3D printing-based drug-loaded implanted prosthesis to prevent breast cancer recurrence post-conserving surgery

作     者：Wenyan Hao Zengjuan Zheng Lin Zhu Lulu Pang JinqiuMa Siqing Zhu Lina Du Yiguang Jin Wenyan Hao;Zengjuan Zheng;Lin Zhu;Lulu Pang;Jinqiu Ma;Siqing Zhu;Lina Du;Yiguang Jin

作者机构：Department of Pharmaceutical SciencesBeijing Institute of Radiation MedicineBeijing 100850China Weifang Medical UniversityWeifang 261000China Shandong University of Traditional Chinese MedicineJinan 250355China Anhui Medical UniversityHefei 230032China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2021年第16卷第1期

页      面：86-96页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Natural Science Foundation of China(No.81472951)for financial support of this work 

主　　题：Prosthesis Breast cancer Microspheres Paclitaxel Doxorubicin Metastasis 

摘      要：Systemic chemotherapy of breast cancer is commonly delivered as a large dose and has toxic side *** chemotherapy would overcome the shortcomings of systemic reconstruction and could play an important role in breast cancer surgery according to personalized *** application of three-dimensional(3D)printing technology makes personalized customization *** designed and prepared a prosthesis containing paclitaxel(PTX)and doxorubicin(DOX)microspheres(PPDM)based on 3D printing to prevent tumor recurrence and metastasis after breast conserving *** has good biocompatibility and was used as a drug carrier in this *** average particle size of the PTX and DOX microspheres were approximately 3.1μm and 2.2μm,*** drug loading of PTX and DOX microspheres was 4.2% and 2.1%,*** vitro drug release studies demonstrated that the 3D-printed prosthesis loaded with PTX and DOXmicrospheres could release the drugs continuously for more than 3 weeks and thereby suppress cancer recurrence with reduced side *** PTX and DOX microspheres not only exerted a synergistic effect,but also achieved a good sustained release *** vivo evaluation showed that the PPDM could effectively inhibit breast cancer recurrence andmetastasis inmice with breast *** are expected to achieve postoperative chemotherapy for breast cancer and be highly efficient to prevent local breast cancer recurrence and metastasis.