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Research progress and prospect of low-carbon biological technology for nitrate removal in wastewater treatment

Frontiers of Environmental Science & Engineering 2024年第7期18卷 1-21页

作者： Ru Zheng kuo zhang Lingrui Kong Sitong Liu College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China Key Laboratory of Water and Sediment Sciences Ministry of Education of ChinaBeijing 100871China Eco-Environment and Resource Efficiency Research Laboratory School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Wastewater treatment plants are the major energy consumers and significant sources of greenhouse gas emissions,among which biological nitrogen removal of wastewater is an important contributor to carbon ***,traditional heterotrophic denitrification still has the problems of excessive residual sludge and the requirement of external carbon ***,the development of innovative low-carbon nitrate removal technologies is *** review outlines the key roles of sulfur autotrophic denitrification and hydrogen autotrophic denitrification in low-carbon wastewater *** discovered nitrate/nitrite dependent anaerobic methane oxidation enables sustainable methane emission reduction and nitrogen removal by utilizing available methane in *** microorganisms exhibited a promising potential to achieve carbon-negative nitrate ***,the algal-bacterial symbiosis system and photogranules offer effective and prospective low-carbon options for nitrogen ***,the emerging nitrate removal technology of photoelectrotrophic denitrification and the underlying,photoelectron transfer mechanisms are ***,we summarize and prospect these technologies,highlighting that solar-driven biological nitrogen removal technology is a promising area for future sustainable wastewater *** review has important guiding significance for the design of low-carbon wastewater treatment systems.

关键词： Carbon emissions Low-carbon Biological nitrogen removal Denitrification

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The free triiodothyronine level correlates with myocardial injury and lipid-lowering effect of statin in patients with acute myocardial infarction

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中国循环杂志 2016年第Z1期31卷 -页

作者： kuo zhang Department of Cardiology Fuwai Hospital State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical Colege Beijing China

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Dynamic self-assembly of block copolymers regulated by time-varying building block composition via reversible chemical reaction

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Science China Chemistry 2019年第12期62卷 1666-1674页

作者： Duo Xu Li Zhao kuo zhang Zhong-Yuan Lu State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryJilin UniversityChangchun 130023China College of Life Sciences Jilin UniversityChangchun 130012China

Dynamic self-assembly processes occurring out of thermodynamic equilibrium underlie many forms of adaptive and intelligent behaviors in natural *** of the continuous input of energy,the dynamic self-assembly provides the opportunity for creating structures that are unattainable in equilibrium *** this paper,we propose a strategy in the dynamic self-assembly of amphiphilic block copolymers regulated by reversible chemical *** time-dependently tuning the reaction direction in the simulations,the amphiphilicity of building block keeps changing *** on this dynamic process,we can obtain exotic self-assembled vesicle with surface pores which is otherwise metastable in an equilibrium *** effects induced by the type of chemical reaction and the reaction period are *** at short reaction period in suitable reversible reaction,novel self-assembly structure *** is attributed to the competition of reaction and diffusion in the dynamic process,by which the local component of building blocks alters a lot,leading to large local surface tension resulting in the formation of perforated *** order to predict the assembled structure in a dynamic process,we build up the relationship between component ratio P,the diffusion effect parameter Pdiff and assembled *** dynamic self-assembly regulated by chemical reaction holds great promise as a rational strategy to realize exotic functional materials that are not easily obtained in equilibrium.

关键词： dynamic self-assembly block copolymer reversible reaction computer simulation

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Recent advances of transformable nanoparticles for theranostics

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Chinese Chemical Letters 2017年第9期28卷 1808-1816页

作者： kuo zhang Pei-Pei Yang Jing-Ping zhang Lei Wang Hao Wang School of Chemistry Northeast Normal University Changchun 130024 China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biological Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190 China

In recent years,various transformable nanoparticles（NPs）were successfully prepared and widely utilized for biomedical *** sizes,surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation,penetration,accumulation and retention *** other way round,the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of ***,we summarized recent advances of transformable NPs for disease diagnostics and *** this review,the transformation of NPs was divided into three groups including changes in size,surface charge and morphology,which was induced by internal stimuli,such as p H,enzyme,receptor or external stimuli,such as light,temperature ***,we focused on the characterization of structural transformation in vivo,as well as the transformation-induced biological effects for theranostics of disease.

关键词： Transformable Nanoparticles Tumor Imaging Therapy

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全髋关节置换后的低蛋白血症:危险因素及列线图预测模型建立

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中国组织工程研究 2025年第15期29卷 3147-3152页

作者：郑泽炜叶凯静张阔赵庆华陈秀天江禹来易艳梓张庆文广州中医药大学第三临床医学院广东省广州市510006 广州中医药大学惠州医院广东省惠州市516005 广州中医药大学第三附属医院关节中心广东省广州市510405

背景:患者接受全髋关节置换后多发低蛋白血症,影响术后愈合及康复。目的:探讨及筛选全髋关节置换后发生低蛋白血症的危险因素,建立列线图为临床中判断全髋关节置换后是否发生低蛋白血症提供指导。方法:共纳入行全髋关节置换患者355例,... 详细信息

背景:患者接受全髋关节置换后多发低蛋白血症,影响术后愈合及康复。目的:探讨及筛选全髋关节置换后发生低蛋白血症的危险因素,建立列线图为临床中判断全髋关节置换后是否发生低蛋白血症提供指导。方法:共纳入行全髋关节置换患者355例,根据术后第1天是否出现低蛋白血症分为低蛋白血症组238例、正常组117例,低蛋白血症发生率为67%。收集患者年龄、性别、糖尿病、高血压、高尿酸血症、高血脂、麻醉方式、置换前白细胞、置换前红细胞、置换前血红蛋白、置换前血小板、置换前血浆凝血酶原时间、置换前活化部分凝血酶原时间、置换前国际标准化比值、置换前凝血酶时间、置换前纤维蛋白原、置换前血沉、置换前C-反应蛋白、置换前D-二聚体、置换前平均红细胞血红蛋白含量、置换前平均红细胞体积、手术时间、体质量指数、置换前降钙素原、置换前红细胞压积等资料。利用SPSS 27.0软件进行单因素分析,随后利用R语言(4.3.1)再次对观察指标进行最小绝对收缩和选择算子回归分析及10倍交叉验证,取二者危险因素交集,使用SPSS 27.0进行多因素二元Logistic回归分析得到最终危险因素,通过R语言构建全髋关节置换后低蛋白血症的预测模型,并构建受试者特征曲线曲线、校准曲线、临床决策曲线评估预测模型预测能力。结果与结论:①经过单因素分析、最小绝对收缩和选择算子回归、多因素二元Logistic回归,筛选出年龄(OR=1.024,P=0.023)、置换前血小板(OR=0.995,P=0.028)、置换前血沉(OR=1.031,P=0.045)在判断置换后是否会发生低蛋白血症方面具有统计学意义(P<0.05);②基于多因素Logistic回归所筛选出的最终危险因素构建列线图预测模型,并通过构建受试者特征曲线评估模型预测能力,经计算受试者工作特征曲线的曲线下面积达到0.835(95%CI=0.779-0.891),C-index=0.835,经临床决策曲线计算,模型在阈值为0-0.83可带来更好的临床效能,该预测模型具有良好的灵敏度与准确性,可为医护人员及患者在全髋关节置换前更好地识别置换后发生低蛋白血症的风险。

关键词：全髋关节置换低蛋白血症危险因素预测模型列线图

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KLVFF peptide functionalized nanoparticles capture Aβ_(42) by co-assembly for decreasing cytotoxicity

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Chinese Chemical Letters 2018年第12期29卷 1811-1814页

作者： Peipei Yang Chao Yang kuo zhang Lei Wang Hao Wang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology (NCNST)

The accumulation of extracellular senile plagues of amyloid β-proteins(Aβ) in the patient brain is one of most important facture in Alzheimer’s disease(AD), which is resulted from abnormal self-assembly of Aβpeptide. Nanoparticles show greatly potential for therapeutic studies due to the sophisticated surface which can mimic the functionality of protein. Herein, we design the bis(pyrene)-Lys-Leu-Val-Phe-PheGly-poly ethylene glycol(BP-KLVFFGPEG) based nanoparticles, which capture Aβthrough recognition and co-assembly of KLVFF. The resulting co-assemblies show different morphologies, such as large aggregates, nanoparticles and nanofibers corresponding to the different length chain of PEG, leading to different capture efficiencies. The co-assembly strategy shows a decrease of cytotoxicity, potentially for AD treatment.

关键词： Co-assembly Morphology Capture Nanoparticles Aβ

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Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice

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Neural Regeneration Research 2024年第2期19卷 416-424页

作者： Guixiang Wang Wenjia Wang Ye zhang Xiaoying Gou Qingqing zhang Yanmiao Huang kuo zhang Haotian zhang Jingyu Yang Yuting Li Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning ProvinceChina Department of Pharmacology Shenyang Pharmaceutical UniversityShenyangLiaoning ProvinceChina

Adolescent binge drinking leads to long-lasting disorders of the adult central nervous system,particularly aberrant hippocampal *** this study,we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells(NSCs)and dendritic spine formation of newborn neurons in the subgranular zone of the dentate *** found abnormal orientation of tamoxifen-induced tdTomato+(tdTom^(+))NSCs in adult mice 2 months after treatment with EtOH(5.0 g/kg,i.p.)for 7 consecutive *** markedly inhibited tdTom^(+)NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to ***(100 mM)also significantly inhibited the proliferation to 39.2%and differentiation of primary NSCs in *** mice exposed to EtOH also exhibited marked inhibitions in dendritic spine growth and newborn neuron maturation in the dentate gyrus,which was partially reversed by voluntary running or inhibition of the mammalian target of rapamycinenhancer of zeste homolog 2 *** vivo tracing revealed that EtOH induced abnormal orientation of tdTom+NSCs and spatial misposition defects of newborn neurons,thus causing the disturbance of hippocampal neurogenesis and dendritic spine remodeling in mice.

关键词： adolescence adulthood ethanol dentate gyrus EZH2 in vivo tracing lineage progression mTOR neural stem cell newborn dendritic spine newborn neurons

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Metallogenesis and ore-forming time of the Changtuxili Mn-Ag-Pb-Zn deposit in Inner Mongolia:Evidence from C-O-S isotopes and U-Pb geochronology

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Geoscience Frontiers 2020年第4期11卷 1369-1380页

作者： kuo zhang Ruo-Shi Jin Feng-Yue Sun Bi-Le Li Peng He Yue-Long zhang Shuo Guo Tian-Fu zhang College of Earth Sciences Jilin UniversityChangchun130061China Tianjin Center China Geological SurveyTianjin300170China North China Center for Geoscience Innovation Tianjin300170China Qiqihar Branch Heilongjiang Institute of Geological Survey and ResearchQiqihar150036China

This paper reports new geochronological(U-Pb) and isotope(C,O,and S) data to investigate the timing of mineralization and mode of ore genesis for the recently discovered Changtuxili Mn-Ag-Pb-Zn deposit,located on the western slopes of the southern Great Hinggan Range in NE *** mineralization is hosted by intermediate-acidic lavas and pyroclastic rocks of the Baiyingaolao *** stages of mineralization are identified:quartz-pyrite(Stage I),galena-sphalerite-tetrahedrite-rhodochrosite(Stage II),and quartz-pyrite(Stage Ⅲ).δ13C and δ18O values for carbonate from the ore vary from-8.51‰ to-4.96‰ and 3.97‰ to 15.90‰,respectively,which are indicative of a low-temperature alteration environment.δ34SV-CDT values of sulfides range from-1.77‰ to 4.16‰ and show a trend of equilibrium fractionation(δ34SPy>δ34SSp>δ34SGn).These features indicate that pyrite,sphalerite,and galena precipitated during the period of *** alteration mineral assemblage and isotope data indicate that the weakly acidic to weakly alkaline ore-forming fluid was derived largely from meteoric water and the ore-forming elements C and S originated from *** the mineralization,a geochemical barrier was formed by changes in the pH of the ore-forming fluid,leading to the precipitation of *** the basis of the mineralization characteristics,new isotope data,and comparison with adjacent deposits,we propose that the Changtuxili Mn-Ag-Pb-Zn deposit is an intermediate-to lowsulfidation epithermal deposit whose formation was controlled by fractures and variability in the pH of the oreforming *** surrounding volcanic rocks yield zircon U-Pb ages of 160-146 Ma(Late Jurassic),indicating that the mineralization is younger than 146 Ma.

关键词： Inner Mongolia Changtuxili Mn-Ag-Pb-Zn deposit C-O-S isotope geochemistry Zircon U-Pb age Intermediate-to low-sulfidation epithermal deposit

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A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis

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Chinese Chemical Letters 2020年第12期31卷 3153-3157页

作者： Shifang Wen kuo zhang Yuan Li Jiaqi Fan Ziming Chen Jjingping zhang Hao Wang Lei Wang Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China

Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and *** on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR *** report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix(ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR *** transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in *** addition,the transformable peptide-based nanomate rial forms ECM-like fibrous netwo rks on VEGFR overexpressed cells,inhibiting the VEGF-VEGFR interactions and the subsequent *** tube formation is reduced by nearly 85.1% after *** strategy shows excellent potential for anti-angiogenesis,and inhibition of tumor invasion and metastasis.

关键词： Self-assembly Peptide VEGF Angiogenesis Biomimetic

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Keyword Extraction Based on tf/idf for Chinese News Document

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Wuhan University Journal of Natural Sciences 2007年第5期12卷 917-921页

作者： LI Juanzi FAN Qi＇na zhang kuo Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Keyword extraction is an important research topic of information retrieval. This paper gave the specification of keywords in Chinese news documents based on analyzing linguistic characteristics of news documents and then proposed a new keyword extraction method based on tf/idf with multi-strategies. The approach selected candidate keywords of uni-, hi- and tri-grams, and then defines the features according to their morphological characters and context information. Moreover, the paper proposed several strategies to amend the incomplete words gotten from the word segmentation and found unknown potential keywords in news documents. Experimental results show that our proposed method can significantly outperform the baseline method. We also applied it to retrospective event detection. Experimental results show that the accuracy and efficiency of news retrospective event detection can be significantly improved.

关键词： keyword extraction keyphrase extraction news keyword

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