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论方回的律诗理念及《瀛奎律髓》的丰富涵容

通化师范学院学报 2024年第5期45卷 38-44页

作者：张兆勇淮北师范大学文学院安徽淮北235000

方回的《瀛奎律髓》作为一本问世于中华民族非常时期对后世产生深远影响的诗选,有丰富明确的选诗理念。方回认为到了隋唐时代律诗的成熟,标志着一种有生命力的文化精神成熟。由此,它对中华文化的传承有不菲的价值。杜甫(老杜)所以被推... 详细信息

方回的《瀛奎律髓》作为一本问世于中华民族非常时期对后世产生深远影响的诗选,有丰富明确的选诗理念。方回认为到了隋唐时代律诗的成熟,标志着一种有生命力的文化精神成熟。由此,它对中华文化的传承有不菲的价值。杜甫(老杜)所以被推为诗圣,在于他以丰富的理性内含成功地掌握律诗。唐宋各家律诗的浮沉在于它们各以自己的特征体现着与杜诗的相依相异。“一祖三宗”说是以此理念推进的诗歌主张。所谓黄山谷、陈后山、陈与义三宗在于他们各以自己的创作回应着时代。《瀛奎律髓》的价值在于以自己的系统理念成功地回应着南宋几大诗话、词话,使江西诗派的诗学精神以选诗的方式传承系统化。

关键词：《瀛奎律髓》律诗正法眼藏杜甫(老杜) “一祖三宗”

Occurrence,sources,and relationships of soil microplastics with adsorbed heavy metals in the Ebinur Lake Basin,Northwest China

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Journal of Arid Land 2022年第8期14卷 910-924页

作者： zhang zhaoyong GUO Jieyi WANG Pengwei School of Environment and Surveying Engineering Suzhou UniversitySuzhou 234000China College of Resource and Environmental Sciences Xinjiang UniversityUrumqi 830046China Key Laboratory of Oasis Ecology Ministry of EducationXinjiang UniversityUrumqi 830046China

There is a lack of research on soil microplastics in arid oases considering the rapid economic development of northwestern China.Here,we studied the occurrence and sources of microplastics in soil,as well as the relationships between microplastics and adsorbed heavy metals in the Ebinur Lake Basin,a typical arid oasis in China.Results showed that(1)the average microplastic content in all soil samples was 36.15(±3.27)mg/kg.The contents of microplastics at different sampling sites ranged from 3.89(±1.64)to 89.25(±2.98)mg/kg.Overall,the proportions of various microplastic shapes decreased in the following order:film(54.25%)>fiber(18.56%)>particle(15.07%)>fragment(8.66%)>foam(3.46%);(2)among all microplastic particles,white particles accounted for the largest proportion(52.93%),followed by green(24.15%),black(12.17%),transparent(7.16%),and yellow particles(3.59%).The proportions of microplastic particle size ranges across all soil samples decreased in the following order:1000-2000μm(40.88%)>500-1000μm(26.75%)>2000-5000μm(12.30%)>100-500μm(12.92%)>0-100μm(7.15%).FTIR(Fourier transform infrared)analyses showed that polyethylene terephthalate(PET),polypropylene(PP),polycarbonate(PC),polyethylene(PE),and polystyrene(PS)occurred in the studied soil;(3)random forest predictions showed that industrial and agricultural production activities and the discharge of domestic plastic waste were related to soil microplastic pollution,in which agricultural plastic film was the most important factor in soil pollution in the study area;and(4)seven heavy metals extracted from microplastics in the soil samples showed significant positive correlations with soil pH,EC,total salt,N,P,and K contents(P<0.01),indicating that these soil factors could significantly affect the contents of heavy metals carried by soil microplastics.This research demonstrated that the contents of soil microplastics are lower than other areas of the world,and they mainly come from industrial and agricultural activities of the Ebinur Lake Basin.

关键词： occurrence characteristics source analysis soil microplastics heavy metals Ebinur Lake Basin

Genetic and pathogenicity diversity of dengue virus type 2 strains circulating in Guangdong,China

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Biosafety and Health 2021年第6期3卷 333-342页

作者： Lu zhang Lingzhai Zhao zhaoyong zhang Wenxin Hong Jian Wang Shuang Qiu Huiqin Yang Mian Gan Jing Sun Jingxian Zhao Yanqun Wang Jincun Zhao Fuchun zhang Institute of Infectious Disease Guangzhou Eighth People's Hospital of Guangzhou Medical UniversityGuangzhou 510120China Technology Center Guangzhou CustomsGuangzhou 510120China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Dengue fever is a mosquito-borne viral disease spread in tropical and subtropical regions caused by the dengue virus(DENV).DENV causes a febrile illness,severe forms including hemorrhagic fevers and shock with fatalities in humans.DENV-2 is frequently associated with severe dengue infections and epidemics.DENV-2 strains from Guangdong,China,have not been characterized to compare the phylogenetics and pathogenicity of different DENV-2 subgenotype strains in both vitro and vivo.A total of 22 patients tested to be DENV-2 positive and were enrolled in this study,22 complete genomes were obtained by virus isolation and high-throughput sequencing.Phylogenetic and single amino polymorphism(SAP)analysis indicated that two major subgenotypes(A and C)of DENV-2 Cosmopolitan were prevalent in Guangdong in 2018.The apparent change of major subgenotypes of DENV-2 circulating in Guangdong indicated the diversity of DENV-2 strains,including endemic genotype and imported genotype.It alerted the risk of cross-border transmission of DENV.A significant difference in replication rate was observed in C6/36 between different DENV-2 strains,although growth kinetics comparison of different DENV-2 Cosmopolitan subgenotypes showed similar profiles.DENV-2 subgenotypes(A and C)replicated efficiently in IFNAR−/−C57BL/6 mice,and subgenotype A of Cosmopolitan infected mice showed increased weight loss and delayed viral clearance compared with the subgenotype C group.DENV-2 prevalent in Guangdong in 2018 showed apparent genetic and pathogenicity diversity in both vitro and vivo,indicating the necessity of molecular surveillance and exploration of the relationship between its pathogenicity and clinical characteristics.

关键词： DENV-2 Genetic Pathogenicity Diversity

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1535-1545页

作者： Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu zhang zhaoyong zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina BGI-Shenzhen ShenzhenChina The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuanGuangdongChina HKU-Pasteur Research Pole School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Infectious Diseases Guangdong Provincial Key Laboratory of Biomedical ImagingGuangdong Provincial Engineering Research Center of Molecular ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdongChina Yangjiang People's Hospital YangjiangGuangdongChina Yangjiang Center for Disease Control and Prevention YangjiangGuangdongChina Guangzhou Eighth People's Hospital of Guangzhou Medical University GuangzhouGuangdongChina Guangzhou Customs District Technology Center GuangzhouChina

Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19.

关键词： pathogenesis urine drug

Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–C

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Chinese Chemical Letters 2024年第3期35卷 234-238页

作者： Qunlong zhang Yang Kuang Le Chang Jingyi Kang Bingjian Wang Chuanke Chong zhaoyong Lu State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300350China

Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common intermediate.The highly strained and bridged eight-membered carbocycle of predysidavarone 6 was constructed by a one-pot intermolecular alkylation and intramolecular arylation of Wieland–Miescher ketone derivative 11 and benzyl bromide 12.The total synthesis of(+)-dysidavarones A–C(1–3)was achieved from predysidavarone 6 in a divergent manner by a late-stage introduction of the ethoxy group,which reveals the possible source of the ethoxy group within(+)-dysidavarones A–C(1–3)and provides a late-stage modifiable route for the synthesis of dysidavarone analogs for further anti-cancer activity evaluation.

关键词： Total synthesis Natural product Dysidavarones A–C Sesquiterpene quinone Meroterpenoid

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE zhang TONY GKLEIJN zhaoyong WU BING LIU YUJIN MA BAOYUE DING DONGFENG YIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival.The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect.To improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone metastases.Doxorubicin(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size distribution.The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release.The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells.Rapid binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model.In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity.In conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

Atomic Dispersed Hetero‑Pairs for Enhanced Electrocatalytic CO_(2)Reduction

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Nano-Micro Letters 2024年第1期16卷 55-67页

作者： zhaoyong Jin Meiqi Yang Yilong Dong Xingcheng Ma Ying Wang Jiandong Wu Jinchang Fan Dewen Wang Rongshen Xi Xiao Zhao Tianyi Xu Jingxiang Zhao Lei zhang David J.Singh Weitao Zheng Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and EngineeringKey Laboratory of Automobile Materials of MOEElectron Microscopy CenterJilin UniversityChangchun 130012People’s Republic of China Key Laboratory of Photonic and Electronic Bandgap Materials Ministry of Educationand College of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025People’s Republic of China College of Chemistry Jilin UniversityChangchun 130012People’s Republic of China Department of Physics and Astronomy and Department of Chemistry University of MissouriColumbiaMO 65211USA

Electrochemical carbon dioxide reduction reaction(CO_(2)RR)involves a variety of intermediates with highly correlated reaction and ad-desorption energies,hindering optimization of the catalytic activity.For example,increasing the binding of the*COOH to the active site will generally increase the*CO desorption energy.Breaking this relationship may be expected to dramatically improve the intrinsic activity of CO_(2)RR,but remains an unsolved challenge.Herein,we addressed this conundrum by constructing a unique atomic dispersed hetero-pair consisting of Mo-Fe di-atoms anchored on N-doped carbon carrier.This system shows an unprecedented CO_(2)RR intrinsic activity with TOF of 3336 h−1,high selectivity toward CO production,Faradaic efficiency of 95.96%at−0.60 V and excellent stability.Theoretical calculations show that the Mo-Fe diatomic sites increased the*COOH intermediate adsorption energy by bridging adsorption of*COOH intermediates.At the same time,d-d orbital coupling in the Mo-Fe di-atom results in electron delocalization and facilitates desorption of*CO intermediates.Thus,the undesirable correlation between these steps is broken.This work provides a promising approach,specifically the use of di-atoms,for breaking unfavorable relationships based on understanding of the catalytic mechanisms at the atomic scale.

关键词： CO_(2)reduction reaction Atomic dispersed catalyst Hetero-diatomic pair Ad-desorption energy Linear scaling relation

膜蛋白配体hMSH2在肺癌中的可溶性表达及影响因素

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中国免疫学杂志 2022年第23期38卷 2897-2901页

作者：代玉梅张昭勇广州医科大学附属妇女儿童医疗中心临床检验部广州市儿研所广州510623 广州医科大学附属第一医院呼吸疾病重点实验室广州510623

目的:探讨Vγ9Vδ2 T细胞识别的肿瘤相关内源性膜蛋白配体人MutS同源蛋白2(hMSH2)在肺癌血清中的可溶性表达及影响因素。方法:ELISA定量检测肺癌、肺结节及健康人群血清hMSH2的可溶(s)形式,分析其表达与肺癌类型、转移、吸烟史/家族史... 详细信息

目的:探讨Vγ9Vδ2 T细胞识别的肿瘤相关内源性膜蛋白配体人MutS同源蛋白2(hMSH2)在肺癌血清中的可溶性表达及影响因素。方法:ELISA定量检测肺癌、肺结节及健康人群血清hMSH2的可溶(s)形式,分析其表达与肺癌类型、转移、吸烟史/家族史及常用血清标志物的相关性。结果:三组血清均首次发现hMSH2的可溶形式,肺癌组shMSH2表达低于肺结节组和健康对照组,但差异无统计学意义(P>0.05),且与肺癌类型、转移、吸烟/家族史及常用血清标志物无明显相关性(P>0.05)。结论:shMSH2可能并非适宜的肺癌血清诊断标志物。

关键词：人MutS同源蛋白2 可溶性表达肺癌影响因素

Dialogue, Thinking and Experiencing the Dao

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Social Sciences in China 2016年第1期37卷 203-204页

作者： zhang zhaoyong

As a collection of papers,Dialogue,Thinking and Experiencing the Dao(对话、思维、体道)aims at reconstructing a larger interpreting space to investigate the academic missions of some Chinese scholars since ancient time... 详细信息

关键词：对话中国学者价值观