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Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-Fan zhang Qian Chen Qin Jiang qiong-Ying Hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

Hypoxia promotes pulmonary vascular remodeling via HIF-1α to regulate mitochondrial dynamics

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Journal of Geriatric Cardiology 2019年第12期16卷 855-871页

作者： Xi CHEN Jia-Mei YAO Xia FANG Cui zhang Yu-Shu YANG Cheng-Ping HU qiong CHEN Guang-Wei zhong National Center for Clinical Medicine for Geriatric Diseases Xiangya HospitalCentral South UniversityChangshaChina Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangshaChina Department of Geriatrics Xiangya HospitalCentral South UniversityChangshaChina International Medical Center Xiangya HospitalCentral South UniversityChangshaChina

Background Increasing research suggests that mitochondrial defect plays a major role in pulmonary hypertension(PH) pathogenesis. Mitochondrial dynamics and quality control have a central role in the maintenance of the cell proliferation and apoptosis balance. However, the molecular mechanism underlying of this balance is still unknown. Methods To clarify the biological effects of hypoxic air exposure and hypoxia-inducible factor-1α(HIF-1α) on pulmonary arterial smooth muscle cell(PASMC) and pulmonary arterial hypertension rats, the cells were cultured in a hypoxic chamber under oxygen concentrations. Cell viability, reactive oxygen species level, cell death, mitochondrial morphology, mitochondrial membrane potential, mitochondrial function and mitochondrial biosynthesis, as well as fission-and fusion-related proteins, were measured under hypoxic conditions. In addition, rats were maintained under hypoxic conditions, and the right ventricular systolic pressure, right ventricular hypertrophy index and right ventricular weight/body weight ratio were examined and recorded. Further, we assessed the role of HIF-1α in the development and progression of PH using HIF-1α gene knockdown using small interfering RNA transfection. Mdivi-1 treatment was performed before hypoxia to inhibit dynamin-related protein 1(Drp1). Results We found that HIF-1α expression was increased during hypoxia, which was crucial for hypoxia-induced mitochondrial dysfunction and hypoxia-stimulated PASMCs proliferation and apoptosis. We also found that targeting mitochondrial fission Drp1 by mitochondrial division inhibitor Mdivi-1 was effective in PH model rats. The results showed that mitochondrial dynamics were involved in the pulmonary vascular remodeling under hypoxia in vivo and in vitro. Furthermore, HIF-1α also modulated mitochondrial dynamics in pulmonary vascular remodeling under hypoxia through directly regulating the expression of Drp1. Conclusions In conclusion, our data suggests that abnorm

关键词： Dynamin-related protein 1 Hypoxia Hypoxia-inducible factor-1α Mitochondrial dynamics Pulmonary vascular remodeling

Spoof surface plasmon polaritons excited leaky-wave antenna with continuous scanning range from endfire to forward

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Chinese Physics B 2020年第9期29卷 320-325页

作者： Tao zhong Hou zhang Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China

A novel leaky-wave antenna(LWA)utilizing spoof surface plasmon polaritons(SSPPs)excitation is proposed with continuous scanning range from endfire to *** designed transmission line unit supports two SSPPS modes,of which the 2nd order mode is applied in the design.A novel strategy has been devised to excite the spatial radiation of the-1st order harmonics by arranging periodic counter changed sinusoidal structures on both sides of the SSPPs transmission *** full-wave simulation and measurement results show that the proposed LWA presents wide scanning angle from endfire to *** the frequency range from 4 GHz to 10 GHz,LWAs achieve scanning from 90°to+20°,covering the entire backward quadrant continuously.

关键词： leaky-wave antenna spoof surface plasmon polaritons wide scanning-angle

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动车组齿轮箱油中硫含量的红外光谱分析

光谱学与光谱分析 2025年第1期45卷 239-245页

作者：杜瑾瑶贺石中杨智宏张琳颖张静茹广州机械科学研究院有限公司设备润滑与检测研究所广东广州510530 工业摩擦润滑技术国家地方联合工程研究中心广东广州510530

针对高铁动车组牵引系统中齿轮箱润滑油中硫元素损失较快的问题,需要对在用齿轮油硫含量进行监测,以确定最佳的换油时机。分析了红外光谱图中齿轮油含硫添加剂特征吸收峰的衰减机制;选择与硫含量相关性最高的1164 cm-1特征峰的峰高作为... 详细信息

针对高铁动车组牵引系统中齿轮箱润滑油中硫元素损失较快的问题,需要对在用齿轮油硫含量进行监测,以确定最佳的换油时机。分析了红外光谱图中齿轮油含硫添加剂特征吸收峰的衰减机制;选择与硫含量相关性最高的1164 cm-1特征峰的峰高作为输入变量构建了一元线性回归模型(LR),采用5折交叉验证下的测试集R^(2)确定最佳主成分个数构建了偏最小二乘回归模型(PLSR),最后根据偏最小二乘回归系数优选了6个特征吸收峰用于构建特征峰优化后的PLSR模型(RF-PLSR)。采用所建的模型分别对预测集39个油样进行预测,结果表明一元线性回归模型和偏最小二乘回归模型均具有很好的预测能力。一元线性回归模型的预测R^(2)为0.961,RMSE为973.1,RPD为5.084。PLSR模型和特征峰优化后的RF-PLSR模型的预测R^(2)分别为0.997和0.994,RMSE分别为250.1和376.3,RPD分别为19.780和13.149。说明经过特征峰优化后建立的RF-PLSR模型在降低模型复杂度的同时,仍可以保持较高的精度和预测能力,由于消除了不相关变量的信息,使模型的可解释性更好。红外光谱技术为齿轮油中硫含量的检测提供了一种可靠而精确的方法,为齿轮油的状态监测提供一种可行的解决方案。

关键词：齿轮箱油硫含量红外光谱在用油监测

Improvement on Hot Workability of γ-TiAl Base Alloy

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Journal of Iron and Steel Research International 2001年第1期8卷 45-49页

作者： SU Xi LI Shi-qiong MA Wan-qing zhong Zeng-yong Central Iron & Steel Research Institute

A constitutive equation reflecting the flow behavior of Superalloy In718 during the counter blow hammer forging process was developed in terms of the relationship of flow stress and hot deformation parameters, such as strain, strain rate, and deformation temperature. A new simplified approach for the complex multi pass stress strain curves has been attempted. The simulation curves calculated by constitutive equation are consistent with the experimental data.

关键词： Superalloy In718 constitutive equation hammer forging

Epigenetics of hepatocellular carcinoma:Role of microRNA

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World Journal of Gastroenterology 2013年第33期19卷 5439-5445页

作者： Sharad Khare qiong zhang Jamal A Ibdah Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Missouri Harry S Truman Memorial Veterans’ Hospital

Hepatocellular carcinoma(HCC)represents a major form of primary liver cancer in ***(miRs),small non-coding single-stranded RNAs of 19-24nucleotides in length,negatively regulate the expression of many target genes at the post-transcriptional and/or translational levels and play a critical role in the initiation and progression of *** this review we have summarized the information of aberrantly expressed miRs in HCC,their mechanism of action and relationship to *** recent advances in HCC research reveal that miRs regulate expression of various oncogenes and tumor suppressor genes,thereby contributing to the modulation of diverse biological processes including proliferation,apoptosis,epithelial to mesenchymal transition and *** a clinical viewpoint,polymorphisms within miR-binding sites are associated with the risk of *** in miR related genes have been shown to correlate with survival or treatment outcome in ***,the review focuses on the potential role of miRs as novel biomarkers and their translational applications for diagnosis and therapy in *** further insights into miR deregulation in HCC,it is expected that novel miR-based therapeutics will ***,we orient the readers to other reviews that may provide better understanding of miR research in HCC.

关键词： MicroRNA Cancer Hepatocellular carcinoma Biomarker Polymorphism

Research on linear/nonlinear viscous damping and hysteretic damping in nonlinear vibration isolation systems

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 983-998页

作者： zhong zhang Muqing NIU Kai YUAN Yewei zhang Science and Technology on Reliability and Environment Engineering Laboratory Beijing Institute of Structure and Environment EngineeringBeijing 100076China School of Science Harbin Institute of TechnologyShenzhen 518055China College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China

A nonlinear vibration isolation system is promising to provide a high-efficient broadband isolation *** this paper,a generalized vibration isolation system is established with nonlinear stiffness,nonlinear viscous damping,and Bouc-Wen(BW)hysteretic *** approximate analytical analysis is performed based on a harmonic balance method(HBM)and an alternating frequency/time(AFT)domain *** evaluate the damping effect,a generalized equivalent damping ratio is defined with the stiffness-varying characteristics.A comprehensive comparison of different kinds of damping is made through numerical *** is found that the damping ratio of the linear damping is related to the stiffness-varying characteristics while the damping ratios of two kinds of nonlinear damping are related to the responding *** linear damping,hysteretic damping,and nonlinear viscous damping are suitable for the small-amplitude,medium-amplitude,and large-amplitude conditions,*** hysteretic damping has an extra advantage of broadband isolation.

关键词： vibration isolation nonlinear damping Bouc-Wen(BW)model harmonic balance method(HBM)

Global patterns of phosphorus transformation in relation to latitude,temperature and precipitation

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Pedosphere 2021年第1期31卷 214-220页

作者： Jia-zhong zhang Ocean Chemistry and Ecosystems Division Atlantic Oceanographic and Meteorological LaboratoryNational Oceanic and Atmospheric AdministrationMiami FL 33149USA

Dear Editor,Phosphorus (P) is essential and often a limiting nutrient for biological production on land and in the seas (Elser et al., 2007). The biologically available P to terrestrial and aquatic ecosystems ultimate... 详细信息

关键词： latitude phosphorus transformation

An Extended Dielectric Crack Model for Fracture Analysis of a Thermopiezoelectric Strip

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Acta Mechanica Solida Sinica 2020年第4期33卷 521-545页

作者： Xianci zhong Yuanbo Wu Keshi zhang School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China School of Mathematics and Information Science Guangxi UniversityNanning 530004China

An extended dielectric crack model is proposed to capture the effects of the physical properties of crack interior on crack-tip thermoelectroelastic *** typical crack-face boundary conditions can be retrieved by considering the limiting cases of electrical permeability and thermal conductivity inside a *** use of the Fourier transform technique,the problem of a thermopiezoelectric strip weakened by a Griffith crack is investigated and transformed to solve the system of the second kind Fredholm integral equations with Cauchy *** Lobatto-Chebyshev collocation method is used to form a nonlinear system of algebraic equations,which is solved by elaborating on an *** crack-tip thermoelectroelastic fields are determined by using the approximate *** simulations are carried out to show the variations of the fracture parameters of concern under applied thermoelectromechanical loads,the physical properties of the dielectric medium inside the crack and the geometry of the cracked thermopiezoelectric *** comparisons with the experimental results are reported to reveal the effectiveness of the extended dielectric crack model.

关键词： Extended dielectric crack model Thermopiezoelectric strip Fourier transform technique Crack-tip field.Experimental comparison