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Aromatic Amide Polymers that Form Two Helical Conformations with Twist Sense Bias in Water

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Chinese Journal of Chemistry 2016年第7期34卷 678-682页

作者： Peng zhang Zekun Wang Liang zhang Hui Wang danwei zhang Junli Hou Zhanting Li Department of Chemistry Collaborative Innovation Centre of Chemistry for Energy Materials ( iChEM) Fudan University Shanghai 200433 China

Two benzene/2,2＇-bipyridine-alternately incorporated amide polymers have been prepared, which are driven by hydrophobicity to form two different helical conformations. Both helices exhibit twist sense bias in water i... 详细信息

关键词： foldamer twist sense bias helix aromatic amide polymer

狂犬病病毒感染N2a细胞引起的转录体差异表达

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中国兽医学报 2024年第8期44卷 1682-1690页

作者：刘晓敏郭艺迪果鑫张艳楠王重阳汪滋辰张丹玮张茂林吉林大学动物医学学院人兽共患病研究教育部重点实验室吉林长春130062

狂犬病是一种人畜共患疾病,对全球公共卫生构成极大威胁。狂犬病病毒(RABV)呈嗜神经性传播,会引发宿主严重的神经功能紊乱,致死率几乎100%。为鉴定RABV影响神经细胞功能的重要基因,本研究采用RNA测序(RNA-seq)方法建立并分析了固定毒株C... 详细信息

狂犬病是一种人畜共患疾病,对全球公共卫生构成极大威胁。狂犬病病毒(RABV)呈嗜神经性传播,会引发宿主严重的神经功能紊乱,致死率几乎100%。为鉴定RABV影响神经细胞功能的重要基因,本研究采用RNA测序(RNA-seq)方法建立并分析了固定毒株CVS-11感染小鼠神经母细胞瘤细胞(Neuro-2a,N2a)的mRNA表达谱,并通过基因本体(GO)和京都基因与基因组百科全书(KEGG)富集分析确定差异表达基因(DEGs)。结果显示,在CVS-11毒株感染的N2a中,共有415个差异表达基因,其中89个为上调基因,326个为下调基因。差异表达基因涉及多种生物学过程,包括轴突传导信号通路、胆固醇代谢通路、氮代谢信号通路、鞘糖脂生物合成信号通路等,其中多种DEGs已被证明与RABV感染密切相关,从中挑选出12个与轴突传导、抗原处理与呈递等通路相关的差异表达基因进行实时荧光定量PCR验证,其变化趋势与RNA-seq结果一致。本研究检测了神经细胞在RABV感染条件下基因转录组变化,为探究RABV感染对神经细胞功能的影响机制提供了新的线索。

关键词：狂犬病病毒 N2a细胞神经系统转录组

N-H…X(X=F,Cl,Br,and Ⅰ)hydrogen bonding in aromatic amide derivatives in crystal structures

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Science China Chemistry 2012年第10期55卷 2018-2026页

作者： WANG DongYun WANG JiLiang zhang danwei LI ZhanTing Department of Chemistry Fudan UniversityShanghai 200433China

Intramolecular N H···X (X=F, Cl, Br, and Ⅰ) hydrogen bonding patterns of aromatic amides in the solid state are summarized. It is revealed that the key for the formation of this kind of weak intramolecular hydrogen bonding in X-ray crystal structures is to suppress the competition of strong intermolecular N H···O C hydrogen bonding of the amide unit. For amides with identical backbones, the bonding capacity of halogen atoms as hydrogen bonding acceptors is in the order of F>Cl>Br>I, which is in accordance with their electronegativity strength. Generally, the five-membered hydrogen bonding is easier to form than the six-membered one.

关键词： hydrogen bond halogen acceptor aromatic amide X-ray crystallography

Social support and long-term health outcomes after acute myocardial infarction:the China PEACE Prospective AMI Study

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中国循环杂志 2018年第S1期 117-118页

作者： Xiqian Huo Xueke Bai Lihua zhang Qianying Wang Xiuling Wang danwei zhang Lixin Jiang China Oxford Center for International Health Research National Center for Cardiovascular Diseases Fuwai HospitalCAMS and PUMC

Background Social support is an important predictor of prognosis after acute myocardial infarction (AMI) in western populations,with previous studies suggested that social support may influence cardiovascular prognosi...

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Risk factors associated with post percutaneous coronary intervention bleeding in China

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中国循环杂志 2018年第S1期 111-112页

作者： Xueke Bai Xiqian Huo Yun Wang Shuang Hu Jiapeng Lu Chaoqun Wu Qianying Wang Yeyong Li danwei zhang Lixin Jiang National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biostatistics Harvard T.H.Chan School of Public Health Center for Outcomes Research and Evaluation Yale New Haven Hospital Richard and Susan Smith Center for Outcomes Research in Cardiology Division of Cardiology Beth Israel Deaconess Medical and Harvard Medical School

Objective Bleeding complications after PCI is an independent risk factor for mortality and prolongs hospital stay, while the knowledge about risk factors associated with the post-PCI bleeding among Chinese patients re...

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分子内氢键促进的大环合成:动力学和热力学控制途径

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有机化学 2012年第11期32卷 2009-2017页

作者：张丹维黎占亭复旦大学化学系上海200433

氢键诱导的线性芳酰胺寡聚体骨架可以采取折叠、螺旋、直线或"之"字型构象.这一结构预组织特征可以被应用于促进大环的合成.在芳酰胺骨架的两端引入适当反应基团,骨架的预组装构象可以诱导它们形成不同的空间取向和距离.当成环反应涉及... 详细信息

氢键诱导的线性芳酰胺寡聚体骨架可以采取折叠、螺旋、直线或"之"字型构象.这一结构预组织特征可以被应用于促进大环的合成.在芳酰胺骨架的两端引入适当反应基团,骨架的预组装构象可以诱导它们形成不同的空间取向和距离.当成环反应涉及到不可逆共价键、碳-金属键或配位键的形成时,前体的结构预组织构象可以促进目标大环形成的产率.当成环反应涉及亚胺及腙等可逆共价键时,在反应达到热力学平衡后,可以高产率或定量地形成大环.

关键词：氢键大环芳香酰胺亚胺动力学控制反应热力学控制反应

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水溶性三维有序超分子和共价有机聚合物

高等学校化学学报 2020年第6期41卷 1139-1150页

作者：张丹维王辉黎占亭复旦大学化学系上海市分子催化与功能材料重点实验室上海200438

总结了近年来在水溶性三维超分子聚合物、超分子有机框架、超分子-金属有机框架杂化结构、超分子-共价-金属有机框架杂化结构及共价有机框架合成\,催化和输送功能方面的研究进展,指出了有序三维聚合物未来研究面临的挑战并展望今后的发... 详细信息

总结了近年来在水溶性三维超分子聚合物、超分子有机框架、超分子-金属有机框架杂化结构、超分子-共价-金属有机框架杂化结构及共价有机框架合成\,催化和输送功能方面的研究进展,指出了有序三维聚合物未来研究面临的挑战并展望今后的发展方向.

关键词：三维聚合物超分子有机框架杂化框架结构共价有机框架孔道有序性水溶性

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多激励作用下的矩形薄板横向非线性振动分析

振动与冲击 2016年第23期35卷 174-179页

作者：张丹伟黄建亮中山大学工学院广州510275

利用增量谐波平衡法(Incremental Harmonic Balance method,IHB法)研究在四边简支条件下,薄板在两个横向简谐激励作用下的非线性振动问题。在给出薄板振动微分方程的基础上,利用Galerkin法导出相应的Duffing型非线性强迫振动方程;引入... 详细信息

利用增量谐波平衡法(Incremental Harmonic Balance method,IHB法)研究在四边简支条件下,薄板在两个横向简谐激励作用下的非线性振动问题。在给出薄板振动微分方程的基础上,利用Galerkin法导出相应的Duffing型非线性强迫振动方程;引入多时间尺度变量τ_i=ω_it(i=1,2,3,…,ms),其中ωi是不可公约的非线性系统响应频率,推导了增量谐波平衡法的计算过程。作为算例,给出了不同条件下,由IHB法得到的系统运动的位移响应图、频谱图、相平面图和Poincaré图,得到了板在多激励作用下的准周期运动特性;同时,将IHB法结果与数值方法得到的结果进行对比,两者相吻合,进一步验证了该方法的精确性与有效性。

关键词：矩形薄板非线性振动增量谐波平衡法多激励力作用准周期运动

Direct ink writing of programmable functional silicone-based composites for 4D printing applications

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Interdisciplinary Materials 2022年第4期1卷 507-516页

作者： Zhiyang Lyu J.ustin Koh Gwendolyn J.H.Lim danwei zhang Ting Xiong Lei zhang Siqi Liu Junfei Duan Jun Ding John Wang Jinlan Wang Yunfei Chen Chaobin He Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjingChina Department of Materials Science and Engineering National University of SingaporeSingaporeSingapore Agency for Science Technologyand Research(A*STAR)Institute of Materials Research and EngineeringSingaporeSingapore School of Materials Science and Engineering Changsha University of Science and TechnologyChangshaChina School of Physics Southeast UniversityNanjingChina

Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and ***,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their *** we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)*** mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional *** taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic *** particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic *** study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices.

关键词： 4D printing 4D-printed batteries direct ink writing PDMS polymer-derived ceramics