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Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease

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Regenerative Biomaterials 2020年第2期7卷 181-193页

作者： Long Yang Jianjun Kong Zhiye qiu Tieliang Shang Siyu Chen Rui zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Orthopaedics Orthopaedic Hospital of XingtaiXingtai 054000China Department of Orthopedic Laboratory Xingtai Institute of OrthopaedicsXingtai 054000China Beijing Allgens Medical Science and Technology Co. LtdBeijing 102609China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaples 80125Italy

As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder ***,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD ***,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was *** introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive *** of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic ***,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or *** months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA *** staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous *** observed gathering of macrophages around the implant was suspected to be the cause of fibrous ***,the interactions of PMMA and PMMA-MC with macrophages were investigated in *** discovered that the addition of MC could hinder the proliferation and fusion of the ***,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with ***,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery.

关键词： mineralized collagen lumbar degenerative disc disease percutaneous cement discoplasty fibrous encapsulation

Synthesis,and anti-inflammatory activities of gentiopicroside derivatives

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Chinese Journal of Natural Medicines 2022年第4期20卷 309-320页

作者： ZHANG qi-Li XIA Peng-Fei PENG Xue-Jing WU Xiao-Yu JIN Hua ZHANG Jian zhao Lei Gansu University of Chinese Medicine Lanzhou 730000China Key Laboratory of Chemistry and Quality of TCM of the College of Gansu Province Lanzhou 730000China Gansu Province Engineering Laboratory for TCM Standardization Technology and Popularization Lanzhou 730000China

A series of 26 novel derivatives have been synthesized through structural modification of gentiopicroside,a lead COX-2 *** their in vivo and in vitro anti-inflammatory activities have been *** in vitro anti-inflammatory activities were evaluated against NO,PGE2,and IL-6 production in the mouse macrophage cell line RAW264.7 stimulated by *** showed that most compounds had good inhibitory *** in vivo inhibitory activities were further tested against xylene-induced mouse ear *** demonstrated that several compounds were more active than the parent compound *** inhibition rate of the most active compound P23(57.26%)was higher than positive control drug celecoxib(46.05%)at dose 0.28 *** docking suggested that these compounds might bind to COX-2 and *** of them,e.g P7,P14,P16,P21,P23,and P24,had high docking scores in accordance with their potency of the anti-inflammatory activitiy,that downregulation of the inflammatory factors,NO,PGE2,and IL-6,was possibly associated with the suppression of iNOS and ***,these gentiopicroside derivatives may represent a novel class of COX-2 and iNOS inhibitors.

关键词： Gentiopicroside derivatives Structural modification Anti-inflammatory activity Selective inhibitors

Synthesis and characterization on a novel series of protic pyrrolidinium surfactants

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Chinese Chemical Letters 2010年第4期21卷 385-387页

作者： Ma, Fu Min Chen, Xiao Wang, Xu Dong zhao, Yu Rong Li, qiu Hong Yue, Xiu Lv, Chao Shandong Univ Minist Educ Key Lab Colloid & Interface Chem Jinan 250100 Peoples R China

A novel series of protic tertiary pyrrolidinium surfactants were prepared and characterized by different *** compounds show good conductivity and efficient ability to reduce surface *** analysis proves their high thermal stability at decomposition temperatures over 250℃.Their lyotropic and thermotropic liquid crystalline properties are also discussed.

关键词： Protic pyrrolidinium surfactants Liquid crystal Conductivity Surface tension

Application of Approximation Full-Load Distribution Method to Pass Scheduling on Plate Mill With Hydro-Bending System

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Journal of Iron and Steel Research International 2006年第4期13卷 22-26页

作者： HU Xian-lei ZHANG qi-sheng zhao Zhong TIAN Yong LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China Plate Plant Hebei Wenfeng Iron and Steel Co Ltd Wu＇an 056300 Hebei China

The influence of positive bending system on plate crown control was researched. The approximation fullload distribution method for pass scheduling was put forward. This method can not only make full use of the mill ca... 详细信息

关键词： hydro-bending pass schedule plate shape crown

基于红外光谱技术与变量选择算法的柴油纯度检测

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化工自动化及仪表 2024年第4期51卷 592-598,613页

作者：周围李安吉吕文敏俞铁铖赵丽娟赵美琪尹冉东北石油大学物理与电子工程学院

为实现柴油纯度的快速检测,采用RS法、KS法和SPXY法对利用红外光谱技术所采集的柴油样本数据进行样本集划分,之后利用蒙特卡洛交叉验证法(MCCV)剔除异常样本,并采用无信息变量消除法(UVE)、竞争性自适应重加权采样法(CARS)、遗传算法(GA... 详细信息

为实现柴油纯度的快速检测,采用RS法、KS法和SPXY法对利用红外光谱技术所采集的柴油样本数据进行样本集划分,之后利用蒙特卡洛交叉验证法(MCCV)剔除异常样本,并采用无信息变量消除法(UVE)、竞争性自适应重加权采样法(CARS)、遗传算法(GA)和自举柔性收缩算法(BOSS)对全光谱变量进行优选,根据所选变量建立偏最小二乘(PLS)模型。结果表明:SPXY法划分样本后所建立的模型效果最好,其预测均方根误差RMSEP为0.0412,预测相关系数R_(P)为0.9921;经MCCV法剔除异常样本后,模型的RMSEP降低了4.85%,R_(P)提高了0.50%;经UVE法选择的变量所建立的PLS模型性能最好,其RMSEP可达0.0239,R_(P)可达0.9977,与全谱模型相比,RMSEP降低了39.03%,R_(P)提高了0.06%,变量减少率可达67.27%。

关键词：柴油纯度检测红外光谱技术变量选择偏最小二乘模型

Cyclization of 2-methoxy-6-(substituted benzyloxy)acetophenone hydrazones in the presence of polyphosphoric acid(PPA)

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Chinese Journal of Chemistry 1993年第4期11卷 335-339页

作者： qiu,Yu-Zhu ZHANG,Zheng ZHONG,Zhen-qi HU,Hong-Wen Department of Chemistry,Nanjing University,Nanjing 210008 Department of Chemistry Nanjing University Nanjing 210008

Cyclization of 2-methoxy-6-benzyloxy acetophenone hydrazone gave 3-methyl-4-meth- oxy indazole and 3-methyl-4-methoxy-7-benzyl indazole in the presence of polyphosphoric acid (PPA).The hydrazone was probably converted to 2-hydroxy-6-methoxy acetophenone hydra- zone and 2-hydroxy-3-benzyl-6-methoxy acetophenone hydrazone followed by cyclization to the corresponding indazoles in acidic *** of 2-methoxy-6-(halo or alkyl or aryl benzyloxy)acetophenone hydrazones gave similar *** of 2-methoxy-6- (p-nitrobenzyloxy)acetophenone hydrazone gave 2-(p-nitrophenyl)-3-methyl-4-methoxy benzo- furan and 3-methyl-4-methoxy indazole while 2-methoxy-6-(m-nitrobenzyloxy)acetophenone hydrazone gave 3-methyl-4-methoxy indazole,3-methyl-4-methoxy-7-(m-nitrophenyl)indazole and 3-methyl-4-(m-nitrobenzyloxy)indazole.

关键词： PPA OCH Cyclization of 2-methoxy-6 substituted benzyloxy)acetophenone hydrazones in the presence of polyphosphoric acid

Effect of Tuina along“bladder meridian”alleviating intervertebral disc degeneration by regulating the transforming growth factor-β1/Smad signaling pathway in a rabbit model

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中医杂志:英文版 2023年第5期43卷 991-1000页

作者： SU Chengguo zhao Xiaoyan YE Jiangnan ZHANG Xin JIANG Yuqing GUO Junjie ZHANG Xiyuan qi Wenchuan ZHU Jun Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075China Clinical Medical School Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610075China

OBJECTIVE:The aim of this study was to investigate the protective effects of Tuina(a traditional Chinese massage therapy)on intervertebral disc(IVD)degeneration and the regulatory mechanisms of the transforming growth factor-β1(TGF-β1)/small mothers against decapentaplegic(Smad)signaling ***:Thirty New Zealand white rabbits were randomized into five groups:the control group,model group,model+Tuina group(Tuina group),model+TGF-β1 group(TGF-β1 group),and model+TGF-β1 inhibitor SB431542 group(SB431542 group).The model was established by posterolateral annulus fibrosus puncturing(AFP).Recombinant TGF-β1 and inhibitor SB431542 was injected into the TGF-β1 group and SB431542 group with a microsyringe,*** rabbits in the Tuina group received Tuina treatment along the bladder meridian for 4 *** resonance imaging(MRI)was performed on rabbits before AFP and after 4 weeks of *** IVDs(L2-L3 to L4-L5)were harvested after *** changes in the IVDs were measured by hematoxylin and eosin(HE)*** I collagen was analyzed by immunohistochemistry *** expression level of matrix metalloproteinase-3(MMP3)was determined by enzyme-linked immunosorbent *** apoptosis was evaluated by terminal deoxynucleotidyl transferasemediated nick end labeling and Western *** polymerase chain reaction and Western blotting were used to analyze the expression of TGF-β1 and Smad2/3/4 and a disintegrin and metalloproteinase with thrombospondin motifs ***:Posterolateral AFP induced IVD degeneration in rabbits with histopathological damage and noticeable changes in MRI *** alleviated histopathological changes and reversed the expression of extracellular matrix degeneration-related molecules and apoptosis-related ***,AFP induced the activation of TGF-β1 and Smad2/3/4,whereas Tuina therapy markedly reduced the protein expression of Smad2/3 and the gene expression of TG

关键词： intervertebral disc degeneration transforming growth factor beta1 Smad proteins Tuina apoptosis extracellular matrix degradation

N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats

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Neural Regeneration Research 2010年第23期5卷 1787-1794页

作者： qiwen Zhu Weijian Hou Jianwen zhao Yu Yang qi Zhang Li Guo Lihong Shang YinglinCao Chunfu Wu Department of Physiology Shenyang Medical College Shenyang 110034 Liaoning Province China Department of Tissue Engineering China Medical University Shenyang 110001 Liaoning Province China Department of Pharmacology Shenyang Pharmaceutical University Shenyang 110016 Liaoning Province China

Lead exposure induces decreased hippocampal N-methyI-D-aspartic acid （NMDA） receptor gene and protein expressions, which influences the molecular mechanisms of learning and memory. However, lead poisoning-induced differences in NMDA subunit expression, and the correlation of lead poisoning with learning and memory, remain poorly understood. The present study measured differences in expression of NMDA receptor subunits NR1, NR2A, and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure. Results demonstrated decreased NR1, NR2A, and NR2B subunit expressions in some memory-related brain areas. The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant, although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure. There was no difference in NR1 expression following exposure to 〈 4.8 mmol/L lead, although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus. Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory. Therefore, lead toxicity was dependent on NMDA receptor subunit composition, and NR1, NR2A, and NR2B expressions were associated with time and concentration of lead exposure.

关键词： lead exposure N-methyI-D-aspartate receptor memory-related brain areas neural regeneration rats

A supramolecular bottlebrush polymer assembled on the basis of cucurbit[8]uril-encapsulation-enhanced donor-acceptor interaction

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Chinese Chemical Letters 2017年第6期28卷 1167-1171页

作者： Zhi-Jian Yin Zong-Quan Wu Feng Lin qiao-Yan qi Xiao-Na Xu Xin zhao Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringHefei University of Technology Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of Sciences

A supramolecular bottlebrush polymer has been constructed in water through the self-assembly of a rigid electron-deficient building block and an electron-rich monomer which bears two tetraethylene glycol chains,driven by CB[8]-encapsulation-enhanced donor-acceptor *** as-formed supramolecular bottlebrush polymer has been characterized by -1H NMR titration experiment,UV-vis spectroscopy,DLS and 2D -1H NMR DOSY.

关键词： Self-assembly Supramolecular polymer Cucurbituril Donor-acceptor interaction Bottlebrush polymer