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The genetic basis and process of inbreeding depression in an elite hybrid rice

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Science China(Life Sciences) 2024年第8期67卷 1727-1738页

作者： Xiaodong Xu Yawen Xu Jian Che Xu Han Zhengji Wang Xianmeng Wang qinghua zhang Xu Li Qinglu zhang Jinghua Xiao Xianghua Li Qifa zhang Yidan Ouyang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Inbreeding depression refers to the reduced performance arising from increased homozygosity,a phenomenon that is the reverse of heterosis and exists among plants and *** a natural self-pollinated crop with strong heterosis,the mechanism of inbreeding depression in rice is largely *** understand the genetic basis of inbreeding depression,we constructed a successive inbreeding population from the F_(2)to F_(4)generation and observed inbreeding depression of all heterotic traits in the progeny along with the decay of heterozygosity in each *** expected depression effect was largely explained by 13 QTLs showing dominant effects for spikelets per panicle,11 for primary branches,and 12 for secondary branches,and these loci constitute the main correlation between heterosis and inbreeding ***,the genetic basis of inbreeding depression is also distinct from that of heterosis,such that a biased transmission ratio of alleles for QTLs with either dominant or additive effects in four segregation distortion regions would result in minor effects in expected ***,two-locus interactions may change the extent and direction of the depression effects of the target loci,and overall interactions would promote inbreeding depression among *** an F_(2:3)variation population,the actual performance of the loci showing expected depression was evaluated considering the heterozygosity decay in the background after *** found inconsistent or various degrees of background depression from the F_(2)to F_(3)generation assuming different genotypes of the target locus,which may affect the actual depression effect of the locus due to *** results suggest that the genetic architecture of inbreeding depression and heterosis is closely linked but also differs in their intrinsic mechanisms,which expand our understanding of the whole-genome architecture of inbreeding depression.

关键词： rice inbreeding depression spikelet development dominance segregation distortion epistasis

Yixian County:a Historic Town of China

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China & The World Cultural Exchange 2011年第7期77卷 34-35页

作者： zhang qinghua

County has played an important role in the history of China since it was first established as a basic administrative unit in the Qin Dynasty more than 2000 years ago.

关键词：中国历史黟县行政单元信息

A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure

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Journal of Genetics and Genomics 2016年第5期43卷 307-318页

作者： Jason Ear Jessica Hsueh Melinda Nguyen qinghua zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Celgene Corporation San Francisco 94158 USA Celgene Corporation Summit NJ 07901 USA Division of Hematology/Oncology Department of Pediatrics Stanford University School of Medicine Stanford CA 94304 USA

5q-syndrome is a distinct form of myelodysplastic syndrome（MDS） where a deletion on chromosome 5 is the underlying *** is characterized by bone marrow failures,including macrocytic *** mapping and studies using various models support the notion that ribosomal protein S14（RPS14） is the candidate gene for the erythroid *** disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal ***,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment *** better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 *** model mirrors the anemic phenotype seen in ***,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes ***,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype.

关键词： 5q-syndrome RPS14 Ribosomopathy Myelodysplastic syndrome

A Superaerophobic Bimetallic Selenides Heterostructure for Efficient Industrial-Level Oxygen Evolution at Ultra-High Current Densities

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Nano-Micro Letters 2020年第8期12卷 213-224页

作者： Jiaxin Yuan Xiaodi Cheng Hanqing Wang Chaojun Lei Sameer Pardiwala Bin Yang Zhongjian Li qinghua zhang Lecheng Lei Shaobin Wang Yang Hou Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Institute of Zhejiang University-Quzhou Quzhou 324000People’s Republic of China Ningbo Research Institute Zhejiang UniversityNingbo 315100People’s Republic of China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Cost-effective and stable electrocatalysts with ultra-high current densities for electrochemical oxygen evolution reaction(OER)are critical to the energy crisis and environmental ***,we report a superaerophobic three dimensional(3D)heterostructured nanowrinkles of bimetallic selenides consisting of crystalline NiSe2 and NiFe2Se4 grown on NiFe alloy(NiSe2/NiFe2Se4@NiFe)prepared by a thermal selenization *** this unique 3D heterostructure,numerous nanowrinkles of NiSe2/NiFe2Se4 hybrid with a thickness of ~100 nm are grown on NiFe alloy in a uniform *** by the large active surface area and high electronic conductivity,the superaerophobic NiSe2/NiFe2Se4@NiFe heterostructure exhibits excellent electrocatalytic activity and durability towards OER in alkaline media,outputting the low potentials of 1.53 and 1.54 V to achieve ultra-high current densities of 500 and 1000 mA cm^−2,respectively,which is among the most active Ni/Fe-based selenides,and even superior to the benchmark Ir/C *** in-situ derived FeOOH and NiOOH species from NiSe2/NiFe2Se4@NiFe are deemed to be efficient active sites for OER.

关键词： Superaerophobicity Bimetallic selenide Heterostructure electrocatalyst Strong interfacial coupling Oxygen evolution reaction

Synthesis and characterization of caprolactone based polyurethane with degradable and antifouling performance

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Chinese Journal of Chemical Engineering 2021年第6期34卷 299-306页

作者： Abid Ali Lina Song Jiankun Hu Jingxian Jiang Qingqing Rao Muhammad Shoaib Shah Fahad Yongjie Cai Xiaoli Zhan Fengqiu Chen qinghua zhang College of Chemical and Biological Engineering Zhejiang Provincial Key Laboratory of Advanced Chemical EngineeringManufacture TechnologyZhejiang UniversityHangzhou 310027China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

In this work,a degradable polyurethane composed of caprolactone(CL)and L-Lactide(LLA)as soft segments,and 4,40-methylenebis(cyclohexyl isocyanate)(H12 MDI)and polytetramethylene ether glycol(PTMEG)as hard segments,was *** degradation experiment revealed that the degradable polyurethane(PU)could be degraded in artificial *** also showed that caprolactone-copolyurethane(CL-PU)copolymer with higher crystallinity degraded much slower in artificial ***,the introduction of LLA resulted in an increase in the hydrophilicity and reduction in the crystallinity of degradable PU,as demonstrated by the contact angle *** result of the scanning electron microscope showed that the surface of degradable PU renewed under static ***,degradable PU was able to be used as a carrier,and it controlled the release rate of 4,5-dichloro-2-octyl-isothiazolone(DCOIT).The anti-diatom(Navicula incerta)test demonstrated that the(caprolactone-co-L-lactide)-co-polyurethane 4(CL/LAx-PU4)with DCOIT contents prevented the adhesion of diatom Navicula incerta(88.37%reduction)due to their self-polishing and the release of ***,the degradable PU consisted of CL,LLA,and DCOIT could be a durable resin with good antifouling activity for the application in the marine anti-biofouling field.

关键词： Antifoulant 4 5-dicholoro-2-octyl-isothiazolone Degradable polyurethane L-Lactide Caprolactone

Dingzhou:Porcelain and Religious Traditions

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China & The World Cultural Exchange 2011年第5期77卷 30-33页

作者： zhang qinghua

County has played an important role in the history of China since it was first established as a basic administrative unit in the Qin Dynasty more than2000years *** counties have not only performed administrative and economic functions but also carried and preserved basic information about culture and traditions of *** long ago,the Photographic Exhibition on the Cultural Heritage of Historic Counties of China,organized by China Cultural Relics Protection Foundation in partnership with the Palace Museum and China Institute of Toponymy,was held at the Forbidden City,displaying photographs on the cultures and traditions of the first16Historic Counties of China,with an objective to enhance the public’s awareness of the conservation of cultural heritage in these historic *** magazine will cover each of these chosen historic counties in each issue.

关键词：传统中国历史故宫博物院文化遗产宗教瓷器中国地名基金会

A BOOSTING APPROACH FOR INTRUSION DETECTION

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Journal of Electronics(China) 2007年第3期24卷 369-373页

作者： Zan Xin Han Jiuqiang zhang Junjie Zheng qinghua Han Chongzhao Dept of Automation School of Electronics and Information Engineering Xi＇an Jiaotong University Xi＇an 710040 China

Intrusion detection can be essentially regarded as a classification problem,namely,dis-tinguishing normal profiles from intrusive behaviors. This paper introduces boosting classification algorithm into the area of intrusion detection to learn attack signatures. Decision tree algorithm is used as simple base learner of boosting algorithm. Furthermore,this paper employs the Principle Com-ponent Analysis (PCA) approach,an effective data reduction approach,to extract the key attribute set from the original high-dimensional network traffic data. KDD CUP 99 data set is used in these ex-periments to demonstrate that boosting algorithm can greatly improve the classification accuracy of weak learners by combining a number of simple “weak learners”. In our experiments,the error rate of training phase of boosting algorithm is reduced from 30.2% to 8% after 10 iterations. Besides,this paper also compares boosting algorithm with Support Vector Machine (SVM) algorithm and shows that the classification accuracy of boosting algorithm is little better than SVM algorithm’s. However,the generalization ability of SVM algorithm is better than boosting algorithm.

关键词： Network security Intrusion Detection System (IDS) Machine learning Boosting algo-rithm Decision tree Support Vector Machine (SVM)

Porous γ-Fe_(2)O_(3) nanoparticle decorated with atomically dispersed platinum: Study on atomic site structural change and gas sensor activity evolution

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Nano Research 2021年第5期14卷 1435-1442页

作者： Qiheng Li Zhi Li qinghua zhang Lirong Zheng Wensheng Yan Xiao Liang Lin Gu Chen Chen Dingsheng Wang Qing Peng Yadong Li Department of Chemistry Tsinghua UniversityBeijing100084China School of Physical Sciences University of Chinese Academy of SciencesBeijing100190China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei230029China

Decorating semi-conducting metal oxide with noble metal has been recognized as a viable approach to improve the sensitivity of gas sensor. However, conventional method which relys on noble metal nanoparticles is confronted with drawback of significantly increased cost. To maximize the atom efficiency and reduce the cost for practical industrial application, designing sensor material with noble metal isolated single atom sites (ISAS) doping is a desired option. Here, we report an atomically dispersed platinum on one-dimensional arranged porous γ-Fe2O3 nanoparticle composites as highly efficient ethanol gas sensor. The optimized sample (Pt1-Fe2O3-ox) exhibited a high response (Ra/Rg = 102.4) and good selectivity to ethanol gas. It is demonstrated only the Pt single atom sites with high valance can effectively promote the adsorption capacity to ethanol and consequently enhance the sensitivity of sensing process by changing the electrical structure of Fe2O3 support. This work indicates the single atom sites could play a vital role in improving the performance of conventional metal oxides gas sensors and pave way for the exploration of ISAS-enhanced gas sensor for other volatile organic compounds (VOCs).

关键词： isolated single atom sites structure-activity relationship gas sensor nanocomposites

PM_(2.5)-bound polyhalogenated carbazoles(PHCZs)in urban Beijing,China:Occurrence and the source implication

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Journal of Environmental Sciences 2023年第9期131卷 59-67页

作者： Peijie Zuo Chu Wang Zengwei Li Dawei Lu Hao Xian Huili Lu Yin Dong Ruiqiang Yang Yingming Li Zhiguo Pei qinghua zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China The People’s Hospital of Yuhuan Yuhuan 317600China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Polyhalogenated carbazoles(PHCZs)are recently raising much attention due to their toxicity and ubiquitous environmental ***,little knowledge is known about their ambient occurrences and the potential *** this study,we developed an analytical method based on GC-MS/MS to simultaneously determine 11 PHCZs in PM_(2.5) from urban Beijing,*** optimized method provided low method limit of quantifications(MLOQs,1.45–7.39 fg/m^(3))and satisfied recoveries(73.4%–109.5%).This method was applied to analyze the PHCZs in the outdoor PM_(2.5)(n=46)and fly ash(n=6)collected from 3 kinds of surrounding incinerator plants(steel plant,medical waste incinerator and domestic waste incinerator).The levels of Σ_(11)PHCZs in PM_(2.5) ranged from 0.117 to 5.54 pg/m^(3)(median 1.18 pg/m^(3)).3-chloro-9H-carbazole(3-CCZ),3-bromo-9H-carbazole(3-BCZ),and 3,6-dichloro-9Hcarbazole(36-CCZ)were the dominant compounds,accounting for 93%.3-CCZ and 3-BCZ were significantly higher in winter due to the high PM_(2.5) concentration,while 36-CCZ was higher in spring,which may be related to the resuspending of surface ***,the levels of11PHCZs in fly ash ranged from 338 to 6101 pg/g.3-CCZ,3-BCZ and 36-CCZ accounted for 86.0%.The congener profiles of PHCZs between fly ash and PM_(2.5) were highly similar,indicating that combustion process could be an important source of ambient *** the best of our knowledge,this is the first research providing the occurrences of PHCZs in outdoor PM_(2.5).

关键词： Polyhalogenated carbazoles PM_(2.5) GC-MS/MS Combustion source