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World Journal of Diabetes 2024年第8期15卷 1811-1819页

作者： Ling-Hua Shen Yan Cui Dong-Xia Fu Wei yang Sheng-Nan Wu Hui-zhen Wang Hai-Hua yang Yong-xing Chen Hai-Yan Wei Department of Endocrinology and Metabolism Henan Key Laboratory of Children's Genetics and Metabolic DiseasesChildren's Hospital Affiliated to Zhengzhou UniversityHenan Children's Hospital Zhengzhou Children's HospitalZhengzhou 450018Henan ProvinceChina

BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of *** often enter remission within several months,although relapse can occur later in *** in the ABCC8 gene,which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells,are associated with TNDM and permanent neonatal *** study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulfonylurea *** SUMMARY We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed,treated,or referred for follow-up between September 2017 and September *** patients were tested for mutations using targeted next-generation *** with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported *** children had an onset of post-infectious diabetic ketoacidosis,which is worth *** a follow-up visit after discontinuing insulin injection,oral glyburide was found to be effective with no adverse *** Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.

关键词： Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels Sulfonylurea Glyburide Insulinulin Case report

Machine learning-based performance predictions for steels considering manufacturing process parameters:a review

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Journal of Iron and Steel Research International 2024年第7期31卷 1555-1581页

作者： Wei Fang Jia-xin Huang Tie-xu Peng yang Long Fu-xing Yin Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China Institute of New Materials Guangdong Academy of ScienceGuangzhou 510651GuangdongChina

Steels are widely used as structural materials,making them essential for supporting our lives and ***,further improving the comprehensive properties of steel through traditional trial-and-error methods becomes challenging due to the continuous development and numerous processing parameters involved in steel *** address this challenge,the application of machine learning methods becomes crucial in establishing complex relationships between manufacturing processes and steel *** review begins with a general overview of machine learning methods and subsequently introduces various performance predictions in steel *** classification of performance pre-diction was used to assess the current application of machine learning model-assisted *** important issues,such as data source and characteristics,intermediate features,algorithm optimization,key feature analysis,and the role of environmental factors,were summarized and *** insights will be beneficial and enlightening to future research endeavors in this field.

关键词： Steel Manufacturing process Machine learning Performance prediction Algorithm

Central environmental protection inspection and carbon emission reduction: A tripartite evolutionary game model from the perspective of carbon neutrality

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Petroleum Science 2024年第3期21卷 2139-2153页

作者： zhen-Hua Zhang Dan Ling Qin-Xin yang Yan-Chao Feng Jing Xiu School of Economics Lanzhou UniversityLanzhou 730000GansuChina Institute of Green Finance Lanzhou UniversityLanzhou 730000GansuChina School of Management Lanzhou UniversityLanzhou 730000GansuChina School of Business Zhengzhou UniversityZhengzhou 450001HenanChina Institute of Economics Jilin Academy of Social SciencesChangchun130033JilinChina

Since the carbon neutrality target was proposed,many countries have been facing severe challenges to carbon emission reduction *** study is conducted using a tripartite evolutionary game model to explore the impact of the central environmental protection inspection(CEPI)on driving carbon emission reduction,and to study what factors influence the strategic choices of each party and how they interact with each *** research results suggest that local governments and manufacturing enterprises would choose strategies that are beneficial to carbon reduction when CEPI *** the initial willingness of all parties increases 20%,50%—80%,the time spent for the whole system to achieve stability decreases from 100%,60%—30%.The evolutionary result of“thorough inspection,regulation implementation,low-carbon management”is the best strategy for the tripartite evolutionary ***,the smaller the cost and the larger the benefit,the greater the likelihood of the three-party game stability strategy *** study has important guiding significance for other developing countries to promote carbon emission reduction by environmental policy.

关键词： Central environmental protection inspection Local government Manufacturing enterprise Tripartite evolutionary game Carbon emission reduction

Time evolutions of scalar field perturbation in Schwarzschild de-Sitter black hole from Einstein-scalar–Gauss–Bonnet theory

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Communications in Theoretical Physics 2024年第1期76卷 76-81页

作者： Cheng Xu zhen-Hao yang Xiao-Mei Kuang Rui-Hong Yue Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou225009China

The scalar-free black hole could be unstable against the scalar field perturbation when it is coupled to a Gauss–Bonnet(GB)invariant in a special *** is known that the tachyonic instability in this scenario is triggered by the sufficiently strong GB *** this paper,we focus on the time domain analysis of massive scalar field perturbation around the Schwarzschild de-Sitter black hole in Einstein-scalar–Gauss–Bonnet *** analyzing the scalar field propagation,we find that the scalar field will finally grow when the GB coupling is large *** could lead to the instability of the background black ***,we demonstrate how the mass of the scalar field and the GB coupling strength affect the onset of tachyonic instability.

关键词： black hole perturbation scalar-Einstein-Gauss-Bonnet gravity time domain evolution me

Stress relaxation properties of calcium silicate hydrate:a molecular dynamics study

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 97-115页

作者： Zhicheng GENG Shengwen TANG yang WANG Hubao A zhen HE Kai WU Lei WANG State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education School of Materials Science and EngineeringTongji UniversityShanghai200092China College of Materials Science and Engineering Xi’an University of Architecture and TechnologyXi’an710055China

The time-dependent viscoelastic response of cement-based materials to applied deformation is far from fully understood at the atomic *** silicate hydrate(C-S-H),the main hydration product of Portland cement,is responsible for the viscoelastic mechanism of cement-based *** this study,a molecular model of C-S-H was developed to explain the stress relaxation characteristics of C-S-H at different initial deformation states,Ca/Si ratios,temperatures,and water contents,which cannot be accessed *** stress relaxation of C-S-H occurs regardless of whether it is subjected to initial shear,tensile,or compressive deformation,and shows a heterogeneous *** plays a crucial role in the stress relaxation process.A large Ca/Si ratio and high temperature reduce the cohesion between the calcium-silicate layer and the interlayer region,and the viscosity of the interlayer region,thereby accelerating the stress relaxation of *** effect of the hydrogen bond network and the morphology of C-S-H on the evolution of the stress relaxation characteristics of C-S-H at different water contents was elucidated by nonaffine mean squared *** results shed light on the stress relaxation characteristics of C-S-H from a microscopic perspective,bridging the gap between the microscopic phenomena and the underlying atomic-level mechanisms.

关键词： Calcium silicate hydrate(C-S-H) Stress relaxation Ca/Si ratio Temperature Water content Atomic simulation

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： Xiao-Yu Li Chun-Ru Xu xing Ji zhen-Peng Zhu zhen-Ke Guo Tian-Yu Cai Jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 195-209页

作者： Yan Zhang zhen-zhen Wang An-Qi Han Ming-Ya yang Li-Xin Zhu Fa-Ming Pan Yong Wang Department of General Surgery The Second Hospital of Anhui Medical UniversityHefei 230601China Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC ***:The correlation between TuBG1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBG1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(GSEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TISIDB)was used to evaluate TuBG1 and *** on the TuBG1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBG1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBG1 in HCC cell lines,more G1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBG1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBG1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBG1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBG1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

Research status and perspectives of MXene-based materials for aqueous zinc-ion batteries

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Rare Metals 2024年第5期43卷 1867-1885页

作者： Xiao-Yu Wang Qi-Hang yang Xin-Yan Meng Meng-Meng zhen zhen-Zhong Hu Bo-Xiong Shen School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300071China

Aqueous zinc-ion batteries(AZIBs)as green battery systems have attracted widespread attention in large-scale electrochemical energy storage devices,owing to their high safety,abundant Zn materials,high theoretica specific capacity and low redox *** there are some thorny issues in AZIBs that hinder their practical application,such as low intrinsic electron conductivity,slow ion migration kinetics,zinc dendrites and side ***-based materials with superior conductivity,large polar surface and abundant active sites can simultaneously serve as cathode materials,electrolyte additive and protection layer of anode to regulate redox reactions of *** various materials have been used to improve electrochemical performances of AZIBs there is a lack of in-depth discussion on the regulation mechanism of MXene-based materials for *** this review,we elaborate the research progress of MXenebased materials in AZIBs,including their application in cathode materials and inhibition of zinc *** the future prospects and development directions of MXenebased materials that may improve performance of AZIBs are prospected.

关键词： MXene Aqueous zinc-ion batteries Composite materials Zinc dendrites

High Voltage Ride-through Control Strategy of Doubly Fed Induction Wind Generators Based on Virtual Impedance

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中国电机工程学报 2012年第27期32卷 I0001-I0001页

作者： XIE zhen ZHANG xing yang Shuying SONG Haihua QU Tingyu Hefei University of Technology

Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-Yan HU Yan-Ling WANG zhen-xing FAN Xi-Peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI