检索结果-南通市图书馆

Adaptive strategies of high and low nucleic acid prokaryotes in response to declining resource availability and selective grazing by protozoa

引用

Science China Earth Sciences 2024年第6期67卷 1872-1884页

作者： Chen hU Liuqian YU Xiaowei ChEN jihua LIU Yao zhang john BATT Xilin XIAO Qiang ShI Rui zhang Tingwei LUO Nianzhi jIAO Dapeng XU College of the Environment and Ecology Xiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102China joint Lab for Ocean Research and Education(LORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China Earth Ocean and Atmospheric Sciences ThrustThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 510000China Institute of Marine Science and Technology Shandong UniversityQingdao 266237China Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Carbon Neutral Innovation Research Center Xiamen UniversityXiamen 361102China

Prokaryotes play a fundamental role in global ocean biogeochemical ***,how the abundance and metabolic activity of ecologically distinct subgroups(i.e.,high nucleic acid(hNA)and low nucleic acid(LNA)cells),and their regulating factors,change in response to changing marine environmental conditions remains poorly ***,we delved into the time-evolving dynamic responses of the hNA and LNA prokaryotic subgroups to declining resource availability and selective grazing by protozoa by conducting a 73-day incubation experiment in a large-volume(117,000 L)macrocosm that facilitates community-level *** found that the metabolic activity of the hNA subgroup was higher than that of the LNA subgroup when the macrocosm was resource replete but that the hNA subgroup declined more rapidly than the LNA subgroup as the resources became increasingly scarce,leading to a steadily increasing contribution of LNA cells to prokaryotic ***,as resources in the macrocosm became limited,protozoan grazing preference shifted from the hNA to the LNA subgroup and the contributions of the LNA subgroup to the carbon flow within the macrocosm *** findings highlight the resilience of LNA cells in resource-limited environments,illuminate the critical role of selective grazing by protozoa in balancing distinct prokaryotic subgroups under changing resource conditions,and demonstrate the complex and adaptive interactions between protozoa and prokaryotes across diverse environmental contexts.

关键词： Microbial loop Macrocosm experiment Prokaryote Top-down and bottom-up controls Carbon flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective photosynthesis of z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions

引用

Carbon Energy 2024年第3期6卷 118-131页

作者： jia-Ni Lu Yunze huang Yuan-Sheng Xia Long-zhang Dong Lei zhang jing-jing Liu Lan-Gui Xie jiang Liu Ya-Qian Lan jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form z-olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of z-alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen *** them,Co_(5)zn_(3)L_(6) shows the highest photocatalytic activity,with a h_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into z-olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis z-olefins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear Registration of Brain Magnetic Resonance Images with Cross Constraints of Intensity and Structure

引用

Computers, Materials & Continua 2024年第5期79卷 2295-2313页

作者： han zhou hongtaoXu Xinyue Chang Wei zhang heng Dong Digital Fujian Research Institute of Big Data forAgriculture and Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China College of Computer and Information Science Fujian Agriculture and Forestry UniversityFuzhou350002China

Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D ***,these methods often lack constraint information and overlook semantic consistency,limiting their *** address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint *** innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature *** encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint *** design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical *** ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic *** on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.

关键词： Medical image registration cross constraint semantic consistency directional consistency dual-channel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein neddylation and its role in health and diseases

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen zhang Qing Yu zhijian Li Yongchao zhao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of head&Neck Cancer Translational Research of zhejiang Province Hangzhou 310022China Department of hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of zhejiang Hangzhou 310024China Research Center for Life Science and human health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advancements on metal oxide semiconductor photocatalysts in photo-electrochemical conversion of carbon dioxide into fuels and other useful products

引用

Frontiers in Energy 2024年第2期18卷 187-205页

作者： jai PRAKASh zhangsen ChEN Shakshi SAINI Gaixia zhang Shuhui SUN Department of Chemistry National Institute of Technology HamirpurHamirpur 177005India Institut National de la Recherche Scientifique(INRS) Centre Énergie Matériaux TélécommunicationsVarennes J3X 1P7Canada Department of Chemistry Indian Institute of Technology MandiHimachal PradeshIndia Department of Electrical Engineering École de Technologie SupérieureMontréal H3C 1K3Canada

Due to its fascinating and tunable optoelectronic properties,semiconductor nanomaterials are the best choices for multidisciplinary ***,the use of semiconductor photocatalysts is one of the promising ways to harness solar energy for useful applications in the field of energy and *** recent years,metal oxide-based tailored semiconductor photocatalysts have extensively been used for photocatalytic conversion of carbon dioxide(CO_(2))into fuels and other useful products utilizing solar *** is very significant not only from renewable energy consumption but also from reducing global warming point of *** current research activities are promising for a better future of *** present mini-review is focused on recent developments(2–3 years)in metal oxide semiconductor hybrid photocatalysts-based photo-electrochemical conversion of CO_(2)into fuels and other useful ***,general mechanism of photo-electrochemical conversion of CO_(2)into fuels or other useful products has been ***,various metal oxide-based emerging hybrid photocatalysts including tailoring of their morphological,compositional,and optoelectronic properties have been discussed with emphasis on their role in enhancing photoelectrochemical ***,mechanism of their photo-electrochemical reactions and applications in CO_(2)conversion into fuels/other useful products have been ***,challenges and future prospects have been discussed followed by a summary.

关键词： metal-oxide semiconductors nanohybrid photocatalysts photo-electrochemical CO_(2)conversion tailoring morphology fuels challenges and future prospects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

引用

Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： jiawen zhang Sihui Yu Qiao Peng Ping Wang Lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transition-metal-catalyzed remote meta-C-h alkylation and alkynylation of aryl sulfonic acids enabled by an indolyl template

引用

Chinese Chemical Letters 2024年第8期35卷 254-259页

作者： Pengfei zhang Qingxue Ma zhiwei jiang Xiaohua Xu zhong jin College of Chemistry State Key Laboratory of Elemento-organic ChemistryNankai UniversityTianjin 300071China Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resource Chemistry College of Chemistry and Environmental SciencesKashi UniversityKashgar 844007China

Transition-metal-catalyzed remote sp^(2)C-h functionalization of aryl sulfonic acids was hardly ever real-ized owing to competitive ortho-C-h functionalization of aryl sulfonates and electron-deficient nature of phenyl ***,with the assistance of a practical biaryl indolyl directing template,palladium-catalyzed remote sp^(2)C-h alkylation of aryl sulfonic acids have been achieved in moderate to good yields with exclusive meta ***,remote meta-selective C-h alkynylation of aryl sulfonic acids was also accomplished with a rhodium *** meta-C-h functionalized products proved to be the superior synthetic precursors,which are difficult to access using the conventional strategy.

关键词： C-h functionalization Aryl sulfonic acid Site-selectivity Transition-metal catalysis Alkylation Alkynylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laminar Flame Structure-Dependent Exergy Destruction Behavior at Auto-Ignition Time Scale:A Case Study of Dimethyl Ether(DME)

引用

journal of Thermal Science 2024年第4期33卷 1257-1271页

作者： WU honghuan hUang Wenlin zhAO hao SUN Wuchuan hUang zuohua zhang Yingjia State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China

hybrid deflagration/auto-ignition flame structures coexist in the combustion of advanced *** exergy destruction caused by different irreversible processes under varied flame regimes is thus important for understanding engine *** this study,the flame propagation modes for the premixed DME/air mixtures are numerically investigated under engine-relevant *** entropy generation and exergy destruction characteristics are compared under different flame *** reveal that as the typical premixed flame transition towards auto-ignition front,the exergy destruction from heat conduction and species mass diffusion gradually vanish and are dominated by chemical *** distributions of temperature and species mole fraction in the flame domain are analyzed to clarify the exergy destruction behaviors caused by heat conduction and mass ***,by dividing the DME oxidation process into four stages,the main reaction channels that contribute to the increase in exergy destruction from chemical reaction have been *** is found that the production and consumption of Ch_(2)O and hO_(2) radical dominate the exergy destruction behavior during DME *** this basis,the kinetic mechanism of low-temperature chemistry causing greater exergy destruction is ***,low-temperature chemistry leads to significant exergy destruction due to(a)the large irreversibility of itself and(b)(mainly)the enhancement of h_(2)O_(2)loop reactions by low-temperature reaction *** the reduction of combustion irreversibility is promising to be achieved by reasonably regulating the fuel oxidation path.

关键词： exergy destruction flame structures entropy generation low-temperature chemistry DME

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large low-field reversible magnetocaloric effect in K_(3)Gd(PO_(4))_(2) at sub-Kelvin temperature

引用

journal of Rare Earths 2024年第6期42卷 1087-1092,I0003页

作者： haojie Wang zhaojun Mo jianjian Gong heng Tu Guochun zhang jun Shen School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Center for Crystal Research and Development Key Laboratory of Functional Crystals and Laser TechnologyKey Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Department of Energy and PowerEngineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing100081China

We synthesized a potassium gadolinium phosphate K3Gd(PO_(4))_(2)with monoclinic structure(P2_(1/m))by the high-temperature solid-state reaction *** lattice constants obtained by Rietveld refinements of XRD curve are a=0.7411 nm,b=0.5624 nm,and c=0.9433 *** and magnetocaloric properties of K_(3)Gd(PO_(4))_(2)were investigated in *** magnetic phase transition temperature of K3Gd(PO_(4))2 was determined by ultra-low temperature testing to be 0.58 K.K_(3)Gd(PO_(4))2 exhibits large magnetic entropy changes(-ΔSM).The maximum-ΔSM are 20.2 and 29.4 j/(kg·K)in the magnetic field variation(Δh)of 1 and 2 T,respectively,which are larger than that of the commercial Gd_(3)Ga_(5)O_(12)(GGG).The maximum adiabatic temperature change(ΔT_(ad))reaches 5.91 K under a magnetic field change(Δh)of 1 T.K_(3)Gd(PO_(4))_(2)is a potential magnetic refrigeration material for obtaining sub-Kelvin temperatures.

关键词： Ultra-low temperature Magnetocaloric effect Magnetic entropy change Magnetic refrigeration Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The key mediator of diabetic kidney disease:Potassium channel dysfunction

引用

Genes & Diseases 2024年第4期11卷 188-200页

作者： jia Guo Chaojie zhang hui zhao Yufan Yan zhangsuo Liu Nephrology Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in henan Province ZhengzhouHenan 450052China Research Center for Kidney Disease ZhengzhouHenan 450052China

Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health *** molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex ***,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney *** channels are important proteins that maintain the physiological functions of cells and *** ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell *** potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as K_(ATP),K_(ca),K_(ir),and K_(v).In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

关键词： Channel dysfunction Diabetic kidney disease End-stage renal disease lon channel Potassium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：