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Formation and thermal stability of amorphous Ni-Mo-P alloys

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 147-151页

作者： zhang Yi MA jun fang Yong-kui DUAN Ji-guo School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090 China College of Chemistry and Chemical Engineering Daqing Petroleum Institute Daqing 163318 China College of Chemistry and Chemical Engineering Daqing Petroleum Institute Daqing 163318 China School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090 China School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090 China

The experimental researches on the chemical deposition of Ni-Mo-P amorphous alloys were carried out by adding Na2 MoO4 into acidic solutions. The optimum technology conditions were obtained by orthogonal design experiments. The structures and the relationship between compositions and their thermal stability were studied by energy spectrum (EC), scanning electron micrograph and X-ray diffraction spectrum. Compared with Ni-P amorphous alloys, the Ni-Mo-P amorphous alloys have high crystallization temperature and thermal stability, and the hardness reaches its peak when the annealing temperature is 500 ℃. With the increase of the heat treatment temperature, the surface morphology of the alloys changes.

关键词： chemical deposition Ni-Mo-P alloy amorphous phase crystallization

Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

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Chinese Journal of Natural Medicines 2020年第12期18卷 934-940页

作者： KANG Li-Hua zhang Guo-Wei zhang jun-fang QIN Bai GUAN Huai-Jin Eye Institute Affiliated Hospital of Nantong UniversityNantong 226000China

A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract *** acid A(GAA),an effective lanostane triterpene,is widely reported as an *** aim of this study is to investigate the potential effects of GAA on cataract *** lens epithelial cells(LECs)were exposed to UVB radiation for different periods,cell viability,apoptosis-related protein levels,malondialdehyde(MDA)and superoxide dismutase(SOD)activities were *** found that cell viability,the Bcl-2/Bax ratio and SOD activity were increased,while Cleaved caspase-3 levels and MDA activity were decreased compared with those in UVB-impaired LECs after GAA ***,GAA activated PI3 K/AKT in UVB-impaired LECs and effectively delayed the occurrence of lens opacity in *** conclusion,these findings demonstrated that GAA exhibited protective functions in SRA01/04 cells and rat lenses against UVB-evoked impairment through elevating cell viability and antioxidant activity,inhibiting cell apoptosis,activating the PI3 K/AKT pathway and delaying lens opacity.

关键词： Ganoderic acid A Cataract Lens epithelial cells Cell vitality Apoptosis

CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes

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World Journal of Gastroenterology 2005年第29期11卷 4530-4535页

作者： Lie-Gang Liu Hong Yan Ping Yao Wen zhang Li-jun Zou fang-fang Song Ke Li Xiu-Fa Sun Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To observe the relationship between ethanol-induced oxidative damage in human primary cultured hepatocytes and cytochrome P450 2E1 （CYP2E1） activity, in order to address if inhibition of CYP2E1 could attenuate ethanol- induced cellular damage. METHODS： The dose-dependent （25-100 mmol/L） and time-dependent （0-24 h） exposures of primary human cultured hepatocytes to ethanol were carried out. CYP2E1 activity and protein expression were detected by spectrophotometer and Western blot analysis respectively. Hepatotoxicity was investigated by determination of lactate dehydrogenase （LDH） and aspartate transaminase （AST） level in hepatocyte culture supernatants, as well as the intracellular formation of malondialdehyde （MDA）. RESULTS： A dose-and time-dependent response between ethanol exposure and CYP2E1 activity in human hepatocytes was demonstrated. Moreover, there was a time-dependent increase of CYP2E1 protein after 100 mmol/L ethanol exposure. Meanwhile, ethanol exposure of hepatocytes caused a time-dependent increase of cellular MDA level, LDH, and AST activities in supernatants. Furthermore, the inhibitor of CYP2E1, diallyl sulfide （DAS） could partly attenuate the increases of MDA, LDH, and AST in human hepatocytes. CONCLUSION： A positive relationship between ethanolinduced oxidative damage in human primary cultured hepatocytes and CYP2E1 activity was exhibited, and the inhibition of CYP2E1 could partly attenuate ethanol-induced oxidative damage.

关键词： Ethanol CYP2E1 Oxidative damage, Human primary hepatocytes

Expression and Emmprin Regulated Function of Aquaporinl in SMMC7221 Cells

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Chemical Research in Chinese Universities 2010年第4期26卷 578-582页

作者： LI Jiang zhang Ai-li TONG Qian zhang jun-fang LI Hai-jing ZHAO Bing MA Tong-hui LI Xiao-men School of Life Sciences Northeast Normal University Changchun 130024 P. R. China Dental Hospital First Hospital Jilin University Changehun 130021 P. R. China Department of Cardiology First Hospital Jilin University Changehun 130021 P. R. China

Herein lie the crosstalk and regulation between AQP1 and Emmprin in SMMC7221 cells by means of siRNA technology and deglycosylation method. Firstly, HAQP1, rather than hAQP3, was selectively upregulated in SMMC7221 cells by FBS, flollowed by the upregulated expression of Emmprin. Emmprin gene silencing caused a remarkable change in the expression ofAQP1 gene, just like its downstream gene, MMP9, meanwhile the water permeability and cell migration were also descended prominently. Furthermore, when treated with tunicamycin, Emmprin was deglycosylated, which made the expression of AQP 1 significantly declined, followed by remarkably decreased cell membrane water permeability and cell migration. Taken together, all the data indicates the expression level and the modification of Emmprin by glycosylation are the key factors in regulating the expression of AQP1.

关键词： Aquaporinl Emmprin Cell migration

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人工智能产业发展及全球化资源配置研究

中国软科学 2017年第S1期 131-141页

作者：张俊芳中国科学技术发展战略研究院北京100038

从人工智能产业对社会经济的影响入手,分析全球人工智能产业的发展与布局,对未来产业发展规模及融资需求进行了测度,并从主要国家的总体战略与资金部署、产业界科技巨头并购行动,以及全球风险投资等方面对行业发展的全球资源配置进行梳... 详细信息

从人工智能产业对社会经济的影响入手,分析全球人工智能产业的发展与布局,对未来产业发展规模及融资需求进行了测度,并从主要国家的总体战略与资金部署、产业界科技巨头并购行动,以及全球风险投资等方面对行业发展的全球资源配置进行梳理与分析.研究认为,从目前全球资金配置情况来看,中国亟需在人工智能领域,特别是基础性研究阶段进行战略性资金部署,形成财政资金、金融资本、社会资本等多方支持的局面.

关键词：人工智能资源配置财政资金风险投资

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基于改进模糊神经网络的配电网故障选线研究

电力系统保护与控制 2010年第22期38卷 120-125页

作者：张俊芳刘鹏南京理工大学江苏南京210094 南京南瑞继保电气有限公司江苏南京211106

在配电网中广泛采用小电流接地方式,传统的单一单相接地故障选线方法适用范围有限。针对单一故障选线方法的不足,提出利用模糊神经网络对多种选线方法进行融合。采用基于小波包从零序电流中提取暂态能量分量和暂态方向分量,和基于FFT从... 详细信息

在配电网中广泛采用小电流接地方式,传统的单一单相接地故障选线方法适用范围有限。针对单一故障选线方法的不足,提出利用模糊神经网络对多种选线方法进行融合。采用基于小波包从零序电流中提取暂态能量分量和暂态方向分量,和基于FFT从零序电流中提取稳态基波分量和五次谐波分量作为故障选线的特征分量。设计模糊神经网络的结构并进行改进,采用BP学习算法。在Matlab 7.1环境下搭建10kV配电网模型,分别仿真不同的故障位置、故障合闸角、故障接地类型和故障线路的故障以验证理论的有效性。

关键词：故障选线稳态基波分量五次谐波分量暂态方向分量暂态能量分量小波包模糊神经网络

A New Statistic for Variable Selection in Questionnaire Analysis

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Journal of Systems Science and Systems Engineering 2001年第3期13卷 315-322页

作者： zhang jun-hua, fang Wei-wu Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Institute of Applied Mathematics Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

In this paper, a new statistic is proposed for variable selection which is one of the important problems in analysis of questionnaire data. Contrasting to other methods, the approach introduced here can be used not on... 详细信息

关键词： questionnaire variable selection information divergence statistic

StreamJacobi： Efficient implementation of 2-D Jacobi on a stream processor

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通讯和计算机（中英文版） 2009年第1期6卷 6-15页

作者： zhang Ying LI Gen YANG Xue-jun zhang Wei fang Xu-dong zhang He-ying School of Computer National University of Defense Technology Changsha Hunan 410073 China

Effects of Hydroxyethyl Starch 130/0.4 Pretreatment on Endotoxin-InducedAcute Lung Injury in Rats

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麻醉与监护论坛 2010年第3期17卷 174-179页

作者： Wei zhang Cai fang jun Ma Yan-hu Xie Juan Li Department of Anesthesiology Affiliated Anhui Provincial Hospital of Anhui Medical University Hefei 230001 China