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Treatment of Lung Cancer with Orally Administered Chinese Herbal Medicine: An Evidence Map between 1970–2020

Chinese Journal of Integrative Medicine 2022年第10期28卷 930-938页

作者： GUI Yue-rong zhang Ying WANG Xue-qian FAN Bing-jie LI Jing-lei zhang Lan-xin FAN Fen CAO Kang-di zhang xiao-gang HOU Wei Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China Cancer Project Team of China Center for Evidence-Based Traditional Chinese Medicine Beijing(100053)China

Objective: Through showing the full picture of double-arm controlled clinical research and systematic review evidence in the field of orally administrated Chinese herbal medicine(CHM) for treatment of lung cancer, to provide a reference for future clinical research and to indicate a direction for future systematic reviews. Methods: A comprehensive search of clinical controlled studies was performed regarding orally administered CHM treatment for lung cancer published from January 1970 to September 2020. The language was restricted to Chinese and English. Relevant data were extracted, the quality of systematic reviews was evaluated, and the research evidence was visually displayed. Results: Randomized controlled trials were the most common type of research design. The research sample sizes were typically small. Oral CHM showed certain curative advantages in treating lung cancer. The key stages in oral CHM intervention for lung cancer are chemotherapy, radiotherapy, and late palliative treatment. The advantageous outcomes of oral CHM treatment of lung cancer are the short-term efficacy, quality of life, and adverse reactions. The perioperative stage, overall survival, pharmacoeconomic evaluation, and Chinese medicine decoctions are weak research areas. Conclusions: CHM has staged and therapeutic advantages in treating lung cancer. The overall methodological quality is poor, and the level of evidence requires improvement. It is necessary to carry out large-scale, standardized, and higherquality research in the superior and weak areas of CHM treatment of lung cancer.

关键词： Chinese medicine clinical study evidence map evidence visualization lung cancer

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日本课后体育服务“学社融合”的变迁、特征及启示

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广州体育学院学报 2024年第2期44卷 69-78页

作者：肖悦张晓林关清文陈润娟张晓刚四川师范大学体育学院四川成都610101 福建师范大学体育科学学院福建福州350108 成都体育学院足球学院四川成都610041

通过深析日本课后体育服务“学社融合”的特点,为我国课后体育服务落实“双减”政策提供有益思路。研究发现:日本课后体育服务“学社融合”的历史变迁可分为“孕育萌芽期”“持续发展期”和“成熟稳定期”,并从组织、场地和内容等课后... 详细信息

通过深析日本课后体育服务“学社融合”的特点,为我国课后体育服务落实“双减”政策提供有益思路。研究发现:日本课后体育服务“学社融合”的历史变迁可分为“孕育萌芽期”“持续发展期”和“成熟稳定期”,并从组织、场地和内容等课后体育服务共识性视角上产生了学社人才融合、学社场地融合和学社活动融合等特征,以多元主体协同治理机制、三级分权制度保障机制、分级资金共筹支持机制和多维评价监管反馈机制牵动着日本课后体育服务的运行。对我国课后体育服务的经验启示:(1)确保参与主体利益,畅通学社协同的合作渠道;(2)完善服务顶层设计,建立各司其职的管理体制;(3)明确服务供给标准,形成多渠道的资助方式;(4)建立服务评价标准,构建PDCA循环评价体系。

关键词：课后体育服务 “双减”政策学社融合课后服务日本

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2023年12月18日甘肃积石山M_(S)6.2地震多点源地震矩张量反演研究

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地震 2024年第2期44卷 169-177页

作者：刘俊清张小刚张宇蔡宏雷陈卓包秀敏吉林建筑大学测绘与勘查工程学院吉林长春130119 吉林省基础地理信息中心吉林省测绘档案资料馆吉林长春130062 吉林省地震局吉林长春130117 辽宁省地震局沈阳地震监测中心站辽宁沈阳110161

基于区域宽频带数字地震台网观测到的地震记录,采用多点源地震矩张量反演方法对2023年甘肃积石山M_(S)6.2地震进行了地震矩张量反演研究。结果显示,该地震震源机制解的NE倾的节面(走向312°,倾角48°,滑动角76°)为发震断裂,主体地震矩... 详细信息

基于区域宽频带数字地震台网观测到的地震记录,采用多点源地震矩张量反演方法对2023年甘肃积石山M_(S)6.2地震进行了地震矩张量反演研究。结果显示,该地震震源机制解的NE倾的节面(走向312°,倾角48°,滑动角76°)为发震断裂,主体地震矩从震源向地表沿滑动矢量的方向(方位角236°,倾伏角40.5°)释放,主破裂持续时间约为5.8 s,与此同时,地震破裂区断层面上发生了次级的双侧破裂。

关键词：积石山6.2级地震地震矩张量多点源发震构造

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Protective effects of edaravone on ischaemia-reperfusion injury in rabbits with haemorrhagic shock

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中华急诊医学杂志 2008年第7期17卷 717-723页

作者： SHI xiao-yan LI Lei-qing SHAO Ju-fang zhang xiao-gang QIN Guang-ming ZHOU Yan Neuroscience cience Care Unit the Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou 310009 China ICU the Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou 310009 China Editorial Department of Chinese Journal of Emergency Medicine Hangzhou 310009 China Internal Medicine Medical Association of Beaver Dam Wisconsin 53916 U. S. A Laboratory Medicine the Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou 310009 China Department of Pathology the Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou 310009 China

目的观察兔失血性休克再灌注过程中血浆丙二醛（MDA）、一氧化氮（NO）与超氧化物岐化酶（SOD）水平的动态变化，以及肺脏、肾脏病理改变；并探讨依达拉奉的保护作用。方法29只家兔全身肝素化后随机分为三组：假手术组（C组，n=7）、失... 详细信息

目的观察兔失血性休克再灌注过程中血浆丙二醛（MDA）、一氧化氮（NO）与超氧化物岐化酶（SOD）水平的动态变化，以及肺脏、肾脏病理改变；并探讨依达拉奉的保护作用。方法29只家兔全身肝素化后随机分为三组：假手术组（C组，n=7）、失血性休克再灌注组（I／R组，n=10）和依达拉奉保护组（I／R—edaravone组，n=12）。后两组制作失血性休克再灌注模型，在10min内通过左股动脉放血，维持平均动脉压（MAP）40 mmHg达到60 min。I／R-edaravone组静脉应用依达拉奉。然后开始复苏，要求在60 min内回输全部失血和等量生理盐水，使MAP维持在失血前70％以上。休克后10 h I／R—edamvone组静脉再次应用依达拉奉。在复苏后20h处死所有家兔，同时取所有兔的右肺部分组织和右肾部分组织作病理检查。分别测休克前、休克1 h、再灌注后1 h、5 h及20 h血浆MDA、SOD、NO含量。结果休克前三组动物血浆MDA、NO及SOD含量均无显著统计学差异。休克后I／R组家兔血浆MDA（5．35±0．29）μmol／L及NO（27．75±2．88）μmol／L水平均较C组的[（4．44±0．59）μmol／L，（25．01±4．95）μmol／L]要高，而I／R组的SOD水平（194．58±14．42）U／ml较C组（210．86±24．54）U／ml要低（P均〈0．01）。复苏后20h这些变化更加明显，I／R组MDA和NO水平持续增加l（5．69±0．24）μmol／L，（28．01±3．10）μmol／L，P〈0．05]，而SOD水平继续下降[（151．83±9．36）U／ml，P〈0．05]。与I／R组比较，I／R-edaravone组的MDA水平显著降低[（3．48±0．23）μmol／L，P〈0．01]，SOD水平明显升高[（19．5．10±11．87）U／ml，P〈0．01]。病理检查提示依达拉奉可以减轻肺脏和肾脏病理损害。结论依达拉奉通过清除自由基，有效减轻失血性休克再灌注过程中重要脏器的损害。

关键词：失血性休克缺血-再灌注自由基依达拉奉

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Classification of knowledge graph completeness measurement techniques

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Journal of Systems Engineering and Electronics 2024年第1期35卷 154-162页

作者： zhang Ying xiao gang Institute of Systems Engineering Academy of Military SciencesBeijing 100107China

At present,although knowledge graphs have been widely used in various fields such as recommendation systems,question and answer systems,and intelligent search,there are always quality problems such as knowledge omissions and errors.Quality assessment and control,as an important means to ensure the quality of knowledge,can make the applications based on knowledge graphs more complete and more accurate by reasonably assessing the knowledge graphs and fixing and improving the quality problems at the same time.Therefore,as an indispensable part of the knowledge graph construction process,the results of quality assessment and control determine the usefulness of the knowledge graph.Among them,the assessment and enhancement of completeness,as an important part of the assessment and control phase,determine whether the knowledge graph can fully reflect objective phenomena and reveal potential connections among entities.In this paper,we review specific techniques of completeness assessment and classify completeness assessment techniques in terms of closed world assumptions,open world assumptions,and partial completeness assumptions.The purpose of this paper is to further promote the development of knowledge graph quality control and to lay the foundation for subsequent research on the completeness assessment of knowledge graphs by reviewing and classifying completeness assessment techniques.

关键词： quality assessment completeness assessment closed world assumptions open world assumption partial completeness assumption

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TGF-β/Smads信号通路在心力衰竭心肌纤维化中的作用及中医药干预研究现状

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中国临床药理学杂志 2024年第3期40卷 444-448页

作者：霍耀辉张静周立蓉张晓刚高永泽刘黎明刘凯甘肃中医药大学中西医结合学院甘肃兰州730000 甘肃省中心医院神经内科甘肃兰州730070

在心力衰竭(HF)进展过程中,转化生长因子-β(TGF-β)/Smads信号通路的异常转导是HF心肌纤维化(MF)的重要机制。TGF-β是MF的关键因子,在HF MF过程中处于过度表达状态。Smads是TGF-β下游的主要效应因子,TGF-β/Smads通路诱导肌成纤维细... 详细信息

在心力衰竭(HF)进展过程中,转化生长因子-β(TGF-β)/Smads信号通路的异常转导是HF心肌纤维化(MF)的重要机制。TGF-β是MF的关键因子,在HF MF过程中处于过度表达状态。Smads是TGF-β下游的主要效应因子,TGF-β/Smads通路诱导肌成纤维细胞异常增殖,加重心肌细胞外基质沉积,使心脏组织抗纤维化能力减弱,在HF MF的发病机制中发挥复杂作用。中医药在防治HF MF方面具有明确抑制心肌胶原沉积、抗心肌纤维化、保护心肌和改善心脏功能等功效。TGF-β/Smads通路是中药单体、中药复方、中成药发挥HF心肌保护作用的关键通路之一。本文对近10年来中医药干预TGF-β/Smads通路治疗HF MF现有的实验研究成果进行综述,以期为HF MF的防治及新药开发提供理论依据。

关键词：中医药转化生长因子-β/Smads信号通路心力衰竭心肌纤维化作用机制

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A STUDY ON TEA-PIGMENTIN PREVENTION OF ATHEROSCLEROSIS

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CHINESE MEDICAL JOURNAL 1989年第8期102卷 579-83页

作者： Lou Fu-qing zhang Mei-fang zhang xiao-gang Liu Ji-min Yuan Wei-long CardiocerebrovascularInstituteandSecondAffiliatedHospital ZhejiangMedicalUniversity Hangzhou

Since Lou Fu-qing et al first reported that tea had effect on the prevention of atherosclerosis (AS) in the 1960s, we have conducted experimental and clinical studies, and found that tea-pigment (TP) could reduce blood coagulability, increase fibrinolysis, prevent platelet adhesion and aggregation, and decrease cholesterol content in aortic walls in vivo (P<0.01). In addition, TP was shown to inhibit the proliferation of cultured human aortic smooth muscle cells in normal and elevated LDL circumstance in vitro (P<0.01), and decreased the level of T x B2 in platcletrich plasma and remote myocardial infarction patients (P<0.01). TP can be used in the prevention of AS.

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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu xiao-Peng zhang gang Liu Wen-Dan Tan Xin-Dan zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was proposed.The digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional area.Each of these three parts was separately modeled.Using the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using VHDL-AMS.In the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area models.Furthermore,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital IC.TID experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose point.This confirms the practicality and accuracy of the proposed modeling method.The TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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How to implement a knowledge graph completeness assessment with the guidance of user requirements

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Journal of Systems Engineering and Electronics 2024年第3期35卷 679-688页

作者： zhang Ying xiao gang Institute of Systems Engineering Academy of Military SciencesBeijing 100107China

In the context of big data, many large-scale knowledge graphs have emerged to effectively organize the explosive growth of web data on the Internet. To select suitable knowledge graphs for use from many knowledge graphs, quality assessment is particularly important. As an important thing of quality assessment, completeness assessment generally refers to the ratio of the current data volume to the total data volume.When evaluating the completeness of a knowledge graph, it is often necessary to refine the completeness dimension by setting different completeness metrics to produce more complete and understandable evaluation results for the knowledge graph.However, lack of awareness of requirements is the most problematic quality issue. In the actual evaluation process, the existing completeness metrics need to consider the actual application. Therefore, to accurately recommend suitable knowledge graphs to many users, it is particularly important to develop relevant measurement metrics and formulate measurement schemes for completeness. In this paper, we will first clarify the concept of completeness, establish each metric of completeness, and finally design a measurement proposal for the completeness of knowledge graphs.

关键词： knowledge graph completeness assessment relative completeness user requirement quality management

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房颤患者血清LOXL2水平与射频消融术后复发的相关性分析

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医药论坛杂志 2024年第1期45卷 5-9,15页

作者：武英彪张小刚郝舒雯金灿金鹿宁忠平上海市浦东新区周浦医院心内科上海201318

目的探究LOXL2在房颤患者血清中的表达情况,研究其与射频消融术后复发的关系及预后作用。方法挑选2017年1月—2019年12月在上海市浦东新区周浦医院就诊的房颤患者173例,这些患者都是第一次使用射频消融术进行治疗,手术结束后开展为期6... 详细信息

目的探究LOXL2在房颤患者血清中的表达情况,研究其与射频消融术后复发的关系及预后作用。方法挑选2017年1月—2019年12月在上海市浦东新区周浦医院就诊的房颤患者173例,这些患者都是第一次使用射频消融术进行治疗,手术结束后开展为期6个月的随访,观察患者是否出现病情反复与复发,依据随访结果将患者分为两组,分别是复发组和非复发组。比较两组的临床资料及各项指标,关注血清LOXL2的情况,分析研究血清LOXL2表达情况和临床血清学指标的关系,评测影响房颤复发的因素。结果参加研究的173例房颤患者全部实施射频消融术,男性患者94例,平均年龄(66.3±10.7)岁。在手术后6个月的随访中,出现62例病情复发。相较于非复发组,房颤复发组患者血清中LOXL2明显升高,而且和体质指数、CHA2DS2-VASC评分、左心房内径(LAD)、BNP、hs-CRP、TGF-β1呈正相关,与左室射血分数(LVEF)呈负相关。运用受试者操作特征(ROC)曲线图,将房颤患者血清LOXL2水平和是否复发作为横纵坐标绘制曲线,确定房颤复发的最佳临界值是LOXL2大于470.94 ng/mL,其敏感性和特异性分别为85.5%和68.5%。多因素logistic回归分析显示,血清LOXL2(OR=1.014,95%CI:1.008~1.021,P<0.001)、BNP、hs-CRP和LVEF是射频消融术后房颤复发的独立预测因子。结论LOXL2蛋白可以作为一种房颤复发的血清生物标志物,术前高水平血清LOXL2提示射频消融术后具有较高的房颤复发风险。

关键词：心房颤动射频消融术赖氨酰氧化酶类2(LOXL2) 心房纤维化

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