An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

作     者：Zhicai Peng Zhuo Wang Shuaichi Guo Bing Tan Ruichao Cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao Zhenming Hu Zhicai Peng;Zhuo Wang;Shuaichi Guo;Bing Tan;Ruichao Cao;Shengqiang Cheng;Jun Chen;Chunwang Xie;Dehong Mao;Zhenming Hu

作者机构：Department of OrthopaedicsYongchuan Traditional Chinese Medicine Hospital of ChongqingChongqing 402160China Department of Orthopaedic SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Spine SurgeryThe Third Hospital of MianyangSichuan Mental Health CenterMianyangSichuan 621000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第2期

页      面：558-560页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：funded by the Chongqing Science and Technology Committee and Health Commission Joint Project(China)(No.2022ZDXM040) 

主　　题：structure metabolism degeneration 

摘      要：Intervertebral disc degeneration(IDD)is the main cause of lower back *** back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral *** new treatments for IDD requires clarifying the mechanisms of *** hypoxia is an important feature of the nucleus pulposus because of its special anatomical *** RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)*** demonstrated possible effects of oxygen concentration and HIF1A on *** addition,our results showed that hypoxia can affect lipid metabolism in NPCs.