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Acta Epileptologica 2024年第1期7卷 14-20页

作者： Guangli li zhenguang li Yingting liu Hunan University of Chinese Medicine Changsha410208Hunan ProvinceChina Epilepsy Center of Brain Hospital of Hunan Province Changsha410007Hunan ProvinceChina

Vagus nerve stimulation(VNS)is an important treatment option for drug-refractory epilepsy(DRE),with well-established efficacy and safety in clinical practice for more than 20 ***,it is very difficult to find the optimal electrophysiological indicators for the effectiveness of VNS on DRE because the mechanism of action is *** this review,we provide an update of the potential applications of VNS outcomes in patients with drug-resistant ***(EEG)activity,event-related potentials,EEG synchronization levels,magnetoencephalographic,laryngeal muscle evoked potentials,and heart rate variability are potential biomarkers for VNS outcomes in people with DRE.

关键词： Electrophysiology Vagus nerve stimulation Drug-refractory epilepsy Efficacy Predictive indicators Electroencephalogram Event-related potential Magnetoencephalography Aryngeal muscle evoked potential Heart rate variability

Depositional environment of terrestrial petroleum source rocks and geochemical indicators in the Songliao Basin

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Science China Earth Sciences 2011年第9期54卷 1304-1317页

作者： FENG ZiHui FANG Wei li zhenguang WANG Xue HUO Qiuli HUANG ChunYan ZHANG JuHe ZENG HuaSen School of Earth and Space Sciences Peking University Beijing 100871 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China

To determine geochemical indicators for depositional environment favored by terrestrial petroleum source rocks, we selected 40 source rock samples from the Late Cretaceous Qingshankou Formation （Kzqn） and the first member of Nenjiang Formation （K2n1） in the Songliao Basin to qualify saturate fraction and aromatic fraction using GC-HRT （gas chromatography high resolution time-of-flight mass spectrometry） and quantify important biomarkers using GC-MS. The results reveal that source rocks from the 1st member of Qingshankou Formation （K2qn1） are characterized by not only high contents of terpanes, regular steranes and 4-methylsteranes but also high contents of dinosteranes, C31 steranes and aryl isoprenoids. Presence of specific biomarkers like elementary sulfur and lanostanes indicates a depositional environment of lagoon characterized by water stratification and high salinity. In the 2nd-3rd members of Qingshankou Formation （K2qn2＋3）, source rocks contain lower contents of biomarkers, indicating a depositional environment of shallow fresh-water lake delta. Source rocks in the K2n1 contain high contents of terpanes, regular steranes and 4-methylsteranes but lower contents of dinosteranes, C31 steranes and aryl isoprenoids, indicating a depositional environment of fresh-brackish open lake characterized by low salinity and poor water stratification, where organic matter is seriously altered by bacteria. Overall analysis shows that primary geochemical indicators for terrestrial petroleum source rocks are as follows： 1） C30 hopanes 〉 1500 ppm; 2） gammacerane 〉190 ppm; 3） C27 steranes 〉200 ppm; 4） 4-methylsteranes 〉 100 ppm; 5） aryl isoprenoids 〉 3 ppm; 6） dehydroxyl-vitamin E 〉 10 ppm.

关键词： Songliao Basin source rock depositional environment geochemistry biomarker

Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration

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Bioactive Materials 2024年第8期38卷 305-320页

作者： Cuijun Deng Chen Qin zhenguang li Laiya Lu Yifan Tong Jiaqi Yuan Feng Yin Yu Cheng Chengtie Wu Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Clinical Research Center for Anesthesiology and Perioperative MedicineTranslational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai200434PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Joint Surgery Shanghai East HospitalSchool of MedicineTongji University150 Jimo RoadShanghai200032PR China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438PR China

Osteochondral regeneration involves the highly challenging and complex reconstruction of cartilage and subchondral ***(Si)ions play a crucial role in bone *** research on Si ions mainly focuses on bone repair,by using silicate bioceramics with complex ion ***,it is unclear whether the Si ions have important effect on cartilage *** a scaffold that solely releases Si ions to simultaneously promote subchondral bone repair and stimulate cartilage regeneration is critically ***(DE)is a natural diatomaceous sediment that can stably release Si ions,known for its abundant availability,low cost,and environmental ***,a hierarchical osteochondral repair scaffold is uniquely designed by incorporating gradient DE into GelMA *** adding DE microparticles provides a specific Si source for controlled Si ions release,which not only promotes osteogenic differentiation of rBMSCs(rabbit bone marrow mesenchymal stem cells)but also enhances proliferation and maturation of ***,DE-incorporated hierarchical scaffolds significantly promoted the regeneration of cartilage and subchondral *** study suggests the significant role of Si ions in promoting cartilage regeneration and solidifies their foundational role in enhancing bone ***,it offers an economic and eco-friendly strategy for developing high value-added osteochondral regenerative bioscaffolds from low-value ocean natural materials.

关键词： Diatomite Si release Hierarchical scaffolds 3D printing Osteochondral regeneration

Application and Model of Term Structure of Stochastic Interest Rate Based on the Inflation Rate

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Journal of Systems Science and Information 2007年第2期5卷 191-199页

作者： Yonghong Ma Rongxi Zhou zhenguang li School of Economics and Management Beijing University of Chemical Technology Beijing 100029 China

In this paper, we build the arbitrage-free term structure model on the inflation rate, and discuss the relations between the arbitrage-free term structure and the equivalent martingale measure. The volatility terms of diffusion processes of the real forward interest rate, the nominal forward interest rate and the inflation index （Jarrow and Yildirim, 2003） are extended into many dimensional Brownian motions. Moreover, as we derive the differential equations of three-factor term structure, our results are generalized. At last, the analytic solutions of European option can be deduced on the inflation rate.

关键词： model of term structure inflation rate equivalent martingale measure European option

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302例患过天花者HBV血清学调查研究

中华流行病学杂志 1991年第2期12卷 83-86页

作者：李振广谢长义河南省驻马店地区人民医院河南省肿瘤研究所免疫室河南省驻马店地区卫生防疫站

对302例患过天花者这一特殊人群进行了HBV血清学调查，结果HBsAg阳性率（1.3%）分别显著低于对照组1（8.3%）和对照组2（8.6%）（P0.05）。患过天花者HBV感染率（19.2%）也分别显著低于对照组1（47.7%）和对照组2（51.3%）（P<0.001）... 详细信息

对302例患过天花者这一特殊人群进行了HBV血清学调查，结果HBsAg阳性率（1.3%）分别显著低于对照组1（8.3%）和对照组2（8.6%）（P0.05）。患过天花者HBV感染率（19.2%）也分别显著低于对照组1（47.7%）和对照组2（51.3%）（P<0.001）。对上述三组细胞免疫功能测定结果，病例组玫瑰花结形成率及淋巴细胞转化率均分别显著高于两对照组。故认为上述结果是患过天花者细胞免疫功能增强，干扰乙型肝炎病毒感染所致。

关键词：天花乙肝病毒感染率

海拉尔盆地贝尔凹陷原油芳烃化合物组成和分布特征

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地质科学 2009年第2期44卷 645-656页

作者：李振广冯子辉霍秋立大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

通过色谱—质谱分析,对海拉尔盆地贝尔凹陷35个原油样品进行聚类分析,将之分成4类。Ⅰ类原油是贝尔凹陷原油主体,占分析样品的77%,特点是菲系列含量高,平均值为64.7%,三芳甾类化合物和三芴类化合物含量次之,分别为11.42%和11.81%。Ⅱ类... 详细信息

通过色谱—质谱分析,对海拉尔盆地贝尔凹陷35个原油样品进行聚类分析,将之分成4类。Ⅰ类原油是贝尔凹陷原油主体,占分析样品的77%,特点是菲系列含量高,平均值为64.7%,三芳甾类化合物和三芴类化合物含量次之,分别为11.42%和11.81%。Ⅱ类原油为高三芳甾类原油,三芳甾类化合物占芳烃化合物的53.9%,是该类原油的主要成份,菲系列化合物含量较低,为32.5%,萘系列含量和三芴化合物含量最低,分别为0.6%和3.54%。Ⅲ类原油为高菲系列和高萤蒽含量原油,菲系列为64%,萤蒽含量高达11%,是其它原油的16倍以上。Ⅳ类原油具有高萘、高三芴化合物和低菲系列化合物的特点,分别占原油芳烃馏分的30%、32%和26%,三芳甾类化合物含量低,占3.6%。这充分说明海拉尔盆地烃源岩沉积期间有不同的沉积环境,原油有不同的生烃母质。Ⅱ类原油以藻类为主要生烃母质,Ⅲ类原油以高等植物为主,Ⅰ类原油介于Ⅱ类和Ⅲ类原油之间,为混合型生烃母质。Ⅳ原油沉积环境和前三类原油明显不同,为咸水强还原湖相沉积环境。

关键词：芳烃特征原油类型生烃母质沉积环境海拉尔盆地

Distribution and significance of C~_(40) alkanes in the extracts of Cretaceous source rocks from the Songliao Basin

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Science China Earth Sciences 2007年第10期50卷 1510-1520页

作者： FENG ZiHui FANG Wei ZHANG JuHe li zhenguang HUANG ChunYan WANG Xue ZHAO Qinling HUO Qiuli Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing 163712 China

Source rock extracts and crude oils from the Songliao Basin were analyzed by high-temperature gas chromatography (HTGC), gas chromatography-mass spectrometry (HTGC-MS) and gas chromatography-isotope ratio-mass spectrometry (GC-IRMS), for high molecular-weight alkanes. The distributions of n-alkanes in the Nenjiang Formation extracts are in the C14―C63 range; a bimodal distribution occurs in the C-21 and C21―40 regions. The C30―C37 n-alkanes are accompanied by C29―C35 hopanes, whereas the high molecular-weight C45―C47 n-alkanes co-occur with abundant isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The high δ 13C values of the n-alkanes and the microscopic maceral compositions indicate a highly diversified organic source input for the Nenjiang Formation source rocks, ranging from aquatic plants, blue alge-bacteria, to land plant material. In contrast, n-alkanes in the rock extracts of the Qingshankou Formation are characterized by a single modal distribution, with relatively low abundances of C29―C35 hopanes, but high molecular-weight isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The relatively low δ 13C values of C22―C44 n-alkanes and organic material compositions indicate that the source rocks in the Qingshankou Formation contain dominantly type I algal organic matter. The relative abundance of C+40 compounds in source rocks changes little at low maturity stage, but decreases drastically at higher maturity levels, with a concurrent reduction in the odd/even carbon predominance. In crude oils, in contrast, the relative abundance of C+40 compounds appears to relate closely with the oil source and oil viscosity.

关键词： Songliao Basin, source rock, high-temperature gas chromatography (HTGC), high-temperature gas chromatography-mass spectrometry (HTGC-MS), gas chromatography-isotope ratio-mass spectrometry (GC-IRMS).

Localization of calmodulin and calmodulin-like protein and their functions in biomineralization in P. fucata

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Progress in Natural Science:Materials International 2008年第4期18卷 405-412页

作者： Zi Fang a, zhenguang Yan a, Shuo li a, Qin Wang a, Weizhong Cao a, Guangrui Xu a, Xunhao Xiong a, liping Xie a,b, Rongqing Zhang a,b, a Institute of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China b Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China Institute of Marine Biotechnology Department of Biological Science and Biotechnology Tsinghua University Beijing 100084 China Protein Science Laboratory of the Ministry of Education Tsinghua University Beijing 100084 China

Calmodulin (CaM) and calmodulin-like protein (CaLP) are two proteins involved in biomineralization. Their localizations in Pinct- ada fucata mantle epithelia were studied by Western blot (WB) analysis of the nuclear/cytosol fraction of primary cultured P. fucata mantle cells and immunogold electron microscopy. The results showed a completely different distribution of these two proteins at the subcellular level. CaM was distributed throughout both the nucleus and cytoplasm of the mantle epithelium but CaLP was distributed only in the cytoplasm. The functions of these two proteins in biomineralization were investigated by shell regeneration. During this pro- cess, the expressions of CaM and CaLP were greatly enhanced in different organelles of the mantle epithelium. Overexpression of these two proteins and a mutant of calmodulin-like protein (M-CaLP) that lacks an extra C-terminal tail in MC3T3-E1 promoted the mRNA expression of osteopontin, a biomineralization marker for osteoblasts. All of the results indicated that CaM and CaLP have completely different distributions in the mantle epithelium and affect the biomineralization process at different levels. The extra C-terminal tail of CaLP is important for its functions in biomineralization in P. fucata.

关键词： Pinctada fucata Calmodulin Calmodulin-like protein Immunogold electron microscopy

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栗生灰黑孔菌合成漆酶最佳发酵条件的优化

纺织学报 2011年第12期32卷 64-70页

作者：李振光沈明浩吉林农业大学食品质量与安全实验室吉林长春130118

研究了碳源、氮源、诱导剂、金属离子、pH值、温度、转速、装液量、接种量等培养条件对栗生灰黑孔菌产漆酶的影响。利用Minitab15软件、Plackett-Burman PB实验设计和响应面分析法对栗生灰黑孔菌产漆酶的发酵条件进行优化。结果表明:最... 详细信息

研究了碳源、氮源、诱导剂、金属离子、pH值、温度、转速、装液量、接种量等培养条件对栗生灰黑孔菌产漆酶的影响。利用Minitab15软件、Plackett-Burman PB实验设计和响应面分析法对栗生灰黑孔菌产漆酶的发酵条件进行优化。结果表明:最佳液态发酵培养基组分为玉米秆粉9.976 g/L,黄豆粉9 g/L,ZnSO4.7H2O 0.3μmol/L,对苯二胺0.5 mmol/L;最佳培养条件为:温度28℃,转速180 r/min,pH值5.913,装液量60 mL/250 mL,接种量10%。在此条件下培养漆酶酶活可达431 U/mL。

关键词：栗生灰黑孔菌漆酶培养条件响应面

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体外预应力技术在工程加固改造中的应用

施工技术 1999年第2期28卷 30-32页

作者：李晨光刘航北京市建筑工程研究院

体外预应力结构体系是指对布置于承载结构主跨本体之外的钢索施加预应力所形成的预应力结构体系。本文结合框架结构托梁截柱、楼屋盖主梁加固实例介绍该技术的设计方法和施工工艺。

关键词：体外预应力结构加固托梁截柱预应力张拉工艺