A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis

作     者：Shifang Wen Kuo Zhang Yuan Li Jiaqi Fan Ziming Chen Jjingping Zhang Hao Wang Lei Wang Shifang Wen;Kuo Zhang;Yuan Li;Jiaqi Fan;Ziming Chen;Jingping Zhang;Hao Wang;Lei Wang

作者机构：Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第12期

页      面：3153-3157页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.51890891,51725302,21807020,51573031 and 51573032) National Key R&D Program of China(No.2018YFE0205400) Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505) 

主　　题：Self-assembly Peptide VEGF Angiogenesis Biomimetic 

摘      要：Vascular endothelial growth factor(VEGF)-vascular endothelial growth factor receptor(VEGFR)pathways are essential in tumor angiogenesis,growth and *** on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR *** report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix(ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR *** transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in *** addition,the transformable peptide-based nanomate rial forms ECM-like fibrous netwo rks on VEGFR overexpressed cells,inhibiting the VEGF-VEGFR interactions and the subsequent *** tube formation is reduced by nearly 85.1% after *** strategy shows excellent potential for anti-angiogenesis,and inhibition of tumor invasion and metastasis.