Epigenetics of hepatocellular carcinoma:Role of microRNA

作     者：Sharad Khare Qiong Zhang Jamal A Ibdah 

作者机构：Division of Gastroenterology and HepatologyDepartment of Internal MedicineUniversity of Missouri Harry S Truman Memorial Veterans’ Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第33期

页      面：5439-5445页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by VA Merit Award project ID 1171590 NCI Cancer Prevention RO3 Grant CA150081-03 to Khare S Raymond E and Vaona H Peck Chair in Cancer Research to Ibdah JA 

主　　题：MicroRNA Cancer Hepatocellular carcinoma Biomarker Polymorphism 

摘      要：Hepatocellular carcinoma(HCC)represents a major form of primary liver cancer in ***(miRs),small non-coding single-stranded RNAs of 19-24nucleotides in length,negatively regulate the expression of many target genes at the post-transcriptional and/or translational levels and play a critical role in the initiation and progression of *** this review we have summarized the information of aberrantly expressed miRs in HCC,their mechanism of action and relationship to *** recent advances in HCC research reveal that miRs regulate expression of various oncogenes and tumor suppressor genes,thereby contributing to the modulation of diverse biological processes including proliferation,apoptosis,epithelial to mesenchymal transition and *** a clinical viewpoint,polymorphisms within miR-binding sites are associated with the risk of *** in miR related genes have been shown to correlate with survival or treatment outcome in ***,the review focuses on the potential role of miRs as novel biomarkers and their translational applications for diagnosis and therapy in *** further insights into miR deregulation in HCC,it is expected that novel miR-based therapeutics will ***,we orient the readers to other reviews that may provide better understanding of miR research in HCC.