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Observation of ballistic-diffusive thermal transport in GaN transistors using thermoreflectance thermal imaging

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Rare Metals 2024年第1期43卷 389-394页

作者： zhi-Ke liu yang Shen han-ling Li Bing-yang Cao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

To develop effective thermal management strategies for gallium-nitride (GaN) transistors, it is essential to accurately predict the device junction temperature. Since the width of the heat generation in the devices is comparable to phonon mean free paths (MFPs) of GaN, phonon ballistic transport exists and can significantly affect the heat transport process.

关键词： temperature. transistors GaN

Search algorithm on strongly regular graphs based on scattering quantum walks

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Chinese Physics B 2017年第1期26卷 108-114页

作者： Xi-ling Xue zhi-Hao liu han-Wu Chen School of Computer Science and Engineering Southeast University Nanjing 210096 China

Janmark, Meyer, and Wong showed that continuous-time quantum walk search on known families of strongly regular graphs（SRGs） with parameters（N, k, λ, μ） achieves full quantum speedup. The problem is reconsidered in terms of scattering quantum walk, a type of discrete-time quantum walks. Here, the search space is confined to a low-dimensional subspace corresponding to the collapsed graph of SRGs. To quantify the algorithm＇s performance, we leverage the fundamental pairing theorem, a general theory developed by Cottrell for quantum search of structural anomalies in star *** search algorithm on the SRGs with k scales as N satisfies the theorem, and results can be immediately obtained, while search on the SRGs with k scales as√N does not satisfy the theorem, and matrix perturbation theory is used to provide an analysis. Both these cases can be solved in O（√N） time steps with a success probability close to 1. The analytical conclusions are verified by simulation results on two SRGs. These examples show that the formalism on star graphs can be applied more generally.

关键词： scattering quantum walk quantum search strongly regular graph

The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish

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Neuroscience Bulletin 2020年第9期36卷 1023-1034页

作者： Jian Zhu han-Tsing Wang Yu-Rong Chen ling-Ya Yan Ying-Ying han ling-Yan liu Ying Cao zhi-zhi liu Hong A.Xu Institute of Life Science Nanchang UniversityNanchang 330031China School of Life Sciences Nanchang UniversityNanchang 330031China Jiangxi Provincial Collaborative Innovation Center for Cardiovascular Digestive and Neuropsychiatric DiseasesNanchang 330031China Department of Molecular and Cell Biology Tongji University School of Life Sciences and TechnologyShanghai 200092China Precise Genome Engineering Center School of Life SciencesGuangzhou UniversityGuangzhou 510006China

Joubert syndrome is characterized by unique malformation of the cerebellar *** than thirty Joubert syndrome genes have been identified,including ARL13 ***,its role in cerebellar development remains *** found that knockdown or knockout of arl13b impaired balance and locomotion in zebrafish *** cells were selectively reduced in the corpus cerebelli,a structure homologous to the mammalian *** cell progenitors were also selectively disturbed *** expression of atoh1 and ptf1,proneural genes of granule and Purkinje cells,respectively,were selectively down-regulated along the dorsal midline of the ***,wnt1,which is transiently expressed early in cerebellar development,was selectively ***,activating Wnt signaling partially rescued the granule cell defects in arl13b *** findings suggested that Arl13 b is necessary for the early development of cerebellar granule and Purkinje *** arl13b-deficient zebrafish can serve as a model organism for studying Joubert syndrome.

关键词： Joubert syndrome arl13b Cerebellum Development Granule cell Purkinje cell Wnt

Effect of an upward magnetic field on nanosized sulfide precipitation in ultra-low carbon steel

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International Journal of Minerals,Metallurgy and Materials 2015年第7期22卷 714-720页

作者： Kang-jia Duan ling Zhang Xi-zhi Yuan Shan-shan han Yu liu Qing-song Huang School of Chemical Engineering Sichuan University School of Materials Science and Engineering Chongqing University Institute of Ion Beam Physics and Materials Research Helmholtz-Zentrum Dresden-Rossendorf (HZDR)

An induction levitation melting （ILM） refining process is performed to remove most microsized inclusions in ultra-low carbon steel （UCS）. Nanosized, spheroid shaped sulfide precipitates remain dispersed in the UCS. During the ILM process, the UCS is molten and is rotated under an upward magnetic field. With the addition of Ti additives, the spinning molten steel under the upward magnetic field ejects particles because of resultant centrifugal, floating, and magnetic forces. Magnetic force plays a key role in removing sub-micrometer-sized particles, composed of porous aluminum titanate enwrapping alumina nuclei. Consequently, sulfide precipitates with sizes less than 50 nan remain dispersed in the steel matrix. These findings open a path to the fabrication of clean steel or steel bearing only a nanosized strengthen- ing phase.

关键词： ultra-low carbon steel magnetic field sulfide precipitation induction levitation titanium

Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 47-51页

作者： Zhong han Xia-ling Lei Hong Zhang Lu liu zhi-Sen Chen Wei yang Zhao-Rong Lun School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationGuangdong Institute of Applied Biological Resources Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangzhou 510990China

Objective: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety,Methods: Acute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice,Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0,540,1 620,and 6 480 mg/kg in SD ***: In the acute toxicity study,mortality was not observed after 14 days,In addition,clinically relevant adverse effects,or variations in body weight or food consumption were not observed,Similarly,after 30 days in the sub-chronic toxicity study,no mortality or significant toxicological effects such as decreased food consumption,body weight,biochemical parameters and vital organs etc,were noticed,Conclusion: The results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration,and therefore is suitable for further development and applications.

关键词： Forsythin Acute toxicity Sub-chronic toxicity Safety

Ultrasound-guided microwave ablation for abdominal wall metastatic tumors: A preliminary study

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World Journal of Gastroenterology 2012年第23期18卷 3008-3014页

作者： Cai Qi Xiao-ling Yu Ping Liang zhi-Gang Cheng Fang-Yi liu zhi-Yu han Jie Yu Department of IntercentJonal Ul-trasound The General Hospital of Chinese People's Liberation ArmyBeijing 100853China

AIM: To evaluate the feasibility, safety and efficacy of ultrasound-guided microwave (MW) ablation for abdominal wall metastatic tumors. METHODS: From August 2007 to December 2010, a total of 11 patients with 23 abdominal wall nodules (diameter 2.59 cm ± 1.11 cm, range 1.3 cm to 5.0 cm) were treated with MW ablation. One antenna was inserted into the center of tumors less than 1.7 cm, and multiple antennae were inserted simultaneously into tumors 1.7 cm or larger. A 21 gauge thermocouple was inserted near important organs which required protection (such as bowel or gallbladder) for real-time temperature monitoring during MW ablation. Treatment outcome was observed by contrast-enhanced ultrasound and magnetic resonance imaging (MRI) [or computed tomography (CT)] during follow-up. RESULTS: MW ablation was well tolerated by all patients. Six patients with 11 nodules had 1 thermocouple inserted near important organs for real-time temperature monitoring and the maximum temperature was 56 ℃. Major complications included mild pain (54.5%), post-ablation fever (100%) and abdominal wall edema (25%). All 23 tumors (100%) in this group were completely ablated, and no residual tumor or local recurrence was observed at a median follow-up of 13 mo (range 1 to 32 mo). The ablation zone was well defined on contrast-enhanced imaging (contrast-enhanced CT, MRI and/or contrast-enhanced ultrasound) and gradually shrank with time. CONCLUSION: Ultrasound-guided MW ablation may be a feasible, safe and effective treatment for abdominal wall metastatic tumors in selected patients.

关键词： Abdominal wall Microwave ablation Neo-plasm metastasis Thermal ablation therapy Ultraso-nography

Two new isospirostanol sapogenins from Reineckia carnea

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Chinese Chemical Letters 2012年第11期23卷 1240-1242页

作者： Yao Wang Na han ling Li Chen zhi Hui liu Li Bo Zou Jun Yin School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Development and Utilization Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Two new isospirostanol sapogenins named （25R）-5/%spirostane-（1αα 3a）-diol （1） and （25R）-5/%spirostane-（1α, 2α, 3α, 4α）- tetrol （2） were isolated from the whole herb ofReineckia carnea （Andr.） Kunth... 详细信息

关键词： Reineckia carnea (Andr) Kunth. Chemical constituent Isospirostanol sapogenin

Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides

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Synthetic and Systems Biotechnology 2022年第4期7卷 1173-1180页

作者： ling Gao Wenjie Ma Zhaoxin Lu Jinzhi han zhi Ma Hongxia liu Xiaomei Bie Nanjing Agricultural University College of Food Science and TechnologyNanjing210095China Jiangnan University The Key Laboratory of Industrial BiotechnologyWuxi214122China

Nonribosomal peptide synthase(NRPS)is a unique molecular assembly mechanism with high *** recombination is conducive to the development of novel ***,there are few reports on NRPS subunit recombination of plipastatin at *** this paper,plipastatin synthase was modified by the forward movement of subunit PPSE and the replacement of the communication-mediating(COM)*** results showed that ppsABE,a new assembly line,could synthesize novel lipopeptides such as cycle pentapeptide(C16-18β-OHFA-E-O-cyclo(Y-T-I),and its antimicrobial activity against Rhizopus stolonifer and Staphylococcus aureus was better than that of ***,the reactivity of ppsABCE disappeared,but the substitution of COM^(D)_(ppsC)/COM^(A)_(ppsD) or COM^(D)_(ppsD)/COM^(A)_(ppsE) for COM^(D)_(ppsC)/COM^(A)_(ppsE) could restore its activity and conduct the biosynthesis of linear hexapeptide(C16-17β-OHFA-E-O-Y-T-E-A/V)and heptapeptide(C17-18β-OHFA-E-O-Y-T-E-A-I).Collectively,these findings indicated that the COM donor domain at the C-terminus of PPSB could communicate with the COM acceptor domain at the N-terminus of PPSE and that the compatible COM domain is an important tool for communication between nonpartner ***,the integrity and selective compatibility of the COM acceptor domain of subunit PPSE are essential to promote the interaction between PPSE and other *** work further complemented the rules of NRPS subunit recombination and provided a theoretical basis for the development of novel high-efficiency lipopeptides.

关键词： Plipastatin Subunit translocation COM domain Compatibility Antimicrobial activity Novel lipopeptides

Molecular mapping of leaf rust resistance genes in the wheat line Yu 356-9

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Journal of Integrative Agriculture 2015年第7期14卷 1223-1228页

作者： han liu-sha LI Zai-feng WANG Jia-zhen SHI ling-zhi ZHU Lin LI Xing liu Da-qun Syed J A Shah College of Plant Protection Agricultural University of Hebei Nuclear Institute for Food and Agricuture

The Chinese wheat line Yu 356-9 exhibits a high level of resistance to leaf rust. In order to decipher the genetic base of resistance in Yu 356-9, gene postulation, inheritance analyses, and chromosome linkage mapping were carried out. Gene postulation completed using 15 leaf rust pathotypes and 36 isogenic lines indicated that Yu 356-9 was resistant to all pathotypes tested. F1 and F2 plants from the cross Yu 356-9 （resistant）/Zhengzhou 5389 （susceptible） were tested with leaf rust pathotype ＂FHNQ＂ in the greenhouse. Results indicated a 3：1 segregation ratio, indicative of the presence of a single dominant leaf rust resistance gene in Yu 356-9 which was temporarily designated as LrYu. Bulk segregant analysis and molecular marker assays were used to map LrYu. Five simple sequence repeat （SSR） markers on chromosome 2BS were found closely linked to LrYu. Among these markers, Xwmc770 is the most closely linked, with a genetic distance of 5.7 cM.

关键词： wheat leaf rust resistance gene inheritance analyses molecular mapping