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Science China(Technological Sciences) 2024年第2期67卷 395-407页

作者： zhang jiexin NIE PingYun zhang Bo State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction ***,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure *** method ensures the tracking error converges in a finite time,even when the system faces *** method also preserves the passivity of the ***,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity *** observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation *** particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot *** effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints.

关键词： motion control elastic joint robot finite-time convergence high-order system state estimation physical human-robot interaction

肾透明细胞癌患者肾组织干扰素调节因子6基因启动子区甲基化与总生存率的相关性研究

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中华医学遗传学杂志 2024年第2期41卷 150-156页

作者：张洁心陈灿卫宇昂陈林媛邵鹏飞徐华国南京医科大学第一附属医院检验学部南京210029 南京医科大学第一附属医院泌尿外科南京210029

目的探讨干扰素调节因子6(IRF6)基因启动子甲基化在判断肾透明细胞癌(KIRC)患者预后中的价值。方法收集2016年1月至2020年1月在南京医科大学第一附属医院首诊的50例KIRC患者的原发灶组织,采用免疫组化法检测其IRF6蛋白的表达情况,并分析... 详细信息

目的探讨干扰素调节因子6(IRF6)基因启动子甲基化在判断肾透明细胞癌(KIRC)患者预后中的价值。方法收集2016年1月至2020年1月在南京医科大学第一附属医院首诊的50例KIRC患者的原发灶组织,采用免疫组化法检测其IRF6蛋白的表达情况,并分析IRF6表达水平与患者生存及肿瘤转移的关系。使用生物信息学方法分别比较KIRC和正常肾组织中IRF6的mRNA及蛋白水平差异,基于大数据库分析癌和癌旁组织中IRF6基因启动子区甲基化率差异;将IRF6基因启动子区甲基化状态与患者总生存率(OS)进行统计分析,筛选出呈现显著负相关的区域,利用细胞系体外验证该启动子区甲基化区域与IRF6转录水平的关系。结果KIRC组织中IRF6 mRNA和蛋白水平均显著低于正常样本(P<0.05),该现象在死亡或发生肿瘤转移的KIRC患者中较为突出。KIRC组织中IRF6基因启动子区甲基化程度远高于临近正常肾组织,并且IRF6基因启动子区甲基化与IRF6 mRNA之间存在显著负相关性(R=-0.52)。IRF6基因启动子区域cg12034118和cg16030177的甲基化程度越高,患者OS越短且预后越差;体外KIRC细胞系实验证实,仅cg12034118中有20个CpG位点呈高度甲基化,使用去甲基化试剂5-Aza-CdR处理KIRC细胞系后IRF6转录水平可呈时间和剂量依赖显著性上调(P<0.05)。结论KIRC患者肾组织中IRF6基因启动子区甲基化与OS密切相关。cg12034118提示可作为供实验室检测的生物标志物,其高甲基化率对KIRC患者的预后判断有一定参考价值。

关键词：干扰素调节因子6 肾透明细胞癌甲基化总生存率

高水平临床研究推动肺动脉高压危险分层内涵发展

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科学通报 2024年第13期69卷 1715-1724页

作者：路丹张洁馨程春燕杨尹鉴刘滕飞张苏欣邱宝晨李贤美郭帆黎婧怡徐希奇孙凯荆志成北京大学航天临床医学院航天中心医院心脏医学部北京100049 中国医学科学院北京协和医学院北京协和医院心内科北京100730 南方医科大学附属广东省人民医院(广东省医学科学院) 广东省心血管病研究所广州510180 中国医学科学院北京协和医学院北京协和医院医学科学研究中心北京100730

肺动脉高压是一种疑难危重罕见病,一直以来被视为“心血管系统的癌症”,患者预后极差.对疾病进行危险分层可以帮助临床医生判断患者病情、指导治疗、评价疗效和预测预后,这需要大量的临床研究作为依据.高水平临床研究是解决临床实践问... 详细信息

肺动脉高压是一种疑难危重罕见病,一直以来被视为“心血管系统的癌症”,患者预后极差.对疾病进行危险分层可以帮助临床医生判断患者病情、指导治疗、评价疗效和预测预后,这需要大量的临床研究作为依据.高水平临床研究是解决临床实践问题的重要手段,我国肺动脉高压队列有着独特的特点,学习和借鉴国外肺动脉高压危险分层发展经验,对建立符合我国肺动脉高压人群的危险分层具有重要意义.本文以肺动脉高压危险分层发展为例,旨在深入剖析通过高水平临床研究解决临床问题的过程与方法.文章概述了肺动脉高压的发现与流行,明确了定义与深入开展临床研究的全过程;重点围绕靶向药治疗时代下肺动脉高压危险分层的建立与更新,总结临床研究推动肺动脉高压诊疗指南和治疗理念不断发展的方式方法;最后通过分析肺动脉高压危险分层在我国的应用现状和问题,希望国外研究肺动脉高压危险分层的思维方式对我国开展临床研究、解决临床实践中的问题有所启示.

关键词：临床研究肺动脉高压危险分层预后预测模型

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新工科视角下汽车构造课程思政建设研究

时代汽车 2024年第14期 81-83页

作者：王瀚张洁馨朱容芳邬忠萍成都工业学院汽车与交通学院四川成都611730

深入研究不同专业课程的特色与优势,挖掘知识体系中的思想价值与精神内涵,是高校课程思政建设过程中的必要措施。汽车构造作为汽车服务工程、车辆工程等汽车类专业的基础课程,对汽车专业培养体系起到重要作用。文章在“新工科”建设发... 详细信息

深入研究不同专业课程的特色与优势,挖掘知识体系中的思想价值与精神内涵,是高校课程思政建设过程中的必要措施。汽车构造作为汽车服务工程、车辆工程等汽车类专业的基础课程,对汽车专业培养体系起到重要作用。文章在“新工科”建设发展的要求下,结合专业特点,对该课程知识体系中所蕴含的思想价值和精神内涵进行提炼总结,将“爱国主义情怀、大国工匠精神、创新精神、责任与担当”作为汽车构造课程思政的五大核心要素,并以此为中心对课程内容包含的思政元素深入挖掘。同时文章也提出“四协同”的课程思政建设方式将课程的思政元素与汽车构造课程内容进行有机融合,将隐性教育灵活渗透到显性教育中,发挥专业课程的育人作用,推进汽车构造课程思政建设,实现立德树人的根本目标。

关键词：课程思政新工科课程建设汽车构造

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Boosting rate and cycling performance of K-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) cathode for high-energy-density sodium-ion batteries

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Green Energy & Environment 2022年第6期7卷 1253-1262页

作者： jiexin zhang YangYang Lai Peng Li Yanxia Wang Faping Zhong Xiangming Feng Weihua Chen Jianjun Liu Xinping Ai Hanxi Yang Yuliang Cao Engineering Research Center of Organosilicon Compounds&Materials of Ministry of Education College of Chemistry and Molecular SciencesWuhan UniversityWuhan430072China National Engineering Research Center of Advanced Energy Storage Materials Hunan410205China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou450001China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai200050China

As a promising cathode material,Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)has attracted wide attention for sodium-ion batteries(SIBs)because of its high operating voltage and high structural ***,the low intrinsic electronic conductivity and insufficient Na ion mobility of NVPF limit its ***,K-doping NVPF is prepared through a facile ball-milling combined calcination *** effects of K-doping on the crystal structure,kinetic properties and electrochemical performance are *** results demonstrate that the Na_(2.90)K_(0.10)V_(2)(PO_(4))_(3)F_(3)(K0.10-NVPF)exhibits a high capacity(120.8 mAh g^(-1) at 0.1 C),high rate capability(66 mAh g^(-1) at 30 C)and excellent cycling performance(a capacity retention of 97.5%at 1 C over 500 cycles).Also,the occupation site of K ions in the lattice,electronic band structure and Na-ion transport kinetic property in K-doped NVPF are investigated by density functional theory(DFT)calculations,which reveals that the K-doped NVPF exhibits improved electronic and ionic conductivities,and located K^(+) ions in the lattice to contribute to high reversible capacity,rate capability and cycling ***,the K-doped NVPF serves as a promising cathode material for high-energy and high-power SIBs.

关键词： Potassium doping Na_(3)V_(2)(PO_(4))_(2)F_(3) Cathode materials Sodium ion batteries Long-term stability

China-Malaysia Tourism Getting Overall Recovery

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China & The World Cultural Exchange 2023年第3期 10-11页

作者： zhang jiexin 不详

With the adjustment of China's domestic policies,outbound travel by Chinese groups,with destinations of 20 countries including Malaysia,is getting recovery in an orderly way,and outbound travel by Chinese tour groups ... 详细信息

关键词： travel Malaysia destination

Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization

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Bioactive Materials 2022年第8期7卷 416-429页

作者： Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan jiexin zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart CenterSino-Japanese Cooperation Platform for Translational Research in Heart FailureZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Biomaterials Research Center School of Biomedical EngineeringSouthern Medical UniversityGuangzhou510515China Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Medical BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell *** direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical *** reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial *** this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics *** results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the *** addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1α*** brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization.

关键词： Artificial stem cells Exosomes Myocardial infarction Coronary collateralization

Surface-engineering enhanced sodium storage performance of Na_3V_2(PO_4)_3 cathode via in-situ self-decorated conducting polymer route

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Science China Chemistry 2017年第12期60卷 1546-1553页

作者： jiexin zhang Tianci Yuan Haiying Wan Jiangfeng Qian Xinping Ai Hanxi Yang Yuliang Cao Hubei Key Laboratory of Electrochemical Power Sources College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China Jincheng Abound Energy Ltd. Jincheng 048000 China

The key to the development of sodium ion battery is materials with a high rate capacity and cycle stability. Conducting coating is an efficient approach to improve electrochemical performance. As a case study, the Na_3V_2(PO_4)_3@PEDOT composite was prepared through an in-situ self-decorated conducting polymer route without further calcination. The Na_3V_2(PO_4)_3 electrode with a 7%poly(3,4-ethylenedioxythiophene)(PEDOT) coating can deliver an initial reversible capacity of 100 mA h g^(-1) at 1 cycle, and 82%capacity retention over 200 cycles. The results also show that the Na_3V_2(PO_4)_3 electrode without and with a thick PEDOT coating exhibits poor electrochemical performance, indicating that an appropriate coating layer is important for improving electronic conductivity and regulating Na-ion insertion. Therefore, this work offers possibility to promote the electrochemical performance of poor-conducting materials in sodium-ion batteries using an in-situ self-decorated conducting polymer.

关键词： PEDOT Na3V2(PO4)3 surface coating cathode sodium ion batteries

Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides

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Nano Research 2024年第3期17卷 1473-1481页

作者： Yue Ouyang Xiaoxiao Li jiexin Zhu Wei Zong Yuhang Dai Xuan Gao Wei zhang Shengyuan Yang Roohollah Bagherzadeh Feili Lai Yue-E Miao Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Advanced Fibrous Materials LAB Institute for Advanced Textile Materials and Technologies(ATMT)School of Advanced Materials and ProcessesAmirkabir University of TechnologyTehran 15914Iran Christopher Ingold Laboratory Department of ChemistryUniversity College London20 Gordon StreetLondon WC1H 0AJUK Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)***,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur *** the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur ***,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume *** expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 ***,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions.

关键词： interface-induced polymerization electrospun porous nanofibers lithium-sulfur(Li-S)batteries high sulfur loading lithium polysulfides(LiPSs)immobilization

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通信网络中的数据库缓存策略与性能优化

通信电源技术 2024年第1期41卷 182-184页

作者：陈汝鹏焦枫张洁心中通服咨询设计研究院有限公司江苏南京210019 中通服网盈科技有限公司江苏南京210019

在通信网络中,数据库的性能优化至关重要,以确保高并发访问和实时数据需求的满足。针对通信网络数据库面临的大规模、高并发访问的特殊需求和挑战,深入研究了数据库缓存策略与性能优化。通过基于内容的缓存策略和基于访问模式的缓存策... 详细信息

在通信网络中,数据库的性能优化至关重要,以确保高并发访问和实时数据需求的满足。针对通信网络数据库面临的大规模、高并发访问的特殊需求和挑战,深入研究了数据库缓存策略与性能优化。通过基于内容的缓存策略和基于访问模式的缓存策略的优化方法,结合数据存储引擎的选择、数据分区与分片、缓存与持久性的平衡以及数据压缩与编码等关键策略,提出了一套完整的性能提升解决方案,以满足通信网络数据库在实时响应、高并发访问方面的需求。

关键词：通信网络数据库缓存策略性能优化内容识别访问模式