟华中国石油西南油气田分公司工程技术研究院四川广汉618300 中国石油西南油气田分公司工程技术处四川成都610051 中国石油西南油气田分公司川中油气矿四川遂宁629000 中国石油西南油气田分公司勘探事业部四川成都610041

衬管完井具有泄流面积大、完井成本低等优势,目前成为水平井完井的主要方式之一。衬管完井水平井酸化改造的关键是如何实现水平井段上的均匀布酸,但由于割缝衬管与岩石壁面之间环形空间未真正封隔,常规分段工艺的应用受到限制,致使衬管... 详细信息

衬管完井具有泄流面积大、完井成本低等优势,目前成为水平井完井的主要方式之一。衬管完井水平井酸化改造的关键是如何实现水平井段上的均匀布酸,但由于割缝衬管与岩石壁面之间环形空间未真正封隔,常规分段工艺的应用受到限制,致使衬管完井水平井均匀布酸困难。为此,通过理论研究和室内实验评价,形成了衬管完井水平井新型均匀布酸技术:(1)预测水平井段上初始表皮系数分布剖面,明确不同井段损害分布特征;(2)建立水平井段上酸液流量数学模型,模拟计算不同井段暂堵转向净压力值;(3)优化设计不同井段衬管割缝参数,优选转向剂加量,实现井底不同转向净压力;(4)采用数值刻画方法定量表征酸蚀蚓孔形态,优选适合的酸液体系。在安岳气田现场应用8口井,井均增产倍比达1.95,井均增加测试产量67.3×104 m3/d,相比射孔完井,单井节约完井成本900万元,对同类型气藏衬管完井水平井均匀布酸技术具有借鉴意义。

关键词：衬管完井水平井均匀布酸表皮系数剖面转向净压力暂堵转向酸蚀蚓孔

Homogeneity analysis of Y-bearing 12Cr ferritic/martensitic steel fabricated by vacuum induction melting and casting

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Journal of Iron and Steel Research International 2020年第8期27卷 940-951页

作者： wei-wei Guo Xiao-xin Zhang Ying-xue chen zhi-yuan Hong Qing-zhi Yan Institute of Nuclear Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060GuangdongChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060GuangdongChina

Advanced oxide metallurgy technique was adopted to produce 100-kg Y-bearing 12Cr ferritic/martensitic steel via vacuum induction melting and casting route. Subsequently, nine specimens at top, middle and bottom regions of the sheet were char-acterized to evaluate the homogeneity of chemical composition, microstructure and mechanical properties. The small vibra-tion of hardness (200–220 HBW), ultimate tensile strength (672–678 MPa), yield strength (468–480 MPa), total elongation (26.2%–30.5%) and Charpy energy at room temperature (98–133 J) and at ??40 ℃ (12–40 J) demonstrated that mechanical properties’ homogeneity of Y-bearing steel was acceptable although slight Y segregation and inhomogeneous microstructure occurred at the bottom. Furthermore, the effect of Y content on microstructure characteristics and mechanical properties was explained and the comparison of failure mechanism for the dual-phase steel between tensile test (i.e., quasi-static loading) and Charpy test (i.e., dynamic loading) was discussed in detail.

关键词： Y-bearing ferritic/martensitic steel Casting Homogeneity Chemical composition Microstructure characteristics Mechanical property

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多层CT灌注成像在肺内肿瘤诊断中的应用

实用放射学杂志 2008年第9期24卷 1194-1198页

作者：周漠玲刘进康熊曾朱智明陈伟中南大学湘雅医院放射科

目的研究16层螺旋CT灌注成像在鉴别肺内肿瘤中的价值。方法对63例肺部单发病变进行前瞻性分析,采用Philips Brilliance16排螺旋CT对肿块行灌注扫描。用CT灌注软件包进行分析。结果高及中分化组的灌注值(PV),最高增强值(PE)及血容量(BV)... 详细信息

目的研究16层螺旋CT灌注成像在鉴别肺内肿瘤中的价值。方法对63例肺部单发病变进行前瞻性分析,采用Philips Brilliance16排螺旋CT对肿块行灌注扫描。用CT灌注软件包进行分析。结果高及中分化组的灌注值(PV),最高增强值(PE)及血容量(BV)值明显高于低分化及未分化组肺癌,差异均有统计学意义(分别为P恶性>良性,其中PV、PE值各组间差异均有统计学意义,而BV值仅炎性病变与良性病变之间差异有统计学意义(P0.05)。中央型与周围型肺癌各灌注参数也无统计学意义(P>0.05)。结论螺旋CT灌注成像对鉴别肺内恶性、良性及炎性病变及判别肺癌恶性程度有较大价值。

关键词：肺灌注成像肿瘤,体层摄影术,X线计算机