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Adjuvant hormone therapy after radical prostatectomy in highrisk localized and locally advanced prostate cancer: First multicenter, observational study in China

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Chinese Journal of Cancer Research 2019年第3期31卷 511-520页

作者： Dingwei ye Wei Zhang Lulin Ma Chuanjun Du Liping Xie Yiran Huang Qiang Wei zhangqun ye Yanqun Na Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Urology Jiangsu Province Hospital Nanjing 210029China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Urology the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China Department of Urology Renji Hospital Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Department of Urology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China Department of Urology Peking University Shougang HospitalBeijing 100144China

Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical *** of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during ***: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 ***: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in

关键词： Adjuvant hormone therapy combined androgen blockade PSA recurrence quality of life radical prostatectomy

Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants

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Asian Journal of Andrology 2011年第1期13卷 166-171页

作者： Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang zhangqun ye Department of Urology Tongii Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Genetics School of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Although some genes that cause Kallmann syndrome （KS） have been identified by traditional linkage analysis and candidate gene techniques, the syndrome＇s molecular etiology in the majority of patients remains poorly understood. In this paper, we present the clinical assessments of a consanguineous Hart Chinese family with three KS descendants. To understand the molecular etiology of KS from a genome-wide perspective, we investigated the genome-wide profile of structural variation in this family using the Affymetrix Genome-Wide Human SNP Array 6.0 platform. The results revealed that the three affected individuals had common copy number variants （microdeletions） on chromosomes lp21.1, 2q32.2, 8q21.13, 14q21.2 and Xp22.31. Moreover, the copy number variants on Xp22.31 were located in the intron of KAL 1, which causes X-linked KS. Two PCR assays were performed on these regions to validate the results obtained using the chips. In addition, genomic microdeletions in this region were verified in one of 29 Han Chinese sporadic KS cases and one of four other family cases, but not in 26 Han Chinese sporadic normosmic idiopathic hypogonadotropic hypogonadism cases and 100 unrelated Han Chinese normal controls. Our results provide a novel insight into the relative contributions of certain copy number variants to KS＇s molecular etiology and generate a list of interesting candidate regions for further studies.

关键词： DNA copy number variations hypogonadism Kallmann syndrome male infertility

Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation

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Signal Transduction and Targeted Therapy 2023年第2期8卷 373-376页

作者： Haoran Liu Chen Duan Xiaoqi Yang Jianhe Liu Yaoliang Deng Hans-Göran Tiselius zhangqun ye Tao Wang Jinchun Xing Hua Xu Department of Urology The First Affiliated Hospital of Anhui Medical University230000HefeiChina Bio-X Stanford University94303StanfordCaliforniaUSA Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430000WuhanChina Department of Urology The Second Affiliated Hospital of Kunming Medical University650000KunmingChina Department of Urology The First Affiliated Hospital of Guangxi Medical University530000NanningChina Division of Urology Department of Clinical SciencesIntervention and TechnologyKarolinska Institutet13820StockholmSweden Department of Urology The First Affiliated Hospital of Xiamen University361000XiamenChina Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center 430000WuhanChina Department of Biological Repositories Zhongnan Hospital of Wuhan University430000WuhanChina Department of Urology Zhongnan Hospital of Wuhan University430000WuhanChina

Dear Editor,Kidney stones are one of the most common clinical diseases in *** 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the ... 详细信息

关键词： Kidney clinical diseases

Comparison of the oncological,perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma:A systematic review and metaanalysis of retrospective studies

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Asian Journal of Urology 2021年第1期8卷 117-125页

作者： Yucong Zhang Gongwei Long Haojie Shang Beichen Ding Guoliang Sun Wei Ouyang Man Liu Yuan Chen Heng Li Hua Xu zhangqun ye Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Objective:To conduct a meta-analysis assessing the perioperative,functional and oncological outcomes of partial nephrectomy(PN)and radical nephrectomy(RN)for T1b *** primary endpoints were the oncological *** secondary endpoints were the perioperative and functional ***:A systematic literature review was performed by searching multiple databases through February 2019 to identify eligible comparative studies according to the Preferred Reporting Items for Systematic Review and Meta-analysis *** reports were assessed according to the Newcastle-Ottawa Scale for nonrandomized controlled ***:Overall,13 retrospective cohort studies were included in the *** undergoing PN were younger(weighted mean difference[WMD]3.49 years,95%confidence interval[CI]5.16 to1.82;p<0.0001)and had smaller masses(WMD0.45 cm,95%CI0.59 to0.31;p<0.0001).There were no differences in the oncological outcome,which was demonstrated by progression-free survival(hazard ratio[HR]0.70;pZ0.22),cancerspecific mortality(HR 0.91;pZ0.57)and all-cause mortality(HR 1.01;pZ0.96).The two procedures were similar in estimated blood loss(WMD16.47 mL;pZ0.53)and postoperative complications(risk ratio[RR]1.32;pZ0.10),and PN provided better renal function preservation and was related to a lower likelihood of chronic kidney disease onset(RR 0.38;pZ0.006).Conclusion:PN is an effective treatment for T1b tumours because it offers similar surgical morbidity,equivalent cancer control,and better renal preservation compared to RN.

关键词： Kidney cancer Partial nephrectomy Radical nephrectomy Renal cancer Survival Renal function

PTEN induces anoikis through its phosphatase activity in human bladder transitional carcinoma cells BIU-87

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The Chinese-German Journal of Clinical Oncology 2007年第4期6卷 373-377页

作者： Yonglian Guo Xiaoping Zhang1, Siwei Zhou~, zhangqun ye~ Xiaoping Zhang Siwei Zhou zhangqun ye Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Urology Xiangfan First People＇s Hospital Xiangfan 441000 China

Objective:To investigate the effects and mechanisms of tumor suppressor gene PTEN on the induction of anoikis of human bladder transitional carcinoma cells ***:BIU-87 cells were transfected with GFP plasmids containing wild-type PTEN or phosphatase inactivating mutant PTEN(C124A-PTEN)in *** PTEN expression and the phosphorylation levels of focal adhesion kinase(FAK)and protein kinase B(PKB/Akt)were detected by Western *** cytometry assay and laser scanning confocal microscopy were used to analyze apoptosis in adherent and non-adherent ***: Compared with the control group,PTEN expression in the cells transfected with wild-type PTEN increased to 210%–260%, while the phosphorylation level of FAK and Akt decreased 59%(P<0.01)and 89%(P<0.01),*** the anoikis percentage increased from 8.32±0.57%to 37.62±2.12%.In the cells transfected with C124A-PTEN,neither the phos- phorylation of FAK and Akt nor the anoikis percentage had obviously changed,although the PTEN expression enhanced remarkably in comparison with the ***:Through its phosphatase activity,tumor suppressor gene PTEN can suppress the phosphorylation of FAK and Akt,and induce anoikis in human bladder transitional carcinoma cells BIU-87.

关键词： tumor suppressor gene PTEN FAK Akt anoikis

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泌尿系结石诊治:聚焦发展,思考未来

中华医学杂志 2021年第38期101卷 3049-3053页

作者：余虓叶章群华中科技大学同济医学院附属同济医院泌尿外科武汉430030

虽然泌尿系结石的微创诊疗技术已经得到广泛开展,但随着影像学、激光技术、内镜科技和材料科学等技术的不断进步和交叉融合,新的泌尿系结石的诊疗设备层出不穷,推动着泌尿系结石诊疗技术的不断进步和革新。通过对影像学、碎石工具、新... 详细信息

虽然泌尿系结石的微创诊疗技术已经得到广泛开展,但随着影像学、激光技术、内镜科技和材料科学等技术的不断进步和交叉融合,新的泌尿系结石的诊疗设备层出不穷,推动着泌尿系结石诊疗技术的不断进步和革新。通过对影像学、碎石工具、新型内窥镜和输尿管支架等方面进展的介绍,并分析其应用前景,展望未来泌尿系结石诊疗的发展趋势。

关键词：泌尿系疾病尿路结石诊断治疗

虚拟膀胱镜技术在非肌层浸润性膀胱癌手术分型中的初步应用

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现代泌尿生殖肿瘤杂志 2024年第3期16卷 144-148页

作者：夏启东孟晓岩胡恒龙宋文胡嘏李凡叶章群李震王少刚刘征华中科技大学同济医学院附属同济医院泌尿外科武汉430030 华中科技大学同济医学院附属同济医院放射科武汉430030

目的浅探基于超薄磁共振灌注成像三维重建的虚拟膀胱镜检查在非肌层浸润性膀胱癌(NMIBC)患者手术分型中应用的可行性。方法回顾性分析2020年7月至8月收治的3例NMIBC患者的资料。术前均行超薄磁共振灌注成像,在获得患者知情同意后采集检... 详细信息

目的浅探基于超薄磁共振灌注成像三维重建的虚拟膀胱镜检查在非肌层浸润性膀胱癌(NMIBC)患者手术分型中应用的可行性。方法回顾性分析2020年7月至8月收治的3例NMIBC患者的资料。术前均行超薄磁共振灌注成像,在获得患者知情同意后采集检查数据,使用3D交互式医学影像控制系统Mimics对影像进行三维重建构建高精度的虚拟膀胱镜模型,在术前用于激光切除术的手术规划。结果3例手术均顺利完成,手术时间分别为20、55、60 min。术后病理报告切缘均为阴性,围手术期3例患者均无Clavien-DindoⅡ级及以上的并发症。术后2~7d恢复出院,其中1例为高级别尿路上皮癌,术后1个月定期行卡介苗灌注治疗,另外2例均为低危NMIBC,术后定期行吉西他滨或沙培林维持灌注,定期随访至今,3例患者均无复发。结论基于超薄磁共振灌注成像的高精度虚拟膀胱镜技术对于NMIBC患者的激光切除术前预分割、减少手术时间有临床辅助意义,同时有待未来进行前瞻性队列研究来明确术前虚拟膀胱镜技术的应用是否有助于降低NMIBC患者的术后复发率。

关键词：虚拟膀胱镜非肌层浸润性膀胱癌多参数磁共振激光切除术并发症

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良性前列腺增生手术时机的探讨

中华泌尿外科杂志 2021年第12期42卷 881-884页

作者：陈忠叶章群华中科技大学同济医学院附属同济医院泌尿外科武汉430030

良性前列腺增生(BPH)是一个缓慢进展的良性疾病,有部分患者不得不接受手术治疗。若手术时机把握不及时,会增加手术风险,降低手术效果。但目前对BPH的最佳手术时机还缺乏一个有效的评估方法,亟需开展大规模、多中心的高质量临床研究,提... 详细信息

良性前列腺增生(BPH)是一个缓慢进展的良性疾病,有部分患者不得不接受手术治疗。若手术时机把握不及时,会增加手术风险,降低手术效果。但目前对BPH的最佳手术时机还缺乏一个有效的评估方法,亟需开展大规模、多中心的高质量临床研究,提出合理的解决方案。

关键词：前列腺增生良性前列腺梗阻手术时机

Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma

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Cancer Communications 2021年第4期41卷 316-332页

作者： Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen zhangqun ye Hua Xu Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Hubei Institute of Urology WuhanHubei 430030P.R.China Department of Urology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330000P.R.China Department of Molecular and Medical Pharmacology David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCA 90095USA Department of Urology The First Affiliated Hospital of Xiamen UniversityXiamenFujian 361003P.R.China Department of Urology The People’s Hospital of Shenzhen CityShenzhenGuangdong 518020P.R.China

Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)***,the function and underlying mechanism of HIF2α in ccRCC remains *** conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ***:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC *** reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer ***:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and *** knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in ***,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment ***:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target.

关键词： renal cell carcinoma junction plakoglobin hypoxia-inducible factor 2α transcriptional activity ubiquitination