Combining Serum Procalcitonin Level,Thromboelastography,and Platelet Count to Predict Short-term Development of Septic Shock in Intensive Care Unit
作者机构：Department of Critical Care MedicineShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China Department of Critical Care MedicineShandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan250021China The First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan250021China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2023年第43卷第1期
页 面：86-92页
核心收录：
学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学]
基 金：supported by grants from the National Natural Science Foundation of China(No.81903086) the Shandong Provincial Natural Science Foundation of China(No.ZR2019QH014)
主 题：sepsis shock thromboelastography procalcitonin platelet
摘 要：Objective Despite the recent advances in diagnosis and treatment,sepsis continues to lead to high morbidity and *** diagnosis and prompt treatment are essential to save ***,most biomarkers can only help to diagnose sepsis,but cannot predict the development of septic shock in high-risk *** present study determined whether the combined measurement of procalcitonin(PCT),thromboelastography(TEG)and platelet(PLT)count can predict the development of septic *** A retrospective study was conducted on 175 septic patients who were admitted to the intensive care unit between January 2017 and February *** patients were divided into two groups:73 patients who developed septic shock were assigned to the septic shock group,while the remaining 102 patients were assigned to the sepsis ***,the demographic,clinical and laboratory data were recorded,and the predictive values of PCT,TEG and PLT count for the development of septic shock were *** Compared to the sepsis group,the septic shock group had statistically lower PLT count and TEG measurements in the R value,K value,αangle,maximum amplitude,and coagulation index,but had longer prothrombin time(DT),longer activated partial thromboplastin time(APTT),and higher PCT ***,the Sequential Organ Failure Assessment(SOFA)score was higher in the septic shock *** multivariate logistic regression analysis revealed that PCT,TEG and PLT count were associated with the development of septic *** area under the curve analysis revealed that the combined measurement of PCT,TEG and PLT count can be used to predict the development of septic shock with higher accuracy,when compared to individual *** The combined measurement of PCT,TEG and PLT count is a novel approach to predict the development of septic shock in high-risk patients.
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