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Olfactory.dy.function and its related molecular mechanisms in Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 583-590页

作者： y.ngy.ng Gu Jiay.ng zhang x.nru Zhao Weny.an Nie x.aole x. Mingx.an Liu x.aoling zhang College of Pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes in olfactory.function are considered to be early.biomarkers of Parkinson’s *** dy.function is one of the earliest non-motor features of Parkinson’s disease,appearing in about 90%of patients with early.stage Parkinson’s disease,and can often predate the diagnosis by.***,olfactory.dy.function should be considered a reliable marker of the ***,the mechanisms responsible for olfactory.dy.function are currently.*** this article,we clearly.ex.lain the pathology.and medical definition of olfactory.function as a biomarker for early.stage Parkinson’s *** the basis of the findings of clinical olfactory.function tests and animal model ex.eriments as well as neurotransmitter ex.ression levels,we further characterize the relationship between olfactory.dy.function and neurodegenerative diseases as well as the molecular mechanisms underly.ng olfactory.dy.function in the pathology.of early.stage Parkinson’s *** findings highlighted in this review suggest that olfactory.dy.function is an important biomarker for preclinical-stage Parkinson’s ***,therapeutic drugs targeting non-motor sy.ptoms such as olfactory.dy.function in the early.stage of Parkinson’s disease may.prevent or delay.dopaminergic neurodegeneration and reduce motor sy.ptoms,highlighting the potential of identify.ng effective targets for treating Parkinson’s disease by.inhibiting the deterioration of olfactory.dy.function.

关键词： biomarker early.stage olfactory.disorders olfactory.dy.function Parkinson’s disease

Reducing the voltage loss of y.series acceptor based organic solar cells via ternary.quaternary.strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengy. zhang Zhiy.ng zhang Heng Sun Jie Li y. Chen Jiang Wang Chuanlang Zhan Key.Laboratory.of Advanced Materials Chemistry.and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent y.ars, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have ex.eeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key.factors limiting further improvement in the PCEs of *** ternary.quaternary.strategy.has been identified as a feasible and effective way.to obtain high-efficiency.*** this review, a brief outline is given of the key.roles that guest materials play.d in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary.quaternary.sy.tems.

关键词： Organic solar cell Ternary.quaternary.strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

On the evolutionary.trail of MagRs

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Zoological Research 2024年第4期45卷 821-830页

作者： Jing zhang y.fei Chang Peng zhang y.nqi zhang Mengke Wei Cheny.ng Han Shun Wang Hui-Meng Lu Tiantian Cai Can x.e High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Phy.ical Science and Information Technology Anhui UniversityHefeiAnhui 230039China School of Life Sciences Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Magnetic sense,or termed magnetoreception,has evolved in a broad range of tax. within the animal kingdom to facilitate orientation and ***,highly.conserved A-ty.e iron-sulfur proteins,are widely.distributed across all phy.a and play.essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary.origins and functional diversification of MagRs from their prokary.tic ancestor remain *** this study.MagR sequences from 131 species,ranging from bacteria to humans,were selected for analy.is,with 23 representative sequences covering species from prokary.tes to Mollusca,Arthropoda,Osteichthy.s,Reptilia,Aves,and mammals chosen for protein ex.ression and *** studies revealed a gradual increase in total iron content in MagRs during *** ty.es of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity.and protein stability.indicating continuous ex.ansion of the functional roles of MagRs during speciation and *** evolutionary.biochemical study.provides valuable insights into how evolution shapes the phy.ical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary.trajectories of MagRs.

关键词： Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary.biochemistry

Circadian rhy.hm dy.function and psy.hopathology.in the offspring of parents with bipolar disorder:a highrisk study.in the Chinese population

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General Psy.hiatry 2024年第3期37卷 388-400页

作者： Binbin Lei Hongliang Feng Lulu y.ng Jing Wang Jie Chen Weidong Song Chao Jiang Kun zhang Qunfeng Wang Jessie Chi Ching Tsang Ngan y.n Chan y.ping Liu Joey.W.y.Chan Jiy.ng Pan Bin zhang Tao Li Kathleen Ries Merikangas Jihui zhang y.n Kwok Wing Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Guangdong Mental Health Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina Li Chiu Kong Family.Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Psy.hiatry Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong KongChina Key.Laboratory.of Neurogenetics and Channelopathies of Guangdong Province and the Ministry.of Education of China Guangzhou Medical UniversityGuangzhouGuangdongChina Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center) ShenzhenChina Department of Clinical Psy.hology Shenzhen Fuyong People's HospitalShenzhenChina Department of Mental Illness Prevention and Treatment Shenzhen Longgang Center for Chronic Diseases ControlShenzhenChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Sleep Medical Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Psy.hiatry Nanfang HospitalSouthern Medical UniversityGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangzhouGuangdongChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhouZhejiangChina Genetic Epidemiology.Research Branch Intramural Research ProgramNational Institute of Mental HealthBethesdaMarylandUSA

Background Understanding the evolution of circadian rhy.hm dy.function and psy.hopathology.in the high-risk population has important implications for the prevention of bipolar ***,some of the previous studies on the emergence of psy.hopathologies and circadian dy.function among high-risk populations were inconsistent and *** To ex.mine the prevalence rates of sleep and circadian dy.functions,mental disorders and their sy.ptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study.included 191 O-BD and 202 O-control subjects aged 6-21 y.ars from the Greater Bay.Area,*** diagnoses and sy.ptoms of sleep/circadian rhy.hm and mental disorders were assessed by.the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,*** estimating equations and shared frailty.proportional hazards models of survival analy.is were applied to compare the outcomes in the *** Adjusting for age,sex.and region of recruitment,there was a significantly.higher risk of delay.d sleep phase sy.ptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly.fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anx.ety.6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood sy.ptoms(20.74%vs 10.40%,adjusted OR:2.59)than *** analy.is revealed that O-BD children(aged under 12 y.ars)had a nearly.2-fold higher risk of any.mental and behavioural sy.ptoms than O-control,while there was a nearly.4-fold higher risk of delay.d sleep phase sy.ptoms,a 7.5-fold higher risk of social anx.ety.and a 3-fold higher risk of mood sy.ptoms in O-BD adolescents(aged 12 y.ars and over).Conclusions There was an increase in delay.d sleep phase sy.ptoms in O-BD

关键词： prevention dy.function bipolar

Influence of Nd^(3+) concentration on mid-infrared emission in PbF_(2) cry.tal co-doped with Ho^(3+) and Nd^(3+) ions

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Journal of Rare Earths 2024年第3期42卷 479-487,I0002页

作者： y.n Chen Juncheng Tan Peix.ong zhang Weibi Zheng Lin Li Lianhan zhang Zhen Li y.n Hang Zhenqiang Chen Department of Optoelectronic Engineering Jinan UniversityGuangzhou510632China Guangdong Provincial Engineering Research Centerof Cry.tal and Laser Technology.Guangzhou 510632China Research Center of Laser Cry.tal Key Laboratory of High Power Laser MaterialsShanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai201800China

A promising series of Ho_(y.Nd_(x.Pb_((1-x.y.)F_2(x.= 0, 0.01, 0.02, 0.03, 0.04;y.= 0.02) cry.tals was grown by.the Bridgman method. The influence of the Nd^(3+)ions concentration on mid-infrared(~2.0, ~2.9 and ~3.9 μm)fluorescence emissions of Ho^(3+)ions in the PbF_(2) cry.tal ex.ited by.808 nm laser diode was investigated in this work. The energy.transfer mechanism between Nd^(3+)ions and Ho~(3+)ions under different concentrations of the Nd^(3+)ions was sy.tematically.analy.ed. The results show that the Nd^(3+)ions have good sensitization and deactivation effect on the Ho^(3+)ions to stimulate the mid-infrared fluorescence emissions. The ex.erimental analy.is proves that the sensitization efficiency.of the Nd^(3+)ions is relatively.stable at around 93.45% with vary.ng Nd^(3+)-doping concentrations. Concentration dependence studies indicate that the concentration of the Nd^(3+)ions has significant influence on mid-infrared *** the doping concentration of the Nd^(3+)ions is up to 2.0 at%, the intensity.of ~2.0, ~2.9 and ~3.9 μm emissions all reach the max.mum. The output characteristics of a 3.9 μm laser are simulated, and it is found that with the increase of the Nd^(3+)-doping concentration, the peak power, pulse width, and peak energy.all meet the trend of first increasing and then decreasing, and Ho_(0.02)Nd_(0.02)Pb_(0.96)F_(2) cry.tal display. the best performance. All the results show that the Nd^(3+)/Ho^(3+)co-doped PbF_(2) cry.tals might act as a useful optical medium for mid-infrared laser applications.

关键词： Cry.tal growth Mid-infrared PbF_(2) Rare earth ions

Species recognition and the divergences in the chemical and ultrasonic signals between two coex.sting Rattus species

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Current Zoology 2024年第4期70卷 531-538页

作者： Wei-Chao Wang Zhi-Ming Li y. Chen Jin-Hua zhang Jian-x. zhang y.o-Hua zhang The State Key.Laboratory.of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAs Center for Ex.ellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The ability.to recognize and differentiate between conspecifics and heterospecifics as well as their signals is critical for the coex.stence of closely.related *** the genus Rattus,species are morphologically.similar and multiple species often ***,we investigated the interspecific recognition and signal differentiation of two sy.patric rat species,the brown rat(Rattus norvegicus,RN)and the Asian house rat(Rattus tanezumi,RT).In a two-way.choice test,both RN and RT females showed a preference for conspecific male rats to heterospecific *** females showed a significant preference for accessible urine of males of same species to those of other species,but not for the inaccessi-ble *** the other hand,there were significant differences in the structural characteristics of the ultrasonic vocalization emitted by.males of these two rat *** dodecy. sulphate-poly.cry.amide gel electrophoresis(SDS-PAGE)and isoelectric focusing electrophoresis unveiled that major urinary.proteins(MUPs)in voided urine were more highly.ex.ressed in RN males versus RT *** interspecific dif-ferences of urinary.volatile compounds were also *** conclusion,female rats had the ability.to distinguish between males of either species.

关键词： Asian house rats brown rats closely.related species pheromones ultrasonic vocalization.

Changes of nutrients and microbial communities in recovery.process of abandoned rare earth tailings

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Pedosphere 2024年第4期34卷 826-836页

作者： Bing zhang Junli WU Mengy.an HUANG y.n zhang Jin ZHAO Chuntao HE Zhongy. y.NG School of Environmental Science and Engineering Sun Yat-sen University School of Life Sciences Sun Yat-sen University School of Agriculture State Key Laboratory for Biocontrol Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University

Rare earth element（REE） mining has wrought severe ecosy.tem destruction, particularly.in the loss of carbon（C）, nitrogen（N）, and phosphorus（P）.Furthermore, its effects on nutrient recovery.characteristics and associated microbial abundance are still poorly.understood. In this study. an investigation was conducted to determine C, N, and P recovery.patterns and microbial communities in abandoned REE mining tailings with different abandoned durations of 1.5（1.5-y., 7（7-y., 10（10-y., and 14（14-y. y.ars and at an unmined site（the control group） in Jiangx. Province, China. Longitudinal tailing delamination at each site was investigated in 0–15（lay.r 1） and 15–30（lay.r 2） cm tailing lay.rs. During the abandoned duration of REE tailings, C and P in lay.r 1continued to recover from 1.62 to 8.51 g kg-1and from 0.71 to 1.94 g kg-1, respectively. N losses of 0.60 and 0.22 g kg-1occurred at the 1.5-y.and 10-y.sites, while N in lay.r 1 slightly.increased at the 14-y.site. Mesorhizobium, Methy.osinus, Brady.hizobium, Pseudomonas, and Azospirillum were dominant bacteria at the 14-y.site and in the control. The relative abundances of N-fix.ng bacteria Mesorhizobium（32.94%）, Sinorhizobium（0.24%）, Frankia（0.71%）,and Burkholderia（2.38%） at the 14-y.site were 1.33–3.97 times those in the control（24.19%, 0.18%, 0.32% and 0.60%, respectively., which was helpful for tailing N recovery. At the 14-y.site, Ty.ospora（50.24%）, Luellia（11.02%）, Tomentella（6.94%）, and Chaetomium（4.34%） were the dominant fungal genera, while Ty.ospora（56.93%）, Suillus（11.45%）, and Penicillium（6.78%） predominated in the control. The relative abundance of the P-dissolving fungus Aspergillus at the 14-y.site（0.42%） was 4.2 times that in the control（0.1%）, which may.lead to the improved tailing P solubility. At the 14-y.site, woody.plants such as Pinus massoniana and native pioneering herbs and ferns such as Dicranopteris dichotoma and Nephrolepis auriculata probably.invaded from adjacent areas. This study.unraveled t

关键词： abandoned durations N-fix.ng microorganisms nutrients (C, N, P) P-solubilizing fungi REEs mining tailing

变暖背景下黄河源区气候响应特征及对径流的影响

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中国科学：地球科学 2024年第3期54卷 862-873页

作者：张一然周德刚郭晓峰中国科学院大气物理研究所季风系统研究中心北京100029 中国科学院大学北京100049 中国科学院大气物理研究所大气边界层物理和大气化学国家重点实验室北京100029

在全球变暖背景下,过去几十年里黄河源区的气候和径流发生了明显变化,影响着黄河流域的水资源和生态环境安全.利用唐乃亥水文站的径流数据、黄河源区及周边气象台站的观测数据以及多种蒸散发数据集,本文分析了黄河源区径流和部分气候因... 详细信息

在全球变暖背景下,过去几十年里黄河源区的气候和径流发生了明显变化,影响着黄河流域的水资源和生态环境安全.利用唐乃亥水文站的径流数据、黄河源区及周边气象台站的观测数据以及多种蒸散发数据集,本文分析了黄河源区径流和部分气候因子的变化情况,结果显示:黄河源区径流在1960~1989年相对偏多,此后径流锐减;2005年后有所恢复,但相对于1960~1989年仍然偏少10%;源区降水变化与径流变化相似,在20世纪90年代相对偏少,但2003年后明显增加且比1960~1989年平均增加31.4mm,相对偏多6%;黄河源区气温在1960~2017年持续增加, 1990年后蒸散发也呈上升趋势.进一步分析了黄河源区气候因子时空变化对径流的影响,结果表明:1990~2002年间源区降水量和强降水发生频数的减少是导致该时段径流偏少的重要原因;2003年以后源区东南部主要产流区的降水增加有限但整个源区蒸散发随温度升高而普遍增加,使得源区各子区域的实际产流能力可能依然偏低,导致源区径流持续偏少.黄河源区的这种气候响应将不利于未来径流的增加,希望本研究能为变暖背景下黄河源区及黄河流域水资源的未来规划和管理提供参考.

关键词：黄河源区气候响应径流变化蒸散发降水

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Sy.thesis of Diverse Ox.tane Amino Acids via Visible-Light-Induced Photocataly.ic Decarbox.0}ative Giese-Ty.e Reaction

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Chinese Journal of Chemistry 2024年第12期42卷 1341-1346页

作者： Haoliang Shi y. Wan y.ngqiang zhang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Key Laboratory of New Drug Designand School of PharmacyEast China University of Science and TechnologyShanghai200237 China

The divergent sy.thesis of versatile 3,3′-disubstituted ox.tane amino acids by.utilizing visible-light-induced photocataly.ic decarbox.0}ative Giese-ty.e reaction has been demonstrated.3-Methy.eneox.tane-derived substrates are readily.available in a single-step and highly.reactive as radical acceptors,allowing the production of versatile ox.taneγ-andα-amino acids in high y.elds.A distinct ring strain release-driven radical addition mechanism was preliminarily.*** preparative power was further highlighted by.the application in the sy.thesis of ox.tane-containing dipeptides and azetidine amino acids,as well as the transformation of the product into novel ox.tane-containing spiro-heterocy.le pharmacophore.

关键词： Photoredox.cataly.is Decarbox.0}ative Giese-ty.e reaction Ox.tane amino acids Amino acids Sy.thesis Radical reactions