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Nuclear Science and Techniques 2022年第2期33卷 87-92页

作者： Wei-Ning Zhang peng-zhi xu School of Physics Dalian University of TechnologyDalian 116024China College of Computer Science and Technology Jilin Normal UniversitySiping 136000China

The squeezed back-to-back correlation(SBBC)of a boson-antiboson pair is sensitive to the time distribution of the particle-emitting source,and the SBBC function for an evolving source is expected to be affected by the relaxation time of the *** this study,we investigated the effect of relaxation time on the SBBC *** propose a method for calculating the SBBC function with relaxation-time approximation for evolving *** functions of D^(0)D^(-0)in relativistic heavy-ion collisions were investigated using a hydrodynamic *** found that the relaxation time reduces the amplitudes of the SBBC *** becomes apparent for long relaxation times and large initial relative deviations of the chaotic and squeezed amplitudes from their equilibrium values in the temporal steps.

关键词： Relaxation time Squeezed back-to-back correlation Evolving source Relativistic heavy-ion collisions

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Research and application of the angular rolling technology for plate mill

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Advances in Manufacturing 2023年第3期11卷 462-476页

作者： zhi-Jie Jiao Jun-Yi Luo zhi-Qiang Wang zhi-peng xu Chun-Yu He Zhong Zhao State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819People's Republic of China

Angular rolling technology can overcome the size limitation of plate mill equipment and product heavy steel plate with large unit weight or improve the production efficiency of small width spreading ratio *** the DEFORM software,the numerical simulation study of the angular rolling process was carried out,and the relation laws of the width,rolling force and strain of the rolled piece under different angular rolling process conditions were *** simulation results show that with the rotation angle increasing,the width of the rolled piece *** with the conventional rolling process,the rolling force changes gradually during the biting and throwing stage of the angular rolling *** the rotation angle increasing,both the equivalent strains in the thickness direction and in the width direction gradually *** to the pattern and dimension's changing formula in the double-pass angular rolling process,the prediction model of angle,reduction and width spreading is *** opening value of side guide is set for the rotation angle *** one 5000 mm heavy plate mill,the automation control system was modified,and the angular rolling technology was applied *** absolute deviation of target width does not exceed±20 mm and the relative deviation does not exceed 1%.The large unit weight plate that cannot be rolled with traditional process,can be produced now,and the annual output increases by 10000 t.

关键词： Plate mill Angular rolling Numerical simulation Width spreading Prediction model Online application

Identification of a novel splice site mutation in the DNAAF4 gene of a Chinese patient with primary ciliary dyskinesia

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Asian Journal of Andrology 2023年第6期25卷 713-718页

作者： Yang xu Jing Wang Ji-Hai Liu Qing-Qiang Gao Bing Wang zhi-peng xu Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Primary ciliary dyskinesia(PCD)is a rare hereditary orphan condition that results in variable phenotypes,including *** 50 gene variants are reported in the scientific literature to cause PCD,and among them,dynein axonemal assembly factor 4(DNAAF4)has been recently ***4 has been implicated in the preassembly of a multiunit dynein protein essential for the normal function of locomotory cilia as well as *** the current study,a single patient belonging to a Chinese family was recruited,having been diagnosed with PCD and *** affected individual was a 32-year-old male from a nonconsanguineous *** also had abnormal spine structure and spinal cord bends at angles diagnosed with *** reports,laboratory results,and imaging data were ***-exome sequencing,Sanger sequencing,immunofluorescence analysis,hematoxylin-eosin staining,and in silico functional analysis,including protein modeling and docking studies,were *** results identified DNAAF4 disease-related variants and confirmed their *** analysis through whole-exome sequencing identified two pathogenic biallelic variants in the affected *** identified variants were a hemizygous splice site c.784-1G>A and heterozygous 20.1 Kb deletion at the DNAAF4 locus,resulting in a truncated and functionless DNAAF4 *** analysis indicated that the inner dynein arm was not present in the sperm flagellum,and sperm morphological analysis revealed small sperm with twisted and curved flagella or lacking *** current study found novel biallelic variants causing PCD and asthenoteratozoospermia,extending the range of DNAAF4 pathogenic variants in PCD and associated with the etiology of *** findings will improve our understanding of the etiology of PCD.

关键词： DNAAF primary ciliary dyskinesia scoliosis splice site

Modulation of SIRT1 expression improves erectile function in aged rats

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Asian Journal of Andrology 2022年第6期24卷 666-670页

作者： Wen Yu Jing Wang Yu-Tian Dai Bin Wang Yang xu Qing-Qiang Gao zhi-peng xu Institute of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000China

Silent information regulator 2-related enzyme 1(SIRT1)is an aging-related protein activated with ***,we evaluated the role of SIRT1 in aging-related erectile *** expression of SIRT1 was modulated in aged Sprague-Dawley rats following intragastric administration of resveratrol(Res;5 mg kg^(-1)),niacinamide(NAM;500 mg kg^(-1))or Res(5 mg kg^(-1))+tadalafil(Tad;phosphodiesterase-5[PDE5]inhibitor;5 mg kg^(-1))for 8 ***,we determined erectile function by the ratio of intracavernosal pressure(IcP)/mean systemic arterial pressure(MAP).Cavernosal tissues were extracted to evaluate histological changes,cell apoptosis,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP),the superoxide dismutase(SOD)/3,4-methylenedioxyamphetamine(MDA)level,and the expression of SIRT1,p53,and forkhead box O3(FOX03a)using immunohistochemistry,terminal deoxynucleotidyl transferase(TdT)-mediated 2'-deoxyuridine 5'-triphosphate(dUTP)nick-end labeling(TUNEL),enzyme-linked immunosorbent assays,and western blot *** with the control,Res treatment significantly improved erectile function,reflected by an increased content of smooth muscle and endothelium,NO/cGMP and SOD activity,and reduced cell apoptosis and MDA *** effect of Res was improved by adding *** addition,the protein expression of SIRT1 was increased in the Res group,accompanied by decreased p53 and FOxO3a *** addition,inhibition of SIRT1 by NAM treatment resulted in adverse results compared with Res ***1 activation ameliorated aging-related erectile dysfunction,supporting the potential of SIRT1 as a target for erectile dysfunction treatment.

关键词： apoptosis erectile function nitric oxide/cyclic guanosine monophosphate signaling oxidative stress SIRT1 expression

The application of intraoperative neurophysiological monitoring in selective dorsal neurotomy for primary premature ejaculation:a prospective single-center study

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Asian Journal of Andrology 2023年第1期25卷 137-142页

作者： Qing-Lai Tang Tao Song You-Feng Han Bai-Bing Yang Jian-Huai Chen zhi-peng xu Chun-Lu xu Yang xu Wen Yu Wei Qiu Jiong Shi En-Si Zhang Yu-Tian Dai Department of Andrology Drum Tower Clinical Medical CollegeNanjing Medical UniversityNanjing 210008China Department of Urology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100China Department of Pathology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100China Department of Pathology Drum Tower Clinical Medical CollegeNanjing Medical UniversityNanjing 210008China

Selective dorsal neurotomy(SDN)is a surgical treatment for primary premature ejaculation(PE),but there is still no standard surgical procedure for selecting the branches of the dorsal penile nerves to be *** performed this study to explore the value of intraoperative neurophysiological monitoring(IONM)of the penile sensory-evoked potential(PSEP)for standard surgical procedures in *** hundred and twenty primary PE patients undergoing SDN were selected as the PE group and 120 non-PE patients were selected as the normal *** PSEP was monitored and compared between the two groups under both natural and general anesthesia(GA)*** addition,patients in the PE group were randomly divided into the IONM group and the non-IONM *** SDN surgery,PSEP parameters of the IONM group were recorded and *** differences in PE-related outcome measurements between the perioperative period and 3 months'postoperation were compared for the PE patients,and the differences in effectiveness and complications between the IONM group and the non-IONM group were *** results showed that the average latency of the PSEP in the PE group was shorter than that in the normal group under both natural and GA states(P<0.001).Three months after surgery,the significant effective rates in the IONM and non-IONM groups were 63.6%and 34.0%,respectively(P<0.01),and the difference in complications between the two groups was significant(P<0.05).IONM might be useful in improving the short-term therapeutic effectiveness and reducing the complications of SDN.

关键词： intraoperative neurophysiological monitoring primary premature ejaculation selective dorsal neurotomy

Effects of abnormal zona pellucida on fertilization and pregnancy in IVF/ICSI-ET

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Journal of Reproduction and Contraception 2015年第2期26卷 73-80页

作者： Jing ZHAO Ning-yuan ZHANG zhi-peng xu Lin-jun CHEN Xia ZHAO Hui-ming ZENG Yi-qun JIANG Hai-xiang SUN The Reproductive Center of Huzhou Maternity and Child Health Care Hospital Center for Reproductive Medicine the Affiliated Drum Tower Hospital of Nanjing University Medical School

Objective To analyze the fertilization rate, embryo development and clinical outcome of oocytes with abnormal zona pellucida after in vitro fertilization （IVF） or intracytoplasmic sperm injection （1CS1）. Methods A retrospective analysis included a total of 43 cycles （27 IVF cycles and 16 ICSI cycles） in which oocytes displaying abnormal zona pellucida were retrieved between January 2006 and December 2011. The fertilization rate, embryo quality, and the cumulative clinical pregnancy rate were analyzed. Results Rescue ICSI was applied in 2 7 IVF cycles in which failed extrusion of the second polar body after conventional IVF was observed, and of them, complete failure to fertilize occurred in 23 IVF cycles. The fertilization rate and the normal fertilization rate for IVF （64.83% and 59.32%, respectively） were significantly lower than those for ICS1 （85.19% and 79.01%, respectively）, whereas the cleavage rate （94.12%） with IVF did not differ significantly from that with ICSI （95.65%, P〉0. 05）. The percentages of good-quality embryos in 1VF group （52. 67%） and 1CSl group （43.75%） also did not differ significantly （P〉0.05）. Although the rates of implantation and pregnancy appeared to be greater in IVF group （33.33% and 40.00%, respectively） compared with those in ICSI group （25.00% and 35. 71%, respectively）, the differences were not significant （P〉0.05）.Conclusions ICSI should be carried out for oocytes with abnormal zona pellucida, for which the risk of lVF failure is high. Rescue ICSI improves the likelihood of fertilization of oocytes with abnormal zona pellucida, but cannot improve the clinical outcome.

关键词： abnormal zona pellucida fertilization development of embryo clinical pregnancy

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Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第1期68卷 337-349页

作者： Meiyun xu Song Gu Fulong Chen Zhe Zhao peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

关键词： quaternized polymer networks adsorption pertechnetate iodide liquid radioactive streams

Effect of the P1 Medium and the ECM Medium on Embryo Quality in IVF

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Journal of Reproduction and Contraception 2009年第2期20卷 67-72页

作者： Qian CHEN Ai-jun ZHANG Yun FENG Xiao-wei LU Dong-mei JI zhi-peng xu Center of Reproductive Medicine Ruijing Hospital Medical School of Shanghai Jiaotong University Shanghai200025 China Center of Reproductive Medicine Drum Tower Hospital Medical School of Nanjin University Nanjin 210008 China

Objective To investigate the effect of the glucose-free preimplantation stage one （P1） medium and the ECM medium on embryo development quality in IVF. Methods The patients with ≥4 zygotes of 2PN were studied. A total of 201 retrieval cycles were included in a prospective randomized study. Each patient was herself control. Half of zygotes of 2PN were transferred into ECM medium （group A） and half into P1 medium （group B）for further culture. Embryo development was evaluated on the day of embryo transfer. The efficacy of ECM was compared with P1 as culture medium for the development of preimplantation embryos. Results No statistically significant differences were noted between the two groups regarding embryo-cleavage rate （97.13% vs 97.55%） and rate of normal-cleaving embryos （58.29% and 58.37%）. The rate of top-quality embryos was statistically higher in group A than in group B （27.59% vs 19.75%, P〈O.05）. Embryo quality, as assessed by morphological parameters （the amount of detached anuclear fragments 〉30%）, was better in group A than in group B （19.86% vs 21.75%）, however, there was no statistically significance. Both the rate of good-quality embryos （47.95% vs 46.17%） and available embryos （63.22% vs 61.19%） were higher in group A than in group B, but there was also no statistically significance. Conclusion The ECM medium may be associated with a better embryo quality compared with the P1 medium.

关键词： culture media IVF preimplantation embryo development

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A Facile Method for Asymmetric Synthesis of β-Hydroxy-α-amino Acids

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有机化学 2004年第Z1期24卷 186-页

作者： LI,Shuo LI,Lei ZHANG,zhi-Hui xu,peng-Fei State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

　　β-Hydroxy-a-amino acids are an important class of amino acids due to their inherent biological investigations[1] and as structural components of more complex biomolecules.[2] β-Hydroxy-a-amino acids have been used as intermediates in the asymmetric synthesis of other compounds.[3] An efficient and convenient concise method for the preparation of optically pure enantiomers of β-hydroxy-α-amino acids would be of general interest.……

关键词： amino acids asymmetric synthesis

Derivatives of local times and Hausdorff dimension of inverse images of space-time anisotropic Gaussian random fields

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Acta Mathematica Sinica,English Series 2025年

作者： Zhenlong Chen peng xu School of Statistics and Mathematics Zhejiang Gongshang University

Let X={X（t）, t∈RN}be a centered space-time anisotropic Gaussian random field with values in Rd. Under some general conditions, the existence, joint continuity and H¨older conditions of higher-order derivative of local times of X are studied. Moreover, we obtain the uniform Hausdorff dimension of the inverse images of X. The existing results of Gaussian random fields are extended to space-time anisotropic Gaussian random fields with approximate independent components.

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