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Fluorescence imaging of drug target proteins using chemical probes

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Journal of Pharmaceutical Analysis 2020年第5期10卷 426-433页

作者： hao zhu Itaru Hamachi Department of Synthetic Chemistry and Biological Chemistry Graduate School of EngineeringKyoto UniversityKatsuraNishikyo-kuKyoto615-8510Japan ERATO Innovative Molecular Technology for Neuroscience Project Japan Science and Technology Agency(JST)Kyoto615-8530Japan

Fluorescence imaging can provide valuable information on the expression,distribution,and activity of drug target *** probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and *** this review,we briefly introduce two classes of fluorescent probes for the visualization of drug target *** activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target ***,specific imaging can be conferred with a ligand that drives the probes to target proteins,where the labeling relies on noncovalent binding,covalent inhibition,or traceless labeling by ligand-directed chemistry.

关键词： Fluorescence imaging Drug target Chemical probe Ligand-directed chemistry

De-noising of radiation pressure signal generated by bubble oscillation based on ensemble empirical mode decomposition

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Journal of Hydrodynamics 2022年第5期34卷 849-863页

作者： Xiang-hao zheng Yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of EnergyPower and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The radiation pressure signals generated by the bubble oscillation are often utilized to recognize the characteristics of the target objects in many ***,these signals are easily contaminated by complex background *** order to accurately extract the effective components of the radiation pressure signal generated by the bubble oscillation,this paper proposes a de-noising procedure for the radiation pressure signal,based on the ensemble empirical mode decomposition(EEMD),the autocorrelation function and the modified wavelet soft-threshold de-noising *** order to verify the effectiveness of the procedure,the typical radiation pressure signal generated based on the Keller-Miksis model under the acoustic excitation is employed for the subsequent de-noising *** results of the qualitative analysis show that the amplitude and the period of the bubble oscillation can be clearly observed in the time-domain diagram of the de-noised signal based on the *** the quantitative analysis,the de-noised signal based on the EEMD has better performance with higher signal-to-noise ratio(SNR),smaller root-mean-square error,and larger correlation coefficient than that based on the wavelet transform(WT)and the empirical mode decomposition(EMD).Furthermore,with the increase of the complexity of the radiation pressure signal(e.g.,the increase of the dimensionless pressure amplitude of the acoustic wave and the decrease of the SNR of the input signal),the above three evaluation indexes of the de-noised signal based on the EEMD are all better than those based on the other two *** the signal is more complex,the de-noising capabilities of the WT,the EMD are greatly reduced,but the EEMD can still maintain the good de-noising capability,which shows the superiority of the signal de-noising procedure proposed in the present paper.

关键词： Radiation pressure cavitation bubble oscillation signal de-noising ensemble empirical mode decomposition(EEMD) autocorrelation function wavelet soft-threshold de-noising

FBCRI Based Real-time Path Planning for Unmanned Aerial Vehicles in Unknown Environments with Uncertainty

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机器人 2013年第6期35卷 641-650页

作者： LIU Wei hao Peng zheng zheng CAI Kaiyuan School of Automation Science and Electrical Engineering Beihang University Science and Technology on Aircraft Control Laboratory High-Tech Institute of Xi'an

This paper presents an FBCRI(feedback based compositional rule of inference)based novel path planning method to satisfy the requirements of real-time navigation,smoothness optimization and probabilistic obstacle *** local path-searching behaviors in regional ranges and global goal-seeking behaviors in holistic ranges,the method infers behavior weights using fuzzy reasoning embedded with feedback,and then coordinates the behaviors to generate new reference *** view of the deterministic decisions and the uncertain states of a UAV(unmanned air vehicle),chance constraints are adopted to probabilistically guarantee the UAV’s safety at a required *** results in representative scenes prove that the method is able to rapidly generate convergent paths in obstacle-rich environments,as well as highly improve the path quality with respect to smoothness and probabilistic safety.

关键词： unmanned aerial vehicle path planning fuzzy reasoning FBCRI(feedback based compositional rule of inference) uncertainty

Mechanical properties and fracture behaviors on 6061 aluminum alloy under shear stress state

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Rare Metals 2011年第5期30卷 550-554页

作者： zhu hao QI Fangjuan College of Materials Science and Engineering Shijiazhuang Tiedao University Shijiazhuang 050043 China

The mechanical properties and fracture behaviors of 6061 aluminum alloy were investigated by the tensile shear tests and in-situ tensile shear tests with tensile shear specimen devised. The results indicate that many slip bands parallel to tensile direction are produced on the surfaces of the specimens. With shear strain rates increasing, the shear yield stress and shear ultimate stress of 6061 aluminum alloy remain constant basically, but the shear fracture strain decreases obviously. The shear strain rates have no influence on the fracture surfaces. The grain boundaries of 6061 aluminum alloy are the weakest area and microcracks initiate at the grain boundaries parallel to tensile direction under shear stress. With the shear stress increasing, the microcracks extend and coalesce. The fracture of specimens is due to coalescence or shearing between the microcracks.

关键词： aluminum alloys tensile shear test mechanical properties fracture

3D printing-based drug-loaded implanted prosthesis to prevent breast cancer recurrence post-conserving surgery

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 86-96页

作者： Wenyan hao Zengjuan zheng Lin zhu Lulu Pang JinqiuMa Siqing zhu Lina Du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Weifang Medical University Weifang 261000China Shandong University of Traditional Chinese Medicine Jinan 250355China Anhui Medical University Hefei 230032China

Systemic chemotherapy of breast cancer is commonly delivered as a large dose and has toxic side *** chemotherapy would overcome the shortcomings of systemic reconstruction and could play an important role in breast cancer surgery according to personalized *** application of three-dimensional(3D)printing technology makes personalized customization *** designed and prepared a prosthesis containing paclitaxel(PTX)and doxorubicin(DOX)microspheres(PPDM)based on 3D printing to prevent tumor recurrence and metastasis after breast conserving *** has good biocompatibility and was used as a drug carrier in this *** average particle size of the PTX and DOX microspheres were approximately 3.1μm and 2.2μm,*** drug loading of PTX and DOX microspheres was 4.2% and 2.1%,*** vitro drug release studies demonstrated that the 3D-printed prosthesis loaded with PTX and DOXmicrospheres could release the drugs continuously for more than 3 weeks and thereby suppress cancer recurrence with reduced side *** PTX and DOX microspheres not only exerted a synergistic effect,but also achieved a good sustained release *** vivo evaluation showed that the PPDM could effectively inhibit breast cancer recurrence andmetastasis inmice with breast *** are expected to achieve postoperative chemotherapy for breast cancer and be highly efficient to prevent local breast cancer recurrence and metastasis.

关键词： Prosthesis Breast cancer Microspheres Paclitaxel Doxorubicin Metastasis

Oxidation behaviors of TA15 titanium alloy and TiBw reinforced TA15 matrix composites prepared by spark plasma sintering

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Journal of Materials Science & Technology 2020年第2期37卷 46-54页

作者： Dongjun Wang hao Li Wei zheng National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Xi’an Space Engine Company Limited Xi’an710100China

The purpose of this study is to investigate the oxidation behaviors of the TA15 titanium alloy and TiBw/TA15 composite with network microstructure in the temperature range of 873–1073 *** results show that the oxidation kinetics of the TA15 titanium alloy and TiBw/TA15 composite follows different laws at various oxidation ***,the effective activation energy Q for oxidation of the TA15 titanium alloy and TiBw/TA15 composite is determined to be 299±19.9 kJ/mol and 339±8.31 kJ/mol at the temperature of 973–1073 K,*** experimental achievements of oxidation kinetics and oxide scales formed in the test temperatures indicate that the TiBw/TA15 composite exhibits a higher oxidation resistance than TA15 titanium alloy.A schematic diagram of oxidation mechanism is established to further reveal the oxidation process for TiBw/TA15 composite at elevated temperatures.

关键词： Composite materials Powder metallurgy Sintering Kinetics Oxidation

Property evolution and service life prediction of novel metallic materials for future lunar bases

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Rare Metals 2024年第10期43卷 5318-5331页

作者： Sen-Kuan Meng Rui-Song zhu Hong-Liang zheng Tong Gao Shi-hao Jiang Wen-hao Wang Shu-hao Zhang Zi-Yuan Zhao Xuan Ge Wei-Min Wang Li-Na Hu zheng Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark

While lunar bases have been a focus of development in recent years,the complex and extreme environment of the lunar surface remains a considerable challenge for lunar *** those on Earth,lunar day and night temperature variations cause the properties of materials,especially metallic materials,to evolve in completely different *** this study,we investigated the property evolution of nine typical highperformance metallic materials using laboratory simulations of the extremely long-period lunar temperature *** lunation treatment improves the properties of all metallic materials,the microscopic mechanisms vary for amorphous and crystalline alloys with different *** treatment reduces both the loosely packed regions and heterogeneity in amorphous alloys while causing significant phase changes in crystalline ***,a conservative prediction of the service life of metallic materials on lunar bases is provided based on analyzing microplastic events,followed by the practical material selection recommendations in various lunar application scenarios.

关键词： Metallic glass Property evolution Lunar exploration Metallic material

汉麻籽多肽靶向抑制胰脂肪酶/胆固醇酯酶的分子作用机制

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食品科学 2025年第2期46卷 38-49页

作者：尹浩朱将雄赵海云钟宇王丹凤邓云上海交通大学农业与生物学院上海200240 上海交通大学云南(大理)研究院云南大理671000 云南省大理白族自治州检验检测院云南大理671000

采用酶活动力学、联合抑制、荧光光谱、等温滴定量热法和分子对接等技术系统探究两种多肽(APAM和RLPA)对胰脂肪酶(pancreatic lipase,PL)和胆固醇酯酶(cholesterol esterase,CE)活性调控效果及分子结合机制。结果表明,RLPA对PL和CE具有... 详细信息

采用酶活动力学、联合抑制、荧光光谱、等温滴定量热法和分子对接等技术系统探究两种多肽(APAM和RLPA)对胰脂肪酶(pancreatic lipase,PL)和胆固醇酯酶(cholesterol esterase,CE)活性调控效果及分子结合机制。结果表明,RLPA对PL和CE具有更强的抑制活性,其半抑制浓度分别为(79.62±3.20)μmol/L和(301.27±14.40)μmol/L。抑制动力学分析表明APAM对两种酶的抑制机制为竞争性抑制,而RLPA则为混合性抑制。联合抑制表明APAM和RLPA在低浓度下均可与奥利司他协同抑制PL和CE,但在高浓度下协同作用减弱,甚至出现拮抗现象。荧光光谱结果表明两种多肽可以通过与PL和CE发生结合产生静态猝灭,改变了酶中脂肪族氨基酸的疏水环境。等温滴定量热法证明多肽与酶的结合过程是自发且放热,主要通过氢键和静电相互作用实现。分子对接模拟进一步分析表明氢键、盐桥和阳离子-π相互作用在多肽与酶的结合中起着至关重要的作用。这项研究丰富了对多肽与PL和CE的相互作用机制的认识,为开发基于汉麻籽蛋白的功能性食品提供了科学依据。

关键词：脂质消化酶抑制机制荧光光谱等温滴定量热法分子模拟

Shipborne radar maneuvering target tracking based on the variable structure adaptive grid interacting multiple model

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第9期14卷 733-742页

作者： zheng-wei zhu School of Information Engineering Southwest University of Science and Technology Mianyang 621010 China

The trajectory of a shipbome radar target has a certain complexity, randomness, and diversity. Tracking a strong maneuvering target timely, accurately, and effectively is a key technology for a shipbome radar tracking system. Combining a variable structure interacting multiple model with an adaptive grid algorithm, we present a variable structure adaptive grid inter- acting multiple model maneuvering target tracking method. Tracking experiments are performed using the proposed method for five maneuvering targets, including a uniform motion - uniform acceleration motion target, a uniform acceleration motion - uni- form motion target, a serpentine locomotion target, and two variable acceleration motion targets. Experimental results show that the target position, velocity, and acceleration tracking errors for the five typical target trajectories are small. The method has high tracking precision, good stability, and flexible adaptability.

关键词： Shipbome radar Target tracking Variable structure Interacting multiple model Adaptive grid algorithm