检索结果-南通市图书馆

World Journal of Emergency Medicine 2024年第3期15卷 229-231页

作者： Yi Yao Na Xu Xiaofang Tang ce zhang Sida Jia Jingjing Xu Ying Song Xueyan Zhao Runlin Gao Jinqing Yuan center for Coronary Heart Disease National Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Acute myocardial infarction (AMI) has been associated with poor prognosis,even after revascularization with percutaneous coronary intervention (PCI),likely due to coronary endothelial cell dysfunction and injury.^([1,2])Endothelin-1 (ET-1),a peptide that serves as a vasoconstrictor of smooth muscle cell proliferation,can reflect endothelial cell functional *** to low circulation levels and short plasma half-life time,measuring plasma ET-1 levels is *** contrast,big ET-1.

关键词： coronary percutaneous endothelin

在线全文

学校读者我要写书评

暂无评论

银行业的跨地联通与区域协同发展

系统工程理论与实践 2023年第1期43卷 1-19页

作者：薛畅何青张策武汉大学经济与管理学院武汉430072 中国人民大学财政金融学院长江经济带研究院北京100872 中国社会科学院金融研究所北京100710

本文基于中国的银行业机构网点数据,研究了地区间银行业联通程度对于中国区域协同发展的影响,发现银行业跨地联通度的上升显著缩小了两地经济增长的差距,促进了区域经济的协同发展,其中主要国有大型商业银行发挥了更强的作用.利用历年... 详细信息

本文基于中国的银行业机构网点数据,研究了地区间银行业联通程度对于中国区域协同发展的影响,发现银行业跨地联通度的上升显著缩小了两地经济增长的差距,促进了区域经济的协同发展,其中主要国有大型商业银行发挥了更强的作用.利用历年城市商业银行改组合并的工具变量控制了内生性后,基准结论仍稳健.进而,本文还以地震和新冠疫情作为风险冲击的案例,发现我国银行体系特别是主要国有大型商业银行能够显著分担灾害对受灾地的负面经济影响.这与发达国家面临灾害冲击时银行体系所产生的加剧受灾地资金外逃、扩大受灾地与外地经济发展差距的作用,形成了鲜明对比.这深化了有关银行体系在中国宏观经济中风险分担功能的研究,从风险分担的视角阐释了银行体系对区域协同发展的影响,对强化金融对实体经济的支持、提升区域间经济发展协调性提供了重要启示.

关键词：银行业联通度金融体系区域协同发展风险分担

Digital Transformation of Higher Education:History and Consensus,Trends and Experiences,Issues and Challenges

在线全文

学校读者我要写书评

暂无评论

计算机教育 2023年第12期 167-179页

作者： ce zhang Peng Liu Yubin Wang Meng Wei the Academic Affairs Office Harbin Institute of Technology(Weihai)Weihai264209China the School of Computer Science and Technology Harbin Institute of Technology(Weihai)Weihai264209China

The rapid development of new-generation information technology has triggered the evolution of education and teaching towards digitalization,accelerating the digital transformation of higher education and bringing an important opportunity for the high-quality development of higher ***,we give an overview of the digital development of higher education and discuss how information technology is reshaping the teaching and learning of higher ***,we explain the consensus on the digital development of higher education,and focus on summarizing the digital achievements of higher education in China and analyzing the successful experience through the introduction of the digital development trend of higher education in the ***,we point out the current problems and challenges and make a preliminary *** empowerment has arrived,and in the era of digitization,the transformation and development of higher education will lead to systemic changes in *** is an inevitable stage in the process of higher education *** transformation will drive higher education to be more competitive,inclusive,and accessible,enabling universities to unleash their digital vitality in various service functions and contribute to the construction of a digital China.

关键词： Higher education Digital transformation Education digitalization strategy and action Metaverse Smart education

Exploring the mechanism of Yishen Daluo decoction in the treatment of multiple sclerosis based on network pharmacology and in vitro experiments

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 186-195页

作者： Shuo Cheng ce zhang Qingyuan Cai Xinghua Wang Zhaoheng Liu Peng Wei Xu Wang Yan Tan Qian Hua School of Life Sciences&School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Biomedical Informatics University of Texas Health Science Center at HoustonHoustonTX77030USA

Objective:To explore the mechanism and related active components of Yishen Daluo decoction(YSDLD)in treating multiple sclerosis(MS).Methods:Targets of YSDLD were collected through the TCMSP,Chemistry,and TCMID *** MS targets were collected through OMIM,DrugBank,Gencards,TTD,and Pharmgkb *** built“componentetarget”network diagrams and proteineprotein interaction(PPI)diagrams and performed topological *** targets were subjected to GO and KEGG enrichment *** docking verification was conducted on selected targets and ***,in vitro experiments were ***2 cells were induced by lipopolysaccharide for model ***8 experiment was conducted to explore the effect of YSDLD and RT-qPCR technology was used to explore the expression of key ***:There were 184 active components in YSDLD and 898 targets of its *** were 940 MS targets,and 215 targets were shared by YSDLD and *** to the“componentetarget”diagram,the top five key components included quercetin,kaempferol,beta-sitosterol,stigmasterol,and ***-6,IL-1 b,TNF-α,AKT1,and VEGFA were the important targets identified by PPI network to-pology analysis.A total of 564 functions were identified by GO enrichment analysis(Pcell body,protein phosphatase binding,and cytokine *** enrichment analysis enriched 98 pathways(Pcentration of 20 m g/mL had no effect on BV2 ***-qPCR indicated that YSDLD at the concentrations of 15 m g/mL and 20 m g/mL alleviated LPS-induced inflammatory injury and lowered the content of inflammatory factors(P<0.05).Conclusion:In this paper,the network pharmacology and in vitro experiments were used to explore the potential mechanism of YSDLD in treating *** research provides a good basis for the development of YSDLD and drugs for MS in future.

关键词： Yishen Daluo decoction Multiple sclerosis Network pharmacology Molecular docking BV2 cell

Teaching Model Integrating Online and Offline in Real Time ——An Exploration of New Teaching Mode for Regular Epidemic Prevention and Control

在线全文

学校读者我要写书评

暂无评论

计算机教育 2022年第12期 106-113页

作者： ce zhang Yongyuan Jiang Peng Liu Meng Wei Academic Affairs Office Harbin Institute of Technology(Weihai)Weihai264209China School Office Harbin Institute of Technology(Weihai)Weihai264209China

During epidemic,students in medium-risk or high-risk areas are unable to return to school on *** response to this new challenge,there is an urgent need to create a new teaching mode to offer on-line courses to those absent from the offline classes,and we propose a model integrating online and offline *** is based on“dual-camera”method,which allows off-campus students to virtually build up a physical classroom scenario on campus through computers and mobile *** this model,students can participate in class *** order to enhance the engagement of off-campus online students,emphasis is placed on interactive *** are required to design their teaching in advance and to work in collaboration with multiple departments,then using information technology and suitable teaching methods to enable students to participate in physical classroom *** model has been tested in practice and has been successful in meeting the ***,4 areas for improvement and refinement are identified.

关键词： Epidemic prevention and control New normal state MOOC Online and offline integrated teaching model

Exploration on MOOC Teaching Pilot College Construction Planning

在线全文

学校读者我要写书评

暂无评论

计算机教育 2021年第12期 81-88页

作者： ce zhang Dianhui Chu Zhenzhou Ji Songlin Gu Academic Affairs Office Harbin Institute of Technology(Weihai)Weihai264209China the School of Computer Science and Technology Harbin Institute of Technology(Weihai)Weihai264209China

The spread and innovative application of MOOC in China has rapidly triggered a profound revolution in the curriculum construction and teaching reform of universities,promoting significant results in teaching and talent *** on the practice of“MOOC teaching pilot colleges”carried out by the China University Computer Education MOOC Consortium in some universities in China,this paper proposes the overall plan of MOOC teaching pilot colleges construction through the analysis of typical cases,pointing out the purpose and significance of the reform of the pilot college and giving the relevant concepts and *** thesis focuses on the reform of teaching methods,assessment methods,grade calculation and credit recognition,and stress assessment,emphasizing the need for a three-dimensional process management of teachers,students,and college teaching administrators,and the need to focus on institutional development to provide *** teaching pilot colleges should reform and innovate in practice,and they should keep solving the problems they encounter and deepen the reform,so as to provide useful experiences and reference practices for the landing and high-quality development of MOOC teaching in more universities.

关键词： MOOC pilot college construction planning teaching reform institutional protection

在线全文

学校读者我要写书评

暂无评论

少齿差环板式减速器的弹性动力学分析

机械工程学报 2008年第2期44卷 118-123,128页

作者：张俊宋轶民张策天津大学机械工程学院天津300072

综合考虑环板、高速轴、齿轮副、轴承的变形和偏心套的误差,构造少齿差环板式减速器的变形协调条件,并结合动态子结构法建立该类传动系统的弹性动力学模型。通过求解系统的弹性动力学方程,获得减速器各环节的真实受力状况及系统的低阶... 详细信息

综合考虑环板、高速轴、齿轮副、轴承的变形和偏心套的误差,构造少齿差环板式减速器的变形协调条件,并结合动态子结构法建立该类传动系统的弹性动力学模型。通过求解系统的弹性动力学方程,获得减速器各环节的真实受力状况及系统的低阶固有特性。弹性动力学仿真结果表明,环板和高速轴支承轴承的弹性对减速器关键零部件的受力状况有较大影响,其中对高速轴行星轴承寿命的影响尤为明显;动力输入方式对系统的动力学性能影响很大,相同参数条件下双动力输入系统的受力性能要优于单输入系统。基于ANSYS的有限元模态分析结果与弹性动力学仿真结果吻合较好,表明所建立的少齿差环板式减速器弹性动力学模型具有较高的计算精度。

关键词：少齿差环板式减速器弹性动力学变形协调条件

在线全文

学校读者我要写书评

暂无评论

机械工程学科:发展简史和演化模式

高等工程教育研究 2017年第5期65卷 42-45,77页

作者：张策天津大学·机械工程学院

本文在简要回顾机械工程学科发展简史的基础上,重点剖析了机械工程发展为一个庞大学科的过程中所经历的四种演化模式。对这段历史的回顾与剖析应能被借鉴于今天的学科建设之中。

关键词：机械工程学科演化模式学科建设规划

Long-term outcome of percutaneous or surgical revascularization with and without prior stroke in patients with threevessel disease

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第8期19卷 583-593页

作者： Na XU ce zhang Lin JIANG Jing-Jing XU Ru LIU Ying SONG Xue-Yan ZHAO Lian-Jun XU Run-Lin GAO Bo XU Jin-Qing YUAN Lei SONG center for Coronary Heart Disease National Clinical Research Center for Cardiovascular DiseasesNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVE To determine whether high-risk patients with three-vessel disease(TVD)with and without prior stroke preferen-tially benefit from three strategies[percutaneous coronary intervention(PCI),coronary artery bypass grafting(CABG)and medical therapy(MT)].METHODS A total of 8943 patients with TVD were included in the *** enrolled were stratified into two categories according to the presence or absence of prior stroke *** primary endpoint was all-cause *** endpoints in-cluded stroke and major adverse cardiac and cerebrovascular event(MACce),a composite of death,myocardial infarction(MI),unplanned revascularization and *** Prior stroke was present in 888 patients(9.9%).These patients were older and had higher rates of ***-ring a median follow-up of 7.5 years,patients with prior stroke were strongly associated with increased risks of all-cause death,cardiac death,stroke and MACce,even after adjusting for confounding variables and results been consistent across either treat-ment subgroup(PCI,CABG and MT)(all adjusted Pce of all-cause death and MACce compared with MT alone,and favorable rates of MACce,MI and unplanned revascularization in the CABG group compared with the PCI group,but with similar rate of all-cause death regardless of prior stroke *** prevalence of stroke was significantly higher after CABG when compared with PCI or MT in no prior stroke patients[hazard ratio(HR)=1.429,95%CI:1.132-1.805 for CABG ***;HR=1.703,95%CI:1.371-2.116 for CABG ***].CONCLUSIONS Patients with TVD and prior stroke have poor clinical *** is essential to balance benefit and risk when determining the optimal treatment strategy for TVD with and without prior stroke.

关键词： patients prior founding

Does Percutaneous Coronary Intervention on Off Days have an Effect on Long-term Prognosis in Patients with Coronary Artery Disease in China?

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第5期34卷 387-394页

作者： LIU Ru GAO Li Jian XU Ou zhang ce JIA Si Da QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Pulmonary Vascular and General Medicine Fuwai Yunnan Cardiovascular HospitalKunming 650102YunnanChina

As generally known,many hospitals provide routine care on weekdays but only emergency or urgent care on holidays and *** staffing is numerically reduced on holidays and weekends,as well as the available expertise on *** onset of acute myocardial infarction (AMI) on off days was reported to be associated with higher short-term mortality[1,2].

关键词： routine Coronary mortality