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Inverting the rock mass P-wave velocity field ahead of deep buried tunnel face while borehole drilling

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International Journal of Mining Science and Technology 2024年第5期34卷 681-697页

作者： liu liu Shaojun li Minzong Zheng Dong Wang Minghao Chen Junbo Zhou Tingzhou Yan zhenming Shi State Key laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China China Railway Eryuan Engineering Group CO. LTD.Chengdu 610031China Department of Hydraulic and Hydropower Engineering Tsinghua UniversityBeijing 100084China Hubei Communications Planning and Design Institute CO. LTD.Wuhan 430051China Key laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China

Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole *** paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography ***-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be *** the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography *** rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.

关键词： Deep buried tunnel Wave velocity field Borehole drilling Tomography Rock mass

Reflections on COPD comorbidities

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Chinese Medical Journal 2024年第12期137卷 1504-1506页

作者： zhenming He Yue Wang lin Shan Yan Mou Yunhuan liu Guanhua Ma Yanxu Wu Huili Zhu Jeffrey l.Curtis Shilei Cui Haiyan Ge Department of Pulmonary and Critical Care Medicine Huadong HospitalFudan UniversityShanghai 200040China Medical Service VA Ann Arbor Healthcare SystemAnn ArborMI 48105USA Pulmonary&Critical Care Medicine Division Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA Graduate Program in Immunology University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic obstructive pulmonary disease(COPD)is a common disease among the elderly,affecting over one-third of the elderly population *** progressive decline in lung function characteristic of COPD significantly impacts the quality of life and employability of affected individuals,resulting in a substantial direct and indirect socioeconomic *** frequently has comorbidities involving other organ *** all elderly COPD patients present with one or more comorbid conditions,collectively exacerbating health and economic *** viral and bacterial infections remain the most common triggers for COPD exacerbations(ECOPD).

关键词： morbid lung collective

In situ Preparation and Visible-light-driven Photocatalytic Degradation Performance of Nano 3C-SiC@Multilayer Graphene Oxide Heterostructure

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Chemical Research in Chinese Universities 2024年第3期40卷 536-547页

作者： YANG Xiaodan GUO Ziqi XU Yichen lI Ziliang ZHOU Yangtao YANG zhenming ZHOU Zishuai GAO Yong ZHANG Jinsong Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016P.R.China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123P.R.China Shenyang SCIENCREAT Chemicals Co. Ltd.Shenyang 110144P.R.China School of Materials Science and Engineering Northeastern UniversityShenyang 110819P.R.China

Nano 3C-SiC@multilayer graphene oxide(NS@MGO)heterostructure was in situ prepared by carbothermal reduction of pyrolyzed precursor composed of highly dispersed cured phenolic resin and silicon dioxide derived from tetraethyl *** heterojunction interface,number of layers of MGO,and defect content in graphene are the three most important factors for promoting photocatalytic *** contact between 3C-SiC nanograins and MGO layers facilitates the photogenerated electrons to migrate across the heterojunction interface and avoid the formation of SiO_(2) nanolayers on the surface of SiC *** number of MGO layers is supposed to be less than ten instead of over-thick *** concentrations of oxygenated components,considered the defect contents,decrease with the increase of sintering temperature for NS@MGO 0.175-T-150,and relative carbon content in the multilayer graphene *** to the heterostructures,properties,and photocatalytic reaction performance of the NS@MGO materials,the highest photocatalytic kinetic rate constant of 0.00891/min for NS@MGO 0.175-1500-150 shows that the significant enhancement in photocatalytic degradation activity under visible light(>420 nm)irradiation is ascribed to the advantageous synergistic effects between the nano 3C-SiC particles and the direct contact multilayer graphene oxide with appropriate layers and sufficient oxygen content of 3.51%(atomic fraction)in MGO.

关键词： Photocatalysis Multilayer graphene oxide Nano 3C-SiC Visiblelight degradation

诱惑与控制:1947—1948年国民政府与美国原子能合作的秘密交涉

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中国科技史杂志 2024年第2期45卷 271-280页

作者：张振明河南科技大学人文学院历史系

二战之后，人类社会进入原子能时代。处于核垄断地位的美国，推行原子能管制政策。鉴于原子弹的巨大威力，其他国家也着手原子能研究。1947年至1948年，国民政府与美国就原子能合作进行秘密交涉，此事长期未引起学界关注。本文通过梳理... 详细信息

二战之后，人类社会进入原子能时代。处于核垄断地位的美国，推行原子能管制政策。鉴于原子弹的巨大威力，其他国家也着手原子能研究。1947年至1948年，国民政府与美国就原子能合作进行秘密交涉，此事长期未引起学界关注。本文通过梳理、对照中美相关外交档案还原这一过程。在秘密交涉中，国民政府希望利用发现的铀、钍等放射性矿产诱惑美国提供原子能技术；美国则利用交涉使国民政府失去与其他第三国合作的机会，执行国际原子能管制政策，控制国民政府的原子能发展。

关键词：中美原子能合作中央研究院中美秘密外交

ZIF-8 coated gold nanospheres: A multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells

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Nano Research 2024年第3期17卷 1772-1784页

作者： Miao lei Weiye Cai luetao Zou Bin Yu lin Chen Yang Cao Shanlin Xiang Chao Song Jiandu lei Wei Jiang zhenming Hu Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou 646699China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China Department of Orthopedics Chongqing University Three Gorges HospitalChongqing 404000China Department of Geriatrics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025China Beijing Key laboratory of lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Photothermal therapy(PTT)has been widely used in the treatment of tumors,but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins(HSPs)caused by high *** article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism.A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase(GOX)and gold nanospheres(AuNPs)loaded with dihydroartemisinin(DHA)with zeolitic imidazolate framework-8(ZIF-8).This platform can take advantage of the micro-environment of osteosarcoma(OS)cells,featuring low pH and high reactive oxygen species(ROS),for precision drug *** can effectively catalyze glucose to produce gluconic acid and H_(2)O_(2),and DHA can also induce ROS production in OS *** produced by GOX and DHA can further generate lipid peroxidation(lPO)and lead to ferroptosis of OS *** the same time,ROS and lPO produced can inhibit the expression of HSPs,thereby increasing the therapeutic effect of *** vitro experiments show that the nanoparticles are pH and ROS responsive.1μg/ml GOX combined with 0.2μg/ml DHA promotes ferroptosis of OS cells,and increases the killing effect of near-infrared(NIR)on OS *** in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS ***,this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods.

关键词： zeolitic imidazolate framework-8(ZIF-8) gold nanospheres(AuNPs) photothermal therapy(PTT) starvation therapy ferroptosis

An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

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Genes & Diseases 2024年第2期11卷 558-560页

作者： Zhicai Peng Zhuo Wang Shuaichi Guo Bing Tan Ruichao Cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao zhenming Hu Department of Orthopaedics Yongchuan Traditional Chinese Medicine Hospital of ChongqingChongqing 402160China Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Spine Surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyangSichuan 621000China

Intervertebral disc degeneration(IDD)is the main cause of lower back *** back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral *** new treatments for IDD requires clarifying the mechanisms of *** hypoxia is an important feature of the nucleus pulposus because of its special anatomical *** RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)*** demonstrated possible effects of oxygen concentration and HIF1A on *** addition,our results showed that hypoxia can affect lipid metabolism in NPCs.

关键词： structure metabolism degeneration

New perspectives on the genetic structure of dotted gizzard shad(Konosirus punctatus)based on RAD-seq

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Marine life Science & Technology 2024年第1期6卷 50-67页

作者： Ying Peng Yifan liu Jiasheng li Kun Zhang Xun Jin Sixu Zheng Yunpeng Wang zhenming lu liqin liu li Gong Bingjian liu National Engineering laboratory of Marine Germplasm Resources Exploration and Utilization Zhejiang Ocean UniversityZhoushan 316022China National Engineering Research Center for Facilitated Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China

To maintain,develop and rationally utilize marine organisms,understanding their genetic structure and habitat adaptation pattern is *** punctatus,which is a commercial fish species inhabiting the Indo-west Pacific Ocean,has shown an obvious annual global capture and aquaculture production decline due to climate changes and human *** the present study,restriction-site associated DNA sequencing(RAD-seq)was used to describe its genome-wide single nucleotide polymorphisms panel(SNPs).Among 146 individuals collected at nine locations scattered in China,Korea and Japan,a set of 632,090 SNPs were *** genetic analysis showed that *** individuals were divided into two significant genetic ***,potential genetic differentiation between northern and southern population of *** was *** results indicated that gene flow existed among sampling locations of ***,especially from southern Japan to ***,candidate genes associated with habitat adaptations of *** were identified,which are involved in diverse physiological processes of *** including growth and development(e.g.,KIDINS220,PAN3),substance metabolism(e.g.,PGM5)and immune response(e.g.,VAV3,CCT7,HSPA12B).Our findings may aid in understanding the possible mechanisms for the population genetic structure and local adaptation of ***,which is beneficial to establish the management and conservation units of ***,guiding the rational use of resources,with reference significance for a profound understanding of the adaptative mechanisms of other marine organisms to the environment.

关键词： Population structure Konosirus punctatus SNP RAD-seq local adaptation

面向未来,久久为功:新征程校园足球再出发——《关于加强和改进新时代青少年校园足球工作的实施意见》的新理念、新策略和新举措

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西安体育学院学报 2024年第2期41卷 141-149页

作者：毛振明郑州大学体育学院郑州450001

教育部等七部委发布的《关于加强和改进新时代青少年校园足球工作的实施意见》标志着新征程校园足球的再出发,具有校园足球未来发展“方向舵”“加油站”和“路线图”的重要作用。主要从2015年提出校园足球“八大任务”的工作成效和校... 详细信息

教育部等七部委发布的《关于加强和改进新时代青少年校园足球工作的实施意见》标志着新征程校园足球的再出发,具有校园足球未来发展“方向舵”“加油站”和“路线图”的重要作用。主要从2015年提出校园足球“八大任务”的工作成效和校园足球机制创新突破2个方面,对近10年校园足球的成绩与不足进行分析,指出校园足球取得了一定的成绩,具体表现在:校园足球助力落实立德树人根本任务;普及足球运动激发学生锻炼热潮并实现学生体质大幅度大面积的提升;以足球课改为突破口促进体育课教学改革;在国民教育体系中建立学生足球青训竞赛系统;通过校园足球训练竞赛新赛道推动国家足球人才培养和竞技水平提升。当然在取得进展的同时也存在不足,仍需要有深层次的改革推进与重大方法论突破。在认真研习《意见》的基础上,结合对校园足球发展中的问题认识,对新征程校园足球发展的新理念、新策略和颇有创新性的10个新举措进行了深入探讨。

关键词：校园足球体教融合八大任务立德树人体育课程教学改革

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华严宗“无情”佛性观辨析

世界宗教文化 2024年第1期 150-156页

作者：曹振明西北大学哲学学院

学界通常认为,华严宗主张“无情无性”的佛性观,并将华严佛性观排除于中国佛教“无情有性”思想之外。但从唐代华严文献的内容分析可知,华严宗明确主张“无情有性”,并将其视为已宗“圆教”的独特标志;与此同时,华严宗的“无情”佛性观... 详细信息

学界通常认为,华严宗主张“无情无性”的佛性观,并将华严佛性观排除于中国佛教“无情有性”思想之外。但从唐代华严文献的内容分析可知,华严宗明确主张“无情有性”,并将其视为已宗“圆教”的独特标志;与此同时,华严宗的“无情”佛性观又呈现出包容性品格,在中国佛教思想史上占有独特的地位。认识华严宗的这一佛性观内涵,对于全面把握乃至重新认识中国佛教“无情”佛性思想的发展进程,也具有重要的理论意义。

关键词：中国佛教佛性观无情华严宗天台宗