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procalcitonin and intestinal ischemia:A review of the literature

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World Journal of Gastroenterology 2014年第47期20卷 17773-17778页

作者： Cyril Cosse Charles Sabbagh Sad Kamel Antoine Galmiche Jean-Marc Regimbeau INSERM U1088 Jules Verne University of Picardie80054 AmiensFrance Department of Digestive and Oncological Surgery Amiens University HospitalJules Verne University of PicardiePlace Victor PauchetF-80054 Amiens cedex 01France Clinical Research Center Amiens University Hospital80054 Amiens Cedex 01France Department of Biochemistry Amiens University HospitalJules Verne University of PicardieF-80054 AmiensFrance EA4294 Jules Verne University of PicardieF-80054 AmiensFrance

Intestinal ischemia is common after emergency gastrointestinal or cardiovascular *** present,there are no diagnostic tools for the early diagnosis of intestinal *** the last decade,procalcitonin(PCT)has been suggested as a marker of this ***,we review the use of PCT as a diagnostic tool for intestinal *** reviewers independently searched the Pub Med and EMBASE databases for articles on intestinal ischemia and *** then considered(1)the criteria applicable to preclinical and clinicaldata;and(2)PCT’s predictive value in the diagnosis of intestinal *** quality was rated according to the STAndards for Reporting of Diagnostic *** 1993 and 2014,seven studies(including two preclinical studies and five clinical studies)dealt with the use of PCT to diagnose intestinal ***’s sensitivity,specificity,positive predictive value and negative predictive value ranged between 72%and 100%;68%and 91%;27%and 90%and 81%and 100%,*** area under the receiver operating characteristic curve ranged from 0.77 to *** view of the preclinical and clinical data,we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia.

关键词： procalcitonin Intestinal Ischemia Diagnosis Review

procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites

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World Journal of Gastroenterology 2014年第9期20卷 2374-2382页

作者： Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel Division of Gastroenterology and Hepatology John H Stroger Hospital of Cook County Chicago IL 60612 United States David H Van Thiel Division of Gastroenterology and HepatologyRush University Medical Center Chicago IL 60612 United States Division of Gastroenterology and Hepatology Victor Babes Infectious Clinic 050094 Bucharest Romania Division of Gastroenterology and Hepatology August Georg University D-37075 Gottingen Germany Division of Gastroenterology and Hepatology Loyola University Medical Center Maywood IL 60153 United States

AIM: To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.

关键词： Ascites Bacterial translocation Inflammatory markers procalcitonin Cirrhosis

procalcitonin and Liver Disease: A Literature Review

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 51-55页

作者： Ruolin Dong Bo Wan Su Lin Mingfang Wang Jiaofeng Huang Yinlian WU Yilong WU Nanwen Zhang Yueyong Zhu The First Affiliated Hospital of Fujian Medical University FuzhouChina Liver Research Center The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of Pharmacology School of PharmacyFujian Medical UniversityFuzhouChina

procalcitonin(PCT)is a widely used biomarker for the diagnosis of bacterial *** is produced by various organs and the liver is considered to be the most important site of *** liver dysfunction has been shown to influence PCT *** with no sources of infection who have liver disease are observed to have increased serum levels of PCT,thereby reducing the diagnostic utility and value within this particular patient ***,we have summarized the relationship between PCT and liver disease,including liver cirrhosis,liver failure,and liver transplantation.

关键词： procalcitonin Liver disease Infection

Clinical significance of serum procalcitonin in patients with ulcerative colitis

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World Journal of Gastroenterology 2013年第45期19卷 8335-8341页

作者： Shigeo Koido Toshifumi Ohkusa Kazuki Takakura Shunichi Odahara Shintaro Tsukinaga Toyokazu Yukawa Jimi Mitobe Mikio Kajihara Kan Uchiyama Hiroshi Arakawa Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of MedicineChiba 277-8567 Japan

AIM:To investigate the association of procalcitonin(PCT)with ulcerative colitis(UC)***:Serum PCT levels,C-reactive protein(CRP)levels,the erythrocyte sedimentation rate,and the white blood cell count were analyzed in 18 patients with UC and 11 healthy *** PCT levels were analyzed by an electrochemiluminescence *** assessments were based on Truelove and Witts’severity *** of serum PCT and CRP levels with UC activity was ***,we assessed serum PCT and CRP levels in patients with a Mayo endoscopic ***:Serum PCT levels in severe UC patients(n=7)(0.096±0.034 ng/mL)were significantly higher than in mild-to-moderate UC patients(n=11)(0.033±0.012 ng/mL)and healthy volunteers(n=11)(0.035±0.005 ng/mL)(P=0.0005 and P<0.0001,respectively).In addition,there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy ***,patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT(0.075±0.043 ng/mL)compared with patients with a subscore of 2 points(0.03±0.011 ng/mL)(P=0.0302).Moreover,CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 ***:Serum PCT levels were significantly correlated with UC activity.

关键词： C-reactive protein Disease activity procalcitonin Severity Ulcerative colitis

The procalcitonin-to-cortisol ratio is a potential prognostic predictor in sepsis with abdominal source:a retrospective observational study

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World Journal of Emergency Medicine 2022年第6期13卷 441-447页

作者： Hui Liu Jie Hu Jian-guo Xiao Hong-jun Kang Fei-hu Zhou Department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND:The aim of the study was to investigate the procalcitonin-to-cortisol ratio(P/C ratio)as a prognostic predictor among septic patients with abdominal ***:We retrospectively enrolled 132 post-surgery patients between 18 and 90 years old with sepsis of the abdominal *** the second day of sepsis onset,cortisol,procalcitonin(PCT),Acute Physiology and Chronic Health Evaluation(APACHE)II score,Sequential Organ Failure Assessment(SOFA)score,C-response protein(CRP),and other baseline characteristics were *** addition,the length of ICU stay,length of mechanical ventilation(MV)days,length of shock days,and 28-day mortality were also *** analysis was performed to screen potential risk *** analysis was used to identify the interaction among the risk *** analysis was also utilized to demonstrate the relationship between the risk factors and *** receiver operator characteristic(ROC)curve analysis was conducted to evaluate the risk factors.A restricted cubic spline(RCS)demonstrated the association between survival outcome and the P/C ratio ***:A total of twenty-nine patients died,and 103 patients survived within 28 *** were significant differences in cortisol,PCT,P/C ratio,interleukin(IL)-6,SOFA,and APACHE II scores between the survival and non-survival *** significant interaction was observed in the stratified *** regression analysis revealed that P/C ratio(P=0.033)was significantly related to 28-day *** on ROC curves,P/C ratio(AUC=0.919)had a higher AUC value than cortisol or *** analysis depicted a positive relationship between survival possibility and P/C ratio ***:P/C ratio might be a potential prognostic predictor in septic patients with abdominal sources.

关键词： Sepsis Cortisol procalcitonin procalcitonin-to-cortisol ratio Adrenal insufficiency

Rapid Detection of Serum procalcitonin by Immunochromatograghy Technology Based on Freeze-dried Up-conversion Nanoparticles/Antibody Conjugates

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Chinese Journal of Chemistry 2017年第12期35卷 1861-1868页

作者： Lijiang Lei Yang Zhou Yuwang Han Hongman Zhang College of Chemistry and Molecular Engineering Nanjing Tech University No. 30 Puzhu Road(S) Nanjing Jiangsu 211816 China

procalcitonin （PCT） is a sensitive and specific biomarker for sepsis diagnosis and widely used as a biomarker to improve the diagnosis of bacterial infections and to guide the antibiotic therapy. In our work, an improved up-converting nanoparticle （UCP） technology based on the immunochromatographic assay （UPT-ICA） was developed for rapid and quantitative detection of PCT. In order to further improve the accuracy, sensitivity and stability of the assay on the basis of our previous study, the UCP coupling with rnonoclonal antibody of PCT （UCP-Abl） was freeze-dried under certain conditions. And the detections of PCT levels with UCP-Abl conjugates before and after freeze-drying were evaluated. The results show that, compared to the UCP-Abl conjugates without freeze-drying, the detection sensitivity of freeze-dried UCP-Abl is slightly improved, having a lower immunochromatogragh background and better stability. This improved method can provide a rapid, accurate, and relatively easy way for the clinical detection of PCT.

关键词： procalcitonin up-converting nanoparticles technology immunochromatographic assay freeze-drying

Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke: an over 10-year intensive care survey

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World Journal of Emergency Medicine 2024年第1期15卷 23-27页

作者： Li Zhong Feifei Shuai Conglin Wang Lipeng Han Zhifeng Liu Ming Wu Department of Traditional Chinese Medicine the First Affi liated HospitalGuizhou University of Chinese MedicineGuiyang 550001China Department of Medical Critical Care Medicine General Hospital of Southern Theatre Command of People’s Liberation ArmyGuangzhou 510010China Department of Infection and Critical Care Medicine Shenzhen Second People’s Hospital&First Affi liated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China Department of Nosocomial Infection Prevention and Control Shenzhen Second People’s HospitalShenzhen 518035China Key Laboratory of Hot Zone Trauma Care and Tissue Repair of People's Liberation Army General Hospital of Southern Theatre Command of People's Liberation ArmyGuangzhou 510010China

BACKGROUND:Heatstroke has become a common emergency event in ***(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains ***:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,inflammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day *** analysis,linear regression and curve fi tting were used to identify the relationship between PCT and ***:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)*** was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation II(APACHE II)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P<0.05).Interestingly,the results of curve fi tting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of<4.6 ng/*** analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill *** PCT concentrations should be interpreted cautiously in patients with EHS in the ED.

关键词： procalcitonin Myoglobin Rhabdomyolysis Exertional heatstroke

Elevated procalcitonin levels in the absence of infection in procalcitonin-secretin hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10811-10816页

作者： Jian-Ting Zeng Yu Wang Yang Wang Zheng-Hua Luo Zhou Qing Yi Zhang Yan-Lin Zhang Jie-Feng Zhang De-Wei Li Xian-Zhang Luo Key Laboratory for Biological Science and Technology of Ministry of Education Chongqing UniversityChongqing University Cancer HospitalChongqing 400044China

BACKGROUND Serum procalcitonin(PCT)is widely used to diagnose bacterial infection and ***,PCT may be elevated in some *** is important to distinguish infection from no infection in such *** relationship between hepatocellular carcinoma(HCC)and PCT is *** SUMMARY A 62-year-old male was admitted due to a hepatic lesion of unknown *** patient had an elevated PCT *** diseases were excluded after appropriate *** then underwent exploratory laparotomy and a left lateral hepatectomy was *** patient recovered with an uneventful postoperative course and PCT level decreased gradually and was normal on day *** was diagnosed by histopathology and no evidence of infection was ***,immunohistochemical analyses revealed that tumor cells were positive for *** HCC cells can secrete PCT in the absence of infection and PCT may be used as a marker to monitor the efficacy of tumor therapy.

关键词： Hepatocellular carcinoma procalcitonin Infection Case report

Early changes in white blood cell,C-reactive protein and procalcitonin levels in children with severe multiple trauma

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World Journal of Emergency Medicine 2022年第6期13卷 448-452页

作者： Cai-fang Xu Ming-chao Huo Jin-hui Huang Chun-feng Liu Wei Xu The Pediatrics Department Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Critical Care Medicine Shanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200062China

BACKGROUND:To analyze early changes in white blood cells(WBCs),C-reactive protein(CRP)and procalcitonin(PCT)in children with multiple trauma,before secondary inflammation ***:This single-center retrospective study collected data from patients with blunt traumatic injury admitted to the pediatric intensive care unit(PICU).According to the prognostic outcome of 28 d after admission to the PICU,patients were divided into survival group(n=141)and non-survival group(n=36).Characteristics between the two groups were *** operation characteristic(ROC)curve analysis was conducted to evaluate the capacity of different biomarkers as predictors of ***:The percentages of children with elevated WBC,CRP,and PCT levels were 81.36%,31.07%,and 95.48%,*** in the non-survival group presented a statistically significantly higher injury severity score(ISS)than those in the survival group:37.17±16.11 vs.22.23±11.24(t=6.47,P<0.01).WBCs were also higher in non-survival group than in the survival group([18.70±8.42]×109/L vs.[15.89±6.98]×109/L,t=2.065,P=0.040).There was no significant difference between the survival and non-survival groups in PCT or *** areas under the ROC curves of PCT,WBC and ISS for predicting 28-day mortality were 0.548(P=0.376),0.607(P=0.047)and 0.799(P<0.01),***:Secondary to multiple trauma,PCT levels increased in more patients,even if their WBC and CRP levels remained ***,early rising WBC and ISS were superior to PCT at predicting the mortality of multiple trauma patients in the PICU.

关键词： Pediatric procalcitonin Injury severity score Multiple trauma