Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery

作     者：Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu Yuming Li;Guixue Hou;Haibo Zhou;Yanqun Wang;Hein Min Tun;Airu Zhu;Jingxian Zhao;Fei Xiao;Shanwen Lin;Dongdong Liu;Dunrong Zhou;Lang Mai;Lu Zhang;Zhaoyong Zhang;Lijun Kuang;Jiao Guan;Qiushi Chen;Liyan Wen;Yanjun Zhang;Jianfen Zhuo;Fang Li;Zhen Zhuang;Zhao Chen;Ling Luo;Donglan Liu;Chunke Chen;Mian Gan;Nanshan Zhong;Jincun Zhao;Yan Ren;Yonghao Xu

作者机构：State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina BGI-ShenzhenShenzhenChina The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuanGuangdongChina HKU-Pasteur Research PoleSchool of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Infectious DiseasesGuangdong Provincial Key Laboratory of Biomedical ImagingGuangdong Provincial Engineering Research Center of Molecular ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdongChina Yangjiang People's HospitalYangjiangGuangdongChina Yangjiang Center for Disease Control and PreventionYangjiangGuangdongChina Guangzhou Eighth People's Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Guangzhou Customs District Technology CenterGuangzhouChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第5期

页      面：1535-1545页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work is supported by the grants from The National Key Research and Development Program of China(2018YFC1200100 to JC2L) National Science and Technology Major Project(2018ZX10301403 to JCZ.) the emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology of Guangdong province(2020A111128008,2020B111112003,2018B020207013,2020B111108001 and 2020B1111320003 to JCZ,2020B1111330001 to NZ.) The National Program on Key Basic Research Project(2017YFC0906702 to Y.W.) National Key Technology R&D Program(2018YFC1311900 to N2.) Guangdong Science and Technology Foundation(2019B030316028,2020A1515010911 to NZ.) Guangzhou Medical University High-level University Innovation Team Training Program(Guangzhou Medical University releasedNo.159 to JCZ and JX2.) 111 project(D18010 to JCZI ).We thank the patients who took part in this study 

主　　题：pathogenesis urine drug 

摘      要：Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient ***,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of *** analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and *** changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe ***,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease *** prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,*** conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19.