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Clinical significance of peripheral blood UL16 and DR-70 for the early diagnosis and prognostic evaluation of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3832-3838页

作者： zhi-ping zong Chen Wu Department of Blood Transfusion Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Clinical Laboratory Jiangsu Province Official HospitalNanjing 210003Jiangsu ProvinceChina

BACKGROUND Early diagnosis of colorectal cancer(CRC)is of great significance to improve the survival rate and quality of life of patients,but early diagnosis of CRC requires more sensitive *** blood UL16-binding protein 2(ULBP2)and human fibrinogen degradation products(DR-70)are the main indicators for the diagnosis of malignant *** To assess ULBP2 and DR-70 potential for the early diagnosis and prognostic evaluation of CRC to provide a *** This study involved 60 patients with early-stage CRC(CRC group),50 patients with benign colorectal tumors(benign group),and 50 healthy patients(control group)enrolled at the Affiliated Hospital of Jiangnan University and Jiangsu Province Official Hospital between January,2020 and January,***2 and DR-70 levels in the blood were determined and differences among the three groups and early diagnostic values for CRC were *** with CRC were divided into the good prognosis and poor prognosis groups,and ULBP2 and DR-70 levels in the blood and diagnostic values were *** ULBP2 and DR-70 serum levels were significantly higher in the CRC group than in the control and benign groups(P0.05).Among the 60 patients with CRC followed up for two years,two died(3.33%)and 15 exhibited tumor metastasis,progression,or recurrence(25.00%).ULBP2 and DR-70 serum levels were significantly higher in the poor prognosis group than in the good prognosis group(P<0.05).A receiver operating characteristic curve was *** under the curve,sensitivity,and specificity of serum ULBP2 with DR-70 for the early diagnosis of CRC were higher than those of the single serum indices(P<0.05)in both the good and poor prognosis *** ULBP2 and DR-70 serum levels were significantly high in patients with early-stage *** improved the diagnostic rate of early-stage CRC and predicted patient prog

关键词： ULBP2 DR-70 Colorectal cancer Early diagnosis Prognosis

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Optimal proportioning of iron ore in sintering process based on improved multi-objective beluga whale optimisation algorithm

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Journal of Iron and Steel Research International 2024年第7期31卷 1597-1609页

作者： zong-ping Li Xu-dong Li Xue-tong Yan Wu Wen Xiao-xin Zeng Rong-jia Zhu Ya-hui Wang Ling-zhi Yi Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina College of Automation and Electronic Information Xiangtan UniversityXiangtan 411105HunanChina College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina

Proportioning is an important part of sintering,as it affects the cost of sintering and the quality of sintered *** address the problems posed by the complex raw material information and numerous constraints in the sintering process,a multi-objective optimisation model for sintering proportioning was established,which takes the proportioning cost and TFe as the optimisation ***,an improved multi-objective beluga whale optimisation(IMOBWO)algorithm was proposed to solve the nonlinear,multi-constrained multi-objective optimisation *** algorithm uses the con-strained non-dominance criterion to deal with the constraint problem in the ***,the algorithm employs an opposite learning strategy and a population guidance mechanism based on angular competition and two-population competition strategy to enhance convergence and population *** actual proportioning of a steel plant indicates that the IMOBWO algorithm applied to the ore proportioning process has good convergence and obtains the uniformly distributed Pareto ***,compared with the actual proportioning scheme,the proportioning cost is reduced by 4.3361¥/t,and the TFe content in the mixture is increased by 0.0367%in the optimal compromise ***,the proposed method effectively balances the cost and total iron,facilitating the comprehensive utilisation of sintered iron ore resources while ensuring quality assurance.

关键词： Sintering process Proportioning Iron ore Multi-objective beluga whale optimisation algorithm Proportioning cost

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Phenomenology of heavy neutral gauge boson at muon collider

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 60-79页

作者： zongyang Lu Honglei Li zhi-Long Han zong-Guo Si Liuxin Zhao School of Physics and Technology University of JinanJinan 250022China School of Physics Shandong UniversityJinan 250100China

Heavy neutral gauge boson Z' is proposed in many new physics *** has rich phenomena at the future muon *** study the properties of Z' boson with the process of μ^(+)μ^(-)→qq,μ^(+)μ^(-)→l^(+)l^(-),μ^(+)μ^(-)→ ZH and μ^(+)μ^(-)→ W^(+)W^(-).The discrepancy of Z' coupling to different types of particles can be shown in the cross section distributions around the resonance peak of various decay *** distributions of the final quark or lepton in μ^(+)μ^(-)→qq/l^(+)l^(-)process are sensitive to the parameters such as mass of Z' and the Z-Z' mixing *** interaction of new gauge boson coupling to the standard model gauge particles and Higgs boson are also studied through μ^(+)μ^(-)→ ZH→l^(+)l^(-)bb and μ^(+)u^(-)→ W^(+)W^(-)→l^(+)l^(-)v_(l)v_(l).The cross section and the final particles' angular distributions with the contribution of Z' boson differ from those processes with only standard model particles.A forward-backward asymmetry defined by the angular distribution is provided to show the potential of searching for new physics at the muon ***,the beam polarization with certain value can effectively enlarge the forward-backward asymmetry.

关键词： Z′boson muon collider new physics

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Progress and Outlook of Carbon-supported Single-atom Electrocatalyst for Oxygen Reduction Reaction

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Chemical Research in Chinese Universities 2024年第3期40卷 462-474页

作者： WANG Chengbin LI ping CHEN Dehong ZHANG Ruiyong WANG Lei zong Lingbo College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071P.R.China

Single-atom catalysts (SACs) have garnered extensive attention in the field of catalysis due to their exceptional inherent reaction activity, optimal utilization of metal atoms, etc. Controlled synthesis plays a crucial role in elucidating the structure-activity relationship of SACs. This paper reviews various synthetic strategies for SACs, encompassing defect engineering, metal-organic frameworks (MOFs) pyrolysis, and ion exchange. With specific examples, the significance of constructing catalysts at the atomic level is discussed, aiming to comprehensively understand the synthetic strategies of SACs. Finally, it addresses the challenges and prospects associated with controlled synthesis techniques for SACs as well as their future applications.

关键词： Single-atom catalyst Synthetic strategy Carbon support Oxygen reduction reaction

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Predicting dynamic compressive strength of frozen-thawed rocks by characteristic impedance and data-driven methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2591-2606页

作者： Shengtao Zhou zong-Xian Zhang Xuedong Luo Yifan Huang zhi Yu Xiaowei Yang Faculty of Engineering China University of GeosciencesWuhan430074China Oulu Mining School University of OuluOulu90570Finland Zijin School of Geology and Mining Fuzhou UniversityFuzhou350116China Department of Earth Science&Engineering Imperial College LondonLondonSW72AZUK

In cold regions,the dynamic compressive strength(DCS)of rock damaged by freeze-thaw weathering significantly influences the stability of rock ***,testing the dynamic strength under freeze-thaw weathering conditions is often both time-consuming and ***,this study considers the effect of characteristic impedance on DCS and aims to quickly determine the DCS of frozen-thawed rocks through the application of machine-learning ***,a database of DCS for frozen-thawed rocks,comprising 216 rock specimens,was *** external load parameters(freeze-thaw cycle number,confining pressure,and impact pressure)and two rock parameters(characteristic impedance and porosity)were selected as input variables,with DCS as the predicted *** research optimized the kernel scale,penalty factor,and insensitive loss coefficient of the support vector regression(SVR)model using five swarm intelligent optimization algorithms,leading to the development of five hybrid *** addition,a statistical DCS prediction equation using multiple linear regression techniques was *** performance of the prediction models was comprehensively evaluated using two error indexes and two trend indexes.A sensitivity analysis based on the cosine amplitude method has also been *** results demonstrate that the proposed hybrid SVR-based models consistently provided accurate DCS *** these models,the SVR model optimized with the chameleon swarm algorithm exhibited the best performance,with metrics indicating its effectiveness,including root mean square error(RMSE)﹦3.9675,mean absolute error(MAE)﹦2.9673,coefficient of determination(R^(2))﹦0.98631,and variance accounted for(VAF)﹦*** suggests that the chameleon swarm algorithm yielded the most optimal results for enhancing SVR ***,impact pressure and characteristic impedance emerged as the two most influential parameters in DCS *** research is

关键词： Freeze-thaw cycle Characteristic impedance Dynamic compressive strength Machine learning Support vector regression

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Development and performance evaluation of high temperature resistant strong adsorption rigid blocking agent

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Petroleum Science 2024年第4期21卷 2650-2662页

作者： Zhe Xu Jin-Sheng Sun Jing-ping Liu Kai-He Lv Xiao-Dong Dong zong-Lun Wang Tai-Feng Zhang Yuan-Wei Sun zhi-Wen Dai School of Petroleum Engineering China University of Petroleum (East China) CNPC Engineering Technology R&D Company Limited

As drilling wells continue to move into deep ultra-deep layers, the requirements for temperature resistance of drilling fluid treatments are getting higher and higher. Among them, blocking agent, as one of the key treatment agents, has also become a hot spot of research. In this study, a high temperature resistant strong adsorption rigid blocking agent(QW-1) was prepared using KH570 modified silica,acrylamide(AM) and allyltrimethylammonium chloride(TMAAC). QW-1 has good thermal stability,average particle size of 1.46 μm, water contact angle of 10.5., has a strong hydrophilicity, can be well dispersed in water. The experimental results showed that when 2 wt% QW-1 was added to recipe A(4 wt% bentonite slurry+0.5 wt% DSP-1(filtration loss depressant)), the API filtration loss decreased from 7.8to 6.4 m L. After aging at 240.C, the API loss of filtration was reduced from 21 to 14 m L, which has certain performance of high temperature loss of filtration. At the same time, it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5 μm ceramic sand discs. Under the same conditions,the blocking performance was superior to silica(5 μm) and calcium carbonate(2.6 μm). In addition, the mechanism of action of QW-1 was further investigated. The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer, thus preventing further intrusion of drilling fluid into the formation.

关键词： High adsorption Rigid microsphere High temperature resistance Blocking performance

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Design and fabrication of lightweight AlCrFeNiTi_(x) compositionally complex alloys with exceptional specific strength

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Rare Metals 2024年第7期43卷 3314-3328页

作者： Jun-zhi Li Wei-zong Bao Jie Chen Bo-Hua Yu Kun Zuo Tian Gao Ze-Yun Cai Guo-Qiang Xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

This study focuses on compositionally complex alloys(CCAs),aiming to achieve a balance between high strength and low density for new energy and aerospace *** composition of AlCrFeNiTi_(x) CCAs is strategically guided by employing density functional theory and the theoretical design of thermodynamic *** CCAs,particularly AlCrFeNiTi_(0.25) alloy,demonstrate remarkable specific yield strength(1640.8 MPa) and 22.7% maximum *** incorporation of Ti facilitates the formation of lightweight and high-strength L2_(1)phase,contributing to the overall high specific *** effects of grain boundary strengthening,solid solution strengthening,Orowan strengthening and Peierls flow stress further enhance *** exploration of micros tructural changes during fracture reveals the role of ordered phases in suppressing crack propagation and absorbing energy within disordered phases,thereby improving the toughness and fracture resistance of *** methods and discoveries establish a robust foundation for advancing the development of novel lightweight CCAs.

关键词： Lightweight Compositionally complex alloys Specific yield strength

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Efficacy of laparoscopic low anterior resection for colorectal cancer patients with 3D-vascular reconstruction for left coronary artery preservation

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1548-1557页

作者： Ye Wang zhi-Sheng Liu zong-Bao Wang Shawn Liu Feng-Bo Sun Department of General Surgery Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033Shandong ProvinceChina Department of Gastrointestinal Surgery National University Hospital of SingaporeSingapore 119228Singapore

BACKGROUND Laparoscopic low anterior resection(LLAR)has become a mainstream surgical method for the treatment of colorectal cancer,which has shown many advantages in the aspects of surgical trauma and postoperative ***,the effect of surgery on patients'left coronary artery and its vascular reconstruction have not been deeply *** the development of medical imaging technology,3D vascular reconstruction has become an effective means to evaluate the curative effect of *** To investigate the clinical value of preoperative 3D vascular reconstruction in LLAR of rectal cancer with the left colic artery(LCA)*** A retrospective cohort study was performed to analyze the clinical data of 146 patients who underwent LLAR for rectal cancer with LCA preservation from January to December 2023 in our *** patients underwent LLAR of rectal cancer with the LCA preserved,and the intraoperative and postoperative data were *** patients were divided into a reconstruction group(72 patients)and a nonreconstruction group(74 patients)according to whether 3D vascular reconstruction was performed before *** clinical features,operation conditions,complications,pathological results and postoperative recovery of the two groups were collected and *** A total of 146 patients with rectal cancer were included in the study,including 72 patients in the reconstruction group and 74 patients in the nonreconstruction *** were 47 males and 25 females in the reconstruction group,aged(59.75±6.2)years,with a body mass index(BMI)(24.1±2.2)kg/m^(2),and 51 males and 23 females in the nonreconstruction group,aged(58.77±6.1)years,with a BMI(23.6±2.7)kg/m^(2).There was no significant difference in the baseline data between the two groups(P>0.05).In the submesenteric artery reconstruction group,35 patients were type Ⅰ,25 patients were type Ⅱ,11 patients were type Ⅲ,and 1 patient was type Ⅳ.There were 37 type Ⅰ patients,24

关键词： Laparoscopic low anterior resection 3D vascular reconstruction Coronary artery Colorectal cancer Retrospective cohort study

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Advances in self-assembly-based circularly polarized luminescent materials

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Science China Chemistry 2024年第10期67卷 3247-3257页

作者： Bing-Hao Liu Yang zong Na Liu zong-Quan Wu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin University The School of Pharmaceutical Sciences Jilin University

Circularly polarized luminescent(CPL) materials have garnered attention for their diverse applications, including three-dimensional(3D) imaging, bio-imaging, chiral sensing, and other emerging fields. Traditionally, the fabrication of CPL-activated materials required the use of chiral luminescent small molecules. The introduction of the idea of self-assembly has transformed the production of CPL-activated materials, providing new and promising opportunities for their advancement. Through utilizing self-assembly, it is now feasible to produce chiral nano-assemblies with CPL activity not only from chiral molecules but also from non-chiral substances and inorganic nanoparticles. In addition, self-assembly routes provide a way to increase the asymmetry factor, creating possibilities for additional refinement and adjustment of CPL material characteristics. This review offers a summary of the current progress and developments in the self-assembly of small molecules and polymers, with a specific emphasis on their capacity to create or enhance CPL in different contexts. The aim of this review is to inspire interest in optical materials that are based on the principles of self-assembly.

关键词： circularly polarized luminescence photochemistry self-assembly chiral materials

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Bioinspired design of integral molded Janus silk fibroin-MXene evaporator for efficient solar vapor generation

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Nano Research 2024年第4期17卷 2824-2835页

作者： Ling-Qing Kong zhi-Cheng Zeng Guang-zong Min Zhao-Hui Meng Guo-Qing Meng Xiao-Xiao Guo Nai-Bo Lin Xiang-Yang Liu The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005China The State Key Laboratory of Marine Environmental Science(MEL) College of Ocean and Earth SciencesXiamen UniversityXiamen 361005China

Solar vapor generation is a promising sustainable technology that uses solar distillation to produce fresh water from seawater and wastewater,helping relieve global water resource ***,inspired by naturally grown integrally molded mulberry leaves with a Janus hydrophilic and hydrophobic structure,a novel,simple,and efficient integrated molding method is proposed to break through the limitations of the traditional split manufacturing strategy and realizes the integrated formation of Janus *** on the spontaneous sedimentation characteristics of MXene in silk fibroin solution and its regulation of mesoscopic structure and hydrophilicity of silk fibroin,layered structures with different compositions and hydrophilicities were obtained in one ***,ethanol and glutaraldehyde were added to construct a physical crystallization-chemical crosslinking dual stabilization structure in silk *** evaporator has the evaporation rate of 3.07 kg·m^(-2)·h^(-1) and the efficiency of 86.8%under 1 sun and maintains high evaporation performance under various extreme test conditions including vigorous washing,repeated compression,and high-intensity ultraviolet(UV)***,the evaporator performs well in practical application scenarios,its evaporation rate in the simulated Dead Sea seawater exceeds 2.13 kg·m^(-2)·h^(-1),and more than 99.9%of the salt,heavy metal ions,oil pollution,and dyes are purified.

关键词： silk fibroin MXene bioinspired integrated molding Janus structure solar vapor generation

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