Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

作     者：KANG Li-Hua ZHANG Guo-Wei ZHANG Jun-Fang QIN Bai GUAN Huai-Jin KANG Li-Hua;ZHANG Guo-Wei;ZHANG Jun-Fang;QIN Bai;GUAN Huai-Jin

作者机构：Eye InstituteAffiliated Hospital of Nantong UniversityNantong 226000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2020年第18卷第12期

页      面：934-940页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81770906 and 81974129) the Science and Technology Project of Nantong Municipality(Nos.JCZ19088 and JCZ19077) the Project of Nantong Municipal Health Commission(No.QA2019061) 

主　　题：Ganoderic acid A Cataract Lens epithelial cells Cell vitality Apoptosis 

摘      要：A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract *** acid A(GAA),an effective lanostane triterpene,is widely reported as an *** aim of this study is to investigate the potential effects of GAA on cataract *** lens epithelial cells(LECs)were exposed to UVB radiation for different periods,cell viability,apoptosis-related protein levels,malondialdehyde(MDA)and superoxide dismutase(SOD)activities were *** found that cell viability,the Bcl-2/Bax ratio and SOD activity were increased,while Cleaved caspase-3 levels and MDA activity were decreased compared with those in UVB-impaired LECs after GAA ***,GAA activated PI3 K/AKT in UVB-impaired LECs and effectively delayed the occurrence of lens opacity in *** conclusion,these findings demonstrated that GAA exhibited protective functions in SRA01/04 cells and rat lenses against UVB-evoked impairment through elevating cell viability and antioxidant activity,inhibiting cell apoptosis,activating the PI3 K/AKT pathway and delaying lens opacity.