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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers

Journal of Animal Science and Biotechnology 2024年第5期15卷 1918-1931页

作者： xinrui zhang Tong Xing Lin zhang Liang Zhao Feng Gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNo.1 WeigangNanjingJiangsu 210095P.R.China

Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens *** examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)***,the underlying mechanisms responsible for the formation of WB in broilers have not been fully *** study aimed to investigate the potential role of hypoxia-mediated programmed cell death(PCD)in the formation of WB *** Histological examination and biochemical analysis were performed on the PM muscle of the control(CON)and WB groups.A significantly increased thickness of the breast muscle in the top,middle,and bottom portions(P<0.01)was found along with pathological structure damage of myofibers in the WB *** number of capillaries per fiber in PM muscle,and the levels of p O_(2) and s O_(2) in the blood,were significantly decreased(P<0.01),while the levels of p CO_(2) and TCO_(2) in the blood were significantly increased(P<0.05),suggesting hypoxic conditions in the PM muscle of the WB *** further evaluated the PCD-related pathways including autophagy,apoptosis,and necroptosis to understand the consequence response to enhanced hypoxic conditions in the PM muscle of birds with *** ratio of LC3 II to LC3 I,and the autophagy-related factors HIF-1α,BNIP3,Beclin1,AMPKα,and ULK1 at the m RNA and protein levels,were all significantly upregulated(P<0.05),showing that autophagy occurred in the PM muscle of the WB *** apoptotic index,as well as the expressions of Bax,Cytc,caspase 9,and caspase 3,were significantly increased(P<0.05),whereas Bcl-2 was significantly decreased(P<0.05)in the WB-affected PM muscle,indicating the occurrence of apoptosis mediated by the mitochondrial ***,the expressions of necroptosis-related factors RIP1,RIP3,and MLKL,as well as NF-κB and the pro-inflammatory cytokines TNF-α,IL-1β,and IL-6,were all significantly enhanced(P<0.05)in the WB-affected PM *** T

关键词： Apoptosis Autophagy Broiler chicken Hypoxia Necroptosis Wooden breast

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Unveiling the protective role of biofilm formation on the photoaging of microplastics

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Science China Technological Sciences 2024年第10期67卷 3067-3078页

作者： zhang HaiYu LIU Peng zhang JiaYu DAI JiaMin zhang xinrui zhang ZiXuan JIA HanZhong Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureCollege of Natural Resources and EnvironmentNorthwest A&F University Key Laboratory of Organic Compound Pollution Control Engineering School of Environmental and Chemical EngineeringShanghai University

In natural water, microplastics（MPs） inevitably undergo microbial colonization to form biofilm, while the effect of biofilm formation on the photoaging of MPs remains unknown. This study systematically investigated the photoaging behavior of disposable box-derived polypropylene（PPMPs） and polystyrene（PSMPs） mediated by formed biofilm in water. After incubating in Weihe water samples for 105 d, the biofilm was validated to form in PPMPs and PSMPs, with higher formation in PSMPs. In particular, biofilm formation inhibited the photoaging of PPMPs and PSMPs, with an 11.1% and 50.6% decrease in photooxidation compared to their virgin counterparts after 20 d of ultraviolet（UV） irradiation. Moreover, the photoaging route of MPs such as the reaction priority of functional groups（e.g., C–H, C=O, and benzene ring） was altered, indicating the important role of biofilm formation in the photoaging process of MPs. The protective effect of the biofilm was mainly caused by the role of optical light filters that absorbed UV energy by sacrificing themselves. Also, as the main attacker on MPs, the production of reactive oxygen species（ROS, mainly1O2and ·OH） was inhibited by biofilm, which was mainly responsible for the decreased photoaging of MPs. This study revealed the important role of biofilm in the photoaging process of MPs and suggested a higher resistance of（micro）plastics in natural water than that in the laboratory using pure MPs, which contributed to a deeper understanding of the environmental fate and pollution of MPs.

关键词： microplastics biofilm photoaging physical shielding reactive oxygen species

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Pore Formation Mechanism in W-C Hard Coatings Using Directed Energy Deposition on Tungsten Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 89-101页

作者： xinrui zhang Weijie Fu Chen Wang Zhenglong Lei Haoran Sun Xudong Li State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

Porosity is a common phenomenon and can significantly hinder the quality of the ***,the pore formation mechanism and the characteristics of the single tracks of the W-C coating using directed energy deposition(DED)are systematically *** forming quality of the tracks,the distribution of the pores,and the elemental distribution near the pores are analyzed by the observations of the cross-sections of the *** temperature field of the melt pool is discussed comprehensively to reveal the pore formation *** results confirm that Ni and Co evaporated during the DED process due to the high temperature of the melt *** were continuously produced adjacent to the fusion line when the melt pool was about to solidify since the temperature at the solidification front was higher than the boiling point of *** vaporization area at the fusion line was proposed,where Ni could also evaporate at the time the melt pool started to *** relationship between the solidification rate,the size of the vaporization area and the DED parameters(laser power and scanning speed)was established to discuss the causes of severe pores above the fusion *** work contains a practical guide to reduce or eliminate the porosity in the coating preparation process on the surface of the tungsten alloy.

关键词： Directed energy deposition(DED)process Tungsten alloy W-C coating Pores Binder phase

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Molecular design of recyclable thermosetting polyimide and its composite with excellent mechanical and tribological properties

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Friction 2024年第3期12卷 452-461页

作者： Xiaoyue WANG Zenghui YANG Tingmei WANG Qihua WANG xinrui zhang Song LI Key Laboratory of Science and Technology on Wear and Protection of Materials Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Recyclability of thermosetting polymers and their composites is a challenge for alleviating environmental pollution and resource *** this study,solvent-recyclable thermosetting polyimide(PI)and its composite were successfully *** tensile strength,elongation at break,and Young’s modulus of PI are 108.70±7.29 MPa,19.35%±3.89%,and 2336.42±128.00 MPa,*** addition of reduced graphene oxide(RGO)not only enhances the mechanical properties of PI but also endows it with excellent tribological *** PI illustrates a high recycling efficiency of 94.15%,but the recycled composite exhibits inferior mechanical *** recycling and utilization of PI and its composite are realized through imine bonds(-C=N),which provides new guidance for solving the problem of environmental pollution and resource waste and is potential application in the field of sustainable tribology.

关键词： thermosetting polyimide(PI) recyclability dynamic covalent bonds friction and wear polymer composites

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High Fischer ratio oligopeptides in food:sources,functions and application prospects

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Journal of Future Foods 2024年第2期4卷 128-134页

作者： Zhen Wang xinrui zhang Luyang Wang Xingqi Ou Jihong Huang State Key Laboratory of Crop Stress Adaptation and Improvement College of AgricultureHenan UniversityKaifeng 475004China Food Laboratory of Zhongyuan Luohe 462300China College of Life Science and Technology Henan Institute of Science and TechnologyXinxiang 453003China College of Biological Engineering Henan University of TechnologyZhengzhou 450001China School of Food and Pharmacy Xuchang UniversityXuchang 461000China

High Fischer ratio oligopeptides(HFROs)are a group of oligopeptides containing high levels of branched-chain amino acids(BCAA)and low levels of aromatic amino acids(AAA).HFROs have received a lot of attention as they are believed to have significant physiological activities,including antioxidant,liver damage repair,anti-fatigue,anti-tumor and energy supply to the *** are available from a wide range of sources and both plant and animal proteins can be used to prepare HFROs but the physiological tolerability and rejection of special populations needs to be *** hydrolysis is the most common method for the preparation of HFROs,but optimization of the separation and purification process is still needed in the *** caused by disruptions in the balance of BCAA and AAA in the blood,such as hepatic encephalopathy,can be treated by supplementing HFROs with drugs or *** addition,HFROs are able to reduce fatigue feedback and assist in the treatment of phenylketonuria at the molecular nutrient *** aim of this review is to review recent research on HFROs and provide new perspectives on the high value use of crops and the development of novel functional and special medical purpose foods.

关键词： Fischer ratio Oligopeptides Amino acids5- Hydroxytryptamine Phenylketonuria

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CNT/PVA@碳布膜的光电联合驱动界面蒸发性能研究

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化工学报 2024年第3期75卷 1028-1039页

作者：张昕锐陈雪梅南京理工大学能源与动力工程学院江苏南京210094

利用电能辅助的太阳能驱动界面蒸发技术是提高淡水产量的一个有效途径,但是如何绿色高效地获取淡水仍是一个挑战。利用带有孔洞的亚克力板作为支撑装置,在碳布上喷涂碳纳米管(CNT)和无水乙醇的混合溶液作为光热电热膜(CNT/PVA@碳布),与... 详细信息

利用电能辅助的太阳能驱动界面蒸发技术是提高淡水产量的一个有效途径,但是如何绿色高效地获取淡水仍是一个挑战。利用带有孔洞的亚克力板作为支撑装置,在碳布上喷涂碳纳米管(CNT)和无水乙醇的混合溶液作为光热电热膜(CNT/PVA@碳布),与隔热装置和供水通道组成一个高效的界面蒸发系统。蒸发性能测试结果表明,该蒸发系统在1个标准太阳光照射下净蒸发速率达到1.5 kg·m^(-2)·h^(-1),而在与2 A电流的联合作用下,净蒸发速率高达5.08 kg·m^(-2)·h^(-1),比仅在1个标准太阳光照射下和仅提供2 A电流的蒸发速率之和高出0.6 kg·m^(-2)·h^(-1)。此外,这种蒸发系统构造简单易于规模化,为绿色高效地提高淡水产量提供了一个新的思路。

关键词：光电联合光热-电热膜界面蒸发蒸发速率绿色高效

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地方人才引进政策与企业成本管理决策

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世界经济 2024年第3期47卷 124-150页

作者：金智张心睿西南财经大学会计学院四川成都611130

地方人才引进政策顺利落实到微观企业行为,对经济高质量发展至关重要。本文以地方出台人才引进政策为准自然实验,采用多期双重差分法考察了地方人才引进政策对当地企业跨期成本决策的影响。研究发现,地方人才引进政策提高了企业成本黏性... 详细信息

地方人才引进政策顺利落实到微观企业行为,对经济高质量发展至关重要。本文以地方出台人才引进政策为准自然实验,采用多期双重差分法考察了地方人才引进政策对当地企业跨期成本决策的影响。研究发现,地方人才引进政策提高了企业成本黏性,改善了跨期成本决策,优化了长期资源配置效率。其原因在于,地方人才引进政策促进了人才需求竞争的同时提高了当地企业发展信心,促使企业更加重视长期激励机制建设和长期价值投资,从而降低了企业在业务收入下降时削减资源投入的动机。本研究从微观企业成本角度揭示了地方人才引进政策影响经济实质的微观机制,既为人才政策的制定与执行提供了理论参考,也丰富了人力资本理论和成本管理方面的研究。

关键词：同人才引进政策成本黏性人力资本高质量发展

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温度应力路径对原状海洋土强度特性影响研究

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岩土工程学报 2024年第2期46卷 357-365页

作者：张鑫蕊孔纲强杨庆河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 大连理工大学海岸与海洋工程国家重点试验室辽宁大连116024 苏州科技大学土木工程学院江苏苏州215009

室内温度和海底原位温度的差异导致传统测量所得海洋土物理力学参数存在一定差异。基于温控三轴仪,对我国南海原状海洋土进行了固结不排水剪切试验,实测了海洋土体变、强度、孔压以及模量的变化,探讨温度、温度循环、围压、超固结比等... 详细信息

室内温度和海底原位温度的差异导致传统测量所得海洋土物理力学参数存在一定差异。基于温控三轴仪,对我国南海原状海洋土进行了固结不排水剪切试验,实测了海洋土体变、强度、孔压以及模量的变化,探讨温度、温度循环、围压、超固结比等因素对原状海洋土力学性质的影响规律。试验结果表明:升温梯度增大会使正常固结海洋土热固结程度增大,其对应的排水体积和强度也增大;升温对超固结海洋土的排水体积具有增强作用,而温度降低了海洋土的强度;温度循环作用对超固结海洋土的排水体积具有增强作用,其对应的强度也增大;本文试验条件下,当OCR=1时,海洋土25℃下不排水抗剪强度测量结果比5℃下测量结果提高8.0%;当OCR=4时,海洋土25℃下不排水抗剪强度测量结果比5℃下测量结果降低1.9%;经过温度循环5℃—45℃—5℃后的抗剪强度比5℃提高了11.9%;4次或10次温度循环后分别提高了13.8%和17.8%。

关键词：海洋土强度特性应力路径温度效应三轴试验

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新时代“情报学+”数智化人才的培育理路

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图书情报知识 2024年第1期41卷 58-68页

作者：张海涛张鑫蕊张春龙栾宇吉林大学商学与管理学院长春130012 吉林大学信息资源研究中心长春130012 吉林大学国家发展与安全研究院长春130012

[目的/意义]数智化时代背景下,更要求情报学学科融入新时代,积极探索数智化人才培育路径。[研究设计/方法]从认知到应用全方位策划“情报学+”数智化人才的培育理路,明晰育人体系,重点描述人才核心素养模型的搭建以及对人才培育路径的思... 详细信息

[目的/意义]数智化时代背景下,更要求情报学学科融入新时代,积极探索数智化人才培育路径。[研究设计/方法]从认知到应用全方位策划“情报学+”数智化人才的培育理路,明晰育人体系,重点描述人才核心素养模型的搭建以及对人才培育路径的思考,展现情报学育人的本土化、特色化、智慧化。[结论/发现]情报学学科未来应致力于培育服务新时代各工作领域和研究情境的复合应用型情报学人才,不断探索更完整的人才培育闭环。[创新/价值]以中国哲学思想赋能新时代情报人才培育的理论遵循和实践路径,体现哲学思想现实价值的同时,为情报学学科的未来发展提供参考。

关键词：情报学+ 数智化人才培育理路核心素养课程新体系

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基于增长混合模型的脑肿瘤患者开颅术后头痛发展轨迹分析

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山东大学学报（医学版） 2024年第6期62卷 102-107页

作者：张新蕊孙鹏李峰山东大学护理与康复学院山东济南250012 山东第一医科大学附属肿瘤医院神经外科山东济南250117

目的确定接受开颅手术治疗的脑肿瘤患者术后头痛(post-craniotomy headache,PCH)症状的轨迹。方法采用纵向研究设计,对2023年3—6月就诊于山东第一医科大学附属肿瘤医院神经外科确诊为脑肿瘤住院治疗的患者304例,在第7天、第1个月、第3... 详细信息

目的确定接受开颅手术治疗的脑肿瘤患者术后头痛(post-craniotomy headache,PCH)症状的轨迹。方法采用纵向研究设计,对2023年3—6月就诊于山东第一医科大学附属肿瘤医院神经外科确诊为脑肿瘤住院治疗的患者304例,在第7天、第1个月、第3个月使用视觉模拟评分量表(visual analogue scale,VAS)评估术后头痛症状,确定PCH发生情况,得分越高表示头痛症状越严重。使用潜增长曲线模型以及增长混合模型来确定VAS评分随时间变化及可能的潜在类别。结果304例脑肿瘤患者的VAS评分完成完整的3个月PCH随访,随访测量期间呈下降趋势且发展趋势存在3个不同的类别。加重组和稳定组分别占1.3%、19.0%,缓解组占79.6%。结论脑肿瘤患者开颅术后头痛发展存在个体差异且有3类头痛症状轨迹,了解开颅术后头痛症状的发展轨迹有助于临床对开颅术后头痛进行更科学的调控。

关键词：脑肿瘤头痛开颅手术发展轨迹增长混合模型

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