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Effectiveness of Lianhua Qingwen Granule and Jingyin Gubiao Prescription in Omicron BA.2 Infection and Hospitalization:A Real-World Study of 56,244 Cases in Shanghai,China

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Chinese Journal of Integrative Medicine 2025年第1期31卷 11-18页

作者： zhang Yu-jie LIU Guo-jian zhang Han LIU Chen CHEN Zhi-qiang XIAN Ji-shu SONG Da-li LIU Zhi YANG xue WANG Ju zhang Zhe zhang Lu-ying FENG Hua zhang Yan-qi TAN Liang Department of Basic Medicine Army Medical UniversityChongqing400038China Department of Radiology The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Pediatrics The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Neurosurgery The First Affiliated Hospital of the Army Medical UniversityChongqing400038China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR519000China Department of Health Statistics College of Military Preventive MedicineArmy Medical UniversityChongqing400038China Department of Critical Care Medicine The First Affiliated Hospital of the Army Medical UniversityChongqing400038China

Objective: To examine the effectiveness of Chinese medicine(CM) Lianhua Qingwen Granule(LHQW) and Jingyin Gubiao Prescription(JYGB) in asymptomatic or mild patients with Omicron infection in the shelter hospital. Methods: This single-center retrospective cohort study was conducted in the largest shelter hospital in Shanghai, China, from April 10, 2022 to May 30, 2022. A total of 56,244 asymptomatic and mild Omicron cases were included and divided into 4 groups, i.e., non-administration group(23,702 cases), LHQW group(11,576 cases), JYGB group(12,112 cases), and dual combination of LHQW and JYGB group(8,854 cases). The length of stay(LOS) in the hospital was used to assess the effectiveness of LHQW and JYGB treatment on Omicron infection. Results: Patients aged 41–60 years, with nadir cycle threshold(CT) value of N gene <25, or those fully vaccinated preferred to receive CM therapy. Before or after propensity score matching(PSM), the multiple linear regression showed that LHQW and JYGB treatment were independent influence factors of LOS(both P<0.001). After PSM, there were significant differences in LOS between the LHQW/JYGB combination and the other groups(P<0.01). The results of factorial design ANOVA proved that the LHQW/JYGB combination therapy synergistically shortened LOS(P=0.032). Conclusions: Patients with a nadir CT value <25were more likely to accept CM. The LHQW/JYGB combination therapy could shorten the LOS of Omicron-infected individuals in an isolated environment.

关键词： Lianhua Qingwen Granule Jingyin Gubiao Prescription Chinese medicine Omicron COVID-19

术中输注氨基酸对胃肠道手术患者脂代谢和体温的影响

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复旦学报（医学版） 2010年第4期37卷 437-441,446页

作者：钟静葛圣金庄小凤仓静薛张纲复旦大学附属中山医院麻醉科上海200032

目的研究术中静脉输注氨基酸对在硬膜外阻滞复合全麻下行胃肠道手术患者脂肪代谢和体温的影响。方法选择择期行胃肠道手术患者32例,ASAⅠ~Ⅱ级,随机分成两组（n=16）：分别在麻醉诱导同时输注18-氨基酸混合液4 ***-1.h-1（即2 ***-1.h-1... 详细信息

目的研究术中静脉输注氨基酸对在硬膜外阻滞复合全麻下行胃肠道手术患者脂肪代谢和体温的影响。方法选择择期行胃肠道手术患者32例,ASAⅠ~Ⅱ级,随机分成两组（n=16）：分别在麻醉诱导同时输注18-氨基酸混合液4 ***-1.h-1（即2 ***-1.h-1,AA组）和乳酸钠林格氏液2 ***-1.h-1（LR组）直至手术结束。监测麻醉前30 min,诱导后手术开始前,手术开始后30 min、2 h,手术结束后30 min、2 h的鼻咽温度,血清胆固醇、三酰甘油、游离脂肪酸（free fatty acid,FFA）浓度和血酮体的变化。结果两组术中鼻咽温度均呈下降趋势,但AA组手术开始后2 h鼻咽温度显著高于LR组（P〈0.05）,手术结束后两组温度有所回升,AA组手术结束后2 h鼻咽温度[（36.89±0.13）℃]较麻醉前30 min[（36.98±0.13）℃]差异无统计学意义（P〉0.05）,且显著高于LR组[（36.10±0.15）℃]（P〈0.05）,LR组仍显著低于麻醉前30 min[（37.04±0.15）℃]（P〈0.05）;两组术中血清胆固醇浓度均呈下降趋势,手术开始后30 min至手术结束后2 h浓度较麻醉前30 min显著降低（P〈0.05）,而两组间差异无统计学意义（P〉0.05）;诱导后手术开始前两组的血清三酰甘油浓度均较术前显著升高（P〈0.05）,LR组手术结束后2 h浓度[（0.71±0.27）mmol/L]较麻醉前30 min[（0.99±0.38）mmol/L]显著降低（P〈0.05）,而在AA组差异无统计学意义（P〉0.05）;两组手术开始后30 min2、h血清FFA浓度均显著低于麻醉前30 min（P〈0.05）,且AA组[（0.52±0.15,0.42±0.09）mmol/L]显著低于LR组[（0.81±0.24,0.82±0.22）mmol/L,P〈0.05],而手术结束后2 h浓度AA组[（1.04±0.28）mmol/L]显著高于LR组[（0.82±0.16）mmol/L,P〈0.05];两组围术期各时间点血酮体均为阴性。结论术中输注氨基酸可减少硬膜外阻滞复合全麻下行胃肠道手术患者体温的降低,并抑制脂肪动员。

关键词：氨基酸体温脂代谢硬膜外麻醉全身麻醉胃肠道手术

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen xue xue-Qing Zhou Zhi-Hui Su Xin-Ran zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian Xia xue-Min zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

A Study for Inter-Satellite Cooperative Computation Offloading in LEO Satellite Networks

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China Communications 2025年第2期22卷 12-25页

作者： gang Yuanshuo zhang Yuexia Wu Peng Zheng Hui Fan Guangteng Key Laboratory of Modern Measurement and Control Technology Ministry of EducationBeijing Information Science and Technology UniversityBeijing 102206China 2 National Innovation Institute of Defense Technology Academy of Military ScienceBeijing 100071China

Low Earth orbit(LEO)satellite networks have the advantages of low transmission delay and low deployment cost,playing an important role in providing reliable services to ground *** paper studies an efficient inter-satellite cooperative computation offloading(ICCO)algorithm for LEO satellite ***,an ICCO system model is constructed,which considers using neighboring satellites in the LEO satellite networks to collaboratively process tasks generated by ground user terminals,effectively improving resource utilization ***,the optimization objective of minimizing the system task computation offloading delay and energy consumption is established,which is decoupled into two *** terms of computational resource allocation,the convexity of the problem is proved through theoretical derivation,and the Lagrange multiplier method is used to obtain the optimal solution of computational *** deal with the task offloading decision,a dynamic sticky binary particle swarm optimization algorithm is designed to obtain the offloading decision by *** results show that the ICCO algorithm can effectively reduce the delay and energy consumption.

关键词： computation offloading inter-satellite co-operation LEO satellite networks

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海洋波导条件下矢量反转镜空间相关特性

声学技术 2008年第3期27卷 333-337页

作者：韩晶周祖华张学刚大连测控技术研究所水下测控技术国防科技重点实验室大连116013

利用简正波理论,对海洋波导条件下的矢量反转镜空间相关特性进行理论分析,并利用10Hz～200Hz低频宽带信号进行仿真计算。仿真结果表明,当仿真信道与实际信道完全匹配时信道相关出现最大峰值,且峰值所在位置即为声目标所在位置。据此给... 详细信息

利用简正波理论,对海洋波导条件下的矢量反转镜空间相关特性进行理论分析,并利用10Hz～200Hz低频宽带信号进行仿真计算。仿真结果表明,当仿真信道与实际信道完全匹配时信道相关出现最大峰值,且峰值所在位置即为声目标所在位置。据此给出矢量反转镜被动定位仿真实例。

关键词：海洋波导矢量反转镜空间相关

几种地下水易污性评价方法在徐州张集地区的应用

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水利水电科技进展 2006年第4期26卷 46-49,86页

作者：毛媛媛张雪刚南京大学环境学院江苏南京210093 河海大学水资源环境学院江苏南京210098

选择GOD法、DRASTIC法S、INTACS法及SI法4种易污性评价方法用于徐州张集地区的地下水易污性评价,应用GIS/ARCINFO输出张集地区的地下水易污性指标图。不同易污性评价方法对张集地区裂隙岩溶地下水的易污性评价得到了不同的结论,经分析,S... 详细信息

选择GOD法、DRASTIC法S、INTACS法及SI法4种易污性评价方法用于徐州张集地区的地下水易污性评价,应用GIS/ARCINFO输出张集地区的地下水易污性指标图。不同易污性评价方法对张集地区裂隙岩溶地下水的易污性评价得到了不同的结论,经分析,SI法更适用于张集地区的实际情况。具体应用时,要根据评价地区的实际条件,并和评价地区污染监测情况结合,选择合适的易污性评价方法评价地下水的易污性。

关键词：地下水易污性评价方法张集地区

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渐开线圆柱齿轮全参数化精确建模研究

组合机床与自动化加工技术 2013年第7期 46-48,57页

作者：张学刚谢永春西华大学机械工程与自动化学院成都610039 攀枝花学院机械工程学院四川攀枝花617000

根据渐开线齿轮的形成原理和齿轮啮合原理推导出包含齿根过度曲线的齿轮齿廓曲线的参数化数学模型,在MATLAB中分模块编写精确齿廓曲线、轴孔曲线的程序,根据输入不同的齿轮参数自动生成多种齿轮的两端面轮廓、引导线、齿轮轴孔轮廓和键... 详细信息

根据渐开线齿轮的形成原理和齿轮啮合原理推导出包含齿根过度曲线的齿轮齿廓曲线的参数化数学模型,在MATLAB中分模块编写精确齿廓曲线、轴孔曲线的程序,根据输入不同的齿轮参数自动生成多种齿轮的两端面轮廓、引导线、齿轮轴孔轮廓和键槽轮廓的数据点并存储在ibl格式文件中,将ibl格式文件修改后导入Pro/E,通过简单处理便可生成全参数化精确直齿圆柱齿轮或斜齿圆柱齿轮的三维模型,从而大大提高了齿轮设计的精度和效率,并为后续的齿轮仿真分析奠定基础。

关键词： MATLAB Pro E 齿轮参数化建模

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu zhang gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota

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World Journal of Gastroenterology 2025年第7期31卷 110-129页

作者： Yi-Tong Qiu Xin-Yi Luo Ya-Feng Deng xue Zheng Jian-Guo Qiu Lin-Sheng zhang Xiao-Qi Huang xue-Bao Zheng Hai-Yang Huang School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 525000Guangdong ProvinceChina Druggability Research Team Dongguan Institute of Guangzhou University of Chinese MedicineDongguan 523808Guangdong ProvinceChina Institute of Traditional Chinese Medicine Dongguan Hospital of Traditional Chinese MedicineDongguan 523000Guangdong ProvinceChina

BACKGROUND Modified Pulsatilla decoction(PD),a PD with licorice and ejiao,is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis(IM)induced by tumor ***,its specific molecular and biological mechanisms remain *** To investigate the therapeutic effect and mechanism of modified PD in *** This study used an IM mouse model established using 5-fluorouracil injections to investigate the effects of the modified PD(3,6,and 12 g/kg)in *** primary chemical components of the modified PD were identified using liquid chromatography-mass *** weight loss,diarrhea scores,intestinal length,histopathological scores,and inflammatory cytokine levels were measured to evaluate the effects of the modified PD in *** on the TLR4/MyD88/NF-κB pathway were evaluated using western blot *** intestinal microbiota was characterized using Illumina NovaSeq *** The results showed that modified PD significantly improved weight loss and diarrhea and shortened the intestines in IM ***,modified PD suppressed the TLR4/MyD88/NF-κB pathway and downregulated the expression of reactive oxygen species,lipopolysaccharides,and pro-inflammatory cytokines(IL-1β,TNF-α,IFN-γ,IL-6,IL-8,and IL-17),while increasing the expression of the anti-inflammatory cytokine ***,modified PD protected the intestinal mucosal barrier by increasing the expression of tight junction proteins(occludin-1,claudin-1,and ZO-1)and ***,16S rDNA sequencing revealed that modified PD improved intestinal *** Our research offers new insights into the potential mechanism of modified PD in alleviating IM and provides experimental evidence supporting its pharmaceutical application in clinical IM treatment.

关键词： Modified Pulsatilla decoction Intestinal mucositis Oxidative stress Gut microbiota,TLR4/MyD88/NF-κB pathway Inflammatory response