Incidence and clinical characteristics of hypertriglyceridemic acute pancreatitis:A retrospective single-center study

作     者：Xue-Yan Lin Yi Zeng Zheng-Chao Zhang Zhi-Hui Lin Lu-Chuan Chen Zai-Sheng Ye 

作者机构：Department of GastroenterologyFujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina Department of Gastrointestinal Surgical OncologyFujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Emergency SurgeryFujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第29期

页      面：3946-3959页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hypertriglyceridemic acute pancreatitis Triglyceride Improved Marshall score Severity of acute pancreatitis Intravenous insulin Hemoperfusion 

摘      要：BACKGROUND The incidence of hypertriglyceridemic acute pancreatitis(HTG-AP)has increased yearly,but updated population-based estimates on the incidence of HTG-AP are *** serum triglyceride(TG)levels quickly is crucial in the early treatment of *** serum TG levels are treated by non-invasive methods,which include anti-lipidemic agents,heparin,low-molecular weight heparin,and insulin,and invasive methods,such as blood purification including hemoperfusion(HP),plasmapheresis,and continuous renal replacement ***,authoritative guidelines have not been *** selection of appropriate treatment is important and beneficial in controlling the development of *** To evaluate the effect between patients treated with intravenous insulin(INS)and HP to guide clinical *** We retrospectively reviewed 371 patients with HTG-AP enrolled in the Department of Fujian Provincial Hospital form April 2012 to March *** inpatient medical and radiologic records were reviewed to determine clinical features,severity,complications,mortality,recurrence rate,and *** logistic regression analyses were used to analyze risk factors for severe *** score matching was used to compare the clinical outcomes of INS and *** A total of 371 patients met the HTG-AP *** incidence of HTG-AP was increased by approximately 2.6 times during the 10 years(8.4%in April 2012-March 2013 and 22.3%in April 2020-March 2021).The highest incidence rate of acute pancreatitis was observed for men in the age group of 30-39 *** amylase level was elevated in 80.1%of patients but was only three times the normal value in 46.9%of *** frequency of severe acute pancreatitis(26.9%),organ failure(31.5%),rate of recurrence(32.9%),and mortality(3.0%)of HTG-AP was *** Marshall score,modified computed tomography severity index score,baseline TG,baseline amylase,C-reactive protein(CRP),albumin,aspar