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Biomedical and Environmental Sciences 2024年第4期37卷 436-439页

作者： LUO Xi LI Xue zhang Miao Miao HUANG Qing Lian zhang yi quan JI Shen Jie LU Ren Fei Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People’s HospitalNantong 226006JiangsuChina Department of Clinical Laboratory Qidong People’s HospitalQidong 226200JiangsuChina

Vibrio parahaemolyticus,a gram-negative halophilic bacterium that naturally inhabits coastal waters,causes gastroenteritis,skin infections,and septicemia in human beings[1].This bacterium produces multiple virulence factors,including thermostable direct hemolysin(TDH),TDH-related hemolysin(TRH),type Ⅲ secretion system 1(T3SS1),T3SS2,type Ⅵ secretion system 1(T6SS1),and T6SS2[1].Furthermore,Ⅴ.parahaemolyticus forms biofilms on the surface,which help it in adapting to unfavorable conditions[2].Mature biofilm formation requires special structures,including lateral and polar flagella,exopolysaccharide(EPS),and type Ⅳ pili[2].

关键词： coastal system T3SS

Reciprocal Regulation between Fur and Two RyhB Homologs in Yersinia pestis,and Roles of RyhBs in Biofilm Formation

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Biomedical and Environmental Sciences 2021年第4期34卷 299-308页

作者： NI Bin WU Hai Sheng XIN You quan zhang Qing Wen zhang yi quan School of Medicine Jiangsu UniversityZhenjiang 212013JiangsuChina Qinghai Institute for Endemic Disease Prevention and Control Xining 811602QinghaiChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122JiangsuChina

Objective To investigate reciprocal regulation between Fur and two RyhB homologs in Yersinia pestis(***),as well as the roles of RyhBs in biofilm *** Regulatory relationships were assessed by a combination of colony morphology assay,primer extension,electrophoretic mobility shift assay and DNase I *** Fur bound to the promoter-proximal DNA regions of ryhB1 and ryhB2 to repress their transcription,while both RyhB1 and RyhB2 repressed the expression of Fur at the post-transcriptional *** addition,both RyhB1 and RyhB2 positively regulated *** biofilm exopolysaccharide(EPS)production and the expression of hmsHFRS and *** Fur and the two RyhB homologs exert negative reciprocal regulation,and RyhB homologs have a positive regulatory effect on biofilm formation in ***.

关键词： Yersinia pestis RyhB Fur Biofilm

Protein Containing the GGDEF Domain Affects Motility and Biofilm Formation in Vibrio cholerae and is Negatively Regulated by Fur and HapR

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Biomedical and Environmental Sciences 2023年第10期36卷 949-958页

作者： GAO He MA Li Zhi QIN Qin CUI Yao MA Xiao Han zhang yi quan KAN Biao State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Medical Risk Management Section Third Medical CentreChinese PLA(People’s Liberation Army)General HospitalBeijing 100039China Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People's HospitalNantong 226006JiangsuChina 3.Department of Clinical LaboratoryAffiliated Nantong Hospital 3 of Nantong UniversityNantong Third People's Hospital

Objective This study aimed to investigate whether the VCA0560 gene acts as an active diguanylate cyclase(DGC)in Vibrio cholerae and how its transcription is regulated by Fur and Hap *** The roles of VCA0560 was investigated by utilizing various phenotypic assays,including colony morphological characterization,crystal violet staining,Cyclic di-GMP(c-di-GMP)quantification,and swimming motility *** regulation of the VCA0560 gene by Fur and Hap R was analyzed by luminescence assay,electrophoretic mobility shift assay,and DNase I *** VCA0560 gene mutation did not affect biofilm formation,motility,and c-di-GMP synthesis in ***,and its overexpression remarkably enhanced biofilm formation and intracellular c-di-GMP level but reduced motility *** transcription of the VCA0560 gene was directly repressed by Fur and the master quorum sensing regulator Hap *** Overexpressed VCA0560 functions as an active DGC in ***,and its transcription is repressed by Fur and Hap R.

关键词： Vibrio cholera Cyclic di-GMP VCA0560 Fur HapR

Transcriptional Regulation of YP3680 by Rov A and Rcs AB in Yersinia pestis biovar Microtus

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Biomedical and Environmental Sciences 2022年第3期35卷 234-238页

作者： LIU Lei FANG Nan LIU Wan Bing HE ying Yu LIU Yan zhang yi quan Department of Transfusion Medicine General Hospital of Central Theater Command of the PLAWuhan 430070HubeiChina The First School of Clinical Medicine Southern Medical UniversityGuangzhou 510280GuangdongChina Beijing USCI Medical Laboratory Co. Ltd.Building C7YiYuan Industrial BaseBeijing 100195China Department of Clinical Laboratory Nantong Third Hospital Affiliated to Nantong UniversityNantong 226006JiangsuChina

Type-VI secretion system(T6SS)is a widespread bacteriophage-like complex in bacteria that participates in multiple physiological processes,including metal ion uptake,bacterial competition,and biofilm formation^([1]).Y... 详细信息

关键词： agent Regulation competition

脑血肿清除术老年患者术前衰弱与术后并发症的相关性

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吉林医学 2024年第9期45卷 2050-2053页

作者：杜宁解立杰张全意林峰静广建于飞孙敏滨州医学院附属医院麻醉科山东滨州256600

目的:脑血肿清除术老年患者术前衰弱与术后并发症的相关性。方法:选取2018年1月~2022年12月滨州医学院附属医院行脑血肿清除术的老年患者100例为研究对象,收集患者基本信息、临床检查等资料,评估患者的术前衰弱情况,采用改良衰弱指数(m... 详细信息

目的:脑血肿清除术老年患者术前衰弱与术后并发症的相关性。方法:选取2018年1月~2022年12月滨州医学院附属医院行脑血肿清除术的老年患者100例为研究对象,收集患者基本信息、临床检查等资料,评估患者的术前衰弱情况,采用改良衰弱指数(mFI)将患者分为衰弱组(n=32)与非衰弱组(n=68)。对患者术后的并发症、入住ICU率、术后1年死亡率进行记录、比较。对影响术后并发症的相关危险因素,通过单因素、多因素进行分析。结果:术后56例(56.00%)患者存在术后并发症。单因素与多因素分析提示,影响老年脑出血患者术后并发症的危险因素是衰弱。结论:衰弱是脑血肿清除术术后并发症的独立危险因素,围术期做好衰弱患者的干预可能降低脑血肿清除患者术后并发症。

关键词：衰弱脑血肿清除术后并发症

A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 168-180页

作者： yi zhang Zhiyan quan Feiyang LOU Yujiao FANG Garth J.THOMPSON Gao CHEN Xiaotong zhang Department of Neurosurgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang UniversityHangzhou310058China Interdisciplinary Institute of Neuroscience and Technology College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou310027China School of Medicine Zhejiang UniversityHangzhou310020China iHuman Institute School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China College of Electrical Engineering Zhejiang UniversityHangzhou310027China

Energy metabolism is fundamental for *** encompasses the utilization of carbohydrates,lipids,and proteins for internal processes,while aberrant energy metabolism is implicated in many *** the present study,using three-dimensional(3D)printing from polycarbonate via fused deposition modeling,we propose a multi-nuclear radiofrequency(RF)coil design with integrated 1H birdcage and interchangeable X-nuclei(^(2)H,^(13)C,^(23)Na,and^(31)P)single-loop coils for magnetic resonance imaging(MRI)/magnetic resonance spectroscopy(MRS).The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface,enabling convenient switching among various nuclei and animal *** to a commercial 1H birdcage coil,the proposed 1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio(SNR).For X-nuclei study,prominent peaks in spectroscopy for phantom solutions showed excellent SNR,and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

关键词： Energy metabolism Magnetic resonance imaging(MRI) Magnetic resonance spectroscopy(MRS) Multi-nuclear Radiofrequency coil Three-dimensional(3D)printing

Effects of two silicone resin coatings on performance of FeSiAl magnetic powder cores

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Journal of Iron and Steel Research International 2024年第5期31卷 1279-1288页

作者： Jia-qi Liu Zheng-qu Zhu Pu Wang yi-fan Li Jing Pang Jia-quan zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao266232ShandongChina

Two silicon resins with excellent thermal stability,JH1123 and JH7102,are used as the insulated agents and binders for the gas-atomized FeSiAl powder,and corresponding magnetic powder cores(MPCs)are *** insulation capability and application prospects of the two silicon resins are evaluated by comparing the magnetic properties of the coated powder and *** scanning electron microscopy,energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy results show that uniform insulation layers are both formed on the powder ***1123 has stronger binding ability,and the JH1123-coated powder exhibits severe agglomeration,with d50(average particle size)approximately twice that of the JH7102-coated *** as-prepared MPCs exhibit outstanding soft magnetic ***,the permeability of FeSiAl@JH1123 is up to 74.0,which is 35.5%higher than that of FeSiAl@JH7102 because JH1123 can further improve the density of the *** for FeSiAl@JH7102,it has better direct current bias and lower core loss of 716.9 mW cm^(−3) at 20 mT and 1000 kHz due to its lower coercivity and greater anti-magnetic saturation ability.A comprehensive comparison shows that FeSiAl@JH1123 is suitable for medium and high frequency applications,while FeSiAl@JH7102 is more suitable for high frequency *** indicates that the use of JH1123 and JH7102 silicon resins for binding and insulated coating not only simplifies the preparation process of MPCs,but also enables the controlled production of MPCs for different applications.

关键词： FeSiAl Insulated coating Magnetic powder core Permeability Core loss

TSC prediction and dynamic control of BOF steelmaking with state-of-the-art machine learning and deep learning methods

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Journal of Iron and Steel Research International 2024年第1期31卷 174-194页

作者： Tian-yi Xie Cai-dong zhang quan-lin Zhou Zhi-qiang Tian Shuai Liu Han-jie Guo Material Technology Research Institute Hesteel GroupShijiazhuang050023HebeiChina Tangsteel Company Hesteel GroupTangshan063611HebeiChina School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Mathematical(data-driven)models based on state-of-the-art(SOTA)machine learning and deep learning models and data collected from 12,786 heats were established to predict the values of temperature,sample,and carbon(TSC)test,including temperature of molten steel(TSC-Temp),carbon content(TSC-C)and phosphorus content(TSC-P),which made prepa-ration for eliminating the TSC *** maximize the prediction accuracy of the proposed approach,various models with different inputs were implemented and compared,and the best models were applied to the production process of a Hesteel Group steelmaking plant in China in the *** number of tabular features(hot metal information,scrap,additives,blowing practices,and preset values)was expanded,and time series(off-gas profiles and blowing practice curves)that could reflect the entire steelmaking process were introduced as ***,the latest machine learning models(LightGBM,CatBoost,TabNet,and NODE)were used to make predictions with tabular features,and the best coefficient of determination R^(2)values obtained for TSC-P,TSC-C and TSC-Temp predictions were 0.435(LightGBM),0.857(Cat-Boost)and 0.678(LightGBM),respectively,which were higher than those of classic models(backpropagation and support vector machine).Then,making predictions was performed by using SOTA time series regression models(SCINet,DLinear,Informer,and MLSTM-FCN)with original time series,SOTA image regression models(NesT,CaiT,ResNeXt,and GoogLeNet)with resized time series,and the proposed Concatenate-Model and Parallel-Model with both tabular features and time *** optimization and comparisons,it was finally determined that the Concatenate-Model with MLSTM-FCN,SCINet and Informer as feature extractors performed the best,and its R^(2)values for predicting TSC-P,TSC-C and TSC-Temp reached 0.470,0.858 and 0.710,*** field test accuracies for TSC-P,TSC-C and TSC-Temp were 0.459,0.850 and 0.685,respectively.A related importance analysis was carri

关键词： BOF steelmaking In-blow prediction TSC test Machine learning Deep learning Field application

Master Quorum Sensing Regulator HapR Acts as A Repressor of the Mannitol Phosphotransferase System Operon in Vibrio cholerae

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Biomedical and Environmental Sciences 2022年第1期35卷 69-72页

作者： zhang yi quan MA Li Zhi GAO Yue QIN Qin LI Jie LOU Jing zhang Miao Miao XUE Xing Fan KAN Biao GAO He Department of Clinical Laboratory Nantong Third Hospital Affiliated to Nantong UniversityNantong 212006JiangsuChina Medical Risk Management Section Third Medical CentreChinese PLA(People’s Liberation Army)General HospitalBeijing 100039China First Affiliated Hospital of Dalian Medical University Dalian 116011LiaoningChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Medicine Jiangsu UniversityZhenjiang 212013JiangsuChina

The phosphoenolpyruvate(PEP):carbohydrate phosphotransferase system(PTS)is widely used by bacteria to take up sugars or sugar derivatives;.PTS is usually composed of a histidine protein(HPr),enzyme I(EI),and several e... 详细信息

关键词： sugar system usual

Aerial refueling scheduling of multi-receiver and multi-tanker under spatial-temporal constraints for forest firefighting

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Chinese Journal of Aeronautics 2024年第5期37卷 71-91,I0001页

作者： Jing HUANG Jiaqi XING Jinrui REN quan quan Youmin zhang Department of Information and Control Engineering Xi’an University of TechnologyXi’an 710048China Jiujiang Measuring Test Technology Research Institute Jiujiang 332000China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Xi’an University of Posts&TelecommunicationsShaanxiXi’an 710121China Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontreal H3G 1M8Canada

Forest fires pose a significant threat to human life and property,so the utilization of unmanned aircraft systems provides new ways for forest *** the constrained load capacities of these aircraft,aerial refueling becomes crucial to extend their operational time and *** order to address the complexities of firefighting missions involving multi-receiver and multi-tanker deployed from various airports,first,a fuel consumption calculation model for aerial refueling scheduling is established based on the receiver ***,two distinct methods,including an integrated one and a decomposed one,are designed to address the challenges of establishing refueling airspace and allocating tasks for *** methods aim to optimize total fuel consumption of the receivers and tankers within the aerial refueling scheduling *** optimization problem is established as nonlinear optimization models along with *** integrated method seamlessly combines refueling rendezvous point scheduling and tanker task allocation into unified *** has a complete solution space and excels in optimizing total fuel *** decomposed method,through the separation of rendezvous point scheduling and task allocation,achieves a reduced computational ***,this comes at the cost of sacrificing optimality by excluding specific feasible ***,numerical simulations are carried out to verify the feasibility and effectiveness of the proposed *** simulations yield insights crucial for the practical engineering application of both the integrated and decomposed methods in real-world *** comprehensive approach aims to enhance the efficiency of forest firefighting operations,mitigating the risks posed by forest fires to human life and property.

关键词： Aerial refueling Scheduling Planning Spatial-temporal constraint Firefighting