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Early detection of noise-induced hearing loss

World Journal of Clinical Cases 2022年第6期10卷 1815-1825页

作者： zhao-li meng Fei Chen Fei zhao Hai-ling Gu Yun Zheng Department of Otorhinolaryngology-Head and Neck Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Cardiff School of Health Science Cardiff Metropolitan UniversityCardiff CF30UJUnited Kingdom Department of Hearing and Speech Science Xinhua CollegeSun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Hearing Speech and Language RehabilitationSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following *** to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young *** is *** minor hearing pathologies before they progress to hearing problems that affect daily life is *** To compare the advantages and disadvantages of extended high frequency(EHF)and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical *** This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019.A total of 86 participants,aged 18-22 years,were recruited to establish normative thresholds for *** 159 adults,aged 18-25 years with normal hearing(0.25-8 kHz≤25 dBHL),were allocated to low noise and noise exposure *** otoacoustic emission(DPOAE),transient evoked otoacoustic emissions(TEOAE),and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced *** chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry(EHFA),DPOAE,and TEOAE.P≤0.05 was considered statistically *** A total of 86 participants(66 females and 20 males)aged between 18 and 22(average:20.58±1.13)years were recruited to establish normative thresholds for *** normative thresholds for 9,10,11.2,12.5,14,16,18,and 20 kHz were 15,10,20,15,15,20,28,and 0 dBHL,respectively.A total of 201 participants were recruited and examined for *** them,159 adults aged between 18 and 25 years were eligible in this *** statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA,DPOAE,and TEOAE(P>0.05)except in the right ear at 4 kHz using TEOAE(abnormal rate 20.4%vs 5.2%,respectively;P=0.05).CONCLUSION These results s

关键词： Early detection superiority Noise-induced hearing loss Otoacoustic emission Extended high frequency Noise Hearing loss

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Combining Serum Procalcitonin Level,Thromboelastography,and Platelet Count to Predict Short-term Development of Septic Shock in Intensive Care Unit

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Current Medical Science 2023年第1期43卷 86-92页

作者： Xue-song zhao zhao-li meng Tuo ZHANG Hong-na YANG Ji-cheng ZHANG Wei FANG Chun-ting WANG Man CHEN Department of Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Department of Critical Care Medicine Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan250021China The First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital) Jinan250021China

Objective Despite the recent advances in diagnosis and treatment,sepsis continues to lead to high morbidity and *** diagnosis and prompt treatment are essential to save ***,most biomarkers can only help to diagnose sepsis,but cannot predict the development of septic shock in high-risk *** present study determined whether the combined measurement of procalcitonin(PCT),thromboelastography(TEG)and platelet(PLT)count can predict the development of septic *** A retrospective study was conducted on 175 septic patients who were admitted to the intensive care unit between January 2017 and February *** patients were divided into two groups:73 patients who developed septic shock were assigned to the septic shock group,while the remaining 102 patients were assigned to the sepsis ***,the demographic,clinical and laboratory data were recorded,and the predictive values of PCT,TEG and PLT count for the development of septic shock were *** Compared to the sepsis group,the septic shock group had statistically lower PLT count and TEG measurements in the R value,K value,αangle,maximum amplitude,and coagulation index,but had longer prothrombin time(DT),longer activated partial thromboplastin time(APTT),and higher PCT ***,the Sequential Organ Failure Assessment(SOFA)score was higher in the septic shock *** multivariate logistic regression analysis revealed that PCT,TEG and PLT count were associated with the development of septic *** area under the curve analysis revealed that the combined measurement of PCT,TEG and PLT count can be used to predict the development of septic shock with higher accuracy,when compared to individual *** The combined measurement of PCT,TEG and PLT count is a novel approach to predict the development of septic shock in high-risk patients.

关键词： sepsis shock thromboelastography procalcitonin platelet

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An Algorithm of Programming Data Flow Analysis Based on Data Flow Expression

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The Journal of China Universities of Posts and Telecommunications 1998年第1期5卷 41-42页

作者： zhao Dongfan, li Wei and meng Qingkai (Department of Computer Engineering, Changchun Institute of Post and Telecommunication, Changchun 130012, P. R. China)

This paper states the basic principle of program data flow analysis in a formal way and gives the concept of data flow expression. On the basis of this concept, an algorithm of finding data flow exceptions is rendered. This algorithm has great generality, with which it is easy to develop a tool for program test. So it is practical in application.

关键词： software test program analysis data flow analysis data flow expression

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基于优化光谱指数的牧草生物量估算

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光谱学与光谱分析 2015年第11期35卷 3155-3160页

作者：安海波李斐赵萌莉刘亚俊内蒙古农业大学生态环境学院内蒙古呼和浩特010019 赤峰市松山区穆家营子镇人民政府内蒙古赤峰024005

牧草生物量是天然和人工草场产出的一个重要指标,能直接反映牧草的长势,它的实时监测是制定合理的草地管理和放牧制度的前提。然而,传统的样方法费时、费力很难满足草地生物量监测的实时性要求。近年来,随着高光谱遥感的发展,为草地的... 详细信息

牧草生物量是天然和人工草场产出的一个重要指标,能直接反映牧草的长势,它的实时监测是制定合理的草地管理和放牧制度的前提。然而,传统的样方法费时、费力很难满足草地生物量监测的实时性要求。近年来,随着高光谱遥感的发展,为草地的快速、无损的监测提供了可能。通过对内蒙古天然和人工草地生物量及其冠层光谱数据分析,探讨了不同类型光谱指数在估算牧草生物量的鲁棒性。研究表明,由于冠层结构和生物量的影响,不同类型草地冠层的光谱反射存在巨大的差异,从而使现有光谱指数对天然草地和不同品种人工草地牧草生物量的预测能力存在显著的差异（R2=0.00~0.65）。在荒漠草原低生物量的条件下,受土壤背景影响不同光谱指数预测能力较小,而在青贮玉米高生物量条件下,基于红光的光谱指数容易发生饱和失去敏感性。把不同草地类型的数据结合后进行简单比率和归一化窄波段光谱指数的波段优化,与出版的光谱指数相比优化后的归一化光谱指数（normalized difference spectral index,NDSI）显著提高了牧草生物量的预测能力,预测生物量模型的决定系数最高（R2=0.72）。敏感性分析进一步证明了基于波段优化算法的优化光谱指数NDSI,（ration spectral index,RSI）有最低的噪声,从而能更好的预测牧草生物量。波段优化算法可以有效提高遥感估算草地牧草生物量的精度,光谱指数及其优化波段的选择会直接影响模型的预测能力。

关键词：优化算法牧草生物量光谱指数

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利用空域和时域信息自动分割MPEG-4视频对象

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天津大学学报（自然科学与工程技术版） 2004年第5期37卷 410-413页

作者：鲁照华李华孟伟天津大学电子信息工程学院天津300072

从视频序列中分割出视频对象是实现基于内容压缩编码方法的关键.该文提出了利用空域和时域信息实现MPEG 4视频对象的自动分割方法,利用相邻两帧的帧差和当前帧的纹理、颜色信息及面部定位、梯度滤波等技术,实现目标的初始化,再利用快速H... 详细信息

从视频序列中分割出视频对象是实现基于内容压缩编码方法的关键.该文提出了利用空域和时域信息实现MPEG 4视频对象的自动分割方法,利用相邻两帧的帧差和当前帧的纹理、颜色信息及面部定位、梯度滤波等技术,实现目标的初始化,再利用快速Hausdorff距离法跟踪目标.处理结果表明,该方法对处理相对静止的头肩序列图像具有较强的稳定性,处理速度较快,能取得较好的分割效果.

关键词：视频对象面部定位梯度滤波空域时域 MPEG-4 图象分割图象编码

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Comparison on Hemocompatibility of MWCNTs and Hydroxyl Modificated MWCNTs

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Chinese Journal of Biomedical Engineering(English Edition) 2013年第1期22卷 1-6页

作者： ZHANG Yi-teng zhao meng-li GUO Mei-xian DENG Xiang-yun li De-jun GU Han-qing WAN Rong-xin College of Physics and Electronic Information Science Tianjin Normal University Tianjin Medical University Ninth People's Hospital Shanghai Jiao Tong University

Objective: To study and compare the hemocompatibility of MWCNTs and hydroxyl modificated MWCNTs (MWCNTs-OH). Methods: MWCNTs and MWCNTs-OH were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, water contact angle assays, platelet-adhesion and hemolytic rate assays. Results: The results showed that the two MWCNTs had a similar surface topography and MWCNTs-OH were functionalized with hydroxyl groups on their surfaces. Water contact angle assays indicated that MWCNTs were hydrophobic materials, whereas MWCNTs-OH was hydrophilic. The platelet-adhesion assays displayed that the platelet-adhesion rate of MWCNTs-OH was much lower than MWCNTs. The hemolytic rate assays showed that the hemolytic rates of both MWCNTs were lower than the standard value of 5%. Conclusion: MWCNTs-OH shows superior anticoagulant capacity over MWCNTs. Both MWCNTs and MWCNTs-OH are nonhemolytic materials.

关键词： multiwalled carbon nanotubes (MWCNTs) hydroxyl modificated MWCNTs hemocompatibility

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NH_2 Ion Implantations Induced Superior Cell Attachment of Carbon Nanotubes

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Chinese Journal of Biomedical Engineering(English Edition) 2012年第4期21卷 151-157页

作者： GUO Mei-xian zhao meng-li ZHANG Yi-teng DENG Xiang-yun li De-jun GU Han-qing WAN Rong-xin College of Physics and Electronic Information Science Tianjin Normal University Tianjin Institute of Urological Surgery Tianjin Medical University Ninth People's Hospital Shanghai Jiao Tong University School of Medicine

Objective： Cell and platelet attachment on the multiwalled carbon nanotubes （MWCNTs） were studied by ion implantation. Methods： NH2 ion implantation was performed at the energy of 30 keV with the fluence of 1 x 1016 ions/era2 at room temperature. Results： The cell attachment tests showed interesting results in that the number of the platclets adhering on the surface of the MWCNTs was reduced significantly after NH2 ion implantation, whereas, mouse fibroblast cells （L929） cultured on NH2 ion implanted MWCNTs displayed higher cell-viability, proliferation, and stretching compared with MWCNTs. Conclusion： No appreciable change in the tensile strength and the optical transmittance of the implanted samples was observed. X-ray photoelectron spectroscopy （XPS） analysis showed that NH2 ion implantation caused the formation of new N-containing groups.

关键词： multiwalled carbon nanotubes NH2 ion implantation platetes mousefibroblast cells

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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内蒙古草地资源合理利用与草地畜牧业持续发展

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资源科学 2000年第1期22卷 73-76页

作者：赵萌莉许志信内蒙古农牧学院草原科学系呼和浩特010018

内蒙古天然草地资源丰富，草地面积７８８０ ×１０４ｈｍ２，占中国草地面积的２２％。由于长期的利用和管理不善，畜牧业生产难以持续发展。内蒙古草地资源的现状是：草地退化，土壤沙化；气候干旱，降水减少；草地植被退化，牧... 详细信息

内蒙古天然草地资源丰富，草地面积７８８０ ×１０４ｈｍ２，占中国草地面积的２２％。由于长期的利用和管理不善，畜牧业生产难以持续发展。内蒙古草地资源的现状是：草地退化，土壤沙化；气候干旱，降水减少；草地植被退化，牧草产量低；草地生态环境恶化，鼠虫害增加。草地畜牧业生产存在畜草矛盾突出；畜产品数量、质量下降；抗灾能力弱等问题。究其原因是多方面的，但主要是人为的不合理利用草地资源而引起的。因此，草地畜牧业可持续发展的策略和措施是：发展生态畜牧业；走畜草平衡、增草增畜的道路；因地制宜；加强草原管理，合理利用草地资源；建立“效益型畜牧业”的经济体制。只要坚持草地开发利用与建设相结合，内蒙古草地畜牧业生产的潜力是较大的，并可持续发展。

关键词：草地资源畜牧业持续发展内蒙古资源利用

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红树植物多样性及其研究进展

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生物多样性 2000年第2期8卷 192-197页

作者：赵萌莉林鹏厦门大学生物系

红树植物是分布于热带、亚热带海岸潮间带的木本植物群落 ,因适应海岸带和海涂的生长环境 ,形成了独特的形态结构和生理生态特性。红树林是海岸有重要价值的湿地。论述了红树植物的物种多样性、适应多样性、物候多样性以及分子水平的多... 详细信息

红树植物是分布于热带、亚热带海岸潮间带的木本植物群落 ,因适应海岸带和海涂的生长环境 ,形成了独特的形态结构和生理生态特性。红树林是海岸有重要价值的湿地。论述了红树植物的物种多样性、适应多样性、物候多样性以及分子水平的多样性及其研究进展。

关键词：红树植物物种多样性适应多样性物侯多样性

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