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Olfactory ensheathing cell transplantation in 106 patients with old spinal cord injury Differences in ages,sexes,disease courses,injured types and sites

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Neural Regeneration Research 2007年第6期2卷 380-384页

作者： Zuncheng zheng chao Liu Lin zhang Rui Gao Shugang Wei Kun zhang Lei zhang Department of Neurosurgery Taian Rongjun Hospital of Shandong Province Taian 271000 Shandong Province China

BACKGROUND： It has been demonstrated that the transplantation of olfactory ensheathing cell （OEC） can promote the recovery of neurological function through ameliorating the local internal environment in spinal cord injury. OBJECTIVE： To evaluate the recent efficacy of OEC transplantation on old spinal cord injury. DESIGN： A self-controlled experiment. SETTING： Department ofNeurosurgery, Taian Rongjun Hospital of Shandong Province. PARTICIPANTS： Totally 106 inpatients with old spinal cord injury were selected from the Department of Neurosurgery, Taian Rongjun Hospital of Shandong Province from June 2004 to December 2006, including 97 males and 9 females. Inclusive criteria： ① Complete data; ② Informed with the fact; ③No further recover neurological function after drug therapy （neurotrophic factor, GM-1）, traditional Chinese medicine, physiotherapy and rehabilitative exercises; ④ No obvious compression of the injured spinal cord displayed by MRI examination. METHODS： ① The olfactory bulb was obtained from embryo of induced labor in middle pregnancy above 4 months supplied voluntarily by pregnant women, and the survived cells after purification and culture for 1 - 2 weeks were collected. Dura mater was incised by posterior approach, then the cultured OEC suspension was transplanted to corresponding regions by means of multi-target injection using microscope. ② The patients were evaluated for twice with the standards suggested by American Spinal Injury Association （ASIA） at admission and 2 - 4 weeks postoperatively, in order to investigate the efficacy in different age groups, different sites and at different time points after the OEC transplantation. ③ Standards for evaluation： The International Standard for Neurological and Functional Classification of Spinal Cord Injury set by ASIA： The highest score of motor function was 100 points; The highest score of sensory function was 112 points for light touch and 112 for acupuncture sense. Frankel grading modified by ASIA in

关键词： olfactory spinal cord injuries transplantation recovery of function

Incidence and clinical characteristics of hypertriglyceridemic acute pancreatitis:A retrospective single-center study

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World Journal of Gastroenterology 2022年第29期28卷 3946-3959页

作者： Xue-Yan Lin Yi Zeng zheng-chao zhang Zhi-Hui Lin Lu-Chuan Chen Zai-Sheng Ye Department of Gastroenterology Fujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina Department of Gastrointestinal Surgical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Emergency Surgery Fujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina

BACKGROUND The incidence of hypertriglyceridemic acute pancreatitis(HTG-AP)has increased yearly,but updated population-based estimates on the incidence of HTG-AP are *** serum triglyceride(TG)levels quickly is crucial in the early treatment of *** serum TG levels are treated by non-invasive methods,which include anti-lipidemic agents,heparin,low-molecular weight heparin,and insulin,and invasive methods,such as blood purification including hemoperfusion(HP),plasmapheresis,and continuous renal replacement ***,authoritative guidelines have not been *** selection of appropriate treatment is important and beneficial in controlling the development of *** To evaluate the effect between patients treated with intravenous insulin(INS)and HP to guide clinical *** We retrospectively reviewed 371 patients with HTG-AP enrolled in the Department of Fujian Provincial Hospital form April 2012 to March *** inpatient medical and radiologic records were reviewed to determine clinical features,severity,complications,mortality,recurrence rate,and *** logistic regression analyses were used to analyze risk factors for severe *** score matching was used to compare the clinical outcomes of INS and *** A total of 371 patients met the HTG-AP *** incidence of HTG-AP was increased by approximately 2.6 times during the 10 years(8.4%in April 2012-March 2013 and 22.3%in April 2020-March 2021).The highest incidence rate of acute pancreatitis was observed for men in the age group of 30-39 *** amylase level was elevated in 80.1%of patients but was only three times the normal value in 46.9%of *** frequency of severe acute pancreatitis(26.9%),organ failure(31.5%),rate of recurrence(32.9%),and mortality(3.0%)of HTG-AP was *** Marshall score,modified computed tomography severity index score,baseline TG,baseline amylase,C-reactive protein(CRP),albumin,aspar

关键词： Hypertriglyceridemic acute pancreatitis Triglyceride Improved Marshall score Severity of acute pancreatitis Intravenous insulin Hemoperfusion

Recurrent testicular undifferentiated pleomorphic sarcoma

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Asian Journal of Andrology 2023年第4期25卷 541-543页

作者： Jun-Ping Han Wen-Xiao Luo Jun-Wen Zeng Wen-Xia Ma Qiang Zhao Yong-Qiang Xie zheng-chao zhang Department of Pathology The Third Affiliated Hospital of Gansu University of Traditional Chinese MedicineBaiyin 730900China Department of Urology The Third Affiliated Hospital of Gansu University of Traditional Chinese MedicineBaiyin 730900China Department of General Surgery The Second Hospital of Lanzhou UniversityLanzhou 730000China

Dear Editor,Undifferentiated pleomorphic sarcoma(UPS)is a subtype of soft tissue sarcoma first reported by O’Brien and Stout in 1964.1 It is a common soft tissue sarcoma in adults,commonly occurring in the extremities and retroperitoneum.2,3 However,the incidence of testicular UPS is extremely rare in China and the rest of the *** addition,radical orchiectomy is the preferred treatment for this disease,but the role of postoperative radiotherapy and chemotherapy remains *** paper reports the diagnosis,treatment process,and prognosis of a case of recurrent testicular *** performing a literature review,it was found that postoperative radiotherapy and chemotherapy may prolong the progression-free survival of the patient,so we present this paper to raise clinicians’understanding of the *** study was approved by the Ethics Committee of The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine(Baiyin,China;approval ***-X2-2020-018).The patient was informed of the content and significance of the study and signed an informed consent form.

关键词： sarcoma diagnosis approval

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper chao Li Li zhang zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Analysis of the efficacy of a modified posteromedial approach for Klammer III posterior Pilon fractures

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Chinese Journal of Traumatology 2022年第2期25卷 83-89页

作者： zheng-chao zhang Wu-Bing He Hao Lin Department of Emergency Surgery Fujian Provincial HospitalFuzhou350001China Provincial Clinical Medical College of Fujian Medical University Fuzhou350001China

Purpose:To analyze the curative effect and technical points of a modified posteromedial approach in the treatment of Klammer III posterior Pilon ***:A retrospective analysis of patients with Klammer III posterior Pilon fractures were conducted in our department from January 2018 to December *** the surgery,the patients were fully relieved of swelling and pain,and a comprehensive examination was carried *** posteromedial approach exposed the posterior and medial fracture block of the distal *** to the fracture of external malleolus,it is determined whether to combine a lateral incision and protect tendons and vascular nerves by a retractor,and then perform a fracture reduction and internal ***,the patients were treated with analgesia,detumescence,anticoagulation and rehabilitation *** American orthopaedic foot and ankle society(AOFAS)score and visual analogue score were recorded at regular follow-up after surgery.A t-test was used for the comparison of the preoperative and final AOFAS ***:There were 7 male and 13 female(n=20)included in the study,aged 22 to 88 years(average age 54.2 years).The injury mechanisms were falling from a height(n=7),traffic accident(n=6),walking injury(n=2)and heavy injury(n=5).The postoperative follow-up duration was 12—24 months(mean 16.95 months).The AOFAS score of the 20 patients before and after surgery were *** preoperative AOFAS score was 38.90±3.91,and the final AOFAS score was 80.55±4.20,(p<0.001).The mean final visual analogue scores at rest,active and weight-bearing walking were 0.30,0.85 and 1.70,*** patient reported poor postoperative wound healing and required a return to hospital for debridement and anti-infection ***:In the treatment of Klammer III posterior Pilon fractures,the modified posteromedial approach can fully expose the fracture block and the collapsed articular surface of the medial malleolus,achieve

关键词： Posterior pilon fracture Klammer III type Modified posteromedial approach

Grid-Connected/Islanded Switching Control Strategy for Photovoltaic Storage Hybrid Inverters Based on Modified Chimpanzee Optimization Algorithm

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Energy Engineering 2025年第1期122卷 265-284页

作者： chao Zhou NarisuWang Fuyin Ni Wenchao zhang School of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001China Jiangsu Key Laboratory of Power Transmission&Distribution Equipment Technology Jiangsu University of TechnologyChangzhou213001China

Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island *** response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization *** proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop ***,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control *** pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid ***,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee *** operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load *** strategy effectively mitigated transient voltage and current surges during mode ***,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid *** enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.

关键词： Photovoltaic storage hybrid inverters modified chimpanzee optimization algorithm droop control seamless switching

Ultrafast photo-induced turning of magnetization and its relaxation dynamics in GaMnAs

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Science China(Physics,Mechanics & Astronomy) 2010年第5期53卷 779-782页

作者： LUO Jing,zheng HouZhi,SHEN chao,zhang Hao,ZHU Ke,ZHU Hui,LIU Jian,LI GuiRong,JI Yang & ZHAO JianHua State Key Laboratory for Superlattices and Microstructures,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,China State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing China

We report that,by linearly polarized pumping of different wavelengths,Kerr transients appear at zero magnetic field only in the case when GaMnAs samples are initialized at 3 K by first applying a 0.8 Tesla field and then returning to zero *** find that,instead of magnetization precession,the near-band gap excitation induces a coherent out-of-plane turning of magnetization,which shows very long relaxation dynamics with no *** photon energy increases,the peak value of the Kerr transient increases,but it decays rapidly to the original slow transient seen under the near-band-gap excitation.

关键词： dilute magnetic semiconductor magneto-crystalline anisotropy time-resolved Kerr rotation coherent precession

A Review on Thermal Management of Li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： CHEN Zhifeng JIA Li YIN Liaofei DANG chao REN Honglei zhang Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

Li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of Li-ion battery and maintain Li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang chao Wang Yunhong zhang Hong Liu Yu zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor