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Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 731-739页

作者： Xiao-Wen Sun Jing-Yi Xu Chang-Zhen zhu Si-Jia Li Lu-Jia Jin zhi-Dong zhu Department of Gastrointestinal Surgery Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China Surgical Department Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China

BACKGROUND Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in anorectal surgery.They are venous clusters formed by con-gestion,expansion,and flexion of the venous plexus in the lower part of the rec-tum.Mixed hemorrhoids bleed easily and recurrently,and this can result in severe anemia.Hence,they may have a negative effect on the health of the patient and surgical treatment is required.Milligan-Morgan hemorrhoidectomy has been widely used since 1937 for the treatment of grade III and IV hemorrhoids.How-ever,most patients experience different degrees of postoperative pain that may cause anxiety.with mixed hemorrhoids post-surgery.METHODS The clinical data of patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy were collected retrospectively.The basic character-istics of the enrolled patients with mixed hemorrhoids were recorded,and based on the Goligher clinical grading system,the hemorrhoids were classified as grades III or IV.The endpoint of this study was the disappearance of pain in all patients.Quantitative data were presented as mean±SD,such as age,pain score,and QoL score.Student’s t-test was used to compare the groups.RESULTS A total of 164 patients were enrolled.The distribution of the visual analog scale pain scores of all patients at 3,7,14 and 28 d after surgery showed that post-surgery pain was significantly reduced with the passage of time.Fourteen days after the operation,the pain had completely disappeared in some patients.Twenty-eight days after the surgery,none of the patients experienced any pain.Comparing the World Health Or-ganization Quality of Life-BREF self-reporting questionnaire scores of patients between 14 and 28 d after surgery,we observed that the quality-of-life scores of the patients post-surgery had significantly improved.There were six items that were compared at 14-and 28-d post-surgery.The mean QoL score 28 d after surgery(4.79±0.46)was higher than that at 14 d post-surgery(3.79±0.57).The mean health condition

关键词： Hemorrhoids Mixed hemorrhoids Milligan organ hemorrhoidectomy Postoperative pain Quality of life Anesthesia mode

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Robust asymmetric Cherenkov radiation in tilted anisotropic medium

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 46-51页

作者： Shuwen Xue Yadong Xu Linkang Han zhi Ning Chen Qiaoliang Bao Shan zhu Huanyang Chen Institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyJiujiang Research InstituteXiamen UniversityXiamen 361005China School of Physical Science and Technology Institute of Theoretical and Applied PhysicsSoochow UniversitySuzhou 215006China Department of Electrical and Computer Engineering National University of SingaporeSingapore 8117583Singapore Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Cherenkov radiation(CR)is available for a wide variety of terahertz(THz)radiation sources,but its efficiency is deeply affected by intrinsic losses.We find that if the tilted angle(α)of anisotropic material and radiation angle(θ)meet the condition ofθ+α=π/2,the intensity of radiation fields for the charged particle bunch(CPB)moving from left to right cannot be influenced by intrinsic losses,which means long-distance radiation can be achieved.Furthermore,we observe an asymmetric CR when the CPB moves from the opposite direction.In addition,we select natural van der Waals(vd W)materialα-MoO3as an example,further confirming that the radiation field can reach the far field and the asymmetric CR radiation can also be observed.These wonderful properties with long-distance radiation will extend the application of CR to a certain extent for future design and fabrication.

关键词： asymmetric Cherenkov radiation intrinsic losses long-distance radiation

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Mode-switchable dual-color infrared quantum cascade detector

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Photonics Research 2024年第2期12卷 253-259页

作者： YIXUAN zhu SHENQIANG ZHAI KUN LI KAI guo QIANGQIANG guo JINCHUAN ZHANG SHUMAN LIU LIJUN WANG FENGQI LIU JUNQI LIU Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

In this paper,a patch-antenna-array enhanced quantum cascade detector with freely switchable operating modes among mid-wave,long-wave,and dual-color was proposed and discussed.The dual-color absorption occurs in a single active region through an optimized coupled miniband diagonal-transition subbands arrangement,and a successful separation of the operation regimes was realized by two nested antenna arrays with different patch sizes up to room temperature.At 77 K,the 5.7-μm channel achieved a peak responsivity of 34.6 mA/W and exhibited a detectivity of 2.0×10^(10)Jones,while the 10.0-μm channel achieved a peak responsivity of 87.5 mA/W,giving a detectivity of 5.0×10^(10)Jones.Under a polarization modulation of the incident light,the minimum cross talk of the mid-wave and the long-wave operating modes was 1:22.5 and 1:7.6,respectively.This demonstration opens a new prospect for multicolor infrared imaging chip integration technology.

关键词： antenna polarization quantum

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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo Ang guo Xiaona zhu Huifang Zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the disease.We have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)children.Eight PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,respectively.Moreover,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as control.Thirty-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and TNBP.These results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin zhi-Peng Ling Yi-Kun Hao Tian-Xi zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second example of c-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Anesthesia,Anesthetics,and Postoperative Cognitive Dysfunction in Elderly Patients

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Current Medical Science 2024年第2期44卷 291-297页

作者： Hong-yu zhu Jian-li YAN Min ZHANG Tian-yun XU Chen CHEN zhi-lin WU Department of Anesthesiology Linhe District People's HospitalBayannur 015000China Department of Neurosurgery Xinzhou District People's HospitalWuhan 430408China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Postoperative cognitive dysfunction(POCD)remains a major issue that worsens the prognosis of elderly surgery patients.This article reviews the current research on the effect of different anesthesia methods and commonly utilized anesthetics on the incidence of POCD in elderly patients,aiming to provide an understanding of the underlying mechanisms contributing to this condition and facilitate the development of more reasonable anesthesia protocols,ultimately reducing the incidence of POCD in elderly surgery patients.

关键词： anesthesia anesthetics postoperative cognitive dysfunction elderly patients

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Electromagnetic scattering and imaging simulation of extremely large-scale sea-ship scene based on GPU parallel technology

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Journal of Electronic Science and Technology 2024年第2期22卷 16-23页

作者： Cheng-Wei Zhang zhi-Qin Zhao Wei Yang Li-Lai Zhou Hai-Yu zhu Southwest China Institute of Electronic Technology Chengdu610036China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Tencent Company Shenzhen518054China

Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is proposed.For the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing tasks.Finally,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing process.By using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as well.It is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.

关键词： Multi graphics processing unit Radar imaging Sea-ship Shooting and bouncing rays

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu zhu Min guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Endoscopic ultrasound-guided lauromacrogol injection for treatment of colorectal cavernous hemangioma:Two case reports

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 966-973页

作者： Hua-Tuo zhu Wen-guo Chen Jing-Jie Wang Jia-Nan guo Fen-Ming Zhang guo-Qiang Xu Hong-Tan Chen Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as colitis.Surgical resection is currently the mainstay of treatment,with an emphasis on sphincter preservation.CASE SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical prognosis.CONCLUSION Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.

关键词： Endoscopic ultrasound Lauromacrogol injection Colorectal cavernous hemangioma Case report

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Phosphorous-doped carbon nanotube/reduced graphene oxide aerogel cathode enabled by pseudocapacitance for high energy and power zinc-ion hybrid capacitors

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Chinese Chemical Letters 2024年第2期35卷 570-576页

作者： Junjun Yao Fuzhi Li Ruyi Zhou Chenchen guo Xinru Liu Yirong zhu Hunan Key Laboratory of Green Metallurgy and New Energy Materials College of Materials and Advanced ManufacturingHunan University of TechnologyZhuzhou 412007China College of packaging and Material Engineering Hunan University of TechnologyZhuzhou 412007China

The design and development of energy storage device with high energy/power density has become a research hotspot.Zinc-ion hybrid capacitors(ZHCs)are considered as one of the most promising candidates.However,the application of ZHCs is hindered by their low energy density at high power density due to the unsatisfactory cathode material.In this study,a novel 3D phosphorus-doped carbon nanotube/reduced graphene oxide(P-CNT/rGO)aerogel cathode is synthesized through a synergistic modification strategy of CNT insertion and P doping modification combined with 3D porous design.The as-obtained P-CNT/rGO aerogel cathode manifests significantly increased surface aera,expanded interlayer spacing,and enhanced pseudocapacitance behavior,thus leading to significantly enhanced specific capacitance and superb ions transport performance.The as-assembled ZHC based on P-CNT/rGO cathode delivers a superior energy density of 42.2 Wh/kg at an extreme-high power density of 80 kW/kg and excellent cycle life.In-depth kinetic analyses are undertaken to prove the enhanced pseudocapacitance behavior and exceptional power output capability of ZHCs.Furthermore,the reaction mechanism of physical and chemical adsorption/desorption of electrolyte ions on the P-CNT/rGO cathode is revealed by systematic ex-situ characterizations.This work can provide a valuable reference for developing advanced graphene-based cathode for high energy/power density ZHCs.

关键词： Graphene aerogel Phosphorus doping Pseudocapacitance Zinc-ion hybrid capacitors Energy storage mechanism

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